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Article ; Online: Science et développement : l’action de François Gros au COPED.

Auger, Pierre / Delseny, Michel

2024 Volume 346, Issue S2, Page(s) 95–101

Abstract: This article is a tribute to the action of François Gros within the COPED (Committee of Developing Countries) which he created in 1997 and led until 2017. The COPED aims to reflect on the major scientific problems posed to developing countries and to try ...

Title translation	Science and development: the action of François Gros at COPED.
Abstract	This article is a tribute to the action of François Gros within the COPED (Committee of Developing Countries) which he created in 1997 and led until 2017. The COPED aims to reflect on the major scientific problems posed to developing countries and to try to provide them with solutions in partnership with them. Its actions have resulted in the organization of mini-forums, workshops, international symposia and reports for governments and authorities. Without being exhaustive, a number of actions carried out by François Gros or on his initiative are described in fields as diverse as health, chemistry, agronomy, energy, applied mathematics, renewable resources management and biodiversity, or education, training and the role of women in the sustainable development of African societies. The diversity of these concerns is a good illustration of the range of areas in which François Gros saw a possible impact of science in the service of development.
Language	French
Publishing date	2024-03-29
Publishing country	France
Document type	Historical Article
ZDB-ID	2072863-3
ISSN	1768-3238 ; 1631-0691
ISSN (online)	1768-3238
ISSN	1631-0691
DOI	10.5802/crbiol.127
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Book ; Conference proceedings: Les estuaires français

Auger, Christian

évolution naturelle et artificielle ; actes du Séminaire National de Travail Évolution Naturelle et Artificielle des Estuaires Français ; quel avenir pour leurs zones d'intérêt biologique? ; Paris, 26 - 27 novembre 1997

(Actes de colloques / Ifremer ; 22)

1998

Event/congress	Séminaire National de Travail Évolution Naturelle et Artificielle des Estuaires Franc̜ais (1997, Paris)
Author's details	Christian Auger
Series title	Actes de colloques / Ifremer ; 22 Actes de colloques / IFREMER
Collection	Actes de colloques / IFREMER
Language	French
Size	367 S. : Ill., graph. Darst., Kt.
Publisher	Ifremer
Publishing place	Plouzané
Publishing country	France
Document type	Book ; Conference proceedings
Note	Zsfassung in engl. Sprache
HBZ-ID	HT014943299
ISBN	2-905434-95-3 ; 978-2-905434-95-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Shelf mark	Loan status	Location
068/2141	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Impact du confinement français en 2020 sur la prise en charge des patients atteints de dégénérescence maculaire liée à l’âge exsudative.

Auger, A / Khanna, R K / Bonicel, P / Pisella, P-J / Le Lez, M-L

Journal francais d'ophtalmologie

2023 Volume 46, Issue 6, Page(s) 596–604

Abstract: ... in France. The most common cause of substantial visual decline was missed intravitreal injections. ...

Title translation	Impact of the French 2020 COVID-19 lockdown on the treatment and follow-up of patients with exudative age-related macular degeneration.
Abstract	Purpose: To assess the impact of the measures taken during the lockdown period from March 17 to May 11, 2020 on the management of patients with exudative age related macular degeneration treated by intravitreal anti-VEGF injections at the University Hospital of Tours. Methods: In this retrospective study, patients were included after analysis of the computerized medical records of patients with age related macular degeneration. Those who were treated for exudative age related macular degeneration who received at least 1 intravitreal injection in the 12 months prior and at least one consultation in the 6 months prior to the lockdown period, were included. The initial and final mean visual acuity were compared with a 5 letter non-inferiority margin. A subgroup analysis was performed according to outcomes. The visual acuities immediately after this period were also recorded. Results: In all, 595 eyes of 493 patients were included. The mean initial visual acuity was 59.6 letters, vs. 58.5 for the final visual acuity, i.e. a difference of -1.13 letters with a lower limit of the confidence interval of less than 5. The visual acuity on release from lockdown was comparable to the other 2 measurements. Initial visual acuity and the number of missed treatments were the main factors associated with functional loss. Conclusion: Patients' visual acuity during the lockdown period was able to be maintained despite the restrictive measures and limitation of care access in France. The most common cause of substantial visual decline was missed intravitreal injections.
MeSH term(s)	Humans ; Infant ; Angiogenesis Inhibitors/therapeutic use ; Ranibizumab ; Follow-Up Studies ; Retrospective Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control ; Macular Degeneration/drug therapy ; Macular Degeneration/epidemiology ; Intravitreal Injections ; Treatment Outcome ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/epidemiology
Chemical Substances	Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
Language	French
Publishing date	2023-05-27
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2022.11.014
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Article ; Online: Cytogenetics in the management of bone marrow failure syndromes: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).

Cuccuini, Wendy / Collonge-Rame, Marie-Agnes / Auger, Nathalie / Douet-Guilbert, Nathalie / Coster, Lucie / Lafage-Pochitaloff, Marina

Current research in translational medicine

2023 Volume 71, Issue 4, Page(s) 103423

Abstract: Bone marrow failure syndromes are rare disorders characterized by bone marrow hypocellularity and resultant peripheral cytopenias. The most frequent form is acquired, so-called aplastic anemia or idiopathic aplastic anemia, an auto-immune disorder ... ...

Abstract	Bone marrow failure syndromes are rare disorders characterized by bone marrow hypocellularity and resultant peripheral cytopenias. The most frequent form is acquired, so-called aplastic anemia or idiopathic aplastic anemia, an auto-immune disorder frequently associated with paroxysmal nocturnal hemoglobinuria, whereas inherited bone marrow failure syndromes are related to pathogenic germline variants. Among newly identified germline variants, GATA2 deficiency and SAMD9/9L syndromes have a special significance. Other germline variants impacting biological processes, such as DNA repair, telomere biology, and ribosome biogenesis, may cause major syndromes including Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome. Bone marrow failure syndromes are at risk of secondary progression towards myeloid neoplasms in the form of myelodysplastic neoplasms or acute myeloid leukemia. Acquired clonal cytogenetic abnormalities may be present before or at the onset of progression; some have prognostic value and/or represent somatic rescue mechanisms in inherited syndromes. On the other hand, the differential diagnosis between aplastic anemia and hypoplastic myelodysplastic neoplasm remains challenging. Here we discuss the value of cytogenetic abnormalities in bone marrow failure syndromes and propose recommendations for cytogenetic diagnosis and follow-up.
MeSH term(s)	Humans ; Anemia, Aplastic/diagnosis ; Anemia, Aplastic/genetics ; Anemia, Aplastic/therapy ; Bone Marrow Diseases/diagnosis ; Bone Marrow Diseases/genetics ; Bone Marrow Diseases/therapy ; Bone Marrow Failure Disorders/diagnosis ; Bone Marrow Failure Disorders/therapy ; Bone Marrow Failure Disorders/complications ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Leukemia, Myeloid, Acute/complications ; Chromosome Aberrations ; Cytogenetic Analysis ; Intracellular Signaling Peptides and Proteins/genetics
Chemical Substances	SAMD9 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-10-18
Publishing country	France
Document type	Practice Guideline
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2023.103423
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Article ; Online: Cytogenetics in the management of myelodysplastic neoplasms (myelodysplastic syndromes, MDS): Guidelines from the groupe francophone de cytogénétique hématologique (GFCH).

Auger, Nathalie / Douet-Guilbert, Nathalie / Quessada, Julie / Theisen, Olivier / Lafage-Pochitaloff, Marina / Troadec, Marie-Bérengère

Current research in translational medicine

2023 Volume 71, Issue 4, Page(s) 103409

Abstract: Myelodysplastic neoplasms (MDS) are clonal hematopoietic neoplasms. Chromosomal abnormalities (CAs) are detected in 40-45% of de novo MDS and up to 80% of post-cytotoxic therapy MDS (MDS-pCT). Lately, several changes appeared in World Health Organization ...

Abstract	Myelodysplastic neoplasms (MDS) are clonal hematopoietic neoplasms. Chromosomal abnormalities (CAs) are detected in 40-45% of de novo MDS and up to 80% of post-cytotoxic therapy MDS (MDS-pCT). Lately, several changes appeared in World Health Organization (WHO) classification and International Consensus Classification (ICC). The novel 'biallelic TP53 inactivation' (also called 'multi-hit TP53') MDS entity requires systematic investigation of TP53 locus (17p13.1). The ICC maintains CA allowing the diagnosis of MDS without dysplasia (del(5q), del(7q), -7 and complex karyotype). Deletion 5q is the only CA, still representing a low blast class of its own, if isolated or associated with one additional CA other than -7 or del(7q) and without multi-hit TP53. It represents one of the most frequent aberrations in adults' MDS, with chromosome 7 aberrations, and trisomy 8. Conversely, translocations are rarer in MDS. In children, del(5q) is very rare while -7 and del(7q) are predominant. Identification of a germline predisposition is key in childhood MDS. Aberrations of chromosomes 5, 7 and 17 are the most frequent in MDS-pCT, grouped in complex karyotypes. Despite the ever-increasing importance of molecular features, cytogenetics remains a major part of diagnosis and prognosis. In 2022, a molecular international prognostic score (IPSS-M) was proposed, combining the prognostic value of mutated genes to the previous scoring parameters (IPSS-R) including cytogenetics, still essential. A karyotype on bone marrow remains mandatory at diagnosis of MDS with complementary molecular analyses now required. Analyses with FISH or other technologies providing similar information can be necessary to complete and help in case of karyotype failure, for doubtful CA, for clonality assessment, and for detection of TP53 deletion to assess TP53 biallelic alterations.
MeSH term(s)	Adult ; Child ; Humans ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Chromosome Deletion ; Trisomy ; Hematologic Neoplasms/genetics ; Cytogenetic Analysis
Language	English
Publishing date	2023-09-17
Publishing country	France
Document type	Practice Guideline
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2023.103409
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Article ; Online: Place des médecins généralistes dans le dispositif de prévention/dépistage des cancers en France.

Aïm-Eusébi, Amélie / Cussac, Fanny / Aubin-Auger, Isabelle

Bulletin du cancer

2019 Volume 106, Issue 7-8, Page(s) 707–713

Abstract: ... In France, general practitioner's involvement is important for colorectal cancer screening. The active ...

Title translation	Cancer prevention and screening: What french GPs could do?
Abstract	An effective health system is based on effective primary care, at the center of which is family medicine. Cancer prevention and screening are integral aspects of general practitioners skills. Prevention is linked with the notion of risk. The relationship between the general practitioner and his or her patient reinforces the prevention of the development of preventable risk factors. It also strengthens information on intrinsic risk factors for patients. The protective factors highlighted by the general practitioner can thus reduce the risk a little more. Screening strategies differs across cancers and countries. In France, general practitioner's involvement is important for colorectal cancer screening. The active participation of their general practitioner, strengths patient's adherence and participation. Their role is to inform and collect data for breast cancer screening. Recently organized cervical cancer screening requires greater involvement of general practitioners who can act as both actors and informants. Family medicine is at the heart of cancer prevention and screening. It is a central hub for improving the health of patients in our healthcare system. The general practitioner knows the patient, which gives him an important advantage to accompany him in the prevention and screening of his risk factors.
MeSH term(s)	Adult ; Aged ; Early Detection of Cancer ; Female ; France ; Harm Reduction ; Humans ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/prevention & control ; Patient Participation ; Physician's Role ; Physician-Patient Relations ; Physicians, Primary Care/psychology ; Primary Health Care/organization & administration ; Risk Factors ; Smoking Prevention
Language	French
Publishing date	2019-01-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2018.11.015
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Article ; Online: Traduction française, adaptation culturelle et évaluation des propriétés psychométriques préliminaires de l’échelle des stratégies de protection comportementale liées à la consommation de cannabis.

Côté, José / Auger, Patricia / Pagé, Gabrielle M / Cossette, Sylvie / Coronado-Montoya, Stephanie / Fontaine, Guillaume / Chicoine, Gabrielle / Rouleau, Geneviève / Genest, Christine / Lapierre, Judith / Jutras-Aswad, Didier

Canadian journal of psychiatry. Revue canadienne de psychiatrie

2021 Volume 67, Issue 8, Page(s) 608–615

Abstract: Objective: Young adults (18- to 24-year-olds) constitute the age group with the highest proportion of cannabis users. In the context of legalization, it is important to promote lower-risk cannabis use. The Protective Behavioral Strategies for Marijuana ... ...

Title translation	French translation, cultural adaptation and assessment of preliminary psychometric properties of the Protective Behavioral Strategies for Marijuana Scale.
Abstract	Objective: Young adults (18- to 24-year-olds) constitute the age group with the highest proportion of cannabis users. In the context of legalization, it is important to promote lower-risk cannabis use. The Protective Behavioral Strategies for Marijuana Scale (PBSM-17) identifies strategies used by consumers. However, this scale is not available in French and is not adapted to the Canadian context. This article presents the process that led to the translation, cultural adaptation and evaluation of the preliminary psychometric properties of PBSM-17. Method: The methodological study was carried out in six steps. The first four steps led to the translation towards French and adaptation of the scale. A validation among 12 young people contributed to establish the criterion equivalency (step 5). The evaluation of psychometric properties (step 6) was carried out among 211 bilingual university students (61 % women; mean age 22 years old). Results: The French version presents satisfactory preliminary psychometric properties: internal consistency is acceptable (α = 0.88); criterion equivalency was established between the French and the original English version (t (210) = 1.04, p = 0.30; 95% CI [-0.20, 0.63]). The scores obtained on both versions by the same participant were found to be strongly correlated (r = 0.95, p <0.001). Conclusion: The results support the use of the French version of PBSM-17. The proposed protective strategies can be used as a measurement tool and represent behaviors that can be targeted in a lower-risk cannabis use context.
MeSH term(s)	Adolescent ; Adult ; Canada ; Cannabis ; Cross-Cultural Comparison ; Female ; Humans ; Male ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires ; Translations ; Young Adult
Language	French
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304227-3
ISSN	1497-0015 ; 0008-4824 ; 0706-7437
ISSN (online)	1497-0015
ISSN	0008-4824 ; 0706-7437
DOI	10.1177/07067437211025216
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Article ; Online: Emergence of optrA-mediated linezolid resistance in enterococci from France, 2006-16.

Sassi, Mohamed / Guérin, François / Zouari, Asma / Beyrouthy, Racha / Auzou, Michel / Fines-Guyon, Marguerite / Potrel, Sophie / Dejoies, Loren / Collet, Anaïs / Boukthir, Sarrah / Auger, Gabriel / Bonnet, Richard / Cattoir, Vincent

The Journal of antimicrobial chemotherapy

2018 Volume 74, Issue 6, Page(s) 1469–1472

Abstract: ... collected in France from 2006 to 2016 and to extensively characterize LRE isolates.: Methods ... in the prevalence of LRE in France over time; this is due to the spread of optrA among E. faecium and E. faecalis ...

Abstract	Objectives: To describe the epidemiological trend of linezolid-resistant enterococci (LRE) collected in France from 2006 to 2016 and to extensively characterize LRE isolates. Methods: The National Reference Center for Enterococci (NRC-Enc) received enterococcal isolates suspected to be VRE and/or LRE from all French hospitals between 2006 and 2016. LRE isolates were phenotypically characterized and their genomes were entirely sequenced by Miseq (Illumina). Transfer of linezolid resistance was attempted by filter mating experiments. Results: Out of 3974 clinical isolates of enterococci received at the NRC-Enc over the period, 9 (0.2%) were LRE (MICs 8 to >32 mg/L), including 6 Enterococcus faecium and 3 Enterococcus faecalis. This overall prevalence significantly increased over the study period, reaching 0.8% in 2016. The five LRE isolated before 2016 were vanA-positive E. faecium whereas strains isolated in 2016 (one E. faecium and three E. faecalis) were susceptible to vancomycin. None of these isolates was part of an outbreak, while E. faecium strains were assigned to four different STs [17 (1), 80 (3), 412 (1) and 650 (1)] and all three E. faecalis belonged to ST480. Except for the strain isolated in 2010, all LRE were positive for optrA, which was located on plasmids (5/8) or in the chromosome (3/8). Plasmid transfer of optrA was successful in three cases. Conclusions: There has been a significant increase in the prevalence of LRE in France over time; this is due to the spread of optrA among E. faecium and E. faecalis human clinical isolates (VRE or not).
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Communicable Diseases, Emerging ; Drug Resistance, Bacterial ; Enterococcaceae/drug effects ; France/epidemiology ; Gene Expression Regulation, Bacterial/drug effects ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Linezolid/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2018-10-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkz097
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Genetic features of the poxtA linezolid resistance gene in human enterococci from France.

Dejoies, Loren / Sassi, Mohamed / Schutz, Sacha / Moreaux, Julie / Zouari, Asma / Potrel, Sophie / Collet, Anaïs / Lecourt, Maxime / Auger, Gabriel / Cattoir, Vincent

The Journal of antimicrobial chemotherapy

2021 Volume 76, Issue 8, Page(s) 1978–1985

Abstract: ... LRE) collected in France from 2016 to 2020 and to extensively characterize its genetic supports and ... circulating among clinical enterococci in France since at least 2016, mostly in E. faecium and independently ...

Abstract	Objectives: To describe the prevalence of poxtA among clinical linezolid-resistant enterococci (LRE) collected in France from 2016 to 2020 and to extensively characterize its genetic supports and environments. Methods: All LRE clinical isolates received at the National Reference Centre for Enterococci from French hospitals between 2016 and 2020 were included. LRE isolates were screened for linezolid resistance genes (cfr-like, optrA and poxtA) by real-time PCR and phenotypically characterized. A collection of 11 representative poxtA-positive isolates (10 Enterococcus faecium and 1 Enterococcus faecalis) underwent WGS by hybrid assembly combining short-read (Illumina MiSeq) and long-read (MinION) approaches. Transferability of poxtA was attempted by filter-mating experiments. Results: Out of 466 LRE received at the National Reference Centre for Enterococci over the period, 47 (10.1%) were poxtA-positive, including 42 E. faecium. The 11 isolates characterized by WGS were confirmed to be epidemiologically unrelated by core genome analysis and eight different STs were assigned to E. faecium isolates. The poxtA gene was found to be plasmid carried and flanked by IS1216E transposase genes in all isolates and frequently linked with fexB, tet(M) and tet(L). A total of seven distinct poxtA-harbouring plasmids were obtained after hybrid assembly and plasmid transfer of poxtA was successful in three cases. For the two poxtA/optrA-positive isolates, those genes were carried by different plasmids. Conclusions: The poxtA gene has been circulating among clinical enterococci in France since at least 2016, mostly in E. faecium and independently from optrA. The poxtA-carrying plasmids often co-carried resistance genes to phenicols and tetracyclines, and could have been co-selected through their veterinary use.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Enterococcus/genetics ; Enterococcus faecalis/genetics ; Enterococcus faecium/genetics ; France/epidemiology ; Gram-Positive Bacterial Infections/epidemiology ; Humans ; Linezolid/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkab116
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Article ; Online: What do women and healthcare professionals expect of decision aids for breast cancer screening? A qualitative study in France.

Amélie, Aïm-Eusébi / Ruelle, Yannick / Frèche, Bernard / Houllemare, Mélanie / Bonillo, Aurélie / Bouaziz, Laurie / Rat, Cédric / Gocko, Xavier / Cerisey, Catherine / Aubin-Auger, Isabelle / Ferrat, Emilie

BMJ open

2022 Volume 12, Issue 3, Page(s) e058879

Abstract: Objective: Breast cancer screening decision aids (DAs) are designed to help women decide whether or not to participate in mammography-based programmes. We aimed to explore women's and healthcare professionals' expectations of a breast cancer screening ... ...

Abstract	Objective: Breast cancer screening decision aids (DAs) are designed to help women decide whether or not to participate in mammography-based programmes. We aimed to explore women's and healthcare professionals' expectations of a breast cancer screening DA, as part of the French DEDICACES study. Methods: This French qualitative study was based on semistructured, individual interviews with women from the general population, general practitioners (GPs), midwives, gynaecologists, radiologists and screening centre managers. Sampling was purposive and used diversification criteria. The inductive analysis was based on grounded theory. Results: Between April 2018 and May 2019, we interviewed 40 people: 13 women, 14 GPs, 4 gynaecologists, 3 midwives, 3 radiologists and 3 screening centre managers. The women and the healthcare professionals considered that a DA could help to improve levels of knowledge, harmonise medical practice and provide reliable, comprehensive information. Overall, the interviewees wanted an easy-to-use, intuitive, graphic-rich, interactive, computer-based, patient-centred DA. Use of the DA might be limited by a lack of familiarity with shared decision-making (SDM), the risk of misuse and a preference for asymmetric positive information. Conclusion: The present results are likely to facilitate the development of the first validated tool for SDM support in French breast cancer screening programmes.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/prevention & control ; Decision Making ; Decision Support Techniques ; Delivery of Health Care ; Early Detection of Cancer/methods ; Female ; France ; Humans ; Qualitative Research
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-058879
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