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Article ; Online: mtDNA caught in the act again.

McArthur, Kate / Kile, Benjamin T

2024 Volume 26, Issue 2, Page(s) 177–178

MeSH term(s)	DNA, Mitochondrial/genetics ; Mitochondria/genetics
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-024-01345-7
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Article: Apoptotic mitochondria prime anti-tumour immunity.

McArthur, Kate / Kile, Benjamin T

Cell death discovery

2020 Volume 6, Issue 1, Page(s) 98

Language	English
Publishing date	2020-10-07
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-020-00335-6
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Article ; Online: Resolving mitochondrial cristae: introducing a new model into the fold.

McArthur, Kate / Ryan, Michael T

The EMBO journal

2020 Volume 39, Issue 14, Page(s) e105714

Abstract: The many functions of mitochondria-the powerhouses of our cells-are intimately linked with their ultrastructure and network morphology. In this issue, Stephan et al (2020) apply a tour de force of microscopic techniques to examine the contributions of ... ...

Abstract	The many functions of mitochondria-the powerhouses of our cells-are intimately linked with their ultrastructure and network morphology. In this issue, Stephan et al (2020) apply a tour de force of microscopic techniques to examine the contributions of specific mitochondrial proteins to crista architecture.
MeSH term(s)	Mitochondria/genetics ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Chemical Substances	Mitochondrial Proteins
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	News ; Comment
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2020105714
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Article ; Online: Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.

Saunders, Tahnee L / Windley, Simon P / Gervinskas, Gediminas / Balka, Katherine R / Rowe, Caitlin / Lane, Rachael / Tailler, Maximilien / Nguyen, Thanh Ngoc / Ramm, Georg / Lazarou, Michael / De Nardo, Dominic / Kile, Benjamin T / McArthur, Kate

Cell death and differentiation

2024 Volume 31, Issue 3, Page(s) 335–347

Abstract: During apoptosis mediated by the intrinsic pathway, BAX/BAK triggers mitochondrial permeabilization and the release of cytochrome-c, followed by a dramatic remodelling of the mitochondrial network that results in mitochondrial herniation and the ... ...

Abstract	During apoptosis mediated by the intrinsic pathway, BAX/BAK triggers mitochondrial permeabilization and the release of cytochrome-c, followed by a dramatic remodelling of the mitochondrial network that results in mitochondrial herniation and the subsequent release of pro-inflammatory mitochondrial components. Here, we show that mitochondrial herniation and subsequent exposure of the inner mitochondrial membrane (IMM) to the cytoplasm, initiates a unique form of mitophagy to deliver these damaged organelles to lysosomes. IMM-induced mitophagy occurs independently of canonical PINK1/Parkin signalling and is driven by ubiquitination of the IMM. Our data suggest IMM-induced mitophagy is an additional safety mechanism that cells can deploy to contain damaged mitochondria. It may have particular relevance in situations where caspase activation is incomplete or inhibited, and in contexts where PINK1/Parkin-mitophagy is impaired or overwhelmed.
MeSH term(s)	Humans ; Mitophagy ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Mitochondrial Membranes/metabolism ; Protein Kinases/metabolism
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-024-01260-2
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Article ; Online: Apoptotic Caspases: Multiple or Mistaken Identities?

McArthur, Kate / Kile, Benjamin T

Trends in cell biology

2018 Volume 28, Issue 6, Page(s) 475–493

Abstract: The mitochondrial caspase cascade was originally thought to be required for apoptotic death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non-apoptotic' functions, including differentiation, proliferation, and ... ...

Abstract	The mitochondrial caspase cascade was originally thought to be required for apoptotic death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non-apoptotic' functions, including differentiation, proliferation, and cellular reprogramming. Recent work has demonstrated that, during apoptosis, the caspase cascade suppresses damage-associated molecular pattern (DAMP)-initiated production of cytokines such as type I interferon by the dying cell. The caspase cascade is not required for death to occur; instead, it shapes the immunogenic properties of the apoptotic cell. This raises questions about the role of apoptotic caspases in regulating DAMP signaling more generally, puts a new perspective on their non-apoptotic functions, and suggests that pharmacological caspase inhibitors might find new applications as antiviral or anticancer agents.
MeSH term(s)	Animals ; Apoptosis ; Caspases/metabolism ; Drug Design ; Humans ; Mice ; Mitochondria/metabolism ; Signal Transduction ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-2-Associated X Protein/metabolism
Chemical Substances	bcl-2 Homologous Antagonist-Killer Protein ; bcl-2-Associated X Protein ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2018-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/j.tcb.2018.02.003
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Article ; Online: Apoptosis in megakaryocytes and platelets: the life and death of a lineage.

McArthur, Kate / Chappaz, Stephane / Kile, Benjamin T

Blood

2017 Volume 131, Issue 6, Page(s) 605–610

Abstract: Despite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and ... ...

Abstract	Despite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability. Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circulation. Important questions remain as to how apoptosis is initiated in these cells at steady state and in response to pathophysiological insults.
MeSH term(s)	Animals ; Apoptosis/physiology ; Blood Platelets/physiology ; Cell Death ; Cell Differentiation ; Cell Lineage/physiology ; Humans ; Megakaryocytes/physiology ; Phagocytosis/physiology
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2017-11-742684
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Article ; Online: Author Reply.

Dawson, Jesse / McArthur, Kate

International journal of stroke : official journal of the International Stroke Society

2011 Volume 6, Issue 1, Page(s) 90

Language	English
Publishing date	2011-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1111/j.1747-4949.2010.00546_1.x
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Article ; Online: Older adults and social prescribing experience, outcomes, and processes: a meta-aggregation systematic review.

Grover, Sanya / Sandhu, Prabhleen / Nijjar, Gurkirat Singh / Percival, Amanda / Chudyk, Anna M / Liang, Jessica / McArthur, Caitlin / Miller, William C / Mortenson, W Ben / Mulligan, Kate / Newton, Christie / Park, Grace / Pitman, Beverley / Rush, Kathy L / Sakakibara, Brodie M / Petrella, Robert J / Ashe, Maureen C

Public health

2023 Volume 218, Page(s) 197–207

Abstract: Objective: Social prescribing is a complex care model, which aims to address unmet non-medical needs and connect people to community resources. The purpose of this systematic review was to synthesize available evidence from qualitative methods (e.g. ... ...

Abstract	Objective: Social prescribing is a complex care model, which aims to address unmet non-medical needs and connect people to community resources. The purpose of this systematic review was to synthesize available evidence from qualitative methods (e.g. interviews or focus groups) on experience, outcomes, and processes for social prescribing and older adults (from the person or provider level). Study design: This was a systematic review using the Joanna Brigg's meta-aggregative approach. Methods: We searched multiple online databases for peer-reviewed studies, which included older adults aged ≥60 years (group mean age) and social prescribing experience, outcomes, or processes. We included all qualitative or mixed methods designs from all years and languages. Date of the last primary search was March 24, 2022. Two authors used online software to conduct the screening independently and then decided on the final list of included studies via notes and online discussion. Results: We screened 376 citations (after duplicates) and included eight publications. There were 197 older adult participants (59% women), and many people were living with chronic health conditions. Few details were provided for participants' ethnicity, education, and related factors. We created five synthesized findings related to (1) the approach of social prescribing; implementation factors such as (2) relationships, (3) behavior change strategies, and (4) the environment; and (5) older adults' perceived health and psychosocial outcomes. Conclusions: Despite the limited number of available studies, data provide an overview of people and processes involved with social prescribing, identified research and practice gaps, and possible next steps for implementing and evaluating social prescribing for older adults in primary care.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Focus Groups ; Social Interaction
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	427333-3
ISSN	1476-5616 ; 0033-3506
ISSN (online)	1476-5616
ISSN	0033-3506
DOI	10.1016/j.puhe.2023.02.016
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Article ; Online: Clinical validation and implementation of droplet digital PCR for the detection of BRAF mutations from cell-free DNA.

Arnolda, Rainier / Howlett, Kerryn / Chan, Timmy / Raleigh, Jeanette / Hatzimihalis, Athena / Bell, Anthony / Fellowes, Andrew / Sandhu, Shahneen / McArthur, Grant A / Fox, Stephen B / Dawson, Sarah-Jane / Hewitt, Chelsee / Jones, Kate / Wong, Stephen Q

Pathology

2022 Volume 54, Issue 6, Page(s) 772–778

Abstract: Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating tumour DNA (ctDNA) for identifying mutations and tracking disease. The transition of ddPCR into the diagnostic setting ... ...

Abstract	Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating tumour DNA (ctDNA) for identifying mutations and tracking disease. The transition of ddPCR into the diagnostic setting requires a number of critical steps including the assessment of accuracy and precision and ultimately implementation into clinical use. Here we present the clinical validation of ddPCR for the detection of BRAF mutations (V600E and V600K) from plasma. We describe the performance characteristics assessed including the limit of blank, limit of detection, ruggedness, accuracy, precision and the effect of the matrix. Overall, each assay could achieve a limit of detection of 0.5% variant allele fraction and was highly accurate, with 100% concordance of results obtained from routine diagnostic testing of formalin fixed tumour samples or reference controls (n=36 for BRAF V600E and n=30 for BRAF V600K). Inter-laboratory reproducibility across 12 plasma samples for each assay was also assessed and results were 100% concordant. Overall, we report the successful validation and translation of a ddPCR assay into clinical routine practice.
MeSH term(s)	Cell-Free Nucleic Acids ; Circulating Tumor DNA/genetics ; DNA Mutational Analysis/methods ; Formaldehyde ; Humans ; Mutation ; Polymerase Chain Reaction/methods ; Proto-Oncogene Proteins B-raf/genetics ; Reproducibility of Results
Chemical Substances	Cell-Free Nucleic Acids ; Circulating Tumor DNA ; Formaldehyde (1HG84L3525) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2022.02.010
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Article ; Online: The ethics of intervening in animal behaviour for conservation.

van Dooren, Thom / Price, Catherine J / Banks, Peter B / Berger-Tal, Oded / Chrulew, Matthew / Johnson, Jane / Lajeunesse, Gabrielle / Lynch, Kate E / McArthur, Clare / Parker, Finn C G / Oakey, Myles / Pitcher, Benjamin J / St Clair, Colleen Cassady / Ward-Fear, Georgia / Widin, Sam / Wong, Bob B M / Blumstein, Daniel T

Trends in ecology & evolution

2023 Volume 38, Issue 9, Page(s) 822–830

Abstract: Conservation behaviour is a growing field that applies insights from the study of animal behaviour to address challenges in wildlife conservation and management. Conservation behaviour interventions often aim to manage specific behaviours of a species to ...

Abstract	Conservation behaviour is a growing field that applies insights from the study of animal behaviour to address challenges in wildlife conservation and management. Conservation behaviour interventions often aim to manage specific behaviours of a species to solve conservation challenges. The field is often viewed as offering approaches that are less intrusive or harmful to animals than, for example, managing the impact of a problematic species by reducing its population size (frequently through lethal control). However, intervening in animal behaviour, even for conservation purposes, may still raise important ethical considerations. We discuss these issues and develop a framework and a decision support tool, to aid managers and researchers in evaluating the ethical considerations of conservation behaviour interventions against other options.
MeSH term(s)	Animals ; Humans ; Conservation of Natural Resources ; Animals, Wild ; Behavior, Animal ; Research Personnel
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	284965-3
ISSN	1872-8383 ; 0169-5347
ISSN (online)	1872-8383
ISSN	0169-5347
DOI	10.1016/j.tree.2023.04.011
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