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  1. Article: Special Issue: Diagnostic and Predictive Tissue Markers in G.I. Cancers.

    Chillotti, Stefano / Vasuri, Francesco

    Cancers

    2023  Volume 15, Issue 4

    Abstract: The compelling advancements in systemic targeted therapies for cancer drastically changed the role of histopathological analyses in recent decades [ ... ]. ...

    Abstract The compelling advancements in systemic targeted therapies for cancer drastically changed the role of histopathological analyses in recent decades [...].
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041329
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  2. Article ; Online: Research Methodologies In Vascular Disease.

    Silvia, Fittipaldi / Francesco, Vasuri

    Journal of visualized experiments : JoVE

    2022  , Issue 186

    MeSH term(s) Humans ; Vascular Diseases/surgery
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/64588
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  3. Article: Hepatopancreatoduodenectomy for locally advanced perihilar cholangiocarcinoma: A case report and a plea not to underestimate surgical resectability.

    Fallani, Guido / Cappelli, Alberta / Siniscalchi, Antonio / Vasuri, Francesco / Germinario, Giuliana / Ravaioli, Matteo

    International journal of surgery case reports

    2022  Volume 98, Page(s) 107495

    Language English
    Publishing date 2022-08-09
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.107495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gastric Melanoma of Unknown Primary.

    Cortellini, Fabio / Marasco, Giovanni / Renzulli, Matteo / Vasuri, Francesco / Ricciardiello, Luigi

    Journal of gastrointestinal and liver diseases : JGLD

    2021  Volume 30, Issue 1, Page(s) 14

    Abstract: We describe a case of a patient with anemia referring to our Digestive Endoscopy Unit. Upper GI endoscopy revealed a polypoid lesion with an ulcerated central depression. Histopathological examination of the biopsy specimen taken during endoscopy ... ...

    Abstract We describe a case of a patient with anemia referring to our Digestive Endoscopy Unit. Upper GI endoscopy revealed a polypoid lesion with an ulcerated central depression. Histopathological examination of the biopsy specimen taken during endoscopy revealed a gastric metastatic melanoma. The dermatologic inspection failed in finding the primary melanoma. The importance of endoscopic examination in the diagnostic process of metastatic patients with unknown primaries is highlited by this case.
    MeSH term(s) Aged, 80 and over ; Endoscopy, Gastrointestinal ; Humans ; Male ; Melanoma ; Neoplasms, Unknown Primary/diagnosis ; Stomach Neoplasms
    Language English
    Publishing date 2021-03-12
    Publishing country Romania
    Document type Case Reports ; Journal Article
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-3420
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    Zs.A 3825: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Cutting-edge technology and automation in the pathology laboratory.

    Munari, Enrico / Scarpa, Aldo / Cima, Luca / Pozzi, Matteo / Pagni, Fabio / Vasuri, Francesco / Marletta, Stefano / Dei Tos, Angelo Paolo / Eccher, Albino

    Virchows Archiv : an international journal of pathology

    2023  Volume 484, Issue 4, Page(s) 555–566

    Abstract: One of the goals of pathology is to standardize laboratory practices to increase the precision and effectiveness of diagnostic testing, which will ultimately enhance patient care and results. Standardization is crucial in the domains of tissue processing, ...

    Abstract One of the goals of pathology is to standardize laboratory practices to increase the precision and effectiveness of diagnostic testing, which will ultimately enhance patient care and results. Standardization is crucial in the domains of tissue processing, analysis, and reporting. To enhance diagnostic testing, innovative technologies are also being created and put into use. Furthermore, although problems like algorithm training and data privacy issues still need to be resolved, digital pathology and artificial intelligence are emerging in a structured manner. Overall, for the field of pathology to advance and for patient care to be improved, standard laboratory practices and innovative technologies must be adopted. In this paper, we describe the state-of-the-art of automation in pathology laboratories in order to lead technological progress and evolution. By anticipating laboratory needs and demands, the aim is to inspire innovation tools and processes as positively transformative support for operators, organizations, and patients.
    MeSH term(s) Humans ; Automation, Laboratory ; Pathology, Clinical/methods ; Artificial Intelligence ; Laboratories, Clinical ; Pathology/methods ; Automation
    Language English
    Publishing date 2023-11-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03637-z
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  6. Article: Synchronous hepatocellular carcinoma and renal cell carcinoma in young woman with sarcoidosis: A case report.

    Simonetti, Mario / Cavaliere, Francesca / Pecorelli, Anna / Fabbrizio, Benedetta / Vasuri, Francesco / Golfieri, Rita

    Radiology case reports

    2022  Volume 18, Issue 1, Page(s) 358–363

    Abstract: Hepatocellular carcinoma (HCC) and clear cell renal carcinoma are both frequent cancers, especially in patients with risk factors such as cirrhosis in the first case or genetic mutations such as Li-Fraumeni syndrome in the second case; however, their ... ...

    Abstract Hepatocellular carcinoma (HCC) and clear cell renal carcinoma are both frequent cancers, especially in patients with risk factors such as cirrhosis in the first case or genetic mutations such as Li-Fraumeni syndrome in the second case; however, their synchronous appearance is very rare especially in young patients with no apparent predisposing factors. We describe the case of a 33-year-old woman with acute pain onset in right hypochondrium. The ultrasound (US) imaging and the contrast-enhanced computed tomography (CECT) of the abdomen revealed 2 abdominal masses: one in the VI-VII segments of the liver and the other one in the right kidney. The chest CECT study, acquired for staging purpose, detected multiple micronodules with patchy peri-bronchial distribution at both lungs. At the histological examination, the tumor arising from the right kidney was finally diagnosed as clear cell renal carcinoma, whereas the tumor arising from the right lateral hepatic lobe as HCC. The histological examination of lung lesions revealed sarcoidosis granulomas. The patient is still being followed up for the occurrence of lung and lymph node metastases from HCC 14 months later.
    Language English
    Publishing date 2022-11-17
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.10.054
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  7. Article ; Online: Prognostic value of microRNA-21 in intra- and extrahepatic cholangiocarcinoma after radical resection: cohort study.

    Boyd, Lenka N C / Ali, Mahsoem / Comandatore, Annalisa / Brandi, Giovanni / Tavolari, Simona / Gaeta, Raffaele / Meijer, Laura L / Le Large, Tessa Y S / Riefolo, Mattia / Vasuri, Francesco / Morelli, Luca / van Laarhoven, Hanneke W M / Giovannetti, Elisa / Kazemier, Geert / Garajová, Ingrid

    BJS open

    2024  Volume 8, Issue 2

    MeSH term(s) Humans ; Prognosis ; Cohort Studies ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/surgery ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology ; MicroRNAs
    Chemical Substances MicroRNAs ; MIRN21 microRNA, human
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrae031
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  8. Article ; Online: The role of cold ischemia time and hypothermic perfusion in predicting early hepatocellular carcinoma recurrences after liver transplantation.

    Dajti, Gerti / Germinario, Giuliana / Prosperi, Enrico / Siniscalchi, Antonio / Vasuri, Francesco / Valente, Sabrina / Odaldi, Federica / Maroni, Lorenzo / Serenari, Matteo / Bertuzzo, Valentina / Laurenzi, Andrea / Del Gaudio, Massimo / Cescon, Matteo / Ravaioli, Matteo

    Artificial organs

    2024  

    Abstract: Aim: The aim of the study was to identify predictors of early tumor recurrence in patients with hepatocellular carcinoma (HCC) after liver transplantation (LT).: Methods: Retrospective cohort study in 237 consecutive liver recipients with HCC between ...

    Abstract Aim: The aim of the study was to identify predictors of early tumor recurrence in patients with hepatocellular carcinoma (HCC) after liver transplantation (LT).
    Methods: Retrospective cohort study in 237 consecutive liver recipients with HCC between 2016 and 2021. Multivariate logistic analysis was performed to identify predictors of early HCC recurrences. The impact of hypothermic-oxygenated perfusion (HOPE) on outcome was analyzed after propensity score weighting.
    Results: Early recurrences were observed in 15 cases. Microvascular invasion (OR 3.737, 95% CI 1.246-11.206, p = 0.019) and cold ischemia time (OR 1.155, 95% CI 1.001-1.333, p = 0.049) were independently associated with a lower risk of HCC recurrences. After balancing for relevant variables, patients in the HOPE group had lower rates of tumor recurrence (weighted OR 0.126, 95% CI 0.016-0.989, p = 0.049) and higher recurrence free survival (weighted HR 0.132, 95% CI 0.017-0.999, p = 0.050).
    Conclusion: Reducing cold ischemia time and graft perfusion with HOPE can lead to lower rates of early HCC recurrences and higher recurrence-free survival.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14715
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    Zs.A 1463: Show issues Location:
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  9. Article ; Online: Donors risk assessment in transplantation: From the guidelines to their real-world application.

    Malvi, Deborah / Vasuri, Francesco / Albertini, Elisa / Carbone, Maurizio / Novelli, Luca / Mescoli, Claudia / Cardillo, Massimo / Pagni, Fabio / D'Errico, Antonia / Eccher, Albino

    Pathology, research and practice

    2024  Volume 255, Page(s) 155210

    Abstract: Transplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing ... ...

    Abstract Transplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies. Although the risk of malignancy transmission is very low in the general transplant setting it must constantly be balanced with the transplant benefits. Guidelines are mainly based on large registries and sparse case reports of transmission, so they cannot cover all the possible situations. For this reason, in 2004 in Italy, the National Transplant Center gave rise to the Second Opinion Service, charged by the Ministry of Health, by structuring expertise in diagnostic oncology and risk transmission and making it available to the Italian Transplant Centers. In this paper the registry of the Italian Oncological Second Opinion was reviewed, from 2016 to 2018, to detail the most frequent and problematic neoplastic topics addressed, those are separately reported and discussed. Furthermore, a review of the most recent strategies and risk stratification is provided, according to the most recent literature evidence and to the European Guidelines.
    MeSH term(s) Humans ; Tissue Donors ; Risk Assessment ; Neoplasms ; Italy ; Registries
    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155210
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  10. Article: Hepatocellular Carcinomas with Concomitant Mutations of TERT, TP53, and CTNNB1: Is There a Role for Artificial Intelligence?

    Chillotti, Stefano / Maloberti, Thais / Degiovanni, Alessio / Malvi, Deborah / D'Errico, Antonia / de Biase, Dario / Vasuri, Francesco

    Critical reviews in oncogenesis

    2023  Volume 28, Issue 3, Page(s) 31–35

    Abstract: TP53, CTNNB1, and TERT-promoter mutations are the most common driver mutations in hepatocellular carcinoma (HCC). The morphological and genetical HCC heterogeneities are difficult to discriminate by the eye of the pathologist. Here, we describe two rare ... ...

    Abstract TP53, CTNNB1, and TERT-promoter mutations are the most common driver mutations in hepatocellular carcinoma (HCC). The morphological and genetical HCC heterogeneities are difficult to discriminate by the eye of the pathologist. Here, we describe two rare cases of HCC with simultaneous co-mutation of all three of genes, which represent a poorly described occurrence in the literature. In these two cases, areas with different tumor grade and different β-catenin and Glutamine Synthetase expression (performed by automated immunohistochemistry) were observed. NGS analysis was performed in these different areas, to check for potential diversity of mutation burden on the different regions, but no differences were found: all micro-areas analyzed showed the co-presence of mutations in TP53, CTNNB1, and TERT. The evidence that all mutations were found in all the different areas analyzed by NGS leads to hypothesize that the tumor is not composed of different clones harboring different mutations. All the variants are harbored by the same neoplastic clone, albeit leading to different phenotypes. Mutation prediction Artificial Intelligence models could help the morpho-genetic classification of HCC in the future, since they can find variabilities not obvious to the human eye, with increased sensitivity, specificity and reproducibility.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/diagnosis ; Liver Neoplasms/genetics ; beta Catenin/genetics ; Artificial Intelligence ; Reproducibility of Results ; Mutation ; Tumor Suppressor Protein p53/genetics ; Telomerase/genetics
    Chemical Substances beta Catenin ; TP53 protein, human ; Tumor Suppressor Protein p53 ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49) ; CTNNB1 protein, human
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1036388-9
    ISSN 0893-9675
    ISSN 0893-9675
    DOI 10.1615/CritRevOncog.2023049650
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