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  1. Article ; Online: Polimialgia reumática tras tratamiento con pembrolizumab.

    Ramirez-Poza, Silvia / Pardo-Cabello, Alfredo José / Salvatierra, Juan

    Medicina clinica

    2023  Volume 161, Issue 6, Page(s) 270–271

    Title translation Polymyalgia rheumatica after pembrolizumab treatment.
    MeSH term(s) Humans ; Polymyalgia Rheumatica/chemically induced ; Polymyalgia Rheumatica/drug therapy ; Giant Cell Arteritis ; Antibodies, Monoclonal, Humanized/adverse effects
    Chemical Substances pembrolizumab (DPT0O3T46P) ; Antibodies, Monoclonal, Humanized
    Language Spanish
    Publishing date 2023-06-02
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.04.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety of COVID-19 vaccines: A comparison between adverse drug reactions among vaccines marketed in Europe.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Luna, Juan de Dios

    European journal of internal medicine

    2023  Volume 112, Page(s) 122–125

    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Vaccines ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Europe ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2023-02-13
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differences in reporting of adverse drug reactions due to COVID-19 vaccines depending on the reporter.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Luna, Juan de Dios

    European journal of internal medicine

    2023  Volume 113, Page(s) 104–106

    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Drug-Related Side Effects and Adverse Reactions ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.03.020
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  4. Article ; Online: Placebo: a brief updated review.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Puche-Cañas, Emilio

    Naunyn-Schmiedeberg's archives of pharmacology

    2022  Volume 395, Issue 11, Page(s) 1343–1356

    Abstract: Our aims were to provide updated information on placebo/nocebo effect and the potential use of placebo in clinical practice. This article can only provide a rough overview on the placebo and nocebo effect and is intended to serve as a starting point for ... ...

    Abstract Our aims were to provide updated information on placebo/nocebo effect and the potential use of placebo in clinical practice. This article can only provide a rough overview on the placebo and nocebo effect and is intended to serve as a starting point for the reader to go deeper into the corresponding literature. The placebo effect has been observed in multiple medical conditions, after oral administration, with manual therapies as well as with surgery and invasive procedures. The use of placebo in clinical trials is fundamental, although the ethics of its use is under discussion. The placebo may behave like a drug from the pharmacokinetic and pharmacodynamic point of view and can also be associated with adverse events (nocebo effect). Placebo can modify treatment by increasing or decreasing the effects of drugs. The factors associated with the occurrence of placebo effect are multiple, but in addition to those that depend on the placebo itself, the doctor-patient relationship would be the most important. As a result of findings that were published in the last two decades, the psycho-neurobiological basis of placebo is becoming better understood, although further studies are needed. In conclusion, the placebo effect in the clinic exhibits weak to moderate intensity. Placebo, in addition to its use in the clinical trial, should be considered another therapeutic remedy either as stand alone or in association with treatment, and could be useful in certain circumstances. The use of placebo should be regulated by the European health authorities through a guide in clinical practice that will improve patient care.
    MeSH term(s) Humans ; Nocebo Effect ; Physician-Patient Relations ; Placebo Effect
    Language English
    Publishing date 2022-08-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-022-02280-w
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  5. Article ; Online: Comparative study of adverse drug reactions among direct-acting oral anticoagulants and vitamin K antagonists using the EudraVigilance database.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Luna, Juan de Dios

    Naunyn-Schmiedeberg's archives of pharmacology

    2021  Volume 394, Issue 7, Page(s) 1477–1485

    Abstract: Our aim was to compare adverse drug reactions (ADRs) associated with direct-acting oral anticoagulants and vitamin K antagonists from the European EudraVigilance (EV) database. The EV database is the system for the analysis of information on suspected ... ...

    Abstract Our aim was to compare adverse drug reactions (ADRs) associated with direct-acting oral anticoagulants and vitamin K antagonists from the European EudraVigilance (EV) database. The EV database is the system for the analysis of information on suspected ADRs that are authorised, or being evaluated in clinical trials, in the European Economic Area. Registered ADRs (from the groups "Gastrointestinal disorders", "General disorders and administration site conditions", "Injury, poisoning and procedural complications", "Nervous system (NS) disorders" and "Vascular disorders") for apixaban, rivaroxaban, dabigatran and vitamin K antagonists (VKA) were collected by age group (< 65 years; 65-85 years and > 85 years) and by sex. The proportional reporting ratio (PRR) was used to compare ADRs in relation to the anticoagulants tested. A total of 274,693 ADRs were analysed. For gastrointestinal ADRs, patients treated with rivaroxaban and dabigatran (PRR 2.17 and 2.51, respectively) were at significantly higher risks than those treated with apixaban and VKA (PRR 1.27 and 1.47, respectively), while risks for vascular disorders were increased by all anticoagulants that were tested. Lastly, none of the anticoagulants significantly increased the risk of ADRs within the NS group. Rivaroxaban and dabigatran were associated with a significantly higher risk of gastrointestinal ADR than apixaban or VKA. All anticoagulants increased the risk of vascular pathology while none of them demonstrated significant increased risk of ADR to NS.
    MeSH term(s) Administration, Oral ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Dabigatran/administration & dosage ; Dabigatran/adverse effects ; Databases, Factual/statistics & numerical data ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Gastrointestinal Diseases/chemically induced ; Humans ; Male ; Middle Aged ; Pharmacovigilance ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Rivaroxaban/administration & dosage ; Rivaroxaban/adverse effects ; Vitamin K/antagonists & inhibitors ; Young Adult
    Chemical Substances Anticoagulants ; Pyrazoles ; Pyridones ; Vitamin K (12001-79-5) ; apixaban (3Z9Y7UWC1J) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2021-03-05
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-021-02073-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.5: Show issues Location:
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  6. Article ; Online: The impact of PIPs on mortality and readmissions in older adults: a retrospective cohort study.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Luna, Juan de Dios

    European journal of clinical pharmacology

    2021  Volume 78, Issue 1, Page(s) 139–145

    Abstract: Purpose: Our aim was to determine the impact of potentially inappropriate prescriptions (PIP), according to "Screening Tool of Older Persons' Prescriptions" criteria version 2 (STOPP-2), on mortality and hospital admissions.: Methods: Monocentric ... ...

    Abstract Purpose: Our aim was to determine the impact of potentially inappropriate prescriptions (PIP), according to "Screening Tool of Older Persons' Prescriptions" criteria version 2 (STOPP-2), on mortality and hospital admissions.
    Methods: Monocentric retrospective cohort study. Patients over 65 years of age and who were consecutively discharged from internal medicine at a Spanish university hospital in 2016 were included. The mortality and hospital admissions of the cohort of patients were analysed using their electronic health records within two years from the time of discharge. Analysis was done based on the type and number of STOPP-2 criteria as well as taking into account the total number of medications. The subdistribution hazard ratios (SHR) were estimated through a competing proportional hazards model.
    Results: A total of 270 patients with a median age of 82 years (interquartile range/IQR 76-86 years), and 152 (56.3%) women were studied. It was found out that 28.3% of patients with PIP died compared to 17.2% of patients without it. Digoxin (B1 STOPP-2 criterion) with a subdistribution hazard ratio (SHR) 2.40 (95% CI 0.63-9.18), selective serotonin re-uptake inhibitors/SSRIs (D4) with a SHR 1.76 (95% CI 0.52-5.96) and neuroleptic drugs (K2) with a SHR 2.01 (95% CI 0.82-4.95) non-significantly increased the risk of death. Dementia (SHR 5.45; 95% CI 2.76-10.78) was then the only statistically significant risk factor for death. Sixty percent of patients with a PIP had shown at least one hospital admission compared to 51% of patients without it. The number of drugs at discharge (SHR 1.03; 95% CI 1.01-1.05) and having 1-2 STOPP-2 criteria (SHR 1.17; 95% CI 1.02-1.35) significantly increased the risk of hospital admission.
    Conclusion: The number of drugs at discharge and having any STOPP criteria significantly increased the risk of hospital admission in this cohort. PIP, only according to some specific STOPP-2 criteria involving digoxin, neuroleptics and SSRIs, might associate with a statistically non-significantly higher risk on mortality.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Electronic Health Records ; Female ; Humans ; Inappropriate Prescribing/statistics & numerical data ; Male ; Mortality/trends ; Patient Readmission/statistics & numerical data ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-09-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-021-03217-7
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    Zs.A 672: Show issues Location:
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  7. Article ; Online: Small cell lung cancer elevates procalcitonin levels in the absence of infection.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria

    Lung cancer (Amsterdam, Netherlands)

    2019  Volume 134, Page(s) 272–273

    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers ; Biopsy ; Humans ; Infections/etiology ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Lung Neoplasms/therapy ; Male ; Procalcitonin/blood ; Procalcitonin/metabolism ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/diagnosis ; Small Cell Lung Carcinoma/metabolism ; Small Cell Lung Carcinoma/therapy ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Biomarkers ; Procalcitonin
    Language English
    Publishing date 2019-06-17
    Publishing country Ireland
    Document type Case Reports ; Letter
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2019.06.018
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  8. Article ; Online: Adverse drug reactions in SARS-COV-2 hospitalised patients: a case series with a focus on drug-drug interactions-comment.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Belda-Rustarazo, Susana / Giner-Escobar, Pilar

    Internal and emergency medicine

    2021  Volume 16, Issue 3, Page(s) 797–798

    MeSH term(s) COVID-19 ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Pharmaceutical Preparations ; SARS-CoV-2
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-01-31
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02645-8
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  9. Article ; Online: Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital.

    Pardo-Cabello, Alfredo Jose / Luna, Juan de Dios / Gómez Jiménez, Francisco Javier / Del Pozo, Esperanza / Puche Cañas, Emilio

    European journal of internal medicine

    2019  Volume 70, Page(s) e14–e16

    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/mortality ; Female ; Hospital Mortality ; Hospitalization/trends ; Hospitals, Teaching/trends ; Humans ; Male ; Middle Aged ; Prevalence ; ROC Curve ; Retrospective Studies ; Risk Factors ; Sex Factors ; Spain/epidemiology
    Language English
    Publishing date 2019-10-17
    Publishing country Netherlands
    Document type Letter ; Observational Study
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.09.011
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  10. Article ; Online: Potential drug-drug interactions in deceased inpatients.

    Pardo-Cabello, Alfredo Jose / Manzano-Gamero, Victoria / Del Pozo, Esperanza / Gómez Jiménez, Francisco Javier / Luna, Juan de Dios / Puche Cañas, Emilio

    Internal and emergency medicine

    2018  Volume 14, Issue 2, Page(s) 325–328

    MeSH term(s) Aged ; Aged, 80 and over ; Cause of Death/trends ; Cross-Sectional Studies ; Drug Interactions ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Polypharmacy ; Spain
    Language English
    Publishing date 2018-10-24
    Publishing country Italy
    Document type Letter ; Observational Study
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-018-1972-1
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