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  1. Book: From Jesus to Paul

    Beare, Francis W / Richardson, Peter

    studies in honour of Francis Wright Beare

    1984  

    Title variant Beare, F. W.: Festschrift
    Author's details Richardson, Peter u.a. [Hrsg.]
    Language English
    Size XXX,233 S, ill
    Publisher Wilfrid Laurier Univ.Pr
    Publishing place Waterloo
    Document type Book
    Note "Bibliography of Francis Wright Beare, compiled by John C. Hurd": p. xxi-xxiv
    ISBN 0889201382 ; 9780889201385
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Online: From Jesus to Paul

    Beare, Francis Wright / Hurd, John Coolidge / Richardson, Peter

    studies in honour of Francis Wright Beare

    1984  

    Abstract: The essays presented here intend to open afresh the complexity of the question of Paul's ... of current research-including that of Francis Wright Beare, in whose honour they have been produced ...

    Author's details edited by Peter Richardson and John C. Hurd
    Abstract The essays presented here intend to open afresh the complexity of the question of Paul's dependence upon and continuity with Jesus. So much attention has been given in the past to this very difficult problem that new solutions are hard to find and suspect when offered. This collection, however, demonstrates diversity in approach, stance, and conclusion. The essays often take issue with the results of current research-including that of Francis Wright Beare, in whose honour they have been produced. They consider a broad range of the recent literature and show that no satisfactory solution has
    Language English
    Size Online-Ressource (xxx, 233 p), port, 23 cm
    Publisher Wilfrid Laurier University Press
    Publishing place Waterloo, Ont
    Document type Book ; Online
    Note "Bibliography of Francis Wright Beare": p. xxi-xxiv -- Includes bibliographical references and index ; Includes some text in French
    ISBN 0889201382 ; 9780889201385
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria.

    Fisher, Derek J / Beare, Paul A

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1202245

    Abstract: The ability to genetically manipulate a pathogen is fundamental to discovering factors governing host-pathogen interactions at the molecular level and is critical for devising treatment and prevention strategies. While the genetic "toolbox" for many ... ...

    Abstract The ability to genetically manipulate a pathogen is fundamental to discovering factors governing host-pathogen interactions at the molecular level and is critical for devising treatment and prevention strategies. While the genetic "toolbox" for many important bacterial pathogens is extensive, approaches for modifying obligate intracellular bacterial pathogens were classically limited due in part to the uniqueness of their obligatory lifestyles. Many researchers have confronted these challenges over the past two and a half decades leading to the development of multiple approaches to construct plasmid-bearing recombinant strains and chromosomal gene inactivation and deletion mutants, along with gene-silencing methods enabling the study of essential genes. This review will highlight seminal genetic achievements and recent developments (past 5 years) for
    MeSH term(s) Humans ; Rickettsia/genetics ; Coxiella burnetii/genetics ; Chlamydia/genetics ; Host-Pathogen Interactions/genetics ; Anaplasma/genetics
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1202245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identification of Type 4B Secretion System Substrates That Are Conserved among Coxiella burnetii Genomes and Promote Intracellular Growth.

    Larson, Charles L / Pullman, Willis / Beare, Paul A / Heinzen, Robert A

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0069623

    Abstract: Coxiella burnetii is a Gram-negative pathogen that infects a variety of mammalian hosts. Infection of domesticated ewes can cause fetal abortion, whereas acute human infection normally manifests as the flu-like illness Q fever. Successful host infection ... ...

    Abstract Coxiella burnetii is a Gram-negative pathogen that infects a variety of mammalian hosts. Infection of domesticated ewes can cause fetal abortion, whereas acute human infection normally manifests as the flu-like illness Q fever. Successful host infection requires replication of the pathogen within the lysosomal
    MeSH term(s) Chlorocebus aethiops ; Animals ; Female ; Sheep ; Humans ; Coxiella burnetii/genetics ; HeLa Cells ; Vero Cells ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Vacuoles/microbiology ; Host-Pathogen Interactions ; Mammals
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00696-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A simple method for enrichment of phase I Coxiella burnetii.

    Anderson, Matthew W / Binette, Picabo / Richards, Crystal / Beare, Paul A / Heinzen, Robert A / Long, Carrie M

    Journal of microbiological methods

    2023  Volume 211, Page(s) 106787

    Abstract: Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. This bacterium undergoes lipopolysaccharide (LPS) phase transition similar to Enterobacteriaciae upon in vitro passage. Full-length, phase I C. burnetii LPS is a critical ... ...

    Abstract Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. This bacterium undergoes lipopolysaccharide (LPS) phase transition similar to Enterobacteriaciae upon in vitro passage. Full-length, phase I C. burnetii LPS is a critical virulence factor and profoundly impacts vaccine-induced immunogenicity; thus, LPS phase is an important consideration in C. burnetii experimentation and Q fever vaccine design. Typically, phase I LPS-expressing organisms are obtained from the tissues of infected experimental animals. In this process, residual phase II LPS-expressing organisms are thought to be cleared by the host immune system. Here, we propose an efficient and non-animal-based method for the enrichment of C. burnetii phase I LPS-expressing bacteria in vitro. We utilize both Vero cell culture to selectively enrich solutions with phase I and intermediate phase LPS-expressing bacteria. This simple and quick method decreases reliance on experimental animals and is a sustainable solution for Q fever diagnostic and vaccine development hurdles.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Coxiella burnetii ; Q Fever/microbiology ; Lipopolysaccharides ; Virulence Factors ; Vero Cells
    Chemical Substances Lipopolysaccharides ; Virulence Factors
    Language English
    Publishing date 2023-07-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2023.106787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: De novo

    Barbian, Kent / Bruno, Daniel / Sykora, Lydia / Ricklefs, Stacy / Chaudhary, Prem Prashant / Beare, Paul A / Myles, Ian A / Martens, Craig M

    Microbiology resource announcements

    2023  Volume 12, Issue 11, Page(s) e0052123

    Abstract: Roseomonas ... ...

    Abstract Roseomonas mucosa
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00521-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: De novo

    Barbian, Kent / Bruno, Daniel / Sykora, Lydia / Ricklefs, Stacy / Chaudhary, Prem Prashant / Beare, Paul A / Myles, Ian A / Martens, Craig M

    Microbiology resource announcements

    2023  Volume 12, Issue 11, Page(s) e0052023

    Abstract: Roseomonas ... ...

    Abstract Roseomonas mucosa
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00520-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comment on: Dark without pressure retinal changes in a paediatric age group.

    Steptoe, Paul J / Beare, Nicholas A V / Semple, Malcolm G

    Eye (London, England)

    2020  Volume 35, Issue 11, Page(s) 3163–3164

    MeSH term(s) Child ; Fluorescein Angiography ; Humans ; Retina/diagnostic imaging
    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01252-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Author Correction: Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain.

    Long, Carrie M / Beare, Paul A / Cockrell, Diane / Binette, Picabo / Tesfamariam, Mahelat / Richards, Crystal / Anderson, Matthew / McCormick-Ell, Jessica / Brose, Megan / Anderson, Rebecca / Omsland, Anders / Pearson, Talima / Heinzen, Robert A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1299

    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45637-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain.

    Long, Carrie M / Beare, Paul A / Cockrell, Diane / Binette, Picabo / Tesfamariam, Mahelat / Richards, Crystal / Anderson, Matthew / McCormick-Ell, Jessica / Brose, Megan / Anderson, Rebecca / Omsland, Anders / Pearson, Talima / Heinzen, Robert A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 697

    Abstract: Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organism leads to ... ...

    Abstract Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organism leads to LPS truncation, which is associated with an attenuated and exempted from select agent status (Nine Mile II, NMII). Here, we demonstrate that NMII was recovered from the spleens of infected guinea pigs. Moreover, these strains exhibit a previously unrecognized form of elongated LPS and display increased virulence in comparison with the initial NMII strain. The reversion of a 3-bp mutation in the gene cbu0533 directly leads to LPS elongation. To address potential safety concerns, we introduce a modified NMII strain unable to produce elongated LPS.
    MeSH term(s) Animals ; Guinea Pigs ; Coxiella burnetii/genetics ; Lipopolysaccharides ; Mutation ; Reproduction ; Spleen
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43972-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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