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Article ; Online: Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery.

Crawford, Dana C / Sedor, John R

Journal of the American Society of Nephrology : JASN

2021 Volume 32, Issue 8, Page(s) 1828–1829

MeSH term(s)	Biological Specimen Banks ; Electronic Health Records ; Genome-Wide Association Study ; Genomics
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2021060836
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Article ; Online: A rare case of pediatric MN1-altered astroblastoma with concomitant ATM germline mutation.

Chou, Stephanie / Nael, Ali / Crawford, John R / Sato, Mariko

Pediatric blood & cancer

2023 Volume 70, Issue 10, Page(s) e30502

MeSH term(s)	Humans ; Child ; Germ-Line Mutation ; Neoplasms, Neuroepithelial/genetics ; Brain Neoplasms/genetics ; Trans-Activators/genetics ; Tumor Suppressor Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/genetics
Chemical Substances	MN1 protein, human ; Trans-Activators ; Tumor Suppressor Proteins ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30502
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Article ; Online: Trait variation in patchy landscapes: Morphology of spotted salamanders (Ambystoma maculatum) varies more within ponds than between ponds.

Green, Elizabeth T / Dell, Anthony I / Crawford, John A / Biro, Elizabeth G / Daversa, David R

PloS one

2024 Volume 19, Issue 4, Page(s) e0299101

Abstract: The influence of intraspecific trait variation on species interactions makes trait-based approaches critical to understanding eco-evolutionary processes. Because species occupy habitats that are patchily distributed in space, species interactions are ... ...

Abstract	The influence of intraspecific trait variation on species interactions makes trait-based approaches critical to understanding eco-evolutionary processes. Because species occupy habitats that are patchily distributed in space, species interactions are influenced not just by the degree of intraspecific trait variation but also the relative proportion of trait variation that occurs within- versus between-patches. Advancement in trait-based ecology hinges on understanding how trait variation is distributed within and between habitat patches across the landscape. We sampled larval spotted salamanders (Ambystoma maculatum) across six spatially discrete ponds to quantify within- and between-pond variation in mass, length, and various metrics associated with their relationship (scaling, body condition, shape). Across all traits, within-pond variation contributed more to total observed morphological variation than between-pond variation. Between-pond variation was not negligible, however, and explained 20-41% of total observed variation in measured traits. Between-pond variation was more pronounced in salamander tail morphology compared to head or body morphology, suggesting that pond-level factors more strongly influence tails than other body parts. We also observed differences in mass-length relationships across ponds, both in terms of scaling slopes and intercepts, though differences in the intercepts were much stronger. Preliminary evidence hinted that newly constructed ponds were a driver of the observed differences in mass-length relationships and morphometrics. General pond-level difference in salamander trait covariation suggest that allometric scaling of morphological traits is context dependent in patchy landscapes. Effects of pond age offer the hypothesis that habitat restoration through pond construction is a driver of variation in trait scaling, which managers may leverage to bolster trait diversity.
MeSH term(s)	Animals ; Ambystoma ; Ponds ; Urodela ; Ecosystem ; Ecology
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299101
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Article ; Online: Central Nervous System Tumors in Children.

Pehlivan, Katherine C / Paul, Megan R / Crawford, John R

Pediatrics in review

2021 Volume 43, Issue 1, Page(s) 3–15

MeSH term(s)	Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/epidemiology ; Central Nervous System Neoplasms/therapy ; Child ; Humans
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2020-004499
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Article ; Online: Endovascular Plug for Endobronchial Management of an Expectorated Pulmonary Artery Embolization Coil: A Case Report.

Crawford, Jesse M / Patel, Priya P / DuCoffe, Aaron R / Tsai, Michael / Hodgson, John A

A&A practice

2023 Volume 17, Issue 2, Page(s) e01663

Abstract: Pulmonary artery aneurysms are frequently managed with endovascular embolization. Rare but serious complications of coil embolization are erosion and migration of the coils into the adjacent airways, posing a risk for massive hemoptysis. We report the ... ...

Abstract	Pulmonary artery aneurysms are frequently managed with endovascular embolization. Rare but serious complications of coil embolization are erosion and migration of the coils into the adjacent airways, posing a risk for massive hemoptysis. We report the case of a medically complex patient with a left main pulmonary artery aneurysm treated with coil embolization who ultimately experienced transbronchial migration and expectoration of the coil. We discuss the challenging anesthetic and surgical management of these serious complications, including the use of an endovascular plug to occlude the erosion site and distal airways.
MeSH term(s)	Humans ; Pulmonary Artery ; Blood Vessel Prosthesis ; Embolization, Therapeutic
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2575-3126
ISSN (online)	2575-3126
DOI	10.1213/XAA.0000000000001663
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Article ; Online: The effect of myelography dye on bone density measurements utilizing Hounsfield units on CT.

Weegens, Ryan / Crawford, Charles H / Glassman, Steven D / Dimar, John R / Gum, Jeffrey L / Carreon, Leah Y

Journal of neurosurgery. Spine

2024 Volume 40, Issue 4, Page(s) 513–518

Abstract: Objective: Hounsfield unit (HU) measurements of bone density on CT are increasingly used for preoperative planning in spine surgery. Postmyelogram CT is another common preoperative diagnostic study. However, there is no current literature evaluating ... ...

Abstract	Objective: Hounsfield unit (HU) measurements of bone density on CT are increasingly used for preoperative planning in spine surgery. Postmyelogram CT is another common preoperative diagnostic study. However, there is no current literature evaluating whether HU measurements on CT are affected by the presence of myelography dye. The purpose of the current study was to determine if the presence of myelography dye affects HU measurements of bone density in CT studies. Methods: Twenty-nine preoperative spine surgery patients who underwent both standard and postmyelography CT performed within 6 months of each other were identified. HU measurements were obtained from an elliptical region of interest using the available software on a standard PACS. Measurements were obtained on the axial cut at the midvertebral body on all lumbar vertebrae on three separate occasions and an average value was calculated for comparative analysis. A 6-week gap was used between measurements of the CT scans and the CT myelograms to diminish bias. Results: The mean age of the cohort was 69 years and the average BMI was 32 kg/m2. Five patients were male and 24 were female. Six of the patients had instrumentation placed prior to the initial CT scan. The average HU measurements for CT levels L1-5 were 165, 171, 145, 154, and 225, respectively, whereas HU measurements for CT myelography of levels L1-5 were 168, 177, 148, 170, and 239, respectively. Strong correlations were noted between the HU measured on CT and CT myelography for L1 (r2 = 0.951), L2 (r2 = 0.966), L4 (r2 = 0.820), and L5 (r2 = 0.900), and moderate for L3 (r2 = 0.668). Conclusions: The presence of myelography dye had no clear effect on CT HU measurements of bone density. The results of this study support the use of CT myelograms for bone density assessment in the absence of standard CT images.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Bone Density ; Osteoporosis ; Absorptiometry, Photon/methods ; Tomography, X-Ray Computed/methods ; Lumbar Vertebrae/diagnostic imaging ; Myelography ; Retrospective Studies
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2158643-3
ISSN	1547-5646 ; 1547-5654
ISSN (online)	1547-5646
ISSN	1547-5654
DOI	10.3171/2023.11.SPINE23890
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Article ; Online: Impacts of including Sweet Bran and wet distillers grains with solubles alone or in combination in finishing cattle diets on physically effective fiber concentrations and rumen buffering characteristics of feedlot cattle.

Spowart, Paige R / Richeson, John T / Crawford, David M / Samuelson, Kendall L

Translational animal science

2022 Volume 6, Issue 3, Page(s) txac091

Abstract: This study evaluated the effects of Sweet Bran (SB) and wet distillers grains with solubles (WDGS) in the diet alone or in combination on physically effective neutral detergent fiber (peNDF), ruminal pH, and rumination behavior of finishing beef cattle. ... ...

Abstract	This study evaluated the effects of Sweet Bran (SB) and wet distillers grains with solubles (WDGS) in the diet alone or in combination on physically effective neutral detergent fiber (peNDF), ruminal pH, and rumination behavior of finishing beef cattle. For this study, 455 steers (373 ± 15.5 kg) were allocated to 48 pens in a randomized complete block design. Treatments (
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txac091
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Article ; Online: Evaluating uncertainty to improve a common monitoring method and guide management decisions for diamond‐backed terrapins

Bradke, Danielle R. / Crawford, Brian A. / Kaylor, Michelle / Maerz, John C.

The Journal of Wildlife Management. 2024 Jan., v. 88, no. 1 p.e22513-

2024

Abstract: Designing monitoring with adequate certainty to evaluate management actions can be challenging, especially for elusive species in relatively inaccessible habitats. The diamond‐backed terrapin (Malaclemys terrapin) is considered a high priority species ... ...

Abstract	Designing monitoring with adequate certainty to evaluate management actions can be challenging, especially for elusive species in relatively inaccessible habitats. The diamond‐backed terrapin (Malaclemys terrapin) is considered a high priority species for management in all states within its range. Among key threats to terrapin populations is bycatch mortality in crab pots, prompting states throughout the species' range to consider crabbing regulations and creating a need for a monitoring approach able to evaluate the success of any new crabbing regulations to benefit terrapins. Because terrapins occupy extensive and often difficult to access estuarine habitat, it is hard to collect sufficient data to estimate population responses accurately and precisely for management. To assist state managers with decisions regarding monitoring bycatch reduction regulations, we modeled 12 years of terrapin capture‐recapture data. We used estimates from those models to simulate capture‐recapture data pre‐ and post‐implementation of bycatch reduction that resulted in a 0.20 absolute increase in mean apparent survival probability. Results indicated weak reliability of a monitoring approach using only manual seining of tidal creeks to detect a real management effect, with a positive management effect detected at the 95% certainty level only 34% of the time. When we considered 85% and 75% certainty thresholds, we detected a positive effect on survival among 61% and 75% of simulations, respectively. Low within‐year recapture probability and the effect of tide amplitude on terrapin availability indicate there is low feasibility of improving monitoring precision at a single site, requiring monitoring of more sites to improve confidence in the detection of the management effect. The number of sites monitored depends on the acceptable level of certainty. We recommend that researchers and management entities that use seining assess the level of certainty they require to evaluate management actions and increase the number of sites sampled to meet that level of certainty. Additionally, the use of multiple monitoring methods and integrated models should be explored to reduce uncertainty and to allow for easier monitoring of more populations over broader spatial scales.
Keywords	Malaclemys terrapin ; bycatch ; crabs ; estuaries ; habitats ; mark-recapture studies ; mortality ; uncertainty ; wildlife management
Language	English
Dates of publication	2024-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	410712-3
ISSN	0022-541X
ISSN	0022-541X
DOI	10.1002/jwmg.22513
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effectiveness of rapid sampling assessments for wetland-breeding amphibians

Crawford, John A. / Peterman, William E. / Kuhns, Andrew R. / Phillips, Christopher A.

Ecological Indicators. 2023 Oct., v. 154 p.110736-

2023

Abstract: A primary response to the Clean Water Act has been the development of numerous indices of biotic integrity (IBI) using various taxonomic groups to assess the condition of water bodies in the United States. The IBI is a frequently used approach for ... ...

Abstract	A primary response to the Clean Water Act has been the development of numerous indices of biotic integrity (IBI) using various taxonomic groups to assess the condition of water bodies in the United States. The IBI is a frequently used approach for assessing the ecological integrity of streams; however, it is less commonly applied to wetland systems, despite the scientific and policy needs to assess wetland condition and develop ecological performance goals for wetland monitoring, creation, and restoration. Although a great deal of attention has been given to wetland acreage due to the “no net loss” policy over the past two decades, much less attention has been given to the ecological integrity of these same wetlands. To assess wetland health and function, regulatory agencies and land managers need clear performance standards that are based on the ecology of wetland organisms. To address this need, we sampled 242 wetlands distributed across 45 managed properties in Illinois, U.S.A. over three years (2012–2014) for adult and larval amphibians (12 samples per wetland). Amphibian assemblages make up critical ecological components of many wetland ecosystems and are considered useful bioindicators of environmental change because they are sensitive to various forms of environmental and habitat alteration. We developed an amphibian-based IBI (hereafter aIBI) for the assessment of seasonal wetlands and optimal sampling strategies to best quantify these wetlands (i.e., assessment of time and effort). The aIBI applied a conservation coefficient to all species captured; conservation coefficients were developed through a survey of amphibian experts (n = 16). We captured 25 amphibian species with an average of 7.11 amphibian species (range 1–13) per site. Using the species occurrence data collected from both dipnet and minnow trap surveys over 12 survey periods, we assessed the average percent error in the estimation of aIBIs and species richness. Our results show that a wetland can be accurately evaluated with amphibians in one field season, but that multiple samples during that field season will be necessary. We show that 4–5 surveys using multiple methods distributed throughout the spring and summer are required. This level of effort may be incongruent with existing definitions of ‘rapid assessment’, but it is the necessary level of effort needed to confidently and accurately evaluate wetlands using amphibians as an indicator taxon. Additionally, aIBI provides a more robust framework to assess wetland integrity compared to simple species richness or other similar methodologies.
Keywords	Clean Water Act ; acreage ; adults ; amphibians ; habitat destruction ; indicator species ; issues and policy ; larvae ; minnows ; species richness ; spring ; summer ; surveys ; wetlands ; Illinois ; Bioindicator ; Conservation ; Detection ; Frog ; Monitoring ; Salamander
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2023.110736
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Article ; Online: Using a Hybrid Approach to Increase the Impact of Medical Response to Natural Disasters.

Levy, Danielle M / Kottler, Jeffrey A / Adams, Jason W / Crawford, John R / Levy, Michael L

Disaster medicine and public health preparedness

2023 Volume 17, Page(s) e303

Abstract: The United Nations (UN) established an umbrella of organizations to manage distinct clusters of humanitarian aid. The World Health Organization (WHO) oversees the health cluster, giving it responsibility for global, national, and local medical responses ... ...

Abstract	The United Nations (UN) established an umbrella of organizations to manage distinct clusters of humanitarian aid. The World Health Organization (WHO) oversees the health cluster, giving it responsibility for global, national, and local medical responses to natural disasters. However, this centralized structure insufficiently engages local players, impeding robust local implementation. The Gorkha earthquake struck Nepal on April 25, 2015, becoming Nepal's most severe natural disaster since the 1934 Nepal-Bihar earthquake. In coordinated response, 2 organizations, Empower Nepali Girls and International Neurosurgical Children's Association, used a hybrid approach integrating continuous communication with local recipients. Each organization mobilized its principal resource strengths-material medical supplies or human capital-thereby efficiently deploying resources to maximize the impact of the medical response. In addition to efficient resource use, this approach facilitates dynamic medical responses from highly mobile organizations. Importantly, in addition to future earthquakes in Nepal, this medical response strategy is easily scalable to other natural disaster contexts and other medical relief organizations. Preemptively identifying partner organizations with complementary strengths, continuous engagement with recipient populations, and creating disaster- and region-specific response teams may represent viable variations of the WHO cluster model with greater efficacy in local implementation of treatment in acute disaster scenarios.
MeSH term(s)	Child ; Female ; Humans ; Natural Disasters ; Disasters ; Earthquakes ; Nepal ; World Health Organization ; Disaster Planning
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2022.263
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