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  1. Article: Toward optimal health: Lesley A. Stevens, M.D. discusses issues of chronic kidney disease in women. Interview by Jodi R. Godfrey.

    Stevens, Lesley A

    Journal of women's health (2002)

    2006  Volume 15, Issue 2, Page(s) 123–126

    MeSH term(s) Age Factors ; Aged ; Biomarkers/blood ; Creatinine/blood ; Diabetes Complications ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Hypertension/complications ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/ethnology ; Kidney Failure, Chronic/therapy ; Middle Aged ; Osteoporosis/complications ; Patient Care Planning ; Renal Dialysis/utilization ; Risk Factors ; United States/epidemiology ; Women's Health/ethnology
    Chemical Substances Biomarkers ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2006-03
    Publishing country United States
    Document type Interview
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1540-9996 ; 1059-7115
    ISSN (online) 1931-843X
    ISSN 1540-9996 ; 1059-7115
    DOI 10.1089/jwh.2006.15.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Storage of

    David, Anura / Scott, Lesley E / Da Silva, Pedro / Mayne, Elizabeth / Stevens, Wendy S

    African journal of laboratory medicine

    2023  Volume 12, Issue 1, Page(s) 2172

    Abstract: Background: Mycobacterium tuberculosis: Objective: The study aimed to determine the feasibility of using Microbank: Methods: In February 2020, 20 isolates in liquid culture were stored in Microbank: Results: Stored liquid isolates demonstrated ... ...

    Abstract Background: Mycobacterium tuberculosis
    Objective: The study aimed to determine the feasibility of using Microbank
    Methods: In February 2020, 20 isolates in liquid culture were stored in Microbank
    Results: Stored liquid isolates demonstrated MTBC growth within an average time-to-detection of 18 days following retrieval, even at 21 months post storage. Contaminating organisms were detected in 2 of 80 (2.5%) culture isolates.
    Conclusion: Microbank
    What this study adds: This study evaluated the use of Microbank
    Language English
    Publishing date 2023-10-25
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2708535-1
    ISSN 2225-2010 ; 2225-2002
    ISSN (online) 2225-2010
    ISSN 2225-2002
    DOI 10.4102/ajlm.v12i1.2172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vesiculation in irradiated and cation-leaky-stored red blood cells.

    Stevens-Hernandez, Christian J / Gyorffy, Gyongyver / Meli, Athinoula / New, Helen V / Cardigan, Rebecca / Bruce, Lesley J

    Transfusion

    2023  Volume 64, Issue 1, Page(s) 150–161

    Abstract: Background: Extracellular vesicles (EVs) are released by red blood cells (RBCs) throughout their life-span and also during hypothermic storage when they accumulate in the blood bag. We queried whether stored RBCs with increased cation permeability, ... ...

    Abstract Background: Extracellular vesicles (EVs) are released by red blood cells (RBCs) throughout their life-span and also during hypothermic storage when they accumulate in the blood bag. We queried whether stored RBCs with increased cation permeability, either from donors with familial pseudohyperkalaemia (FP) or caused by irradiation, vesiculate more readily.
    Study design and methods: Recent technical advances have revealed at least two sub-populations of MVs in RBC storage units: macrovesicles (2-6 μm) and microvesicles (1-2 μm). Using nanoparticle tracking analysis, imaging flow cytometry, and protein quantification methods, we measured and characterized vesicles released by RBCs from control and FP individuals at three different storage time-points (day 4, day 17, and day 29). The RBCs had either been stored untreated or irradiated on either day 1 or day 14 of storage.
    Results: We found no difference in the number or size of vesicles released between cation-leaky FP RBCs and non-FP controls. Similarly, irradiated and non-irradiated RBCs showed very similar patterns of vesicle release to during cold-storage. The only significant difference in vesicle release was the increase in accumulated vesicles with length of storage time which has been reported previously.
    Discussion: EVs in stored blood are potential contributors to adverse transfusion reactions. The number of vesicles released during 35-day hypothermic storage varies between donors and increases with storage duration. However, increased cation permeability and irradiation do not appear to affect vesicle formation during RBC cold-storage.
    MeSH term(s) Humans ; Erythrocytes/metabolism ; Blood Transfusion ; Extracellular Vesicles ; Anemia, Hemolytic, Congenital ; Tissue Donors ; Blood Preservation/methods
    Language English
    Publishing date 2023-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: More Than a Decade of GeneXpert

    da Silva, Manuel Pedro / Cassim, Naseem / Ndlovu, Silence / Marokane, Puleng Shiela / Radebe, Mbuti / Shapiro, Anne / Scott, Lesley Erica / Stevens, Wendy Susan

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 20

    Abstract: This study seeks to describe the rollout and current state of South Africa's GeneXpert molecular diagnostic program for tuberculosis (TB). Xpert MTB/RIF was introduced in 2011 with a subsequent expansion to include extra-pulmonary and paediatric testing, ...

    Abstract This study seeks to describe the rollout and current state of South Africa's GeneXpert molecular diagnostic program for tuberculosis (TB). Xpert MTB/RIF was introduced in 2011 with a subsequent expansion to include extra-pulmonary and paediatric testing, followed by Xpert MTB/RIF Ultra in 2017. Through a centralised laboratory information system and the use of a standardised platform for more than a decade, over 23 million tests were analysed, describing the numbers tested,
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13203253
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  5. Article ; Online: Antigen-Based Point of Care Testing (POCT) for Diagnosing SARS-CoV-2: Assessing Performance.

    Keshav, Vidya / Scott, Lesley / David, Anura / Noble, Lara / Mayne, Elizabeth / Stevens, Wendy

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2452, Page(s) 45–62

    Abstract: Currently, the most accurate way to diagnose an active SARS-CoV-2 (COVID-19) infection is through detection of viral RNA using reverse transcription polymerase chain reaction (RT-PCR) test. While RT-PCR tests are the most sensitive for identifying ... ...

    Abstract Currently, the most accurate way to diagnose an active SARS-CoV-2 (COVID-19) infection is through detection of viral RNA using reverse transcription polymerase chain reaction (RT-PCR) test. While RT-PCR tests are the most sensitive for identifying infection, there are significant limitations, such as global access to sufficient test kits, turnaround times (TAT) from specimen collection to test result is often greater than 24 h and the need for skilled operators in accredited laboratories requiring specialized equipment. A rapid test performed at the point of care (POC) could provide a result within an approximate time of 30 min post specimen collection, be performed by a health care worker and comprise a simple workflow, improving both turnaround time and potentially decreasing costs (e.g., transport, cold-chain, skilled laboratory staff, complex equipment). Determining the performance of SARS-CoV-2 RT-PCR tests is, however, easier to assess than antigen-based POCT, as residual clinical specimens (swabs in universal transport media [UTM]) are readily available in laboratory environments, and do not require patient informed consent. Evaluating the performance of POCT requires informed-consent driven studies, with patients required to provide a standard of care specimen as well as study evaluation specimens, which is often not acceptable as nasopharyngeal swabbing can be invasive, clinical field trials are costly and time consuming. Many institutions and regulatory bodies also require preliminary data prior to use in field settings. Therefore, we have developed a method to determine the performance of antigen based POCT that can be used by implementers in national healthcare programs, regulators and rapid test developers. The method investigates both quantitative and qualitative parameters, with the latter providing insights into the capability for implementation and national program uptake.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Nasopharynx ; Point-of-Care Testing ; SARS-CoV-2/genetics ; Sensitivity and Specificity
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2111-0_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Challenges and complexities in evaluating severe acute respiratory syndrome coronavirus 2 molecular diagnostics during the COVID-19 pandemic.

    Scott, Lesley E / Noble, Lara D / Singh-Moodley, Ashika / Kahamba, Trish / Hardie, Diana R / Preiser, Wolfgang / Stevens, Wendy S

    African journal of laboratory medicine

    2022  Volume 11, Issue 1, Page(s) 1429

    Language English
    Publishing date 2022-04-26
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2708535-1
    ISSN 2225-2010 ; 2225-2002
    ISSN (online) 2225-2010
    ISSN 2225-2002
    DOI 10.4102/ajlm.v11i1.1429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Development of a Standardized Quality Assessment Material to Support Xpert

    Noble, Lara Dominique / Scott, Lesley Erica / Bongwe, Asiashu / Da Silva, Pedro / Stevens, Wendy Susan

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 2

    Abstract: The tiered laboratory framework for human immunodeficiency virus (HIV) viral load monitoring accommodates a range of HIV viral load testing platforms, with quality assessment critical to ensure quality patient testing. HIV plasma viral load testing is ... ...

    Abstract The tiered laboratory framework for human immunodeficiency virus (HIV) viral load monitoring accommodates a range of HIV viral load testing platforms, with quality assessment critical to ensure quality patient testing. HIV plasma viral load testing is challenged by the instability of viral RNA. An approach using an RNA stabilizing buffer is described for the Xpert
    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11020160
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  8. Article ; Online: Assessment of the Degree of Osteoarthritis in Aging Male and Female Femoral Condyles: A Cadaveric Study.

    Immonen, Jessica / Stevens, Kelsey / Albin, Alexa / Chaus, David / Gilmer, Lesley / Zdilla, Matthew

    Cartilage

    2020  Volume 13, Issue 1_suppl, Page(s) 1684S–1695S

    Abstract: Objective: Determine if femoral chondral cartilage degeneration on cadaveric knee joints exacerbate differently with aging between the sexes.: Methods: A total of 85 cadaveric femurs were assessed for macroscopic femoral condyle pathology using a ... ...

    Abstract Objective: Determine if femoral chondral cartilage degeneration on cadaveric knee joints exacerbate differently with aging between the sexes.
    Methods: A total of 85 cadaveric femurs were assessed for macroscopic femoral condyle pathology using a scale for gross signs of osteoarthritis. Raters scored specimens and raters' scores were averaged to provide each specimen a Disease Severity Score (DSS).
    Results: The DSS for the 80+-year-old population was greater than the DSS of the 70- to 79-year-old population (*
    Conclusions: No difference was shown between the sexes in the severity or location of degeneration indicating that men and women are likely affected by the same biomechanical changes that spur on osteoarthritis in their eighth decade of life (70s) and later. Lateral femoral degeneration predominates in younger populations. When patients approach their 70s, medial degeneration begins to predominate likely based on an increase in shearing at the knee joint.
    MeSH term(s) Aged ; Aged, 80 and over ; Cadaver ; Cartilage, Articular/pathology ; Female ; Femur/pathology ; Humans ; Knee Joint/pathology ; Male ; Osteoarthritis, Knee/pathology ; Patella
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515870-3
    ISSN 1947-6043 ; 1947-6035
    ISSN (online) 1947-6043
    ISSN 1947-6035
    DOI 10.1177/1947603520916530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Rationale for the shielding policy for clinically vulnerable people in the UK during the COVID-19 pandemic: a qualitative study.

    Porter, Alison / Akbari, Ashley / Carson-Stevens, Andrew / Dale, Jeremy / Dixon, Lucy / Edwards, Adrian / Evans, Bridie / Griffiths, Lesley / John, Ann / Jolles, Stephen / Kingston, Mark Rhys / Lyons, Ronan / Morgan, Jennifer / Sewell, Bernadette / Whiffen, Anthony / Williams, Victoria Angharad / Snooks, Helen

    BMJ open

    2023  Volume 13, Issue 8, Page(s) e073464

    Abstract: Introduction: Shielding aimed to protect those predicted to be at highest risk from COVID-19 and was uniquely implemented in the UK during the first year of the pandemic from March 2020. As the first stage in the EVITE Immunity evaluation (Effects of ... ...

    Abstract Introduction: Shielding aimed to protect those predicted to be at highest risk from COVID-19 and was uniquely implemented in the UK during the first year of the pandemic from March 2020. As the first stage in the EVITE Immunity evaluation (Effects of shielding for vulnerable people during COVID-19 pandemic on health outcomes, costs and immunity, including those with cancer:quasi-experimental evaluation), we generated a logic model to describe the programme theory underlying the shielding intervention.
    Design and participants: We reviewed published documentation on shielding to develop an initial draft of the logic model. We then discussed this draft during interviews with 13 key stakeholders involved in putting shielding into effect in Wales and England. Interviews were recorded, transcribed and analysed thematically to inform a final draft of the logic model.
    Results: The shielding intervention was a complex one, introduced at pace by multiple agencies working together. We identified three core components: agreement on clinical criteria; development of the list of people appropriate for shielding; and communication of shielding advice. In addition, there was a support programme, available as required to shielding people, including food parcels, financial support and social support. The predicted mechanism of change was that people would isolate themselves and so avoid infection, with the primary intended outcome being reduction in mortality in the shielding group. Unintended impacts included negative impact on mental and physical health and well-being. Details of the intervention varied slightly across the home nations of the UK and were subject to minor revisions during the time the intervention was in place.
    Conclusions: Shielding was a largely untested strategy, aiming to mitigate risk by placing a responsibility on individuals to protect themselves. The model of its rationale, components and outcomes (intended and unintended) will inform evaluation of the impact of shielding and help us to understand its effect and limitations.
    MeSH term(s) Humans ; COVID-19/prevention & control ; Pandemics/prevention & control ; Qualitative Research ; England ; Social Support
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073464
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  10. Article: Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF.

    Scott, Lesley Erica / Shapiro, Anne Nicole / Da Silva, Manuel Pedro / Tsoka, Jonathan / Jacobson, Karen Rita / Emch, Michael / Moultrie, Harry / Jenkins, Helen Elizabeth / Moore, David / Van Rie, Annelies / Stevens, Wendy Susan

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 20

    Abstract: An investigation was carried out to examine the use of national Xpert MTB/RIF data (2013-2017) and GIS technology for MTB/RIF surveillance in South Africa. The aim was to exhibit the potential of using molecular diagnostics for TB surveillance across the ...

    Abstract An investigation was carried out to examine the use of national Xpert MTB/RIF data (2013-2017) and GIS technology for MTB/RIF surveillance in South Africa. The aim was to exhibit the potential of using molecular diagnostics for TB surveillance across the country. The variables analysed include
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13203163
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