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Article ; Online: Measures for Identifying Malnutrition in Geriatric Rehabilitation: A Scoping Review.

Nishioka, Shinta / Kokura, Yoji / Momosaki, Ryo / Taketani, Yutaka

2024 Volume 16, Issue 2

Abstract: Malnutrition is a common condition in geriatric rehabilitation settings; however, the accuracy and predictive validity of the measures to identify malnutrition have not been established. The current scoping review followed the Joanna Briggs Institute's ... ...

Abstract	Malnutrition is a common condition in geriatric rehabilitation settings; however, the accuracy and predictive validity of the measures to identify malnutrition have not been established. The current scoping review followed the Joanna Briggs Institute's evidence synthesis manual and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews checklist. Literature published through September 2023 was searched using MEDLINE and CINAHL. The inclusion criteria selected studies reporting malnutrition measures, which include static body weight and weight loss. Identified tools were classified as nutritional screening tools, nutritional assessment tools, or diagnostic criteria. The domains of each tool/criterion and their accuracy and predictive validity were extracted. Fifty-six articles fulfilled the inclusion criteria, and six nutritional screening tools, three nutritional assessment tools, and three diagnostic criteria for malnutrition were identified. These measures consisted of various phenotypes, e.g., weight loss, causes such as inflammation/disease, and risk factors of malnutrition, e.g., functional impairment. The predictive validity of nutritional screening tools (
MeSH term(s)	Humans ; Aged ; Nutrition Assessment ; Nutritional Status ; Malnutrition/diagnosis ; Body Weight ; Weight Loss
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020223
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Article ; Online: Role of Vitamins and Minerals in Health and Diseases.

Tanaka, Kiyoshi / Taketani, Yutaka / Angeles-Agdeppa, Imelda / Kambe, Taiho

Journal of nutritional science and vitaminology

2022 Volume 68, Issue Supplement, Page(s) S70–S72

Abstract: We have adopted the following four topics: 1) dietary phosphorus management in chronic kidney disease (CKD) patients, 2) inadequate nutrient intakes in Filipino schoolchildren and adolescents, 3) clinical and societal implications of vitamin ... ...

Abstract	We have adopted the following four topics: 1) dietary phosphorus management in chronic kidney disease (CKD) patients, 2) inadequate nutrient intakes in Filipino schoolchildren and adolescents, 3) clinical and societal implications of vitamin insufficiency, and 4) zinc transporters. Vitamins and minerals play essential roles in health promotion in clinical and societal perspectives with marked advances in understanding the mechanism underlying such effects.
MeSH term(s)	Adolescent ; Humans ; Child ; Vitamins ; Vitamin A ; Minerals ; Vitamin K ; Phosphorus
Chemical Substances	Vitamins ; Vitamin A (11103-57-4) ; Minerals ; Vitamin K (12001-79-5) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2022-09-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.68.S70
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Article ; Online: Investigation of Amino Acid and Fatty Acid Profiles of Japanese Diets Using the Food Exchange Lists for Diabetes Diet.

Tsumura, Ayari / Yamanaka-Okumura, Hisami / Kawakami, Hana / Yamamoto, Shiori / Oura, Mayu / Tatano, Hiroshi / Ohminami, Hirokazu / Masuda, Masashi / Taketani, Yutaka

Journal of nutritional science and vitaminology

2024 Volume 70, Issue 1, Page(s) 25–35

Abstract: Dietary Reference Intakes for Japanese provide target values for proteins, fats, and carbohydrates. However, they do not provide information on reference values for amino acids (AAs) and fatty acids (FAs), which determine the quality of foods in detail. ... ...

Abstract	Dietary Reference Intakes for Japanese provide target values for proteins, fats, and carbohydrates. However, they do not provide information on reference values for amino acids (AAs) and fatty acids (FAs), which determine the quality of foods in detail. Therefore, we evaluated AAs and FAs using the Food Exchange Lists-Dietary Guidance for Persons with Diabetes (in Japanese) Utilization, Second Edition Sample Menus and Practice (FELD) as an ideal Japanese diet. Based on FELD, 15 different daily meal patterns were employed with combinations of three levels of carbohydrates %energy (high carbohydrate [HC], 60%; middle carbohydrate [MC], 55%; and low carbohydrate [LC], 50%) and five levels of energy (1,200-2,000 kcal). Using the Japanese Food Composition Table 2020 adjusted for 1,000 kcal, 18 AAs, 49 FAs, and calorie densities (CDs, kcal/g) were calculated and compared among the three groups. Dietary AA was rich in glutamic acid, aspartic acid, and leucine; in order, no significant differences were observed among HC, MC, and LC for 18 AAs. Dietary FA was higher for 18:1 total, 16:0, and 18:2 n-6. Moreover, 16:0, 20:0, and 18:1 total in LC and 22:0 and 18:3 n-3 in MC were significantly higher than those in HC. The HC, MC, and LC CD was low at 0.82, 0.84, and 0.93 kcal/g, respectively. No significant differences in 18 AAs and CD were noted among HC, MC, and LC in FELD; however, significant differences were observed in the FA profiles. This study suggests the importance of evaluating diet using AA and FA units.
MeSH term(s)	Fatty Acids ; Amino Acids ; Japan ; Dietary Carbohydrates ; Diet ; Dietary Fats ; Diabetes Mellitus
Chemical Substances	Fatty Acids ; Amino Acids ; Dietary Carbohydrates ; Dietary Fats
Language	English
Publishing date	2024-02-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.70.25
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Article: Dietary phosphate disturbs of gut microbiome in mice.

Oda, Naoko / Sugihara, Kohei / Uebanso, Takashi / Ohminami, Hirokazu / Ohnishi, Kohta / Masuda, Masashi / Yamanaka-Okumura, Hisami / Taketani, Yutaka

Journal of clinical biochemistry and nutrition

2023 Volume 73, Issue 3, Page(s) 221–227

Abstract: Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. ... ...

Abstract	Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake of phosphate on gut microbiome. Five-week-old male C57BL/6J mice were fed either control diet or high phosphate diet for eight weeks. Analysis of the gut microbiota was carried out using MiSeq next generation sequencer, and short-chain fatty acids were determined with GC-MS. In analysis of gut microbiota, significantly increased in
Language	English
Publishing date	2023-07-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.23-9
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Zs.B 2981: Show issues

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Article ; Online: Predictive validity of the Mini Nutritional Assessment Short-Form for rehabilitation patients: A retrospective analysis of the Japan Rehabilitation Nutrition Database.

Nishioka, Shinta / Wakabayashi, Hidetaka / Kayashita, Jun / Taketani, Yutaka / Momosaki, Ryo

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

2021 Volume 34, Issue 5, Page(s) 881–889

Abstract: Background: Malnutrition is associated with worse outcome in rehabilitation patients; however, appropriate malnutrition screening tools for this population have not been investigated. We examined the predictive validity of specific cut-off values of the ...

Abstract	Background: Malnutrition is associated with worse outcome in rehabilitation patients; however, appropriate malnutrition screening tools for this population have not been investigated. We examined the predictive validity of specific cut-off values of the Mini Nutritional Assessment Short-Form version 2 (MNA-SFv2) for Japanese rehabilitation patients. Methods: This retrospective cohort study analyzed adult patients (≥ 20 years) in the Japan Rehabilitation Nutrition Database who were in convalescent rehabilitation wards after stroke or hip fracture. Patients were classified into three categories based on MNA-SFv2 original (0-7, 8-11 and 12-14 points, respectively) or modified (0-5, 6-7 and 8-14 points, respectively) cut-off values: malnutrition, at risk of malnutrition or well-nourished. Functional independence measure (FIM) and home discharge were compared between the categories. Results: Overall, 489 patients were analyzed. Based on the MNA-SFv2 original and modified cut-off values, 64.4% and 36.0% were malnourished, 32.3% and 28.4% were at risk of malnutrition, and 3.3% and 35.6% were well-nourished, respectively. Malnutrition defined by both cut-off values was significantly associated with the FIM at admission, whereas only those defined by modified cut-off values predicted the FIM at discharge (B, -7.1; 95% confidence interval = -12.3 to -1.9). Neither original, nor modified cut-off values predicted discharge to home and long-term care facilities. Conclusions: An MNA-SFv2 score of 0-5 points may be useful to identify Japanese patients with poor outcomes in a rehabilitation setting.
MeSH term(s)	Aged ; Geriatric Assessment ; Humans ; Japan ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Nutrition Assessment ; Nutritional Status ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645183-4
ISSN	1365-277X ; 0952-3871 ; 1465-8178
ISSN (online)	1365-277X
ISSN	0952-3871 ; 1465-8178
DOI	10.1111/jhn.12887
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Zs.A 2551: Show issues

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Article ; Online: Diaper-zero program (prompted voiding care) improves diaper use in nursing home residents.

Kohno, Kazuyo / Umemoto, Nobuhiko / Tsutsumi, Rie / Kawakami, Ayuka / Sakaue, Hiroshi / Tamura, Kyousuke / Morishita, Teruhiro / Taketani, Yutaka / Uyama, Kimihito / Takeda, Eiji

The journal of medical investigation : JMI

2023 Volume 70, Issue 1.2, Page(s) 221–225

Abstract: With an aging population, the number of older adults admitted to nursing homes has increased. Diapers are often used to manage nursing home resident urinary incontinence, yet only one-third of these required assistance from caregivers to urinate. ... ...

Abstract	With an aging population, the number of older adults admitted to nursing homes has increased. Diapers are often used to manage nursing home resident urinary incontinence, yet only one-third of these required assistance from caregivers to urinate. Unnecessary diaper use was reported in 23.9% of peop1e, mostly for precautionary purposes. In this study, the Diaper-zero program caregivers asked residents regularly (every 2-3 h) whether they required voiding and prompted them to void. Over 11 months, the effects on 38 nursing home residents' diaper use, nursing care level, physical activity, daily energy, and water intake were measured. A higher rate of diaper wearing was initially observed with lower daily energy and water intakes at the beginning of the Diaper-zero program, but this association was not observed after 11 months of the program. The diaper usage rate decreased significantly from 71.1% to 47.4% after 11 months. During this period, for all subjects, nursing care level, physical activity, and total daily intakes of energy and water were unchanged. In conclusion, this program enhances the desire to void, minimizing diaper usage, thus protecting the human dignity of nursing home residents. J. Med. Invest. 70 : 221-225, February, 2023.
MeSH term(s)	Humans ; Aged ; Nursing Homes ; Urinary Incontinence
Language	English
Publishing date	2023-05-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.70.221
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Zs.A 264: Show issues

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Article ; Online: Elevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6 nephrectomized rats.

Okumura, Yosuke / Abe, Kotaro / Sakai, Shoko / Kamei, Yuki / Mori, Yuki / Adachi, Yuichiro / Takikawa, Masaki / Kitamura, Ayano / Ohminami, Hirokazu / Ohnishi, Kohta / Masuda, Masashi / Kambe, Taiho / Yamamoto, Hironori / Taketani, Yutaka

American journal of physiology. Renal physiology

2024 Volume 326, Issue 3, Page(s) F411–F419

Abstract: Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is ...

Abstract	Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is often impaired; however, the mechanism underlying Zn malabsorption remains unclear. Here, we evaluated intestinal Zn absorption capacity in a rat model of CKD induced by 5/6 nephrectomy (5/6 Nx). Rats were given Zn and the incremental area under the plasma Zn concentration-time curve (iAUC) was measured as well as the expression of ZIP4, an intestinal Zn transporter. We found that 5/6 Nx rats showed lower iAUC than sham-operated rats, but expression of ZIP4 protein was upregulated. We therefore focused on other Zn absorption regulators to explore the mechanism by which Zn absorption was substantially decreased. Because some phosphate compounds inhibit Zn absorption by coprecipitation and hyperphosphatemia is a common symptom in advanced CKD, we measured inorganic phosphate (P
MeSH term(s)	Humans ; Rats ; Animals ; Phosphates/metabolism ; Hyperphosphatemia/drug therapy ; Zinc ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/complications ; Nephrectomy/adverse effects ; Intestinal Absorption
Chemical Substances	Phosphates ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00310.2023
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Article ; Online: All-trans retinoic acid induces lipophagy through the activation of the AMPK-Beclin1 signaling pathway and reduces Rubicon expression in adipocytes.

Mori, Yuki / Masuda, Masashi / Yoshida-Shimizu, Risa / Aoyagi, Saki / Adachi, Yuichiro / Nguyen, Anh The / Maruyama, Yusuke / Okumura, Yosuke / Kamei, Yuki / Sakai, Maiko / Ohnishi, Kohta / Ohminami, Hirokazu / Taketani, Yutaka

The Journal of nutritional biochemistry

2024 Volume 126, Page(s) 109589

Abstract: Lipophagy is defined as a lipolysis pathway that degrades lipid droplet (LD) via autophagy. All-trans retinoic acid (atRA), a metabolite of vitamin A, stimulates lipolysis through hormone-sensitive lipase and β-oxidation. However, the regulation of ... ...

Abstract	Lipophagy is defined as a lipolysis pathway that degrades lipid droplet (LD) via autophagy. All-trans retinoic acid (atRA), a metabolite of vitamin A, stimulates lipolysis through hormone-sensitive lipase and β-oxidation. However, the regulation of lipolysis by atRA-induced autophagy in adipocytes remains unclear. In this study, we investigated the effect of atRA on autophagy in epididymal fat of mice and the molecular mechanisms of autophagy in 3T3-L1 adipocytes. Western blotting showed that atRA decreased the expression of p62, a cargo receptor for autophagic degradation, and increased the expression of the lipidated LC3B (LC3B-II), an autophagy marker, in epididymal fat. Next, we confirmed that atRA increased autophagic flux in differentiated 3T3-L1 cells using the GFP-LC3-RFP-LC3ΔG probe. Immunofluorescent staining revealed that the colocalization of LC3B with perilipin increased in differentiated 3T3-L1 cells treated with atRA. The knockdown of Atg5, an essential gene in autophagy induction, partly suppressed the atRA-induced release of non-esterified fatty acid (NEFA) from LDs in differentiated 3T3-L1 cells. atRA time-dependently elicited the phosphorylation of AMPK and Beclin1, autophagy-inducing factors, in mature 3T3-L1 adipocytes. Inversely, atRA decreased the protein expression of Rubicon, an autophagy repressor, in differentiated 3T3-L1 cells and epididymal fat. Interestingly, the expression of ALDH1A1, atRA-synthesizing enzymes, increased in epididymal fat with decreased protein expression of Rubicon in aged mice. These results suggest that atRA may partially induce lipolysis through lipophagy by activating the AMPK-Beclin1 signaling pathway in the adipocytes and increased atRA levels may contribute to decreased Rubicon expression in the epididymal fat of aged mice. (248/250 words).
MeSH term(s)	Mice ; Animals ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Beclin-1/genetics ; Beclin-1/metabolism ; Signal Transduction ; Lipolysis ; Tretinoin/pharmacology ; Tretinoin/metabolism ; Autophagy ; Adipocytes ; 3T3-L1 Cells
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Beclin-1 ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2024.109589
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Article: [Sodium-dependent phosphate transporters and cardiovascular disease].

Taketani, Yutaka

Seikagaku. The Journal of Japanese Biochemical Society

2010 Volume 82, Issue 8, Page(s) 727–729

MeSH term(s)	Animals ; Apoptosis ; Atherosclerosis/etiology ; Calcinosis/etiology ; Cardiovascular Diseases/etiology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Hyperphosphatemia/complications ; Hyperphosphatemia/metabolism ; Nitric Oxide/metabolism ; Oxidative Stress ; Phosphates/metabolism ; Reactive Oxygen Species/metabolism ; Risk Factors ; Sodium-Phosphate Cotransporter Proteins/physiology ; Vascular Diseases/etiology
Chemical Substances	Phosphates ; Reactive Oxygen Species ; Sodium-Phosphate Cotransporter Proteins ; Nitric Oxide (31C4KY9ESH)
Language	Japanese
Publishing date	2010-08
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	282319-6
ISSN	0037-1017
ISSN	0037-1017
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Book ; Online: Roles of marine biota in the formation of atmospheric bioaerosols, cloud condensation nuclei, and ice-nucleating particles over the North Pacific Ocean, Bering Sea, and Arctic Ocean

Kawana, Kaori / Taketani, Fumikazu / Matsumoto, Kazuhiko / Tobo, Yutaka / Iwamoto, Yoko / Miyakawa, Takuma / Ito, Akinori / Kanaya, Yugo

eISSN: 1680-7324

2024

Abstract: We investigated the association of marine biological indicators (polysaccharides, protein-like gel particles, and chl a ) with the formation of fluorescent aerosol particles, cloud condensation nuclei (CCNs), and ice-nucleating particles (INPs) over the ... ...

Abstract	We investigated the association of marine biological indicators (polysaccharides, protein-like gel particles, and chl a ) with the formation of fluorescent aerosol particles, cloud condensation nuclei (CCNs), and ice-nucleating particles (INPs) over the North Pacific Ocean, Bering Sea, and Arctic Ocean during September–November 2019. The abundance of bioindicators was high in the North Pacific Ocean and the Bering Sea (e.g., up to 1.3 mg m −3 of chl a ), suggesting high biological activity due to a phytoplankton bloom. In the North Pacific Ocean, particles were characterized by high mass fractions of organics and sulfate with a predominance of terrestrial air masses. Conversely, in the Bering Sea and the Arctic Ocean, particles were characterized by high mass fractions of sea salt and sulfate with a predominance of maritime air masses. The averaged range/value of the CCN concentration at 0.4 % supersaturation were 99–151, 43–139, and 36 cm −3 over the North Pacific Ocean with terrestrial influences, over the Bering Sea with marine biogenic influences, and over the Arctic Ocean with marine influences, respectively, and the corresponding range/value of the hygroscopicity parameter κ were 0.17–0.59, 0.42–0.68, and 0.66, respectively. The averaged INP concentration ( N INP ) measured at temperatures of − 18 and − 24 ∘ C with marine sources in the North Pacific and Bering Sea was 0.01–0.09 and 0.1–2.5 L −1 , respectively, and that over the Arctic Ocean was 0.001–0.016 and 0.012–0.27 L −1 , respectively. When marine sources were dominant, fluorescent bioaerosols in the fine mode were strongly correlated with all bioindicator types ( R : 0.81–0.88) when the effect of wind-induced uplift from the sea surface to the atmosphere was considered. Correlations between N INP measured at − 18 and − 24 ∘ C and all bioindicator types ( R : 0.58–0.95 and 0.79–0.93, respectively) were positive, even when the extreme outlier point was omitted, as were those between N INP and fluorescent bioaerosols ( R : 0.50 and 0.60, ...
Subject code	333
Language	English
Publishing date	2024-02-08
Publishing country	de
Document type	Book ; Online
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