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Article: Myco-Facilitated Biosynthesis of Nano-Silver From Wasp Nest Fungus,

Nayak, B K / Prabhakar, V / Nanda, Anima

2022 Volume 13, Page(s) 841666

Abstract: The utility of fungi as stabilizing and reducing agents in the biogenic synthesis of silver nanoparticles is striking due to the production of large quantities of biomolecules of minute toxic residuals. During the current study, sunlight- and dark- ... ...

Abstract	The utility of fungi as stabilizing and reducing agents in the biogenic synthesis of silver nanoparticles is striking due to the production of large quantities of biomolecules of minute toxic residuals. During the current study, sunlight- and dark-assessed silver nanoparticles were synthesized from wasp nest fungus,
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.841666
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Article ; Online: Elevated CO

Vanaja, M / Sarkar, B / Sathish, P / Jyothi Lakshmi, N / Yadav, S K / Mohan, Ch / Sushma, A / Yashavanth, B S / Srinivasa Rao, M / Prabhakar, M / Singh, V K

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2928

Abstract: The rising temperatures and levels of carbon dioxide in the atmosphere are anticipated to have a significant impact on the productivity of agricultural crops. Although, the individual effects of elevated ... ...

Abstract	The rising temperatures and levels of carbon dioxide in the atmosphere are anticipated to have a significant impact on the productivity of agricultural crops. Although, the individual effects of elevated CO
MeSH term(s)	Carbon Dioxide/metabolism ; Temperature ; Zea mays ; Photosynthesis/physiology ; Edible Grain/metabolism ; Crops, Agricultural/metabolism
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53343-2
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Article ; Online: Do rainfed production systems have lower environmental impact over irrigated production systems?: On -farm mitigation strategies.

Pratibha, G / Srinivas, I / Raju, B M K / Suvana, S / Rao, K V / Rao, M Srinivasa / Jha, Anamika / Anna, Shivakumar / Prabhakar, M / Singh, V K / Islam, Adlul / Singh, Rajbir / Choudhary, S K

The Science of the total environment

2024 Volume 917, Page(s) 170190

Abstract: The intensive agriculture practices improved the crop productivity but escalated energy inputs (EI) and carbon foot print (CF) which contributes to global warming. Hence designing productive, profitable crop management practices under different ... ...

Abstract	The intensive agriculture practices improved the crop productivity but escalated energy inputs (EI) and carbon foot print (CF) which contributes to global warming. Hence designing productive, profitable crop management practices under different production systems with low environmental impact (EI and CF) is the need of the hour. To identify the practices, quantification of baseline emissions and the major sources of emissions are required. Indian agriculture has diversified crops and production systems but there is dearth of information on both EI and CF of these production systems and crops. Hence the present study was an attempt to find hot spots and identify suitable strategies with high productivity, energy use efficiency (EUE) and carbon use efficiency (CUE). Energy and carbon balance of castor, cotton, chickpea, groundnut, maize, rice (both rainfed and irrigated), wheat, sugarcane (only irrigated), pigeon pea, soybean, sorghum, pearl millet (only rainfed) in different production systems was assessed. Field specific data on different crop management practices as well as grain and biomass yields were considered. Rainfed production systems had lower EI and CF than irrigated system. The nonrenewable sources of energy like fertilizer (64 %), irrigation (78 %), diesel fuel (75 %) and electricity (67 %) are the major source of energy input. Rainfed crops recorded higher CUE over irrigated condition. Adoption of technologies like efficient irrigation strategies (micro irrigation), enhancing fertilizer use efficiency (site specific nutrient management or slow release fertilizer), conservation agriculture (conservation or reduced tillage) rice cultivation methods (SRI or Direct seeded rice) were the mitigation strategies. These results will help policy makers and stake holders in adoption of suitable strategies for sustainable intensification.
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170190
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Article ; Online: Pest scenario of Helicoverpa armigera (Hub.) on pigeonpea during future climate change periods under RCP based projections in India.

Srinivasa Rao, M / Rama Rao, C A / Raju, B M K / Subba Rao, A V M / Gayatri, D L A / Islam, Adlul / Prasad, T V / Navya, M / Srinivas, K / Pratibha, G / Srinivas, I / Prabhakar, M / Yadav, S K / Bhaskar, S / Singh, V K / Chaudhari, S K

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6788

Abstract: Gram pod borer, Helicoverpa armigera (Hub.) is the major insect pest of pigeonpea and prediction of number of generations (no. of gen.) and generation time (gen. time) using growing degree days (GDD) approach during three future climate change periods ... ...

Abstract	Gram pod borer, Helicoverpa armigera (Hub.) is the major insect pest of pigeonpea and prediction of number of generations (no. of gen.) and generation time (gen. time) using growing degree days (GDD) approach during three future climate change periods viz., Near (NP), Distant (DP) and Far Distant (FDP) periods at eleven major pigeonpea growing locations of India was attempted. Multi-model ensemble of Maximum (Tmax) and Minimum (Tmin) temperature data of four Representative Concentration Pathways viz., RCP 2.6, 4.5, 6.0 and 8.5 of Coupled Model Inter comparison Project 5 (CMIP5) models was adopted here. The increase in projected Tmax and Tmin are significant during 3 climate change periods (CCPs) viz., the NP, DP and FDP over base line (BL) period under four RCP scenarios at all locations and would be higher (4.7-5.1 °C) in RCP 8.5 and in FDP. More number of annual (10-17) and seasonal (5-8) gens. are expected to occur with greater percent increase in FDP (8 to 38%) over base line followed by DP (7 to 22%) and NP (5to 10%) periods with shortened annual gen. time (4 to 27%) across 4 RCPs. The reduction of crop duration was substantial in short, medium and long duration pigeonpeas at all locations across 4 RCPs and 3 CCPs. The seasonal no.of gen. is expected to increase (5 to 35%) with shortened gen. time (4 to 26%) even with reduced crop duration across DP and FDP climate periods of 6.0 and 8.5 RCPs in LD pigeonpea. More no. of gen. of H. armigera with reduced gen. time are expected to occur at Ludhiana, Coimbatore, Mohanpur, Warangal and Akola locations over BL period in 4 RCPs when normal duration of pigeonpeas is considered. Geographical location (66 to 72%), climate period (11 to 19%), RCPs (5-7%) and their interaction (0.04-1%) is vital and together explained more than 90% of the total variation in future pest scenario. The findings indicate that the incidence of H. armigera would be higher on pigeonpea during ensuing CCPs in India under global warming context.
MeSH term(s)	Animals ; Climate Change ; Moths ; Global Warming ; Temperature ; India
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-32188-1
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Article ; Online: Evaluating area-specific adaptation strategies for rainfed maize under future climates of India.

Subba Rao, A V M / Sarath Chandran, M A / Bal, Santanu Kumar / Pramod, V P / Sandeep, V M / Manikandan, N / Raju, B M K / Prabhakar, M / Islam, Adlul / Naresh Kumar, S / Singh, V K

The Science of the total environment

2022 Volume 836, Page(s) 155511

Abstract: This study investigates the spatio-temporal changes in maize yield under projected climate and identified the potential adaptation measures to reduce the negative impact. Future climate data derived from 30 general circulation models were used to assess ... ...

Abstract	This study investigates the spatio-temporal changes in maize yield under projected climate and identified the potential adaptation measures to reduce the negative impact. Future climate data derived from 30 general circulation models were used to assess the impact of future climate on yield in 16 major maize growing districts of India. DSSAT model was used to simulate maize yield and evaluate adaptation strategies during mid (2040-69) and end-centuries (2070-99) under RCP 4.5 and 8.5. Genetic coefficients were calibrated and validated for each of the study locations. The projected climate indicated a substantial increase in mean seasonal maximum (0.9-6.0 °C) and minimum temperatures (1.1-6.1 °C) in the future (the range denotes the lowest and highest change during all the four future scenarios). Without adaptation strategies, climate change could reduce maize yield in the range of 16% (Tumkur) to 46% (Jalandhar) under RCP 4.5 and 21% (Tumkur) to 80% (Jalandhar) under RCP 8.5. Only at Dharwad, the yield could remain slightly higher or the same compared to the baseline period (1980-2009). Six adaptation strategies were evaluated (delayed sowing, increase in fertilizer dose, supplemental irrigation, and their combinations) in which a combination of those was found to be effective in majority of the districts. District-specific adaptation strategies were identified for each of the future scenarios. The findings of this study will enable in planning adaptation strategies to minimize the negative impact of projected climate in major maize growing districts of India.
MeSH term(s)	Adaptation, Physiological ; Agriculture ; Climate Change ; Crops, Agricultural ; Zea mays
Language	English
Publishing date	2022-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.155511
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Article ; Online: Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression.

Al-Ostoot, Fares Hezam / Sherapura, Ankith / V, Vigneshwaran / Basappa, Giridhara / H K, Vivek / B T, Prabhakar / Khanum, Shaukath Ara

Pharmacological reports : PR

2021 Volume 73, Issue 5, Page(s) 1328–1343

Abstract: Background: Hypoxic microenvironment is a common feature of solid tumors, which leads to the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic conditions stimulates tumor angiogenesis, favoring HIF-1α as a promising ... ...

Abstract	Background: Hypoxic microenvironment is a common feature of solid tumors, which leads to the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic conditions stimulates tumor angiogenesis, favoring HIF-1α as a promising anticancer agent. On the other hand, synthetic Indolephenoxyacetamide derivatives are known for their pharmacological potentiality. With this background here, we have synthesized, characterized, and validated the new IPA (8a-n) analogs for anti-tumor activity. Methods: The new series of IPA (8a-n) were synthesized through a multi-step reaction sequence and characterized based on the different spectroscopic analysis FT-IR, Results: Screening for anti-proliferative studies inferred, IPA (8k) is a lead molecule with an IC Conclusion: The IPA (8k) is a potent anti-proliferative molecule with anti-angiogenic activity and specifically targets HIF1α, thereby modulates its downstream regulatory genes both in vitro and in vivo. The study provides scope for new target-specific drug development against HIF-1α for the treatment of solid tumors.
MeSH term(s)	Acetamides/chemical synthesis ; Acetamides/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Lymphoma/drug therapy ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/drug therapy ; Rats ; Rats, Wistar ; Signal Transduction ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Chemical Substances	Acetamides ; Antineoplastic Agents ; Hif1a protein, rat ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2186248-5
ISSN	2299-5684 ; 1734-1140
ISSN (online)	2299-5684
ISSN	1734-1140
DOI	10.1007/s43440-021-00266-8
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Article: Notch Signaling Suppresses Melanoma Tumor Development in BRAF/Pten Mice.

Mikheil, Dareen / Prabhakar, Kirthana / Ng, Tun Lee / Teertam, Sireesh / Longley, B Jack / Newton, Michael A / Setaluri, Vijayasaradhi

Cancers

2023 Volume 15, Issue 2

Abstract: ... of mouse melanoma by crossing BRAFCA/+/Pten+/+/Tyr-CreER+ (B) and BRAFCA/+/Pten-/-/Tyr-CreER + (BP) mice ... but not in B mice with or without the deletion of either Notch1 or Notch2. These data show that the loss ...

Abstract	Both oncogenic and tumor suppressor roles have been assigned to Notch signaling in melanoma. In clinical trials, Notch inhibitors proved to be ineffective for melanoma treatment. Notch signaling has also been implicated in melanoma transdifferentiation, a prognostic feature in primary melanoma. In this study, we investigated the role of Notch signaling in melanoma tumor development and growth using the genetic model of mouse melanoma by crossing BRAFCA/+/Pten+/+/Tyr-CreER+ (B) and BRAFCA/+/Pten-/-/Tyr-CreER + (BP) mice with Notch1 or Notch2 floxed allele mice. The topical application of tamoxifen induced tumors in BP mice but not in B mice with or without the deletion of either Notch1 or Notch2. These data show that the loss of either Notch1 nor Notch2 can substitute the tumor suppressor function of Pten in BRAFV600E-induced melanomagenesis. However, in Pten-null background, the loss of either Notch1 or Notch2 appeared to accelerate BRAFV600E-induced tumor development, suggesting a tumor suppressor role for Notch1 and Notch2 in BRAFV600E/Pten-null driven melanomagenesis. Quantitative immunochemical analysis of a human cutaneous melanoma tissue microarray that consists of >100 primary tumors with complete clinical history showed a weak to moderate correlation between NOTCH protein levels and clinical and pathological parameters. Our data show that Notch signaling is involved during melanomagenesis and suggest that the identification of genes and signaling pathways downstream of Notch could help devise strategies for melanoma prevention.
Language	English
Publishing date	2023-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020519
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Article: Evaluating area-specific adaptation strategies for rainfed maize under future climates of India

Subba Rao, A.V.M. / Sarath Chandran, M.A. / Bal, Santanu Kumar / Pramod, V.P. / Sandeep, V.M. / Manikandan, N. / Raju, B.M.K. / Prabhakar, M. / Islam, Adlul / Naresh Kumar, S. / Singh, V.K.

Science of the total environment. 2022 Aug. 25, v. 836

2022

Abstract	This study investigates the spatio-temporal changes in maize yield under projected climate and identified the potential adaptation measures to reduce the negative impact. Future climate data derived from 30 general circulation models were used to assess the impact of future climate on yield in 16 major maize growing districts of India. DSSAT model was used to simulate maize yield and evaluate adaptation strategies during mid (2040-69) and end-centuries (2070-99) under RCP 4.5 and 8.5. Genetic coefficients were calibrated and validated for each of the study locations. The projected climate indicated a substantial increase in mean seasonal maximum (0.9–6.0 °C) and minimum temperatures (1.1–6.1 °C) in the future (the range denotes the lowest and highest change during all the four future scenarios). Without adaptation strategies, climate change could reduce maize yield in the range of 16% (Tumkur) to 46% (Jalandhar) under RCP 4.5 and 21% (Tumkur) to 80% (Jalandhar) under RCP 8.5. Only at Dharwad, the yield could remain slightly higher or the same compared to the baseline period (1980–2009). Six adaptation strategies were evaluated (delayed sowing, increase in fertilizer dose, supplemental irrigation, and their combinations) in which a combination of those was found to be effective in majority of the districts. District-specific adaptation strategies were identified for each of the future scenarios. The findings of this study will enable in planning adaptation strategies to minimize the negative impact of projected climate in major maize growing districts of India.
Keywords	climate ; climate change ; corn ; environment ; fertilizer rates ; irrigation ; meteorological data ; India
Language	English
Dates of publication	2022-0825
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.155511
Database	NAL-Catalogue (AGRICOLA)

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Article: Biogenic synthesis of silver nanoparticle from wasp nest soil fungus, Penicillium italicum and its analysis against multi drug resistance pathogens

Nayak, B.K / A. Nanda / V. Prabhakar

Biocatalysis and agricultural biotechnology. 2018 Oct., v. 16

2018

Abstract: The mortality rate has increased robustly due to the drug resistant microorganisms and is a major challenge before scientist. Since nature provides the clues to us to defend against unfavorable situation, the proposed study has focus on an insect-microbe ...

Abstract	The mortality rate has increased robustly due to the drug resistant microorganisms and is a major challenge before scientist. Since nature provides the clues to us to defend against unfavorable situation, the proposed study has focus on an insect-microbe symbiosis which plays a vital role for producing the natural product for an alternate source of antibiotic. In our present study we have isolated fungi Penicillium italicum from wasp nest soil and checked the symbiotic relation is more promising than the individual growth. Further the study was subjected to extracellular biosynthesis of silver nanoparticles. The biosynthesized nanoparticles were characterized by various techniques followed by antibacterial and antifungal activity against multi drug bacterial pathogens like Staphylococcus aureus, Vibrio parahaemolyticus, E. coli, Shewanella putrefaciens and fungal pathogen of Candida albicans. The silver nanoparticles were synthesized by adding silver nitrate to the culture extract of Penicillium italicum. The UV-Vis spectrophotometer showed the absorption peak at 419–421 nm and the Scanning Electron Microscopy showed the particle size of 33 nm. The Synthesized silver nanoparticles were found to have diverse antimicrobial activities against the pathogens at different pH. Antimicrobial assay of silver nanoparticles from P. italicum revealed that the synthesized nanoparticle had good effect at different levels to MDR pathogen of Staphylococcus aureus, Shewanella putrefaciens and fungal pathogen of Candida albicans. Synthesized nanoparticles from the fungi specially cultivated from the wasp nest soil has better antimicrobial activity against multi drug resistant pathogens MDRs and is reliable, ecofriendly economic to synthesizes the noble nanomaterials.
Keywords	Candida albicans ; Escherichia coli ; Penicillium italicum ; Shewanella putrefaciens ; Staphylococcus aureus ; Vibrio parahaemolyticus ; absorption ; antibiotics ; antifungal properties ; biosynthesis ; drug resistance ; drugs ; mortality ; nanoparticles ; nanosilver ; nests ; pH ; particle size ; pathogens ; scanning electron microscopy ; silver nitrate ; soil ; soil fungi ; symbiosis ; ultraviolet-visible spectroscopy ; wasps
Language	English
Dates of publication	2018-10
Size	p. 412-418.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2018.09.014
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bilateral abducens palsy in closed head injury

Sandeep B V / Rekha K R / Manpreet Singh Banga / Anantha Kishan / Vittal I Nayak / Sneha Priya Prabhakar

Asian Journal of Medical Sciences, Vol 12, Iss 10, Pp 164-

A comprehensive review of literature based on a case report

2021 Volume 170

Abstract: Isolated bilateral sixth nerve palsies are rare, particularly in the setting of trauma. Most post-head injury cases with bilateral abducens palsy involve either basal skull fractures, particularly clival fractures. We present a case of bilateral abducens ...

Abstract	Isolated bilateral sixth nerve palsies are rare, particularly in the setting of trauma. Most post-head injury cases with bilateral abducens palsy involve either basal skull fractures, particularly clival fractures. We present a case of bilateral abducens palsy after closed head injury in a young male who presented to the emergency department and a comprehensive literature review based on our clinical case. A Medline search for bilateral abducens palsy in closed head injury showed 89 results. Articles were excluded if crush head injury, non-traumatic bilateral abducens nerve palsy, associated vascular malformations were reported. After thorough search and filtering of those articles, fifty-one publications were found which reported and discussed about traumatic bilateral abducens palsy with closed head injury. In these 51 articles, a total of 139 cases were recorded. Several theories have been postulated to explain mechanisms of abducens nerve injury in trauma both in immediate and delayed settings. In our case, patient presented with immediate onset of bilateral abducens palsy. On imaging, clival fracture was seen in CT brain, which can be attributed for the nerve injury. Cases with retroclival extradural haematoma had higher chances of multiple cranial nerve injuries. Cases with multiple basal skull fracture involving petrous temporal bone fracture had higher chances of facial nerve injury. Along with bilateral involvement, the poorer outcome for recovery can be related with the severity of the adduction deficit. Our case showed no improvement in bilateral abduction during follow-up at 6 months. Clinical presentation of traumatic bilateral abducens nerve palsy is rare following closed head trauma and is usually associated with other injuries which are incompatible with life. It can be associated with other nerve injuries depending on basal skull fractures.
Keywords	bilateral abducens palsy ; head injury ; clival fracture ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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