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  1. Article: New approaches to T-cell acute lymphoblastic leukemia.

    Teachey, David T

    Clinical advances in hematology & oncology : H&O

    2022  Volume 20, Issue 5, Page(s) 295–298

    MeSH term(s) Humans ; Mutation ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; T-Lymphocytes
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  2. Article ; Online: PI3king apart a rare disease with targeted therapy.

    Newman, Haley / Teachey, David T

    Blood

    2023  Volume 141, Issue 9, Page(s) 963–964

    MeSH term(s) Humans ; Rare Diseases/drug therapy
    Chemical Substances leniolisib
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022019105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  3. Article ; Online: TORing the impact of sirolimus on immune health.

    Gollomp, Kandace / Teachey, David T

    Blood

    2023  Volume 141, Issue 3, Page(s) 212–214

    MeSH term(s) Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Tacrolimus ; TOR Serine-Threonine Kinases ; T-Lymphocytes/immunology
    Chemical Substances Sirolimus (W36ZG6FT64) ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Please eat me! Targeting CD47 and CD38 in T-ALL.

    Diorio, Caroline / Teachey, David T

    Blood

    2022  Volume 140, Issue 1, Page(s) 6–8

    MeSH term(s) Antibodies, Monoclonal ; CD47 Antigen ; Child ; Humans ; Immunotherapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    Chemical Substances Antibodies, Monoclonal ; CD47 Antigen ; CD47 protein, human ; daratumumab (4Z63YK6E0E)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016774
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  5. Article ; Online: A Bright Horizon: Immunotherapy for Pediatric T-Cell Malignancies.

    Newman, Haley / Teachey, David T

    International journal of molecular sciences

    2022  Volume 23, Issue 15

    Abstract: ... immunotherapies. For pediatric patients with T-cell malignancies, translating immunotherapies has proved more ... concerns over T-cell aplasia. Despite these hurdles, many creative and promising strategies are ... on the horizon. We review challenges in the development of immunotherapy for T-cell malignancies, strategies ...

    Abstract Immunotherapy has transformed the treatment of hematologic malignancies in the past two decades. The treatment of acute lymphoblastic leukemia (ALL), in particular, has been highly impacted by multiple novel immunotherapies. For pediatric patients with T-cell malignancies, translating immunotherapies has proved more challenging due to the complexities of fratricide, risk of product contamination with malignant cells, and concerns over T-cell aplasia. Despite these hurdles, many creative and promising strategies are on the horizon. We review challenges in the development of immunotherapy for T-cell malignancies, strategies to overcome these challenges, as well as therapies currently being investigated and starting to reach the clinic. Immunotherapy will hopefully successfully treat patients with relapsed and refractory T-cell malignancies and may someday be incorporated in up-front protocols in order to prevent relapses.
    MeSH term(s) Child ; Hematologic Neoplasms/therapy ; Humans ; Immunotherapy/methods ; Immunotherapy, Adoptive/methods ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Antigen, T-Cell ; T-Lymphocytes/pathology
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23158600
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  6. Article ; Online: SOHO State of the Art Updates and Next Questions | Novel Approaches to Pediatric T-cell ALL and T-Lymphoblastic Lymphoma.

    Summers, Ryan J / Teachey, David T

    Clinical lymphoma, myeloma & leukemia

    2022  Volume 22, Issue 10, Page(s) 718–725

    Abstract: While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic ... lymphoma (T-LL) have improved significantly with contemporary therapy, outcomes for patients with relapsed ... of novel therapeutics have the potential to improve outcomes further in T-ALL/T-LL by limiting relapse risk ...

    Abstract While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LL) have improved significantly with contemporary therapy, outcomes for patients with relapsed or refractory (r/r) disease remain dismal. Improved risk stratification and the incorporation of novel therapeutics have the potential to improve outcomes further in T-ALL/T-LL by limiting relapse risk and improving salvage rates for those with r/r disease. In this review we will discuss the challenges and new opportunities for improved risk stratification in T-ALL and T-LL. We will further discuss the recent incorporation of the novel therapeutics nelarabine and bortezomib into front-line therapy for children with T-ALL and T-LL. Finally, we will address new classes of targeted small molecule inhibitors, immunotherapeutics, and chimeric antigen receptor T-cell therapies under investigation in r/r T-ALL and T-LL.
    MeSH term(s) Bortezomib ; Child ; Humans ; Immunotherapy, Adoptive ; Lymphoma, Non-Hodgkin ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Chimeric Antigen ; T-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen ; Bortezomib (69G8BD63PP)
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2022.07.010
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    Zs.A 5903: Show issues Location:
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  7. Article ; Online: Excellent outcomes for patients with B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses.

    Teachey, David T

    The Lancet. Haematology

    2019  Volume 6, Issue 4, Page(s) e172–e173

    MeSH term(s) B-Lymphocytes ; Bone Marrow ; Bone Marrow Transplantation ; Child ; Follow-Up Studies ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Recurrence
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30032-8
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  8. Article ; Online: Cytokine Storm Syndromes in Pediatric Patients.

    Diorio, Caroline / Teachey, David T / Canna, Scott W

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 6, Page(s) 1636–1644

    Abstract: Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host factors, including genetic risk and predisposing ... ...

    Abstract Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host factors, including genetic risk and predisposing conditions, and acute triggers such as infections. CSS present differently in adults than in children, who are more likely to present with monogenic forms of these disorders. Individual CSS are rare, but in aggregate represent an important cause of severe illness in both children and adults. We present 3 rare, illustrative cases of CSS in pediatric patients that describe the spectrum of CSS.
    MeSH term(s) Humans ; Child ; COVID-19/complications ; SARS-CoV-2 ; Cytokine Release Syndrome ; Cytokines ; Immune System
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.03.033
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  9. Article ; Online: Anti-CD7 CAR T cells for T-ALL: impressive early-stage efficacy.

    Teachey, David T / Hunger, Stephen P

    Nature reviews. Clinical oncology

    2021  Volume 18, Issue 11, Page(s) 677–678

    MeSH term(s) Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; T-Lymphocytes
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-021-00556-3
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    Zs.A 6029: Show issues Location:
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  10. Article ; Online: Taking a BiTE Out of CAR-T Cell Efficacy.

    Newman, Haley M / Teachey, David T

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 40, Issue 9, Page(s) 921–923

    MeSH term(s) Humans ; Immunotherapy, Adoptive ; Receptors, Chimeric Antigen ; T-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.02465
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