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Article ; Online: Whole-Genome Sequence of a Stenotrophomonas maltophilia Isolate from Tap Water in an Intensive Care Unit.

Zainulabid, Ummu Afeera / Siew, Shing Wei / Musa, Siti Munirah / Soffian, Sharmeen Nellisa / Periyasamy, Petrick / Ahmad, Hajar Fauzan

Microbiology resource announcements

2023 Volume 12, Issue 2, Page(s) e0099522

Abstract: Here, we present a 4,508,936-bp complete genome sequence of Stenotrophomonas maltophilia strain HW002Y, which was isolated from the tap water in an intensive care unit at Sultan Ahmad Shah Medical Centre at the International Islamic University of ... ...

Abstract	Here, we present a 4,508,936-bp complete genome sequence of Stenotrophomonas maltophilia strain HW002Y, which was isolated from the tap water in an intensive care unit at Sultan Ahmad Shah Medical Centre at the International Islamic University of Malaysia (Kuantan, Pahang, Malaysia). Sequencing was performed using a Nanopore Flongle flow cell.
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00995-22
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Article ; Online: Clinical utility of procalcitonin in implementation of procalcitonin-guided antibiotic stewardship in the South-East Asia and India: evidence and consensus-based recommendations.

Kwa, Andrea Lay-Hoon / Aninda Sidharta, Brigitte Rina / Son, Do Ngoc / Zirpe, Kapil / Periyasamy, Petrick / Plongla, Rongpong / Swaminathan, Subramanian / Loho, Tonny / Van Giap, Vu / Apisarnthanarak, Anucha

Expert review of anti-infective therapy

2024 Volume 22, Issue 1-3, Page(s) 45–58

Abstract: Introduction: The South-East Asian (SEA) region and India are highly susceptible to antibiotic resistance, which is caused due to lack of antimicrobial stewardship (AMS) knowledge, uncontrolled use of antibiotics, and poor infection control. ... ...

Abstract	Introduction: The South-East Asian (SEA) region and India are highly susceptible to antibiotic resistance, which is caused due to lack of antimicrobial stewardship (AMS) knowledge, uncontrolled use of antibiotics, and poor infection control. Nonadherence to national/local guidelines, developed to combat antimicrobial resistance, is a major concern. A virtual advisory board was conducted to understand the current AMS standards and challenges in its implementation in these regions. Areas covered: Procalcitonin (PCT)-guided antibiotic use was discussed in various clinical conditions across initiation, management, and discontinuation stages. Most experts strongly recommended using PCT-driven antibiotic therapy among patients with lower respiratory tract infections, sepsis, and COVID-19. However, additional research is required to understand the optimal use of PCT in patients with organ transplantation and cancer patients with febrile neutropenia. Implementation of the solutions discussed in this review can help improve PCT utilization in guiding AMS in these regions and reducing challenges. Expert opinion: Experts strongly support the inclusion of PCT in AMS. They believe that PCT in combination with other clinical data to guide antibiotic therapy may result in more personalized and precise targeted antibiotic treatment. The future of PCT in antibiotic treatment is promising and may result in effective utilization of this biomarker.
MeSH term(s)	Humans ; Procalcitonin ; Antimicrobial Stewardship ; Consensus ; Sepsis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Biomarkers ; India ; Asia, Eastern
Chemical Substances	Procalcitonin ; Anti-Bacterial Agents ; Biomarkers
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2023.2296066
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Zs.A 6106: Show issues

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Article ; Online: A Spuriously Negative Cryptococcal Antigen Assay Result in Disseminated Cryptococcosis: the Deception of the Postzone Phenomenon.

Malik, Afifah Aqilah Abdul / Periyasamy, Petrick / Kori, Najma / Wahab, Asrul Abdul / Ding, Chuan Hun

Annals of clinical and laboratory science

2021 Volume 51, Issue 3, Page(s) 430–433

Abstract: ... ...

Abstract	Cryptococcus
MeSH term(s)	Adult ; Antigens, Fungal/immunology ; CD4 Lymphocyte Count ; Cryptococcosis/diagnosis ; Cryptococcosis/microbiology ; Cryptococcosis/virology ; Cryptococcus/immunology ; Cryptococcus/isolation & purification ; False Negative Reactions ; HIV/physiology ; HIV Infections/complications ; HIV Infections/virology ; Humans ; Male
Chemical Substances	Antigens, Fungal
Language	English
Publishing date	2021-06-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Zs.A 942: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Pulmonary Embolism in an Asymptomatic COVID-19 Patient Detected on Ventilation/Perfusion SPECT/CT.

Mahaletchumy, Thanuja / Muhamad, Maimanah / Mohammad Kazmin, Nur Ezzaty / Kori, Najma / Periyasamy, Petrick

Clinical nuclear medicine

2021 Volume 46, Issue 7, Page(s) e360–e362

Abstract: Abstract: Severe COVID-19 infection is associated with significant coagulopathy. We would like share a case of an asymptomatic 26-year-old man who tested positive for COVID-19 and had elevated d-dimer levels. Because of inconclusive CTPA findings, V/Q ( ... ...

Abstract	Abstract: Severe COVID-19 infection is associated with significant coagulopathy. We would like share a case of an asymptomatic 26-year-old man who tested positive for COVID-19 and had elevated d-dimer levels. Because of inconclusive CTPA findings, V/Q (ventilation/perfusion) SPECT/CT was performed, which confirmed the presence of pulmonary embolism. This case highlights the fact that pulmonary embolism should not be overlooked in a COVID-19 patient who has raised d-dimer levels, even in the absence of symptoms. It also highlights the importance of performing a V/Q study when CTPA results are inconclusive or when there are contraindications for iodinated contrast media.
MeSH term(s)	Adult ; Asymptomatic Diseases ; COVID-19/complications ; Humans ; Male ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnostic imaging ; Single Photon Emission Computed Tomography Computed Tomography ; Ventilation-Perfusion Ratio
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003513
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Zs.A 1276: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Catheter-Related Bloodstream Infections and Catheter Colonization among Haemodialysis Patients: Prevalence, Risk Factors, and Outcomes.

Shahar, Shamira / Mustafar, Ruslinda / Kamaruzaman, Lydia / Periyasamy, Petrick / Pau, Kiew Bing / Ramli, Ramliza

International journal of nephrology

2021 Volume 2021, Page(s) 5562690

Abstract: Introduction: Catheter-related bloodstream infection (CRBSI) and catheter colonization (CC) are two complications among haemodialysis (HD) patients that lead to increased morbidity and mortality. This study aims to evaluate the prevalence of CRBSI and ... ...

Abstract	Introduction: Catheter-related bloodstream infection (CRBSI) and catheter colonization (CC) are two complications among haemodialysis (HD) patients that lead to increased morbidity and mortality. This study aims to evaluate the prevalence of CRBSI and CC among HD patients registered at Universiti Kebangsaan Malaysia Medical Centre and to identify the factors involved by focusing on the demographic profile of the patients as well as their clinical characteristics and outcomes. Method: This is a retrospective study of end-stage renal disease patients with suspected CRBSI during the period from 1 January 2016 to 31 December 2018. Data on patients who fulfilled the blood culture criteria for CRBSI and CC diagnosis were further analysed for clinical manifestations, comorbidities, history of dialysis, catheter characteristics, and microbiological culture results. The outcomes of CRBSI and CC were also assessed.
Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573904-9
ISSN	2090-2158 ; 2090-214X
ISSN (online)	2090-2158
ISSN	2090-214X
DOI	10.1155/2021/5562690
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Article ; Online: Aerosolized SARS-CoV-2 transmission risk: Surgical or N95 masks?

Periyasamy, Petrick / Ng, B H / Ali, Umi K / Rashid, Zetti Z / Kori, Najma

Infection control and hospital epidemiology

2020 Volume 42, Issue 9, Page(s) 1150–1152

MeSH term(s)	COVID-19 ; Humans ; Masks ; N95 Respirators ; Respiratory Protective Devices ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.465
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Zs.A 1714: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: COVID-19 Prediction With Machine Learning Technique From Extracted Features of Photoplethysmogram Morphology.

Nayan, Nazrul Anuar / Jie Yi, Choon / Suboh, Mohd Zubir / Mazlan, Nur-Fadhilah / Periyasamy, Petrick / Abdul Rahim, Muhammad Yusuf Zawir / Shah, Shamsul Azhar

Frontiers in public health

2022 Volume 10, Page(s) 920849

Abstract: At present, COVID-19 is spreading widely around the world. It causes many health problems, namely, respiratory failure and acute respiratory distress syndrome. Wearable devices have gained popularity by allowing remote COVID-19 detection, contact tracing, ...

Abstract	At present, COVID-19 is spreading widely around the world. It causes many health problems, namely, respiratory failure and acute respiratory distress syndrome. Wearable devices have gained popularity by allowing remote COVID-19 detection, contact tracing, and monitoring. In this study, the correlation of photoplethysmogram (PPG) morphology between patients with COVID-19 infection and healthy subjects was investigated. Then, machine learning was used to classify the extracted features between 43 cases and 43 control subjects. The PPG data were collected from 86 subjects based on inclusion and exclusion criteria. The systolic-onset amplitude was 3.72% higher for the case group. However, the time interval of systolic-systolic was 7.69% shorter in the case than in control subjects. In addition, 12 out of 20 features exhibited a significant difference. The top three features included dicrotic-systolic time interval, onset-dicrotic amplitude, and systolic-onset time interval. Nine features extracted by heatmap based on the correlation matrix were fed to discriminant analysis, k-nearest neighbor, decision tree, support vector machine, and artificial neural network (ANN). The ANN showed the best performance with 95.45% accuracy, 100% sensitivity, and 90.91% specificity by using six input features. In this study, a COVID-19 prediction model was developed using multiple PPG features extracted using a low-cost pulse oximeter.
MeSH term(s)	COVID-19/diagnosis ; Humans ; Machine Learning ; Neural Networks, Computer ; Photoplethysmography/methods ; Support Vector Machine
Language	English
Publishing date	2022-07-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.920849
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Article ; Online: Corticosteroid effectiveness among hospitalised COVID-19 patients in Malaysia.

Kori, Najma / Islahudin, Farida / Abd Rahim, Muhammad Yusuf Zawir / Periyasamy, Petrick / Mohamed Shah, Noraida / Md Hatah, Ernieda / Lan, Lau Chee

Journal of infection in developing countries

2022 Volume 16, Issue 9, Page(s) 1390–1397

Abstract: Introduction: Using steroids to manage hospitalised coronavirus disease 2019 (COVID-19) patients caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been shown to reduce the need for mechanical ventilation and ... ...

Abstract	Introduction: Using steroids to manage hospitalised coronavirus disease 2019 (COVID-19) patients caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been shown to reduce the need for mechanical ventilation and mortality. To date, low-dose dexamethasone and methylprednisolone corticosteroids have been effective in reducing the infection's progress in hospitalised patients. However, it is unknown if high dosages of corticosteroids can achieve a better clinical outcome. This study aims to compare the clinical outcomes of hospitalised COVID-19 patients who are given a 10-day low-dose corticosteroid treatment (IV 2 mg/kg/day methylprednisolone loading dose (LD) then 0.25 mg/kg four times a day (q.i.d.)) with patients given a 10-day high-dose corticosteroid treatment (IV 20 mg dexamethasone once daily (o.d.) or a 1.5 mg/kg prednisolone tablet o.d.). Methodology: Retrospective data on hospitalised COVID-19 patients were collected for this study, and the primary outcome measure was the patients' clinical status based on the World Health Organization's (WHO) Ordinal Scale for Clinical Improvement (OSCI) on Day-5 and Day-10 post-steroid. Results: The results demonstrated that using steroids significantly improved patients' clinical outcomes from a WHO OSCI level of 4 (0.1) on Day-1 to 2.6 (2.5) on Day-5 (p < 0.001). There was no significant difference in clinical outcome between low-dose and high-dose corticosteroid treatment on Day-5 (H = 2.15; p = 0.34) and Day-10 (H = 1.12; p = 0.58). Conclusions: This study concludes that using low-dose corticosteroids is recommended for hospitalised COVID-19 patients to ensure clinical outcomes are optimised.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; COVID-19/drug therapy ; Dexamethasone/therapeutic use ; Humans ; Malaysia ; Methylprednisolone/therapeutic use ; RNA, Viral ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Adrenal Cortex Hormones ; RNA, Viral ; Dexamethasone (7S5I7G3JQL) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2022-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.16039
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Article ; Online: Diversity and Dissemination of Methicillin-Resistant

Mohamad Farook, Nurul Amirah / Argimón, Silvia / Abdul Samat, Muttaqillah Najihan / Salleh, Sharifah Azura / Sulaiman, Sunita / Tan, Toh Leong / Periyasamy, Petrick / Lau, Chee Lan / Ismail, Zalina / Muhammad Azami, Nor Azila / Ang, Mia Yang / Neoh, Hui-Min

Tropical medicine and infectious disease

2022 Volume 7, Issue 12

Abstract: Methicillin- ... ...

Abstract	Methicillin-resistant
Language	English
Publishing date	2022-12-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed7120438
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Article: Anxiety among hospitalized COVID-19 patients: a case-control study from a tertiary teaching hospital in Malaysia.

Tan, Hui Jan / Shahren, Abdool Alleem Hj / Khoo, Ching Soong / Ng, Chen Fei / Zaidi, Wan Asyraf Wan / Kori, Najma / Periyasamy, Petrick / Eu, Choon Leng / Payus, Alvin Oliver / Hod, Rozita

Frontiers in psychiatry

2023 Volume 14, Page(s) 1148019

Abstract: Introduction: Anxiety has been increasingly recognized as part of the psychosocial health issues in COVID-19 patients. However, the impact of this topic may be underestimated in low- and middle-income countries. This study aimed to estimate the ... ...

Abstract	Introduction: Anxiety has been increasingly recognized as part of the psychosocial health issues in COVID-19 patients. However, the impact of this topic may be underestimated in low- and middle-income countries. This study aimed to estimate the prevalence of and risk factors of anxiety in COVID-19 patients compared to controls in a local tertiary teaching hospital in Malaysia. Methods: In this case-control study, we analyzed data on adult patients aged 18 years and above hospitalized for COVID-19 infection with matched hospitalized controls. The demographic, clinical data and anxiety measures using the Generalized Anxiety Disorder-7 questionnaire were analyzed using univariate and multivariate analysis. Results: 86.6% in the COVID-19 group had anxiety, significantly higher than 13.4% in the control group ( Discussion: COVID-19 patients experience a significant disruption in psychosocial functioning due to hospitalization. The burden of anxiety is notably high, compounded by a diagnosis of COVID-19 itself and neurological symptomatology. Early psychiatric referrals are warranted for patients at risk of developing anxiety symptoms.
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1148019
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