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  1. Book ; Thesis: Die Rolle der Radiotherapie und der kombinierten RAdio-Chemotherapie bei nicht-metastasierten und ossär metastasierten primären Lebermalignomen

    Haase, Kristina

    eine monoinstitutionelle retrospektive Studie

    2012  

    Author's details vorgelegt von Kristina Haase
    Language German
    Size 105 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2012
    HBZ-ID HT017586029
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 E 270 order for loan Magazin

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  2. Book: Alkoholismus bei Menschen mit einer geistigen Behinderung

    Haase, Kristina

    2009  

    Author's details Kristina Haase
    Language German
    Size 108 S. : graph. Darst., 27 cm
    Publisher Diplomica-Verl
    Publishing place Hamburg
    Publishing country Germany
    Document type Book
    Note Literaturverz. S. 98 - 105
    HBZ-ID HT016064856
    ISBN 978-3-8366-7220-7 ; 3-8366-7220-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4639 order for loan Magazin

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  3. Book ; Thesis: Untersuchungen an Mausmutanten zur physiologischen Rolle des basischen Fibroblastenwachstumsfaktors bei der peripheren Nervenregeneration

    Haase, Kristina

    2009  

    Author's details vorgelegt von Kristina Haase
    Language German
    Size 103 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2009
    HBZ-ID HT016194310
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 949 order for loan Magazin

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  4. Article ; Online: A Bioengineered Model for Studying Vascular-Pericyte Interactions of the Placenta.

    Cherubini, Marta / Haase, Kristina

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2608, Page(s) 409–423

    Abstract: Investigating the complex cellular interactions of the placenta has remained, until now, a challenge in the field. Given the ethical limitations of studying human placentae, and the interspecies differences that exist between mammals, in vitro models are ...

    Abstract Investigating the complex cellular interactions of the placenta has remained, until now, a challenge in the field. Given the ethical limitations of studying human placentae, and the interspecies differences that exist between mammals, in vitro models are a valuable tool for investigating developmental and pathologic processes related to the human placenta. A number of in vitro models have been recently employed to investigate various aspects of placental development, with many focusing on the maternal-fetal interface including the trophoblasts and an endothelial barrier. One critical aspect in mimicking the physiology of the placenta is to include perfusable microvessels. As this organ is highly vascularized, it is pertinent to represent the exchange of oxygen and nutrients from the maternal blood to the embedded vessels of the fetus. Using hydrogel-laden microfluidics, it is now possible to bioengineer these and other microvessels in a reproducible manner. By using HUVEC, fetal-like vessels can be generated on a chip and can be studied in a controlled manner. This chapter introduces the concept of generating a triculture vasculature on-chip system, which can be employed to study placental pericyte-endothelial interactions. We describe strategies for generating the vessels on-chip, as well as for quantifying vascular morphology and function. This methodology allows for unique microvessel-related biological questions to be addressed, including how stromal cells impact vascular remodeling over time.
    MeSH term(s) Animals ; Pregnancy ; Female ; Humans ; Placenta ; Pericytes ; Trophoblasts ; Microvessels/pathology ; Vascular Remodeling/physiology ; Mammals
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2887-4_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article: Self-organization of vascularized skeletal muscle from bovine embryonic stem cells.

    Sanaki-Matsumiya, Marina / Villava, Casandra / Rappez, Luca / Haase, Kristina / Wu, Jun / Ebisuya, Miki

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Cultured beef holds promising potential as an alternative to traditional meat options. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. To produce cultured beef ...

    Abstract Cultured beef holds promising potential as an alternative to traditional meat options. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. To produce cultured beef steaks, current manufacturing plans often require the separate preparation of multiple cell types and intricate engineering for assembling them into structured tissues. In this study, we propose and report the co-induction of skeletal muscle, neuronal, and endothelial cells from bovine embryonic stem cells (ESCs) and the self-organization of tissue structures in 2- and 3-dimensional cultures. Bovine myocytes were induced in a stepwise manner through the induction of presomitic mesoderm (PSM) from bovine ESCs. Muscle fibers with sarcomeres appeared within 15 days, displaying calcium oscillations responsive to inputs from co-induced bovine spinal neurons. Bovine endothelial cells were also co-induced via PSM, forming uniform vessel networks inside tissues. Our serum-free, rapid co-induction protocols represent a milestone toward self-organizing beef steaks with integrated vasculature and innervation.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  6. Article: Engineering Breast Cancer On-chip-Moving Toward Subtype Specific Models.

    Moccia, Carmen / Haase, Kristina

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 694218

    Abstract: Breast cancer is the second leading cause of death among women worldwide, and while hormone receptor positive subtypes have a clear and effective treatment strategy, other subtypes, such as triple negative breast cancers, do not. Development of new drugs, ...

    Abstract Breast cancer is the second leading cause of death among women worldwide, and while hormone receptor positive subtypes have a clear and effective treatment strategy, other subtypes, such as triple negative breast cancers, do not. Development of new drugs, antibodies, or immune targets requires significant re-consideration of current preclinical models, which frequently fail to mimic the nuances of patient-specific breast cancer subtypes. Each subtype, together with the expression of different markers, genetic and epigenetic profiles, presents a unique tumor microenvironment, which promotes tumor development and progression. For this reason, personalized treatments targeting components of the tumor microenvironment have been proposed to mitigate breast cancer progression, particularly for aggressive triple negative subtypes. To-date, animal models remain the gold standard for examining new therapeutic targets; however, there is room for
    Language English
    Publishing date 2021-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.694218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Once upon a dish: engineering multicellular systems.

    Haase, Kristina / Freedman, Benjamin S

    Development (Cambridge, England)

    2020  Volume 147, Issue 9

    Abstract: In February 2020, the European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the globe to discuss emerging topics in 'Engineering Multicellular Systems'. As ... ...

    Abstract In February 2020, the European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the globe to discuss emerging topics in 'Engineering Multicellular Systems'. As we review here, key themes that arose throughout the meeting included the ethics of organoids in developmental biology, bottom-up versus top-down models, tissue organizing principles, and the future of improving these systems to better mimic the natural world.
    MeSH term(s) Animals ; Bioengineering/methods ; Developmental Biology/methods ; Humans ; Organoids ; Synthetic Biology/methods ; Tissue Engineering/methods
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.188573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 91: Show issues

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  8. Book ; Audio / Video ; Online: Anwenderfreundliche Fischartentests

    Bade, Patrizia / Schroeder, Ute / Kappel, Kristina / Haase, Ilka / Fritsche, Jan

    2023  

    Keywords Text ; ddc:610
    Language German
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article: Modelling the Human Placental Interface In Vitro-A Review.

    Cherubini, Marta / Erickson, Scott / Haase, Kristina

    Micromachines

    2021  Volume 12, Issue 8

    Abstract: Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fetus, ...

    Abstract Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fetus, the placenta evolves throughout pregnancy, making it a particularly difficult organ to study. Research into placental development and dysfunction poses a unique scientific challenge due to ethical constraints and the differences in morphology and function that exist between species. Recently, there have been increased efforts towards generating in vitro models of the human placenta. Advancements in the differentiation of human induced pluripotent stem cells (hiPSCs), microfluidics, and bioprinting have each contributed to the development of new models, which can be designed to closely match physiological in vivo conditions. By including relevant placental cell types and control over the microenvironment, these new in vitro models promise to reveal clues to the pathogenesis of placental dysfunction and facilitate drug testing across the maternal-fetal interface. In this minireview, we aim to highlight current in vitro placental models and their applications in the study of disease and discuss future avenues for these in vitro models.
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12080884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fast and User-Friendly Detection of Flatfish Species (

    Wax, Nils / Pförtner, Laura Sophie / Holz, Nathalie / Sterzl, Svenja / Melnik, Melina / Kappel, Kristina / Bade, Patrizia / Schröder, Ute / Haase, Ilka / Fritsche, Jan / Fischer, Markus

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 40, Page(s) 14795–14805

    Abstract: The detection of a ... ...

    Abstract The detection of a Cytochrome
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c03917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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