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  1. Article ; Online: Bizarre parosteal osteocondromatous proliferation (BPOP) of the acromion with soft tissue recurrence.

    Karp, John / Malik, Faizan / Zhang, Paul J / Alizai, Hamza

    Skeletal radiology

    2024  

    Abstract: Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign but rare periosteal-originating chondrogenic tumor. It commonly arises from the hands and feet. It is slow-growing and often presents as a painless lump. On imaging, the mass is well- ... ...

    Abstract Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign but rare periosteal-originating chondrogenic tumor. It commonly arises from the hands and feet. It is slow-growing and often presents as a painless lump. On imaging, the mass is well-marginated and almost always remains contiguous with the cortical bone. Histologically, the lesion is composed of a disorganized admixture of fibrous tissue, bone, and cartilage with bizarre features. Treatment is surgical and local recurrence is common contiguous with bone. This case report demonstrates an uncommon acromial BPOP with the first reported recurrence not contiguous with the underlying cortex.
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-024-04646-y
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  2. Article ; Online: Balancing risks and benefits: nuisance medication and cognitive decline in late-life.

    Karp, Jordan F / Erisman, Matthew / Singh, Jasmine

    International psychogeriatrics

    2023  Volume 36, Issue 2, Page(s) 89–91

    MeSH term(s) Humans ; Cognitive Dysfunction/drug therapy ; Risk Factors
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610223000534
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  3. Article: Psychosocial interventions to improve adherence in depressed and anxious older adults prescribed antidepressant pharmacotherapy: a scoping review.

    Stahl, Sarah T / Kincman, Joelle / Karp, Jordan F / Anne Gebara, Marie

    Therapeutic advances in psychopharmacology

    2023  Volume 13, Page(s) 20451253231212322

    Abstract: Medication nonadherence in depressed and anxious older adults is prevalent and associated with non-response to antidepressant pharmacotherapy. Evidence-based options to improve medication adherence are limited in this population. To review the state of ... ...

    Abstract Medication nonadherence in depressed and anxious older adults is prevalent and associated with non-response to antidepressant pharmacotherapy. Evidence-based options to improve medication adherence are limited in this population. To review the state of the literature on the types and efficacy of psychosocial interventions for improving antidepressant pharmacotherapy adherence in depressed and anxious older adults. We conducted a scoping review according to PRISMA-ScR guidelines. PubMed/Medline and article references starting in 1980 up to 28 February 2023 were reviewed. Of the 710 records screened, 4 psychosocial interventions were included in the review. All studies included depressed older adults, and none included anxious older adults. Samples included racial and ethnic minorities and were primarily women. The psychosocial interventions consisted mainly of psychoeducation with usual care as the control comparison. Measures of antidepressant adherence included self-reported adherence or pill counting. Three of the four randomized controlled trials improved medication adherence rates and reduced depression symptom burden. Effective interventions exist for improving antidepressant medication adherence in depressed older adults. Improved adherence can reduce depression symptom burden. The lack of interventions for anxious older adults highlights the need to develop and deliver interventions for anxious older adults prescribed antidepressant pharmacotherapy.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2646542-5
    ISSN 2045-1261 ; 2045-1253
    ISSN (online) 2045-1261
    ISSN 2045-1253
    DOI 10.1177/20451253231212322
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  4. Article ; Online: Dynamic Feedback Between Antidepressant Placebo Expectancies and Mood.

    Peciña, Marta / Chen, Jiazhou / Karp, Jordan F / Dombrovski, Alexandre Y

    JAMA psychiatry

    2023  Volume 80, Issue 4, Page(s) 389–398

    Abstract: Importance: Despite high antidepressant placebo response rates, the mechanisms underlying the persistence of antidepressant placebo effects are still poorly understood.: Objective: To investigate the neurobehavioral mechanisms underlying the ... ...

    Abstract Importance: Despite high antidepressant placebo response rates, the mechanisms underlying the persistence of antidepressant placebo effects are still poorly understood.
    Objective: To investigate the neurobehavioral mechanisms underlying the evolution of antidepressant placebo effects using a reinforcement learning (RL) framework.
    Design, setting, and participants: In this acute within-patient cross-sectional study of antidepressant placebos, patients aged 18 to 55 years not receiving medication for major depressive disorder (MDD) were recruited at the University of Pittsburgh between February 21, 2017, to March 1, 2021.
    Interventions: The antidepressant placebo functional magnetic resonance imaging task manipulates placebo-associated expectancies using visually cued fast-acting antidepressant infusions and controls their reinforcement with sham visual neurofeedback while assessing expected and experienced mood improvement.
    Main outcomes and measures: The trial-by-trial evolution of expectancies and mood was examined using multilevel modeling and RL, relating model-predicted signals to spatiotemporal dynamics of blood oxygenation level-dependent (BOLD) response.
    Results: A bayesian RL model comparison in 60 individuals (mean [SE] age, 24.5 [0.8] years; 51 females [85%]) with MDD revealed that antidepressant placebo trial-wise expectancies were updated by composite learning signals multiplexing sensory evidence (neurofeedback) and trial-wise mood (bayesian omnibus risk <0.001; exceedance probability = 97%). Placebo expectancy, neurofeedback manipulations, and composite learning signals modulated the visual cortex and dorsal attention network (threshold-free cluster enhancement [TFCE] = 1 - P >.95). As participants anticipated antidepressant infusions, learned placebo expectancies modulated the salience network (SN, TFCE = 1 - P >.95), positively scaling with depression severity.
    Conclusions and relevance: Results of this cross-sectional study suggest that on a timescale of minutes, antidepressant placebo effects were maintained by positive feedback loops between expectancies and mood improvement. During learning, representations of placebos and their perceived effects were enhanced in primary and secondary sensory cortices. Latent learned placebo expectancies were encoded in the SN.
    MeSH term(s) Adult ; Female ; Humans ; Young Adult ; Antidepressive Agents/therapeutic use ; Bayes Theorem ; Cross-Sectional Studies ; Depressive Disorder, Major/drug therapy ; Feedback
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.0010
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  5. Article ; Online: CYP2D6 Phenotype Influences Pharmacokinetic Parameters of Venlafaxine: Results from a Population Pharmacokinetic Model in Older Adults with Depression.

    Men, Xiaoyu / Taylor, Zachary L / Marshe, Victoria S / Blumberger, Daniel M / Karp, Jordan F / Kennedy, James L / Lenze, Eric J / Reynolds, Charles F / Stefan, Cristiana / Mulsant, Benoit H / Ramsey, Laura B / Müller, Daniel J

    Clinical pharmacology and therapeutics

    2024  Volume 115, Issue 5, Page(s) 1065–1074

    Abstract: In this study, we aimed to improve upon a published population pharmacokinetic (PK) model for venlafaxine (VEN) in the treatment of depression in older adults, then investigate whether CYP2D6 metabolizer status affected model-estimated PK parameters of ... ...

    Abstract In this study, we aimed to improve upon a published population pharmacokinetic (PK) model for venlafaxine (VEN) in the treatment of depression in older adults, then investigate whether CYP2D6 metabolizer status affected model-estimated PK parameters of VEN and its active metabolite O-desmethylvenlafaxine. The model included 325 participants from a clinical trial in which older adults with depression were treated with open-label VEN (maximum 300 mg/day) for 12 weeks and plasma levels of VEN and O-desmethylvenlafaxine were assessed at weeks 4 and 12. We fitted a nonlinear mixed-effect PK model using NONMEM to estimate PK parameters for VEN and O-desmethylvenlafaxine adjusted for CYP2D6 metabolizer status and age. At both lower doses (up to 150 mg/day) and higher doses (up to 300 mg/day), CYP2D6 metabolizers impacted PK model-estimated VEN clearance, VEN exposure, and active moiety (VEN + O-desmethylvenlafaxine) exposure. Specifically, compared with CYP2D6 normal metabolizers, (i) CYP2D6 ultra-rapid metabolizers had higher VEN clearance; (ii) CYP2D6 intermediate metabolizers had lower VEN clearance; (iii) CYP2D6 poor metabolizers had lower VEN clearance, higher VEN exposure, and higher active moiety exposure. Overall, our study showed that including a pharmacogenetic factor in a population PK model could increase model fit, and this improved model demonstrated how CYP2D6 metabolizer status affected VEN-related PK parameters, highlighting the importance of genetic factors in personalized medicine.
    MeSH term(s) Aged ; Humans ; Cyclohexanols/pharmacokinetics ; Cyclohexanols/therapeutic use ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2D6/metabolism ; Depression/drug therapy ; Desvenlafaxine Succinate ; Genotype ; Phenotype ; Venlafaxine Hydrochloride/pharmacokinetics ; Venlafaxine Hydrochloride/therapeutic use
    Chemical Substances Cyclohexanols ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Desvenlafaxine Succinate (ZB22ENF0XR) ; Venlafaxine Hydrochloride (7D7RX5A8MO)
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3162
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  6. Article ; Online: Corrigendum to Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized. Am J Geriatr Psychiatry 2019;27(10):1138-1152. doi: 10.1016/j.jagp.2019.04.005.

    Cristancho, Pilar / Lenard, Emily / Lenze, Eric J / Miller, J Philip / Brown, Patrick J / Roose, Steven P / Montes-Garcia, Carolina / Blumberger, Daniel M / Mulsant, Benoit H / Lavretsky, Helen / Rollman, Bruce L / Reynolds, Charles F / Karp, Jordan F

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2023  Volume 31, Issue 6, Page(s) 472–473

    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2023.02.042
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    Zs.A 4443: Show issues Location:
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  7. Article ; Online: Sex differences in plasma proteomic markers in late-life depression.

    Xue, Xiangning / Demirci, Derya / Lenze, Eric J / Reynolds Iii, Charles F / Mulsant, Benoit H / Wetherell, Julie Loebach / Wu, Gregory F / Blumberger, Daniel M / Karp, Jordan F / Butters, Meryl A / Mendes-Silva, Ana Paula / Vieira, Erica L / Tseng, George / Diniz, Breno S

    Psychiatry research

    2024  Volume 334, Page(s) 115773

    Abstract: Previous studies have shown significant sex-specific differences in major depressive disorder (MDD) in multiple biological parameters. Most studies focused on young and middle-aged adults, and there is a paucity of information about sex-specific ... ...

    Abstract Previous studies have shown significant sex-specific differences in major depressive disorder (MDD) in multiple biological parameters. Most studies focused on young and middle-aged adults, and there is a paucity of information about sex-specific biological differences in older adults with depression (aka, late-life depression (LLD)). To address this gap, this study aimed to evaluate sex-specific biological abnormalities in a large group of individuals with LLD using an untargeted proteomic analysis. We quantified 344 plasma proteins using a multiplex assay in 430 individuals with LLD and 140 healthy comparisons (HC) (age range between 60 and 85 years old for both groups). Sixty-six signaling proteins were differentially expressed in LLD (both sexes). Thirty-three proteins were uniquely associated with LLD in females, while six proteins were uniquely associated with LLD in males. The main biological processes affected by these proteins in females were related to immunoinflammatory control. In contrast, despite the smaller number of associated proteins, males showed dysregulations in a broader range of biological pathways, including immune regulation pathways, cell cycle control, and metabolic control. Sex has a significant impact on biomarker changes in LLD. Despite some overlap in differentially expressed biomarkers, males and females show different patterns of biomarkers changes, and males with LLD exhibit abnormalities in a larger set of biological processes compared to females. Our findings can provide novel targets for sex-specific interventions in LLD.
    MeSH term(s) Middle Aged ; Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Depression ; Depressive Disorder, Major ; Sex Characteristics ; Proteomics ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115773
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  8. Article ; Online: Change in patient-centered outcomes of psychological well-being, sleep, and suicidality following treatment with intravenous ketamine for late-life treatment-resistant depression.

    Vanderschelden, Benjamin / Gebara, Marie Anne / Oughli, Hanadi Ajam / Butters, Meryl A / Brown, Patrick J / Farber, Nuri B / Flint, Alastair J / Karp, Jordan F / Lavretsky, Helen / Mulsant, Benoit H / Reynolds, Charles F / Roose, Steven P / Lenze, Eric J

    International journal of geriatric psychiatry

    2023  Volume 38, Issue 7, Page(s) e5964

    Abstract: Objective: To examine whether psychological well-being, sleep, and suicidality improved with treatment with intravenous (IV) ketamine for late-life treatment-resistant depression (TRD).: Methods: This is an analysis of secondary outcomes in an open- ... ...

    Abstract Objective: To examine whether psychological well-being, sleep, and suicidality improved with treatment with intravenous (IV) ketamine for late-life treatment-resistant depression (TRD).
    Methods: This is an analysis of secondary outcomes in an open-label late-life TRD study examining the safety, tolerability, and feasibility of IV ketamine infusions. In the acute phase, participants (N = 25) aged 60 years or older received twice-a-week IV ketamine for 4 weeks. Then, participants with Montgomery-Asberg Depression Rating Scale (MADRS) total score <10 or ≥ 30% reduction from baseline proceeded to the continuation phase, an additional four weeks of once-a-week IV ketamine. The secondary outcomes analyzed here are based on the National Institute of Health Toolbox Psychological Well-Being subscales for Positive Affect and General Life Satisfaction, the Pittsburgh Sleep Quality Index, and the Scale for Suicidal Ideation.
    Results: Psychological well-being, sleep, and suicidality improved during the acute phase and those improvements were sustained during the continuation phase. Greater improvements in measures of psychological well-being and sleep were seen in participants who had greater improvements in MADRS scores and moved onto the continuation phase. All but one of the few participants with high suicidality at baseline improved; there were no cases of treatment-emergent suicidality.
    Conclusions: Psychological well-being, sleep, and suicidality improved in participants with late-life TRD who received IV ketamine for 8 weeks. A future larger and longer controlled trial is needed to confirm and extend these findings.
    Registration: ClinicalTrials.gov identifier: NCT04504175.
    MeSH term(s) Humans ; Depression ; Ketamine/therapeutic use ; Patient-Centered Care ; Psychological Well-Being ; Sleep ; Suicidal Ideation ; Suicide
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5964
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  9. Article ; Online: Erratum for Proctor et al., "Resources To Facilitate Use of the Altered Schaedler Flora (ASF) Mouse Model To Study Microbiome Function".

    Proctor, Alexandra / Parvinroo, Shadi / Richie, Tanner / Jia, Xinglin / Lee, Sonny T M / Karp, Peter D / Paley, Suzanne / Kostic, Aleksandar D / Pierre, Joseph F / Wannemuehler, Michael J / Phillips, Gregory J

    mSystems

    2023  Volume 8, Issue 2, Page(s) e0120522

    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.01205-22
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  10. Article ; Online: Association between lean muscle mass and treatment-resistant late-life depression in the IRL-GRey randomized controlled trial.

    Ainsworth, Nicholas J / Brender, Ram / Gotlieb, Neta / Zhao, Haoyu / Blumberger, Daniel M / Karp, Jordan F / Lenze, Eric J / Nicol, Ginger E / Reynolds, Charles F / Wang, Wei / Mulsant, Benoit H

    International psychogeriatrics

    2023  Volume 35, Issue 12, Page(s) 707–716

    Abstract: Objective: To investigate the relationship between lean muscle mass and treatment response in treatment-resistant late-life depression (TR-LLD). We hypothesized that lower lean muscle mass would be associated with older age, higher physical ... ...

    Abstract Objective: To investigate the relationship between lean muscle mass and treatment response in treatment-resistant late-life depression (TR-LLD). We hypothesized that lower lean muscle mass would be associated with older age, higher physical comorbidities, higher depressive symptom severity, and poorer treatment response.
    Design: Secondary analysis of a randomized, placebo-controlled trial.
    Setting: Three academic hospitals in the United States and Canada.
    Participants: Adults aged 60+ years with major depressive disorder who did not remit following open treatment with venlafaxine extended-release (XR) (n = 178).
    Measurements: We estimated lean muscle mass using dual-energy X-ray absorptiometry (DEXA) scans prior to and following randomized treatment with aripiprazole or placebo added to venlafaxine XR. Multivariate regressions estimated influence of demographic and clinical factors on baseline lean muscle mass, and whether baseline lean muscle mass was associated with treatment response, adjusted for treatment arm.
    Results: Low lean muscle mass was present in 22 (12.4%) participants. Older age and female sex, but not depressive symptom severity, were independently associated with lower lean muscle mass at baseline. Marital status, baseline depressive symptom severity, and treatment group were associated with improvement of depressive symptoms in the randomized treatment phase. Baseline lean muscle mass was not associated with improvement, regardless of treatment group.
    Conclusion: As expected, older age and female sex were associated with lower lean muscle mass in TR-LLD. However, contrary to prior results in LLD, lean muscle mass was not associated with depression severity or outcome. This suggests that aripiprazole augmentation may be useful for TR-LLD, even in the presence of anomalous body composition.clinicaltrials.gov Identifier: NCT00892047.
    MeSH term(s) Humans ; Female ; Venlafaxine Hydrochloride/therapeutic use ; Aripiprazole/therapeutic use ; Treatment Outcome ; Depression/therapy ; Depressive Disorder, Major/drug therapy ; Muscles ; Double-Blind Method
    Chemical Substances Venlafaxine Hydrochloride (7D7RX5A8MO) ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610222000862
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