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  1. Article ; Online: Globusgefühl nach Trampolinspringen bei einem 13-jährigen Kind.

    Guderian, Daniela B / Loth, Andreas G / Stöver, Timo / Winkelmann, Ria / Burck, Iris / Diensthuber, Marc

    Laryngo- rhino- otologie

    2023  Volume 103, Issue 2, Page(s) 125–127

    Title translation Globus sensation after trampoline jumping in a 13-year-old child.
    MeSH term(s) Adolescent ; Humans ; Athletic Injuries ; Globus Sensation ; Risk Factors
    Language German
    Publishing date 2023-09-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-2144-4299
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  2. Article ; Online: Cochlear implant therapy improves the quality of life and social participation in the elderly: a prospective long-term evaluation.

    Issing, Christian / Loth, Andreas G / Sakmen, Kenan D / Guchlerner, Leon / Helbig, Silke / Baumann, Uwe / Pantel, Johannes / Stöver, Timo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose: In recent years, the number of elderly cochlear implant (CI) candidates is continuously rising. In addition to the audiological improvement, other positive effects of CI treatment can also be observed in clinical routine. The "quality of life" ... ...

    Abstract Purpose: In recent years, the number of elderly cochlear implant (CI) candidates is continuously rising. In addition to the audiological improvement, other positive effects of CI treatment can also be observed in clinical routine. The "quality of life" as a parameter of success directly experienced by the patient is increasingly becoming the focus of clinical research. Although there are already clear indications of a rapid and significant improvement in quality of life, there is still a lack of systematic, prospectively collected longitudinal long-term data in patients over the age of 65.
    Methods: This prospective longitudinal observational study included 31 patients between the age of 71 and 92 years who had first been treated unilaterally with a CI 6 years ago. In addition to free-field monosyllable recognition, quality of life was assessed using the World Health Organization Quality-of-Life Scale-old (WHOQL-OLD). The results were compared with the data from our previous study, in which we focused on the short- and medium-term effects on quality of life. In both studies, the same patient population was examined. In addition, these study data were compared with an age-matched average population.
    Results: In speech recognition, there was no significant change from the control 6 months postoperatively compared with the results 6 years postoperatively. No significant changes occurred in the total quality of life score or any of the other six facets of quality of life when comparing the results 6 months postoperatively with the results 6 years postoperatively. In "Social participation", the CI patients even exceed the values of the age-matched average population 6 years after treatment.
    Conclusion: Improvement in the quality of life and especially in social participation appears stable over many years in elderly patients after hearing rehabilitation with a CI.
    Language English
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08443-6
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  3. Article: Globusgefühl nach Trampolinspringen bei einem 13-jährigen Kind

    Guderian, Daniela B. / Loth, Andreas G. / Stöver, Timo / Winkelmann, Ria / Burck, Iris / Diensthuber, Marc

    Laryngo-Rhino-Otologie

    2023  Volume 103, Issue 02, Page(s) 125–127

    Language German
    Publishing date 2023-09-04
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/a-2144-4299
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  4. Article ; Conference proceedings: Gesetzter Vortrag aus der Univ. HNO-Klinik Frankfurt/M.: Erhebung zu Komplikationen bei MRT-Untersuchungen mit bedingt MRT-tauglichen Cochlea-Implantaten

    Loth, G. Andreas / Leinung, Martin / Amthauer, Nelly / Stöver, Timo / Helbig, Silke

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766746
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  5. Article ; Online: Long-term effects on the quality of life following cochlear implant treatment in older patients.

    Issing, Christian / Holtz, Svea / Loth, Andreas G / Baumann, Uwe / Pantel, Johannes / Stöver, Timo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 11, Page(s) 5135–5144

    Abstract: Purpose: Even in older patients, hearing rehabilitation with a cochlear implant has become an established method for deafened or severely hearing-impaired patients. In addition to the hearing improvement, numerous other effects of CI treatment can be ... ...

    Abstract Purpose: Even in older patients, hearing rehabilitation with a cochlear implant has become an established method for deafened or severely hearing-impaired patients. In addition to the hearing improvement, numerous other effects of CI treatment can be observed in clinical routine. In the literature, there is multiple evidence for a rapid and significant improvement in quality of life with CI treatment. The aim of this study was to evaluate the long-term effects of hearing rehabilitation using CI on the quality of life in older patients (≥ 65 years).
    Methods: This prospective cross-sectional study examined 84 patients between the age of 65 and 101 years who received unilateral CI treatment for the first time between one and 10 years ago. The World Health Organization Quality-of-Life Scale-Old (WHOQL-OLD) was used to determine the quality of life. The study cohort was divided into three groups to compare the quality of life over time: group I (1-3 years after CI treatment), group II (4-6 years after CI treatment), and group III (7-10 years after CI treatment). In addition, the data from this study were compared with the results of our previous study (Issing et al. 2020) in which we focused on the first 6 months after CI treatment.
    Results: In all three groups, there was a significant improvement in monosyllabic discrimination within 1 year after CI fitting (p > 0.001). No significant differences were found between the three groups. There were no significant differences between the three groups in the WHOQOL-OLD total score (p = 0.487) or any of the other six facets. Moreover, no significant differences were found compared to the study group of our previous study 6 months after CI treatment.
    Conclusion: This study demonstrates the long-term stability of the improved quality of life following unilateral CI treatment in patients aged 65 years or older.
    MeSH term(s) Aged ; Aged, 80 and over ; Cochlear Implantation/methods ; Cochlear Implants ; Cross-Sectional Studies ; Humans ; Prospective Studies ; Quality of Life ; Speech Perception ; Treatment Outcome
    Language English
    Publishing date 2022-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07354-2
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  6. Article ; Online: Fluoreszenzbasierte Konfokalmikroskopie – vollständige Digitalisierung der Pathologie.

    Loth, Andreas G / Fassl, Anne / Chun, Felix K H / Köllermann, Jens / Hartmann, Sylvia / Gretser, Steffen / Ziegler, Paul K / Flinner, Nadine / Schulze, Falko / Wild, Peter J / Kinzler, Maximilian N

    Pathologie (Heidelberg, Germany)

    2024  Volume 45, Issue 3, Page(s) 211–217

    Abstract: ... and malignancy, and a high level of agreement for, e.g., macrovesicular steatosis, inflammation ...

    Title translation Fluorescence confocal microscopy-complete digitization of pathology.
    Abstract Background: Fluorescence-based confocal microscopy (FCM) can be used to create virtual H&E sections in real time. So far, FCM has been used in dermato-, uro-, and gynecopathology. FCM allows the creation of a completely digitized frozen section, which could potentially replace conventional frozen sections in the future.
    Objective: The aim of the current work is to implement FCM technology as a component of fully digitized processes in the pathological workflow. For this purpose, the current use of FCM in liver transplant pathology will be extended to other disciplines such as urology and otorhinolaryngology.
    Materials and methods: The FCM technique continues to be used prospectively on native tissue samples from potential donor livers. Conventional frozen sections are used comparatively to virtual FCM scans.
    Results: The data show a nearly perfect agreement for the detection of cholangitis, fibrosis, and malignancy, and a high level of agreement for, e.g., macrovesicular steatosis, inflammation, steatohepatitis, and necrosis between virtual FCM scans and conventional routine diagnostic frozen sections.
    Conclusion: Since the availability of time- and cost-intensive frozen section diagnostics in the context of transplant pathology in continuous operation (24/7) is now only established at very few university centers in Germany due to an increasing shortage of specialists, the use of FCM could be an important building block in the current process leading towards a fully digitized pathology workflow and should thus be extended to various disciplines.
    MeSH term(s) Microscopy, Confocal/methods ; Humans ; Liver Transplantation ; Frozen Sections/methods ; Microscopy, Fluorescence/methods ; Liver/pathology ; Liver/diagnostic imaging
    Language German
    Publishing date 2024-03-06
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-024-01311-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of bandaging techniques to prevent cochlear implant magnet displacement following MRI.

    Leinung, Martin / Loth, Andreas G / Kroth, Michaela / Burck, Iris / Stöver, Timo / Helbig, Silke

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2021  Volume 278, Issue 11, Page(s) 4209–4216

    Abstract: Introduction: For cochlear implants (CI) with removable magnets, a pressure bandage usually is recommended during MR imaging to avoid magnet dislocation. Nevertheless, this complication is regularly observed despite applying a pressure bandage. The aim ... ...

    Abstract Introduction: For cochlear implants (CI) with removable magnets, a pressure bandage usually is recommended during MR imaging to avoid magnet dislocation. Nevertheless, this complication is regularly observed despite applying a pressure bandage. The aim of this study was to compare various bandaging techniques to avoid magnet displacement.
    Materials and methods: As an experimental model a force measuring stand was developed and validated, on which the process of magnet dislocation could be simulated on a cochlear implant. In a test series with six combinations of cohesive and elastic bandages with different counter pressure elements (CPE), the forces required to induce magnet dislocation against the resistance of a compression bandage was determined. In addition, the inter- and intraindividual variability of the compression bandages was measured for ten different users.
    Results: The cohesive bandage had the lowest average holding force of 10.70 N. The elastic bandage developed more than four times the retention force of the cohesive bandage (44.88 N, p < 0.01). By adding a CPE, these values could be increased highly significantly up to factor 3. The optimum combination in terms of fixation force against magnet dislocation was an elastic bandage plus a cylindrical CPE (76.60 N). The data showed a high interindividual variability.
    Conclusion: Even though most CI manufacturers now offer 3T-conditional implants, a pressure bandage will have to be applied to thousands of patients with previous implant generations to prevent magnet dislocation. We examined for the first time force measurements to compare different bandaging techniques by detecting the holding force of the CI magnet. We were able to identify an optimized combination of a bandage and a CPE to immobilize the CI magnet. However, our data also demonstrated a significant scatter amongst different examiners. Although our data provide valuable data for potential clinical application, future development of the dressing technique is required for human use.
    MeSH term(s) Cochlear Implantation ; Cochlear Implants ; Humans ; Magnetic Resonance Imaging ; Magnets ; Surgical Sponges
    Language English
    Publishing date 2021-01-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06504-8
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  8. Article ; Conference proceedings: 4D-Analyse von Lymphozytenbewegungen in frischem Lymphknotengewebe als Grundlage zukünftiger Diagnostik bei malignen Lymphomen

    Loth, Andreas G. / Leinung, Martin / Scharf, Sonja / Hansmann, Martin-Leo / Hartmann, Sylvia / Stöver, Timo

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1747230
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  9. Article ; Conference proceedings: 4D analysis of lymphocyte movements in fresh lymph node tissue as a basis for future diagnostics in malignant lymphomas

    Loth, Andreas G. / Leinung, Martin / Scharf, Sonja / Hansmann, Martin-Leo / Hartmann, Sylvia / Stöver, Timo

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1746593
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  10. Article ; Online: Hat die SARS-CoV-2-Pandemie die Lehre verbessert? – Virtueller Unterricht im Fach HNO-Heilkunde aus Sicht der Studierenden.

    Krambeck, Alexa / Loth, Andreas G / Leinung, Martin / Syed-Ali, Anwar / Filmann, Natalie / Kramer, Sabine / Baumann, Uwe / Stöver, Timo / Diensthuber, Marc

    HNO

    2022  Volume 70, Issue 9, Page(s) 655–665

    Abstract: Background: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV‑2) pandemic has significantly changed the education of medical students. Due to the contact restrictions and the associated requirement for distance learning, digital ... ...

    Title translation Has the SARS-CoV-2 pandemic improved teaching?-Virtual education in otorhinolaryngology from the students' perspective.
    Abstract Background: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV‑2) pandemic has significantly changed the education of medical students. Due to the contact restrictions and the associated requirement for distance learning, digital teaching formats had to be implemented within a short period of time. The aim of our work was to analyze student evaluation data for virtual teaching in otorhinolaryngology (ORL) during the SARS-CoV‑2 pandemic and to compare the data with previously obtained evaluation data under face-to-face conditions.
    Materials and methods: Evaluation data for the block practical courses in winter semester 2020/21 and summer semester 2021, which were carried out in a virtual format with a short face-to-face phase as well as those for the block practical courses from summer semester 2018 to winter semester 2019/20, which had been performed completely in a conventional face-to-face format, were analyzed. The anonymous survey of the students focused on various aspects of the courses such as organization, didactics and learning atmosphere.
    Results: Of 16 surveyed categories, 14 (87.5%) showed significantly better evaluation results for the virtual courses compared to the courses carried out previously under face-to-face conditions. This very positive assessment of the digital teaching offer showed no significant change during the course of the pandemic over the period of two semesters.
    Conclusions: Our data show a high acceptance of digital teaching in ORL for students. Even though essential components of the medical education such as teaching on the patient and clinical-practical skills can still only be realized in a face-to-face format, our data suggest that digital elements could also play a role in medical education after the SARS-CoV‑2 pandemic.
    MeSH term(s) COVID-19/epidemiology ; Curriculum ; Humans ; Otolaryngology/education ; Pandemics ; SARS-CoV-2 ; Students, Medical ; Teaching
    Language German
    Publishing date 2022-06-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-022-01192-8
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