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  1. Book ; Online ; E-Book: Mechanisms of molecular carcinogenesis / Volume 2

    Haybaeck, Johannes

    2017  

    Author's details Johannes Haybaeck editor
    Collection Mechanisms of molecular carcinogenesis
    Language English
    Size 1 Online-Ressource (viii, 374 Seiten), Illustrationen
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019407550
    ISBN 978-3-319-53661-3 ; 9783319536606 ; 3-319-53661-3 ; 3319536605
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Mechanisms of molecular carcinogenesis / Volume 1

    Haybaeck, Johannes

    2017  

    Author's details Johannes Haybaeck editor
    Collection Mechanisms of molecular carcinogenesis
    Language English
    Size 1 Online-Ressource (viii, 299 Seiten), Illustrationen
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019407540
    ISBN 978-3-319-53659-0 ; 9783319536576 ; 3-319-53659-1 ; 3319536575
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book ; Online: Mechanisms of molecular carcinogenesis

    Haybaeck, Johannes

    2017  

    Author's details Johannes Haybaeck editor
    Keywords Medicine ; Cancer research ; Gene expression ; Molecular biology ; Oncology ; Cytokines ; Growth factors
    Language English
    Dates of publication 2017-9999
    Size Online-Ressource
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID HT019407529
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Digitale Pathologie in Österreich.

    Schatz, Christoph / Qerimi, Adelina / Haybaeck, Johannes

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue Suppl 3, Page(s) 229–231

    Abstract: The situation regarding digital pathology in Austria is manageable compared to other countries. Active Austrian examples are the consortium EMPAIA, the private-public partnership Bigpicture, the Austrian Society for Clinical Pathology and Molecular ... ...

    Title translation Digital pathology in Austria.
    Abstract The situation regarding digital pathology in Austria is manageable compared to other countries. Active Austrian examples are the consortium EMPAIA, the private-public partnership Bigpicture, the Austrian Society for Clinical Pathology and Molecular Pathology (OEGPath), the company TissueGnostics, and the Austrian Platform for Personalized Medicine (OEPPM).
    MeSH term(s) Austria ; Telepathology ; Pathology, Clinical ; Pathology, Molecular ; Precision Medicine
    Language German
    Publishing date 2023-11-21
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-023-01278-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis.

    Driva, Tatiana S / Schatz, Christoph / Haybaeck, Johannes

    Biomolecules

    2023  Volume 13, Issue 8

    Abstract: Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under the umbrella term "endometriosis-associated ovarian cancer" (EAOC), since they frequently arise from ectopic endometrium settled in the ovaries. The ... ...

    Abstract Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under the umbrella term "endometriosis-associated ovarian cancer" (EAOC), since they frequently arise from ectopic endometrium settled in the ovaries. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is known to be aberrantly activated both in endometriosis and EAOC; however, its role in the progression of endometriosis to ovarian cancer remains unclear. In fact, cancer-associated alterations in the mTOR pathway may be found in normal uterine epithelium, likely acting as a first step towards ovarian cancer, through the intermediary stage of endometriosis. This review aims to summarize the current knowledge regarding mTOR signaling dysregulation in the uterine endometrium, endometriosis, and EAOC while focusing on the interconnections between the PI3K/AKT/mTOR pathway and other signaling molecules that give rise to synergistic molecular mechanisms triggering ovarian cancer development in the presence of endometriosis.
    MeSH term(s) Female ; Humans ; Proto-Oncogene Proteins c-akt ; Phosphatidylinositol 3-Kinases ; Endometriosis ; Ovarian Neoplasms ; TOR Serine-Threonine Kinases ; Phosphatidylinositol 3-Kinase ; Carcinoma
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13081253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Targeting α-Synuclein in Parkinson's Disease and Multiple System Atrophy.

    Fellner, Lisa / Richter, Franziska / Brundin, Patrik / Haybaeck, Johannes

    Frontiers in neurology

    2022  Volume 13, Page(s) 942313

    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.942313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: "Dendroarchitectonics": From Santiago Ramón y Cajal to Enrique Ramón‑Moliner or vice versa?

    Geser, Felix / Haybaeck, Johannes / Yilmazer-Hanke, Deniz

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 12, Page(s) 7015

    Language English
    Publishing date 2022-06-19
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-06218-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cd44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor.

    Zhou, Ziqi / Li, Can / Wang, Zhiyu / Haybaeck, Johannes / Zhang, Cuiwei

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 7, Page(s) 583–588

    Abstract: Introduction: Due to the limited number of studies focusing on the optimal treatment of multiple Krukenberg tumor (KT)-gastric carcinoma (KT - GC), it is necessary to conduct large-scale studies to confirm the definite role of serum tumor markers in the ...

    Abstract Introduction: Due to the limited number of studies focusing on the optimal treatment of multiple Krukenberg tumor (KT)-gastric carcinoma (KT - GC), it is necessary to conduct large-scale studies to confirm the definite role of serum tumor markers in the diagnosis and prognosis of KT. Moreover, the clinical significance of variant 6 of CD44 (CD44v6) in transcoelomic metastasis should be considered.
    Areas covered: This review covers molecular pre-cancer diagnosis, gastric carcinoma metastasis, and anti-cancer treatments. Additionally, gastrointestinal cancer metastasis is a key area for improvement.
    Expert opinion: The detection of CD44v6 differs in the World Health Organization Classification of Gastric Adenocarcinoma, the Lauren Classification of Gastric Adenocarcinoma, and the anatomic location of gastric adenocarcinoma. The results were compared among the three groups. The mechanism of gastric adenocarcinoma metastasis still requires further elucidation. CD44v6 molecular detection helps clarify the pre-cancer diagnosis of KT before seeding. If subsequent studies confirm its role as a signaling molecule, it could pave the way for new research directions in clinical practice; however, additional academic confirmation is necessary.
    MeSH term(s) Female ; Humans ; Krukenberg Tumor/diagnosis ; Krukenberg Tumor/genetics ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Biomarkers, Tumor ; Carcinoma ; Ovarian Neoplasms
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2223981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6073: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Genetic alterations of GI-NECs involving three main signaling pathways.

    Dai, Qiong / Zhang, Jinping / Long, Weili / Haybaeck, Johannes / Yang, Zhihui

    Cancer medicine

    2023  Volume 12, Issue 7, Page(s) 8238–8250

    Abstract: Background: Gastrointestinal (GI)-neuroendocrine neoplasms (NENs) are subclassified in neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs). The genetic characteristics of GI-NEN ... ...

    Abstract Background: Gastrointestinal (GI)-neuroendocrine neoplasms (NENs) are subclassified in neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs). The genetic characteristics of GI-NEN has been a hot issue in recent years, but more studies are needed to provide further details. This study aims to provide additional data about genomic characteristics of GI-NENs and the genetic differences between NETs and NECs.
    Patients and methods: Thirteen samples were selected for next-generation sequencing (NGS) analysis with a 425-gene panel. Microsatellite instability (MSI) and tumor mutational burden (TMB) were calculated as well as immunohistochemistry (IHC) was used to test for protein expression.
    Results: Genetic alterations were very common in NECs, but rare in NETs. The average TMB of NETs and NECs was 2.3 and 6.9, respectively. The TMB of NECs was significantly higher compared to NETs. The TP53 mutation rate was significantly higher in NECs than in NETs (100% vs. 20%), other mutations involved MTOR (n = 2, 15.4%), DDR2 (n = 3, 23.1%), ERBB4 (n = 1, 7.7%), BRCA1 (n = 1, 7.7%), BRCA2 (n = 1, 7.7%), ATM (n = 1, 7.7%), and SMAD4 (n = 1, 7.7%). Deep loss of SMAD4 (1/3, 33.3%), SDHB (1/3, 33.3%), RB1 (1/3, 33.3%), and BRCA2 (1/3, 33.3%), high-level amplification of CRKL (1/3, 33.3%), CCNE1(1/3, 33.3%), and MCL1(1/3, 33.3%) were found in NECs. The integrated analysis found these genetic alterations frequently involve DNA repair and cell cycle, PI3K/AKT/mTOR and TGF-β/SMAD4 signaling pathways.
    Conclusion: Genetic alterations were very common in NECs and rare in NETs, and frequently involved three main signaling pathways. NEC patients harboring these genetic alterations may benefit from targeted therapy and PD-1/PD-L1 immunotherapy.
    MeSH term(s) Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Carcinoma, Neuroendocrine/genetics ; Carcinoma, Neuroendocrine/pathology ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/pathology ; Neuroendocrine Tumors/pathology ; Mutation ; Signal Transduction/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Biomarkers, Tumor ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Translational Bridge between Inflammation and Hepatocarcinogenesis.

    Gufler, Sabine / Seeboeck, Rita / Schatz, Christoph / Haybaeck, Johannes

    Cells

    2022  Volume 11, Issue 3

    Abstract: Viral infections or persistent alcohol or drug abuse, together with intrinsic factors, lead to hepatitis, which often ends in the development of liver cirrhosis or hepatocellular carcinoma (HCC). With this review, we describe inflammatory liver diseases, ...

    Abstract Viral infections or persistent alcohol or drug abuse, together with intrinsic factors, lead to hepatitis, which often ends in the development of liver cirrhosis or hepatocellular carcinoma (HCC). With this review, we describe inflammatory liver diseases, such as acute liver failure, virus-induced hepatitis, alcoholic- and non-alcoholic steatohepatitis, and autoimmune hepatitis, and highlight their driving mechanisms. These include external factors such as alcohol misuse, viral infection and supernutrition, as well as intrinsic parameters such as genetic disposition and failure, in immune tolerance. Additionally, we describe what is known about the translational machinery within all these diseases. Distinct eukaryotic translation initiation factors (eIFs) with specific functional roles and aberrant expression in HCC are reported. Many alterations to the translational machinery are already triggered in the precancerous lesions described in this review, highlighting mTOR pathway proteins and eIFs to emphasize their putative clinical relevance. Here, we identified a lack of knowledge regarding the roles of single eIF proteins. A closer investigation will help to understand and treat HCC as well as the antecedent diseases.
    MeSH term(s) Carcinogenesis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Ethanol ; Hepatitis, Viral, Human ; Humans ; Inflammation ; Liver Cirrhosis ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Non-alcoholic Fatty Liver Disease ; TOR Serine-Threonine Kinases
    Chemical Substances Ethanol (3K9958V90M) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11030533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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