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Article ; Online: Renal function estimating equations performance during pregnancy and postpartum.

Zaghloul, Dina E / Ryu, Rachel / Kestenbaum, Bryan / Smith, Chase / Fay, Emily / Hebert, Mary F

2023 Volume 43, Issue 5, Page(s) 359–371

Abstract: Study objectives: The objectives of this study were to evaluate the performance of renal function estimating equations compared to measured creatinine clearance (CrCl) during pregnancy and postpartum and to evaluate which body weight (pre-pregnancy ... ...

Abstract	Study objectives: The objectives of this study were to evaluate the performance of renal function estimating equations compared to measured creatinine clearance (CrCl) during pregnancy and postpartum and to evaluate which body weight (pre-pregnancy weight (PPW), actual body weight (ABW), and ideal body weight (IBW)) provides the best performance. Design: A retrospective study. Setting: Collections tookplace in the University of Washington clinical research unit. Patients: Women (n = 166) who completed ≥1 pharmacokinetic (PK) study with a 6-24 h measured CrCl during pregnancy and/or ≥3 months postpartum were included. Intervention: CrCl was estimated utilizing estimated glomerular filtration rate (eGFR) and CrCl equations with common weight descriptors. Analyses included Bland-Altman, relative accuracies within 10% and 25%, and root mean squared error (RMSE). Overall performance was determined by summation of rank for evaluation parameters. Measurements and main results: During pregnancy, correlations between measured CrCl and estimated CrCl were between 0.5-0.8; equations with slopes closest to one were Modification of Diet in Renal Disease (MDRD2; PPW and ABW) and Cockcroft-Gault (CG) (PPW); and y-intercept closest to zero was Preeclampsia Glomerular Filtration Rate (PGFR). The lowest bias was seen with CG (ABW), and the highest accuracy within 25% was CG (ABW). CG (PPW) had the lowest RMSE. Postpartum, the best correlation was found with MDRD2 (PPW), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI (ABW)), and CKD-EPI 2021 (PPW). For slopes closest to one, MDRD2 (ABW) was best, whereas the equation with y-intercept closest to zero was CKD-EPI (ABW). CG (PPW) had the highest accuracy within 25%, and 100/serum creatinine (SCr) had the lowest bias. Based on overall performance, CG (PPW) was the best followed by CG (ABW) and PGFR during pregnancy and 100/SCr followed by CG (PPW) and CG (ABW) postpartum. Conclusion: The new CKD-EPI 2021 equation did not perform well during pregnancy. When 24-h CrCls are not available during pregnancy, CG (PPW or ABW) performed the best overall, whereas at 3 months postpartum, 100/SCr performed the best overall.
MeSH term(s)	Humans ; Female ; Pregnancy ; Retrospective Studies ; Kidney Function Tests ; Glomerular Filtration Rate ; Renal Insufficiency, Chronic/epidemiology ; Creatinine ; Kidney/physiology ; Body Weight
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.2800
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Article ; Online: Working the Edge: The Emotional Experiences of Commissioning and Funding Arrangements for Service Leaders in the Sexual Violence Voluntary Sector.

Gunby, Clare / Isham, Louise / Smailes, Harriet / Bradbury-Jones, Caroline / Damery, Sarah / Harlock, Jenny / Maxted, Fay / Smith, Deb / Taylor, Julie

Violence against women

2024 Volume 30, Issue 8, Page(s) 1783–1803

Abstract: The specialist voluntary sector plays a crucial role in supporting survivors of sexual violence. However, in England, short-term funding underpins the sector's financial stability. This article examines sector leaders' ways of coping, resisting and being ...

Abstract	The specialist voluntary sector plays a crucial role in supporting survivors of sexual violence. However, in England, short-term funding underpins the sector's financial stability. This article examines sector leaders' ways of coping, resisting and being affected by funding practices. Using the concept of edgework, we show how funding and commissioning dynamics push individuals to the edge of service sustainability, job satisfaction, and emotional well-being. We examine how these edges are "worked," for example, by circumventing and remolding the edge. We offer an original way to theorize participants, make visible the emotional toll of service precarity and offer suggestions for support.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2031375-5
ISSN	1552-8448 ; 1077-8012
ISSN (online)	1552-8448
ISSN	1077-8012
DOI	10.1177/10778012241239945
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Article ; Online: Cropping management in a livestock-pasture-crop integration modifies microbial communities, activity, and soil health score.

Menefee, Dorothy S / Collins, Harold / Smith, Douglas / Haney, Richard Lee / Fay, Philip / Polley, Wayne

Journal of environmental quality

2022 Volume 52, Issue 3, Page(s) 434–447

Abstract: Understanding indicators of soil health is crucial for developing agricultural systems that are sustainable and climate resilient. Labile soil carbon (C), microbial properties, and nutrient status are all incorporated into the Haney Soil Health Tool with ...

Abstract	Understanding indicators of soil health is crucial for developing agricultural systems that are sustainable and climate resilient. Labile soil carbon (C), microbial properties, and nutrient status are all incorporated into the Haney Soil Health Tool with the goal of summarizing several indicators into one index. Monthly soil samples from an integrated crop-livestock system in Central Texas were collected from 2017 to 2019. Fields represented a range of management practices, including cover crops, no-till, rotational grazing, and a native prairie remnant. Soil samples were analyzed for total C, water-soluble C, macro- and micronutrient content and bioavailability, and phospholipid fatty acids (PLFAs). Microbial activity was determined via a 24-h CO
MeSH term(s)	Animals ; Soil ; Livestock ; Agriculture ; Crops, Agricultural ; Microbiota ; Carbon
Chemical Substances	Soil ; Carbon (7440-44-0)
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.1002/jeq2.20315
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Article ; Online: Investigating chromatin accessibility during development and differentiation by ATAC-sequencing to guide the identification of cis-regulatory elements.

Louise Smith, Emily / Mok, Gi Fay / Münsterberg, Andrea

Biochemical Society transactions

2022 Volume 50, Issue 3, Page(s) 1167–1177

Abstract: Mapping accessible chromatin across time scales can give insights into its dynamic nature, for example during cellular differentiation and tissue or organism development. Analysis of such data can be utilised to identify functional cis-regulatory ... ...

Abstract	Mapping accessible chromatin across time scales can give insights into its dynamic nature, for example during cellular differentiation and tissue or organism development. Analysis of such data can be utilised to identify functional cis-regulatory elements (CRE) and transcription factor binding sites and, when combined with transcriptomics, can reveal gene regulatory networks (GRNs) of expressed genes. Chromatin accessibility mapping is a powerful approach and can be performed using ATAC-sequencing (ATAC-seq), whereby Tn5 transposase inserts sequencing adaptors into genomic DNA to identify differentially accessible regions of chromatin in different cell populations. It requires low sample input and can be performed and analysed relatively quickly compared with other methods. The data generated from ATAC-seq, along with other genomic approaches, can help uncover chromatin packaging and potential cis-regulatory elements that may be responsible for gene expression. Here, we describe the ATAC-seq approach and give examples from mainly vertebrate embryonic development, where such datasets have identified the highly dynamic nature of chromatin, with differing landscapes between cellular precursors for different lineages.
MeSH term(s)	Cell Differentiation ; Chromatin ; Gene Regulatory Networks ; High-Throughput Nucleotide Sequencing/methods ; Sequence Analysis, DNA/methods
Chemical Substances	Chromatin
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST20210834
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Article: Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences.

Dunstan, Isobel K / McLeod, Ross / Radford-Smith, Daniel E / Xiong, Wenzheng / Pate, Trinity / Probert, Fay / Anthony, Daniel C

Frontiers in cellular neuroscience

2024 Volume 18, Page(s) 1345441

Abstract: Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we ... ...

Abstract	Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic interplay between behaviour, metabolism, and inflammation downstream of TLR-7 activation compared to TLR-4 activation in male and female CD1 mice. Methods: Animals received either a TLR-4 (LPS; 0.83 mg/kg) or TLR-7 (R848, 5 mg/kg) agonist, or saline, and behaviour was analysed in an Open Field (OF) at 24 h ( Results: TLR-4 and TLR-7 activation decreased distance travelled and rearing in the OF, but activation of each receptor induced distinct cytokine responses and metabolome profiles. LPS increased IL-1β expression and CXCL1 in the PFC, but TLR7 activation did not and strongly induced PFC CXCL10 expression. Thus, TLR7 induced sickness behaviour is independent of IL-1β expression. In both cases, the behavioural response to TLR activation was sexually dimorphic: females were more resilient. However, dissociation was observed between the resilient female mice behaviour and the levels of gene cytokine expression, which was, in general, higher in the female mice. However, the metabolic shifts induced by immune activation were better correlated with the sex-dependent behavioural dimorphisms; increased levels of antioxidant potential in the female brain are intrinsic male/female metabolome differences. A common feature of both TLR4 and TLR7 activation was an increase in N-acetyl aspartate (NAA) in the PFC, which is likely be an allostatic response to the challenges as sickness behaviour is inversely correlated with NAA levels. Discussion: The results highlight how the cytokine profile induced by one PAMP cannot be extrapolated to another, but they do reveal how the manipulation of the conserved metabolome response might afford a more generic approach to the treatment of post-infection syndromes.
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2024.1345441
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Article ; Online: HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation.

Radford-Smith, Daniel E / Yates, Abi G / Rizvi, Laila / Anthony, Daniel C / Probert, Fay

Lipids in health and disease

2023 Volume 22, Issue 1, Page(s) 54

Abstract: Endotoxemia and sepsis induce neuroinflammation and increase the risk of neurodegenerative disorders although the mechanism by which peripheral infection leads to brain inflammation is not well understood. While circulating serum lipoproteins are known ... ...

Abstract	Endotoxemia and sepsis induce neuroinflammation and increase the risk of neurodegenerative disorders although the mechanism by which peripheral infection leads to brain inflammation is not well understood. While circulating serum lipoproteins are known immunometabolites with the potential to modulate the acute phase response and cross the blood brain barrier, their contribution to neuroinflammation during systemic infection is unknown. The objective of this study was to elucidate the mechanisms by which lipoprotein subclasses modulate lipopolysaccharide (LPS)-induced neuroinflammation. Adult C57BL/6 mice were divided into 6 treatment groups, including a sterile saline vehicle control group (n = 9), an LPS group (n = 11), a premixed LPS + HDL group (n = 6), a premixed LPS + LDL group (n = 5), a HDL only group (n = 6) and an LDL only group (n = 3). In all cases injections were administered intraperitoneally. LPS was administered at 0.5 mg/kg, and lipoproteins were administered at 20 mg/kg. Behavioural testing and tissue collection was performed 6 h post-injection. The magnitude of peripheral and central inflammation was determined by qPCR of pro-inflammatory genes in fresh liver and brain. Metabolite profiles of liver, plasma and brain were determined by
MeSH term(s)	Mice ; Animals ; Lipopolysaccharides/pharmacology ; Endotoxemia ; Neuroinflammatory Diseases ; Mice, Inbred C57BL ; Lipoproteins ; Inflammation/chemically induced ; Endotoxins/adverse effects ; Encephalitis ; Sepsis
Chemical Substances	Lipopolysaccharides ; Lipoproteins ; Endotoxins
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-023-01817-z
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Article ; Online: Reliability of the evidence to guide decision-making in foot ulcer prevention in diabetes: an overview of systematic reviews.

Crawford, Fay / Nicolson, Donald J / Amanna, Aparna E / Smith, Marie

BMC medical research methodology

2022 Volume 22, Issue 1, Page(s) 274

Abstract: Background: Reliable evidence on the effectiveness of interventions to prevent diabetes-related foot ulceration is essential to inform clinical practice. Well-conducted systematic reviews that synthesise evidence from all relevant trials offer the most ... ...

Abstract	Background: Reliable evidence on the effectiveness of interventions to prevent diabetes-related foot ulceration is essential to inform clinical practice. Well-conducted systematic reviews that synthesise evidence from all relevant trials offer the most robust evidence for decision-making. We conducted an overview to assess the comprehensiveness and utility of the available secondary evidence as a reliable source of robust estimates of effect with the aim of informing a cost-effective care pathway using an economic model. Here we report the details of the overview. [PROSPERO Database (CRD42016052324)]. Methods: Medline (Ovid), Embase (Ovid), Epistomonikos, Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effectiveness (DARE), and the Health Technology Assessment Journals Library were searched to 17th May 2021, without restrictions, for systematic reviews of randomised controlled trials (RCTs) of preventive interventions in people with diabetes. The primary outcomes of interest were new primary or recurrent foot ulcers. Two reviewers independently extracted data and assessed the risk of bias in the included reviews. Findings: The overview identified 30 systematic reviews of patient education, footwear and off-loading, complex and other interventions. Many are poorly reported and have fundamental methodological shortcomings associated with increased risk of bias. Most concerns relate to vague inclusion criteria (60%), weak search or selection strategies (70%) and quality appraisal methods (53%) and inexpert conduct and interpretation of quantitative and narrative evidence syntheses (57%). The 30 reviews have collectively assessed 26 largely poor-quality RCTs with substantial overlap. Interpretation: The majority of these systematic reviews of the effectiveness of interventions to prevent diabetic foot ulceration are at high risk of bias and fail to provide reliable evidence for decision-making. Adherence to the core principles of conducting and reporting systematic reviews is needed to improve the reliability of the evidence generated to inform clinical practice.
MeSH term(s)	Humans ; Diabetes Mellitus/prevention & control ; Diabetic Foot/prevention & control ; Reproducibility of Results ; Systematic Reviews as Topic
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-022-01738-y
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Article: The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition.

Enthoven, Luke F / Shi, Yuanyuan / Fay, Emily E / Moreni, Sue / Mao, Jennie / Honeyman, Emma M / Smith, Chase K / Whittington, Dale / Brockerhoff, Susan E / Isoherranen, Nina / Totah, Rheem A / Hebert, Mary F

Metabolites

2023 Volume 13, Issue 2

Abstract: Limited data are available on the effects of pregnancy on the maternal metabolome. Therefore, the objective of this study was to use metabolomics analysis to determine pathways impacted by pregnancy followed by targeted confirmatory analysis to provide ... ...

Abstract	Limited data are available on the effects of pregnancy on the maternal metabolome. Therefore, the objective of this study was to use metabolomics analysis to determine pathways impacted by pregnancy followed by targeted confirmatory analysis to provide more powerful conclusions about metabolic alterations during pregnancy. Forty-seven pregnant women, 18-50 years of age were included in this study, with each subject serving as their own control. Plasma samples were collected between 25 and 28 weeks gestation and again ≥3 months postpartum for metabolomics analysis utilizing an HILIC/UHPLC/MS/MS assay with confirmatory targeted specific concentration analysis for 10 of the significantly altered amino acids utilizing an LC/MS assay. Principle component analysis (PCA) on metabolomics data clearly separated pregnant and postpartum groups and identified outliers in a preliminary assessment. Of the 980 metabolites recorded, 706 were determined to be significantly different between pregnancy and postpartum. Pathway analysis revealed three significantly impacted pathways, arginine biosynthesis (
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13020242
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Article ; Online: Ruxolitinib Cream Has Dual Efficacy on Pruritus and Inflammation in Experimental Dermatitis.

Scuron, Monika D / Fay, Brittany L / Connell, Andrew J / Peel, Michael T / Smith, Paul A

Frontiers in immunology

2021 Volume 11, Page(s) 620098

Abstract: The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs ...

Abstract	The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs patients' quality of life, with pruritus being a common complaint. The sensation of itch results from the interplay between epidermal barrier dysfunction, upregulated immune signaling and the activation of the central nervous system. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a central role in pro-inflammatory cytokine signaling in AD. Ruxolitinib cream is a potent and selective JAK1/2 inhibitor currently undergoing clinical evaluation in adults with mild-to-moderate AD (NCT03745638, NCT03920852 and NCT03745651). The efficacy of ruxolitinib cream was tested in murine models of acute and chronic dermatitis and was also characterized in an
MeSH term(s)	Administration, Cutaneous ; Animals ; Betamethasone/administration & dosage ; Betamethasone/therapeutic use ; Clobetasol/administration & dosage ; Clobetasol/therapeutic use ; Cytokines/biosynthesis ; Cytokines/genetics ; Cytokines/toxicity ; Dermatitis/drug therapy ; Disease Models, Animal ; Drug Eruptions/drug therapy ; Drug Eruptions/immunology ; Drug Evaluation, Preclinical ; Female ; Fluorescein-5-isothiocyanate/toxicity ; Grooming/drug effects ; Humans ; In Vitro Techniques ; Interleukin-33/genetics ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/therapeutic use ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Ointments ; Organ Culture Techniques ; Pruritus/drug therapy ; Pyrazoles/administration & dosage ; Pyrazoles/therapeutic use ; Random Allocation ; Signal Transduction/drug effects ; Skin/drug effects ; Specific Pathogen-Free Organisms ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; Transcriptome
Chemical Substances	Cytokines ; Il33 protein, mouse ; Interleukin-33 ; Janus Kinase Inhibitors ; Ointments ; Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Betamethasone (9842X06Q6M) ; Clobetasol (ADN79D536H) ; thymic stromal lymphopoietin (GT0IL38SP4) ; Fluorescein-5-isothiocyanate (I223NX31W9)
Language	English
Publishing date	2021-02-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.620098
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Article ; Online: The PI3Kδ inhibitor parsaclisib ameliorates pathology and reduces autoantibody formation in preclinical models of systemic lupus erythematosus and Sjӧgren's syndrome.

Scuron, Monika D / Fay, Brittany L / Connell, Andrew J / Oliver, Julian / Smith, Paul A

International immunopharmacology

2021 Volume 98, Page(s) 107904

Abstract: Dysregulation of phosphoinositide 3-kinase δ (PI3Kδ) signaling pathway has been implicated in the pathogenesis of inflammatory and autoimmune diseases. Parsaclisib (INCB050465) represents a potent and selective PI3Kδ inhibitor, which is being clinically ... ...

Abstract	Dysregulation of phosphoinositide 3-kinase δ (PI3Kδ) signaling pathway has been implicated in the pathogenesis of inflammatory and autoimmune diseases. Parsaclisib (INCB050465) represents a potent and selective PI3Kδ inhibitor, which is being clinically investigated for treatment of autoimmune hemolytic anemia and hematological malignancies. We characterized the potential of parsaclisib to ameliorate autoimmune mechanisms implicated in the pathophysiology of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Spontaneous mouse models of SLE and SS were utilized to elucidate the efficacy of orally administered parsaclisib on autoreactive B-cell-mediated antibody-driven disease. Parsaclisib significantly reduced disease symptoms and pathology in three distinct mouse models of SLE. Parsaclisib effectively preserved renal function as measured by glomerular filtration rate, abrogated histopathological evidence of nephritis, modulated discrete immune cell subsets, and decreased anti-dsDNA antibody level. Furthermore, parsaclisib demonstrated efficacy in two spontaneous mouse models of SS. Oral parsaclisib treatment ameliorated the severity of salivary gland inflammation and reduced circulating levels of autoantibodies. Parsaclisib mediated improvement of salivary gland inflammation coincided with reduced B-cell activating cytokine (BAFF) in saliva. Transcriptomic analysis of kidney and salivary gland tissues revealed a downregulation in inflammatory gene expression consistent with PI3Kδ pathway inhibition. Parsaclisib reduced autoreactive B-cells and autoantibody levels, and significantly improved nephritis and salivary gland inflammation. These data provide the scientific rationale for PI3Kδ inhibition as a therapeutic strategy for treatment of B-cell-mediated antibody-driven autoimmune diseases.
MeSH term(s)	Animals ; Autoantibodies/blood ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Disease Models, Animal ; Humans ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Mice ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Sjogren's Syndrome/blood ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/immunology
Chemical Substances	Autoantibodies ; Pyrazoles ; Pyrimidines ; Pyrrolidines ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Pik3cd protein, mouse (EC 2.7.1.137) ; parsaclisib (OS7097575K)
Language	English
Publishing date	2021-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.107904
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