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  1. Article: Nickel chloride catalyzed synthesis of pyrazoles and phthalazin-1(2H)-ones from hydrazines at room temperature

    Konwar, Manashjyoti / Saikia, Munmi / Hazarika, Roktopol / Sarma, Diganta

    Tetrahedron letters. 2022 May 25, v. 98

    2022  

    Abstract: Herein an efficient and simple protocol was developed for the synthesis of pyrazoles and phthalazin-1(2H)-ones from a common precursor hydrazines catalyzed by nickel chloride. The reactions proceeded in water at room temperature. The advantages of the ... ...

    Abstract Herein an efficient and simple protocol was developed for the synthesis of pyrazoles and phthalazin-1(2H)-ones from a common precursor hydrazines catalyzed by nickel chloride. The reactions proceeded in water at room temperature. The advantages of the protocol are that both the medicinally important scaffolds could be synthesized with low-cost catalyst, green solvent, relatively lower reaction time and superior yield of the product making the protocol synthetically very useful. Electronically diversed pyrazoles and phthalazinones could be achieved in good to excellent yields in relatively shorter reaction time.
    Keywords ambient temperature ; catalysts ; nickel ; pyrazoles ; solvents
    Language English
    Dates of publication 2022-0525
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.153842
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  2. Article: Advances in developing small molecule SARS 3CLpro inhibitors as potential remedy for corona virus infection

    Konwar, Manashjyoti / Sarma, Diganta

    Tetrahedron. 2021 Jan. 01, v. 77

    2021  

    Abstract: Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health ... ...

    Abstract Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health Organization’s (WHO’s) report, September 2020) and the number is exponentially increasing with no remedy whatsoever discovered till date. But it is not the first time this infectious viral disease has appeared, in 2002 SARS-CoV infected more than 8000 individuals of which 9.6% patients died and in 2012 approximately 35% of MERS-CoV infected patients have died. Literature reports indicate that a chymotripsin-like cystein protease (3CLᵖʳᵒ) is responsible for the replication of the virus inside the host cell. Therefore, design and synthesis of 3CLᵖʳᵒ inhibitor molecules play a great impact in drug development against this COVID-19 pandemic. In this review, we are discussing the anti-SARS effect of some small molecule 3CLᵖʳᵒ inhibitors with their various binding modes of interactions to the target protein.
    Keywords Coronavirus infections ; Severe acute respiratory syndrome coronavirus ; World Health Organization ; design ; drug development ; infection ; literature ; mortality ; pandemic ; patients ; people ; proteinases ; respiratory tract diseases ; synthesis ; viruses ; China
    Language English
    Dates of publication 2021-0101
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2020.131761
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  3. Article: Advances in developing small molecule SARS 3CL

    Konwar, Manashjyoti / Sarma, Diganta

    Tetrahedron

    2020  Volume 77, Page(s) 131761

    Abstract: Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health ... ...

    Abstract Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health Organization's (WHO's) report, September 2020) and the number is exponentially increasing with no remedy whatsoever discovered till date. But it is not the first time this infectious viral disease has appeared, in 2002 SARS-CoV infected more than 8000 individuals of which 9.6% patients died and in 2012 approximately 35% of MERS-CoV infected patients have died. Literature reports indicate that a chymotripsin-like cystein protease (3CL
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2020.131761
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  4. Article ; Online: Preparation of a novel environmentally friendly hydrophobic deep eutectic solvent ChCl-THY and its application in removal of hexavalent chromium from aqueous solution.

    Rajput, Mohit Kumar / Konwar, Manashjyoti / Sarma, Diganta

    Water environment research : a research publication of the Water Environment Federation

    2021  Volume 93, Issue 10, Page(s) 2250–2260

    Abstract: A liquid-liquid extraction methodology was developed for the removal of Cr(VI) from contaminated water using a novel green hydrophobic deep eutectic solvent (DES) as an efficient sole extracting agent. The hydrophobic DES was obtained by mixing choline ... ...

    Abstract A liquid-liquid extraction methodology was developed for the removal of Cr(VI) from contaminated water using a novel green hydrophobic deep eutectic solvent (DES) as an efficient sole extracting agent. The hydrophobic DES was obtained by mixing choline chloride and thymol in 1:4 molar ratio at 70°C for 10 min and was denoted as ChCl-THY(1:4). The ChCl-THY(1:4) works efficiently for removal of high (20 mg/L) and low (500 µg/L) concentration of Cr(VI) from artificially contaminated natural water with >95% extraction efficiency (E%) at optimized reaction conditions (pH 2-6, 40°C). The DES was characterized by
    MeSH term(s) Chromium ; Hydrophobic and Hydrophilic Interactions ; Solvents ; Water
    Chemical Substances Solvents ; Water (059QF0KO0R) ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9)
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098976-6
    ISSN 1554-7531 ; 1047-7624 ; 1061-4303
    ISSN (online) 1554-7531
    ISSN 1047-7624 ; 1061-4303
    DOI 10.1002/wer.1597
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  5. Article: Synthetic advances in C(sp2)-H/N–H arylation of pyrazole derivatives through activation/substitution

    Konwar, Manashjyoti / Hazarika, Roktopol / Sarma, Diganta

    Tetrahedron. 2021 Dec. 03, v. 102

    2021  

    Abstract: N-heterocyclic compounds and their biological activities are very well known to every researcher. Out of all N-heterocycles, pyrazole is one of the important N-heterocyclic compounds which is a planar five membered aromatic ring with six delocalized π- ... ...

    Abstract N-heterocyclic compounds and their biological activities are very well known to every researcher. Out of all N-heterocycles, pyrazole is one of the important N-heterocyclic compounds which is a planar five membered aromatic ring with six delocalized π-electrons. As there are various synthetic routes available in literature for the synthesis of pyrazoles, we put our effort for C(sp²)-H arylation of pyrazole derivatives. In this review, we try to describe C(sp²)-H arylation in various positions of pyrazole ring (C-3, C-4, C-5 and N–arylation) through activation or substitution and their medicinal properties associated with it. As the literature reveals, such kind of C(sp²)-H and N–H arylated pyrazoles possess astonishing medicinal properties, they can be firmly incorporated into novel drug molecules which is enough for these molecules to promote themselves as an interesting topic in the present era.
    Keywords aromatic compounds ; arylation ; drugs ; pyrazoles ; researchers
    Language English
    Dates of publication 2021-1203
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2021.132504
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  6. Article: Hydrophobic natural deep eutectic solvent THY-DA as sole extracting agent for arsenic (III) removal from aqueous solutions

    Rajput, Mohit Kumar / Konwar, Manashjyoti / Sarma, Diganta

    Environmental technology & innovation. 2021 Nov., v. 24

    2021  

    Abstract: This study was aimed to develop a methodology for removal of toxic arsenite (As³＋) species from contaminated aqueous solution using hydrophobic natural deep eutectic solvent (NADES) as a sole extracting agent. Herein, thymol (THY) and decanoic acid (DA) ... ...

    Abstract This study was aimed to develop a methodology for removal of toxic arsenite (As³＋) species from contaminated aqueous solution using hydrophobic natural deep eutectic solvent (NADES) as a sole extracting agent. Herein, thymol (THY) and decanoic acid (DA) based hydrophobic NADESs THY-DA (1:1), THY-DA (2:1) and THY-DA (1:2) were prepared. THY-DA (1:2) offers advantageous physicochemical properties in comparison of other two DESs, therefore, employed as the sole extracting agent for removal of As³＋ species in natural water conditions. More than 90 % extraction efficiency (E%) for As³＋ was attained for high (5 mg/L) as well as low (100 μg/L) concentration at optimal extraction conditions (100 mg of DES, 6 min sonication, pH 6.5–7, 25 °C). DES was characterised by nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopy. Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectroscopy (EDS) techniques were used to confirm the presence of arsenic in the DES phase. Physicochemical properties such as density, melting point, moisture and solubility of DESs were also investigated. The DES was regenerated using 0.1 M HCl as stripping agent and reused thrice without observing any significant drop in extraction efficiency (E%). The FTIR spectra of the DES phase were recorded before and after the extraction of As³＋ species to better comprehend the extraction mechanism.
    Keywords Fourier transform infrared spectroscopy ; aqueous solutions ; arsenic ; arsenites ; decanoic acid ; energy-dispersive X-ray analysis ; environmental technology ; hydrophobicity ; nuclear magnetic resonance spectroscopy ; pH ; solubility ; solvents ; sonication ; thymol ; toxicity
    Language English
    Dates of publication 2021-11
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2352-1864
    DOI 10.1016/j.eti.2021.102017
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  7. Article ; Online: Advances in Developing Small Molecule SARS 3CL(pro) Inhibitors as Potential Remedy for Corona Virus Infection

    Konwar, Manashjyoti / Sarma, Diganta

    Tetrahedron

    Abstract: Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health ... ...

    Abstract Originated in China, coronavirus disease 2019 (COVID-19)- the highly contagious and fatal respiratory disease caused by SARS-CoV-2 has already infected more than 29 million people worldwide with a mortality rate of 3.15% (according to World Health Organization’s (WHO’s) report, September 2020) and the number is exponentially increasing with no remedy whatsoever discovered till date. But it is not the first time this infectious viral disease has appeared, in 2002 SARS-CoV infected more than 8000 individuals of which 9.6% patients died and in 2012 approximately 35% of MERS-CoV infected patients have died. Literature reports indicate that a chymotripsin-like cystein protease (3CL(pro)) is responsible for the replication of the virus inside the host cell. Therefore, design and synthesis of 3CL(pro) inhibitor molecules play a great impact in drug development against this COVID-19 pandemic. In this review, we are discussing the anti-SARS effect of some small molecule 3CL(pro) inhibitors with their various binding modes of interactions to the target protein.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.tet.2020.131761
    Database COVID19

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  8. Article: Preparation of a novel environmentally friendly hydrophobic deep eutectic solvent ChCl‐THY and its application in removal of hexavalent chromium from aqueous solution

    Rajput, Mohit Kumar / Konwar, Manashjyoti / Sarma, Diganta

    Water environment research. 2021 Oct., v. 93, no. 10

    2021  

    Abstract: A liquid–liquid extraction methodology was developed for the removal of Cr(VI) from contaminated water using a novel green hydrophobic deep eutectic solvent (DES) as an efficient sole extracting agent. The hydrophobic DES was obtained by mixing choline ... ...

    Abstract A liquid–liquid extraction methodology was developed for the removal of Cr(VI) from contaminated water using a novel green hydrophobic deep eutectic solvent (DES) as an efficient sole extracting agent. The hydrophobic DES was obtained by mixing choline chloride and thymol in 1:4 molar ratio at 70°C for 10 min and was denoted as ChCl‐THY(1:4). The ChCl‐THY(1:4) works efficiently for removal of high (20 mg/L) and low (500 µg/L) concentration of Cr(VI) from artificially contaminated natural water with >95% extraction efficiency (E%) at optimized reaction conditions (pH 2–6, 40°C). The DES was characterized by ¹H NMR and FTIR spectroscopy, and the data suggest that interaction occurs between Cl⁻ ion of choline chloride and H atoms of thymol molecules. Physicochemical properties such as density, melting point, moisture, and solubility were studied and discussed. Herein, no sharp melting point was observed for ChCl‐THY(1:4) in DSC curve. DES was regenerated using 0.1 M NaOH as stripping agent, and 50%–60% extraction efficiency could be attained in the next cycle. A plausible mechanism of interaction between Cr(VI) species and DES was also explored with the help of FTIR spectroscopy. PRACTITIONER POINTS: A novel hydrophobic DES (ChCl‐THY) is prepared by mixing choline chloride and thymol at 1:4 molar ratio. ChCl‐THY(1:4) is employed for the first time as sole extracting agent to remove the Cr(VI) from contaminated aqueous solution. >95% extraction efficiency was achieved by ChCl‐THY(1:4) in natural water conditions at µg/L and mg/L level of contamination. Both the component used to prepare the DES are naturally abundant; hence, DES is not toxic for biota. The element present in natural water did not show any interference with extraction of Cr(VI).
    Keywords Fourier transform infrared spectroscopy ; aqueous solutions ; choline chloride ; chromium ; environment ; hydrophobicity ; liquid-liquid extraction ; pH ; research ; solubility ; solvents ; thymol ; toxicity ; water ; water pollution
    Language English
    Dates of publication 2021-10
    Size p. 2250-2260.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1098976-6
    ISSN 1554-7531 ; 1047-7624 ; 1061-4303
    ISSN (online) 1554-7531
    ISSN 1047-7624 ; 1061-4303
    DOI 10.1002/wer.1597
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    Z 4344: Show issues

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  9. Article: A Low-Cost, Well-Designed Catalytic System Derived from Household Waste "Egg Shell": Applications in Organic Transformations.

    Konwar, Manashjyoti / Chetia, Mitali / Sarma, Diganta

    Topics in current chemistry (Cham)

    2019  Volume 377, Issue 1, Page(s) 6

    Abstract: A waste feedstock-derived economical basic alternative catalyst is described in this review. Eggshell is one of the household wastes created in tons of weight daily. Therefore, in order to reduce the environmental pollution-related problems, its use in ... ...

    Abstract A waste feedstock-derived economical basic alternative catalyst is described in this review. Eggshell is one of the household wastes created in tons of weight daily. Therefore, in order to reduce the environmental pollution-related problems, its use in heterogeneous catalysis can be attributed as a great contribution for the chemical and material science society to carry out several known reactions and for the much-needed energy alternative biodiesel production as low-cost catalytic system. Keeping green chemistry in mind, industrial use of these catalysts may also reduce the use of other traditionally used high-cost chemical catalytic systems.
    MeSH term(s) Animals ; Biofuels/economics ; Biofuels/supply & distribution ; Catalysis ; Egg Shell/chemistry ; Garbage ; Recycling/economics
    Chemical Substances Biofuels
    Language English
    Publishing date 2019-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2848485-X
    ISSN 2364-8961 ; 2365-0869
    ISSN (online) 2364-8961
    ISSN 2365-0869
    DOI 10.1007/s41061-018-0230-3
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  10. Article: A green protocol for peptide bond formation in WEB

    Konwar, Manashjyoti / Abdul Aziz Ali / Diganta Sarma

    Tetrahedron letters. 2016 May 25, v. 57

    2016  

    Abstract: A simple, efficient, and environmentally friendly approach has been developed for the synthesis of peptides in aqueous medium. In this work, peptides are easily synthesized in water extract of banana (WEB)/ethylene glycol and without using external base ... ...

    Abstract A simple, efficient, and environmentally friendly approach has been developed for the synthesis of peptides in aqueous medium. In this work, peptides are easily synthesized in water extract of banana (WEB)/ethylene glycol and without using external base under mild condition.
    Keywords bananas ; chemical reactions ; chemical structure ; organic compounds ; peptides
    Language English
    Dates of publication 2016-0525
    Size p. 2283-2285.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2016.04.041
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