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Article ; Online: 18F-FDG and 18F-Fluciclovine Uptake in Poorly Differentiated Lung Adenocarcinoma in the Setting of Biochemically Recurrent Prostatic Adenocarcinoma.

Trak, Joseph / Hasanovic, Adnan / Gavane, Somali

2022 Volume 47, Issue 12, Page(s) 1077–1078

Abstract: Abstract: A 64-year-old man with a history of Gleason 7 (3 + 4) pT2cN0 prostatic adenocarcinoma status post prostatectomy underwent a fluciclovine PET/CT that showed a tracer-avid right upper lobe spiculated solitary pulmonary nodule. Follow-up FDG PET/ ... ...

Abstract	Abstract: A 64-year-old man with a history of Gleason 7 (3 + 4) pT2cN0 prostatic adenocarcinoma status post prostatectomy underwent a fluciclovine PET/CT that showed a tracer-avid right upper lobe spiculated solitary pulmonary nodule. Follow-up FDG PET/CT showed a hypermetabolic right upper lobe spiculated solitary pulmonary nodule. Fine-needle aspiration was consistent with primary lung adenocarcinoma. Subsequently, right upper lobectomy was performed, and poorly differentiated lung adenocarcinoma was confirmed.
MeSH term(s)	Male ; Humans ; Middle Aged ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Solitary Pulmonary Nodule ; Radiopharmaceuticals ; Lung Neoplasms/diagnostic imaging ; Neoplasm Recurrence, Local ; Adenocarcinoma of Lung/diagnostic imaging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals ; fluciclovine F-18 (38R1Q0L1ZE)
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004387
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Article ; Online: Glomangiopericytoma of the sphenoethmoid complex.

Shemen, Larry / Yan, Wayne / Hasanovic, Adnan / Tong, Jiankun

BMJ case reports

2020 Volume 13, Issue 12

Abstract: Sinonasal glomangiopericytoma is a rare sinonasal tumour accounting for less than. 5% of all sinonasal tumours. This tumour often presents as another, more common type of vascular lesion and is similarly prone to haemorrhage. The optimal treatment ... ...

Abstract	Sinonasal glomangiopericytoma is a rare sinonasal tumour accounting for less than. 5% of all sinonasal tumours. This tumour often presents as another, more common type of vascular lesion and is similarly prone to haemorrhage. The optimal treatment includes complete surgical resection. We, herein, present two such cases adding to the world literature of this rare tumour.
MeSH term(s)	Aged ; Diagnosis, Differential ; Endoscopy ; Ethmoid Sinus/diagnostic imaging ; Ethmoid Sinus/pathology ; Ethmoid Sinus/surgery ; Female ; Hemangiopericytoma/diagnostic imaging ; Hemangiopericytoma/pathology ; Hemangiopericytoma/surgery ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/pathology ; Paranasal Sinus Neoplasms/surgery ; Sphenoid Sinus/diagnostic imaging ; Sphenoid Sinus/pathology ; Sphenoid Sinus/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-12-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-236048
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Article ; Online: A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis.

Bohm, Avri / Asiry, Saeed / Hasanovic, Adnan / Machnicki, Stephen

Chest

2019 Volume 155, Issue 2, Page(s) e37–e42

Abstract: Case presentation: A 58-year-old postmenopausal woman presented to her primary care physician with lower back pain. She denied respiratory symptoms. Her medical history is significant for hypertension, hyperlipidemia, and prediabetes. Her surgical ... ...

Abstract	Case presentation: A 58-year-old postmenopausal woman presented to her primary care physician with lower back pain. She denied respiratory symptoms. Her medical history is significant for hypertension, hyperlipidemia, and prediabetes. Her surgical history consists of a tonsillectomy and a remote dilatation and curettage procedure. She denied a history of smoking, alcohol use, or recreational drug use. A review of systems was otherwise negative.
MeSH term(s)	Back Pain/diagnostic imaging ; Back Pain/etiology ; Female ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Pulmonary Sclerosing Hemangioma/diagnostic imaging ; Pulmonary Sclerosing Hemangioma/pathology ; Pulmonary Sclerosing Hemangioma/surgery
Language	English
Publishing date	2019-01-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2018.10.045
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Article ; Online: Assessment of Lumbar Spine Disc Degeneration in Coherence to Pfirrman Grades and Oswestry Disability Index

Suada Hasanović-Vučković / Merim Jusufbegović / Sandra Vegar-Zubović / Lejla Milišić / Adnan Šehić / Ilvana Hasanbegović / Adnan Beganović

Journal of Health Sciences (2020)

2020

Abstract: Introduction: Intervertebral disc (IVD) degeneration (IDD) is one of the main causes of low back pain (LBP). Standardized diagnostic algorithms for adequate estimation and classification of changes of lumbar discs are mandatory before starting with ... ...

Abstract	Introduction: Intervertebral disc (IVD) degeneration (IDD) is one of the main causes of low back pain (LBP). Standardized diagnostic algorithms for adequate estimation and classification of changes of lumbar discs are mandatory before starting with therapy. Methods: One hundred patients who were indicated for lumbar magnetic resonance imaging (MRI) were included in the study. Pfirrmann grading system was used for the determination of IDD, while the visual analog scale (VAS) is used for evaluation of the intensity of LBP. To quantification of disability for LBP, we used the Oswestry Disability Index (ODI). Result: Results showed higher Pfirrmann grades II and III for L2/L3 and L3/L4 lumbar levels and lower scores at L4/L5 and L5/S1. The analysis also showed low scores at the L2/3 and L3/4 lumbar level for Pfirrmann grades IV and V, and there was an increased at more inferior lumbosacral levels L4/5 and L5/S1. There was a significant correlation between Pfirrmann grades and ODI (p = 0.24) as well as VAS (p = 0.16). Conclusion: Higher Pfirrmann grades correlated with increased ODI and VAS. Therefore, MRI can be used as a strong indicator of clinical appearance, but it is important to take into consideration that LBP should be correlated with clinical features. By summing Pfirrmann grades of all lumbar intervertebral levels in each patient, we can get more accurate insight for the status of the lumbar spine.
Keywords	Magnetic resonance ; lumbar spine ; low back pain ; disc degeneration ; Oswestry Disability Index ; Pfirrmann disc grade ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	University of Sarajevo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Upgrade rate of intraductal papilloma without atypia on breast core needle biopsy: A clinical, radiological and pathological correlation study.

Genco, Iskender Sinan / Tugertimur, Bugra / Manolas, Panagiotis A / Hasanovic, Adnan / Hajiyeva, Sabina

American journal of surgery

2020 Volume 220, Issue 3, Page(s) 677–681

Abstract: Background: The aim of the study was to determine the upgrade rate on excision of intraductal papilloma (IDP) without atypia diagnosed on breast core needle biopsy (CNB).: Methods: We searched our pathology department database for breast CNB with a ... ...

Abstract	Background: The aim of the study was to determine the upgrade rate on excision of intraductal papilloma (IDP) without atypia diagnosed on breast core needle biopsy (CNB). Methods: We searched our pathology department database for breast CNB with a diagnosis of IDP from 2013 to 2018. The exclusion criteria included radiologic-pathologic discordance, atypia on the same CNB, absence of histologic slides to review or absence of excision information. Upgrade was defined as ductal carcinoma in situ (DCIS) or invasive cancer identified on excision. Results: 126 IDP without atypia cases from 94 patients were identified. The upgrade rate was 1.58% (2/126). Both upgrade cases showed DCIS with low and intermediate nuclear grade. Histologic size of IDP ≥1 cm was the only statistically significant predictor factor for an upgrade on excision. Conclusion: The results suggest that non-surgical management of patients with radiologic-pathologic concordant IDP without atypia diagnosed on CNB may be appropriate in routine practice.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Correlation of Data ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Papilloma, Intraductal/diagnostic imaging ; Papilloma, Intraductal/pathology ; Papilloma, Intraductal/surgery
Language	English
Publishing date	2020-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2020.01.040
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Article ; Online: Molecular Testing in Multiple Synchronous Lung Adenocarcinomas: Case Report and Literature Review.

Rafael, Oana C / Lazzaro, Richard / Hasanovic, Adnan

International journal of surgical pathology

2016 Volume 24, Issue 1, Page(s) 43–46

Abstract: Discovery of driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology with major impact on therapy and diagnosis. Testing for EGFR, ALK, and KRAS mutations has become part of everyday practice. We report a case with ... ...

Abstract	Discovery of driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology with major impact on therapy and diagnosis. Testing for EGFR, ALK, and KRAS mutations has become part of everyday practice. We report a case with multiple synchronous primary pulmonary adenocarcinomas in a 72-year-old female with previous history of smoking. The patient presented with cough and bilateral lung ground glass opacities. A positron emission tomography/computed tomography scan showed no activity in mediastinal lymph nodes. She underwent a left upper lobe biopsy and a right upper lobe wedge resection. Pathology revealed 4 morphologically distinct adenocarcinoma foci, suggestive of synchronous primary lung tumors. Molecular testing demonstrated no mutation in the left tumor. Three different driver mutations were present in the right lung tumors: KRAS codon 12 G12D and G12V and EGFR exon 21 L858R mutation, confirming the initial histologic impression. Subsequently, left upper lobe lobectomy showed 3 additional foci of adenocarcinoma with different morphologies, suggestive of synchronous primaries as well. No additional molecular testing was performed. Synchronous pulmonary adenocarcinomas are not uncommon; however, 4 or more synchronous tumors are rare. Distinguishing multiple primary tumors from intrapulmonary metastases is a common problem in thoracic oncology with major implications for staging, prognosis, and treatment. Lung adenocarcinoma subclassification based on predominant and coexisting histologic patterns can greatly facilitate differentiation between intrapulmonary metastases and multiple synchronous tumors. Use of molecular profiling is recommended since it further increases confidence in the diagnostic workup of multiple pulmonary adenocarcinomas and helps guiding therapy.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Aged ; Female ; Humans ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mutation ; Neoplasms, Multiple Primary/diagnosis ; Neoplasms, Multiple Primary/metabolism ; Neoplasms, Multiple Primary/pathology ; Pathology, Molecular ; Prognosis ; Smoking
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/1066896915604544
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Article: Molecular characterization by immunocytochemistry of lung adenocarcinoma on cytology specimens.

Moreira, Andre L / Hasanovic, Adnan

Acta cytologica

2012 Volume 56, Issue 6, Page(s) 603–610

Abstract: The discovery of targetable driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology by the introduction of oral small molecule tyrosine kinase inhibitors that target specific EGFR mutations and EML-4/ALK ... ...

Abstract	The discovery of targetable driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology by the introduction of oral small molecule tyrosine kinase inhibitors that target specific EGFR mutations and EML-4/ALK rearrangement. Therefore, testing for EGFR gene mutations and ALK rearrangements has become part of everyday clinical practice. The majority of lung cancer patients present at an advanced stage, where small biopsy and cytology specimens are often the only available material for diagnostic workup and molecular characterization. Mutation testing has become the standard of care. Nonetheless, the technical complexity and relative high cost of the test have challenged the widespread use of molecular techniques in everyday clinical settings. Recently, antibodies to specific molecular alterations have become available and have the potential to become instruments for the molecular characterization of tumors. In this review article we will discuss practical issues in molecular characterization of lung adenocarcinoma on cytology material and the use of immunocytochemical stains for the detection of mutant protein as an alternative or adjunct to molecular techniques.
MeSH term(s)	Adenocarcinoma/diagnosis ; Animals ; Cytodiagnosis ; Humans ; Immunoenzyme Techniques ; Lung Neoplasms/diagnosis
Language	English
Publishing date	2012
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	80003-x
ISSN	1938-2650 ; 0001-5547
ISSN (online)	1938-2650
ISSN	0001-5547
DOI	10.1159/000339794
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Article ; Online: Expression of GATA-3 in Testicular and Gynecologic Mesothelial Neoplastic and Non-neoplastic Tissues.

Ronaghy, Arash / Xiao, Guang-Qian / Santagada, Eugene / Hasanovic, Adnan / Unger, Pamela

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

2017 Volume 37, Issue 3, Page(s) 284–289

Abstract: GATA-3 expression in testicular/gynecologic mesothelial neoplasms and benign mesothelia have not been completely investigated. We graded GATA-3, calretinin, and WT1 staining in 20 adenomatoid tumors [9/20 (para)testicular and 11/20 tubal/uterine] and 38 ... ...

Abstract	GATA-3 expression in testicular/gynecologic mesothelial neoplasms and benign mesothelia have not been completely investigated. We graded GATA-3, calretinin, and WT1 staining in 20 adenomatoid tumors [9/20 (para)testicular and 11/20 tubal/uterine] and 38 normal mesothelia (20/38 tunica vaginalis and 18/38 fallopian tubes) as either 0 (≤5%), +1 (>5% and <25%), +2 (≥25% and ≤50%), and +3 (>50%). Adenomatoid tumor GATA-3 staining: 2 urologic cases were positive (2/9, +3 and +1), no gynecologic cases were positive (0/11), and all were positive for WT1/calretinin (20/20,+2 to +3). The normal tunica vaginalis mesothelia: 3 of 20 were GATA-3 positive (+2) while 20 of 20 were WT1/calretinin (+2 to +3) positive. The gynecologic cases with walthard nests: are positive for GATA-3 (18/18,+3), WT1 (11/18, +2 to +3), and calretinin (1/18,+2). The nonmetaplastic gynecologic mesothelia were GATA-3 negative (18/18) and WT1/calretinin postive (18/18,+2 to +3). All 18 epididymi were GATA-3 positive (+3) and negative for WT1/calretinin. All 11 efferent ductules examined were negative for GATA-3, WT1/calretinin (0/11). Although GATA-3 rarely stains adenomatoid tumors, gynecologic walthard nests are consistently positive with GATA-3 staining but lose mesothelial markers reflecting a metaplastic change. Excluding the walthard nests, GATA-3 is rarely positive in normal urologic and gynecologic mesothelia. GATA-3 is uniformally positive in epididymi and negative in efferent ductules, which may be due to their embryological evolvement. Awareness of the GATA-3 staining patterns in the genitourinary and gynecologic mesothelial tissues and their respective neoplasms is important to prevent misdiagnosis and possible unnecessary interventions.
MeSH term(s)	Adenomatoid Tumor/metabolism ; Adenomatoid Tumor/pathology ; Biomarkers, Tumor/metabolism ; Calbindin 2/metabolism ; Epithelium/metabolism ; Epithelium/pathology ; Female ; GATA3 Transcription Factor/metabolism ; Genital Neoplasms, Female/metabolism ; Genital Neoplasms, Female/pathology ; Humans ; Immunohistochemistry ; Male ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Testicular Neoplasms/metabolism ; Testicular Neoplasms/pathology ; WT1 Proteins/metabolism
Chemical Substances	Biomarkers, Tumor ; CALB2 protein, human ; Calbindin 2 ; GATA3 Transcription Factor ; GATA3 protein, human ; WT1 Proteins ; WT1 protein, human
Language	English
Publishing date	2017-06-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604859-6
ISSN	1538-7151 ; 0277-1691
ISSN (online)	1538-7151
ISSN	0277-1691
DOI	10.1097/PGP.0000000000000403
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Article ; Online: Molecular Characterization by Immunocytochemistry of Lung Adenocarcinoma on Cytology Specimens

Moreira, Andre L. / Hasanovic, Adnan

Acta Cytologica - The Journal of Clinical Cytology and Cytopathology

2012 Volume 56, Issue 6, Page(s) 603–610

Abstract	The discovery of targetable driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology by the introduction of oral small molecule tyrosine kinase inhibitors that target specific EGFR mutations and EML-4/ALK rearrangement. Therefore, testing for EGFR gene mutations and ALK rearrangements has become part of everyday clinical practice. The majority of lung cancer patients present at an advanced stage, where small biopsy and cytology specimens are often the only available material for diagnostic workup and molecular characterization. Mutation testing has become the standard of care. Nonetheless, the technical complexity and relative high cost of the test have challenged the widespread use of molecular techniques in everyday clinical settings. Recently, antibodies to specific molecular alterations have become available and have the potential to become instruments for the molecular characterization of tumors. In this review article we will discuss practical issues in molecular characterization of lung adenocarcinoma on cytology material and the use of immunocytochemical stains for the detection of mutant protein as an alternative or adjunct to molecular techniques.
Keywords	Lung ; Adenocarcinoma ; EGFR ; ALK ; Immunocytochemistry
Language	English
Publisher	S. Karger AG
Publishing place	Basel
Publishing country	Switzerland
Document type	Article ; Online
ISSN	1938-2650 ; 0001-5547 ; 0001-5547
ISSN (online)	1938-2650
ISSN	0001-5547
DOI	10.1159/000339794
Database	Karger publisher's database

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Article ; Online: Metastatic thyroid carcinoma without identifiable primary tumor within the thyroid gland: a retrospective study of a rare phenomenon.

Xu, Bin / Scognamiglio, Theresa / Cohen, Perry R / Prasad, Manju L / Hasanovic, Adnan / Tuttle, Robert Michael / Katabi, Nora / Ghossein, Ronald A

Human pathology

2017 Volume 65, Page(s) 133–139

Abstract: Metastatic papillary thyroid carcinoma (PTC) without an identifiable primary tumor despite extensive microscopic examination of the thyroid gland is a rare but true phenomenon.We retrieved 7 of such cases and described in detail the clinical and ... ...

Abstract	Metastatic papillary thyroid carcinoma (PTC) without an identifiable primary tumor despite extensive microscopic examination of the thyroid gland is a rare but true phenomenon.We retrieved 7 of such cases and described in detail the clinical and pathologic features of these tumors. BRAF V600E immunohistochemistry and Sequenom molecular profile were conducted in selected cases. All patients harbored metastatic disease in the central (n=3), lateral (n=3), or both neck compartments (n=1). The histotype of the metastatic disease was PTC (n=5), poorly differentiated thyroid carcinoma in association with a PTC columnar variant (n=1), and anaplastic thyroid carcinoma in association with a PTC tall cell variant (n=1). Fibrosis was present in the thyroid of 5 patients. All patients with PTC were alive without evidence of recurrence. The 76-year-old patient with poorly differentiated thyroid carcinoma did not recur and died of unknown causes. Finally, the patient with anaplastic thyroid carcinoma was alive with distant metastasis at last follow-up. The median follow-up for this cohort was 2.2years (range, 0.8-17). BRAF V600E was detected in 4 of 6 cases by immunohistochemistry. In conclusion, metastatic nodal disease without identifiable thyroid primary is a rare but real phenomenon of unknown mechanisms. Although most tumors are low grade and well differentiated, aggressive behavior due to poorly differentiated or anaplastic carcinoma can happen. Most cases are BRAF
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/genetics ; Carcinoma/genetics ; Carcinoma/secondary ; Carcinoma/therapy ; Carcinoma, Papillary ; Cell Differentiation ; DNA Mutational Analysis ; Female ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation ; Neoplasm Grading ; Neoplasms, Unknown Primary/genetics ; Neoplasms, Unknown Primary/pathology ; Neoplasms, Unknown Primary/therapy ; Phenotype ; Proto-Oncogene Proteins B-raf/genetics ; Retrospective Studies ; Thyroid Cancer, Papillary ; Thyroid Carcinoma, Anaplastic/genetics ; Thyroid Carcinoma, Anaplastic/secondary ; Thyroid Carcinoma, Anaplastic/therapy ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/therapy
Chemical Substances	Biomarkers, Tumor ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2017-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2017.05.013
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