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Article ; Online: Comment on: multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial hypotension.

Esposito, Antonio / Ugga, Lorenzo / Tedeschi, Enrico / Iodice, Rosa / Moccia, Marcello

Journal of neurology, neurosurgery, and psychiatry

2024 Volume 95, Issue 2, Page(s) 196–197

MeSH term(s)	Humans ; Intracranial Hypotension/diagnosis ; Intracranial Hypotension/therapy ; Headache/diagnosis ; Headache/etiology ; Headache/therapy ; Magnetic Resonance Imaging ; Cerebrospinal Fluid Leak
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Letter
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2023-331981
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Article ; Online: Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone.

Di Nicola, Marco / Pepe, Maria / Panaccione, Isabella / Moccia, Lorenzo / Janiri, Luigi / Sani, Gabriele

Current neuropharmacology

2023 Volume 21, Issue 11, Page(s) 2195–2205

Abstract: Background: Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) are major public health concerns because of their high prevalence and clinical and functional severity. MDD and AUD commonly co-occur, but effective therapeutic approaches for ... ...

Abstract	Background: Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) are major public health concerns because of their high prevalence and clinical and functional severity. MDD and AUD commonly co-occur, but effective therapeutic approaches for comorbidity are still scarce. Available evidence on selective serotonin reuptake inhibitors and tricyclic antidepressants held mixed results, and further pharmacological categories have been less investigated. Trazodone is an approved antidepressant drug for adults and has shown efficacy on symptoms like anxiety and insomnia observed in AUD patients as well. Thus, this study aims to evaluate the effect of extended-release trazodone on clinical and functional features in MDD + AUD subjects. Methods: One hundred MDD + AUD outpatients were retrospectively evaluated at 1, 3, and 6 months of treatment with extended-release trazodone (150-300 mg/day, flexibly dosed). Improvement in depressive symptoms was the primary outcome measure. Changes in anxiety, sleep, functioning, quality of life, clinical global severity, and alcohol craving were also investigated. Results: Trazodone reduced depressive symptoms (p < 0.001) with 54.5% remission at the endpoint. Similar improvements were observed in all secondary outcomes, including anxiety, sleep alterations, and craving (p < 0.001). Only mild side effects were reported and disappeared over time. Conclusion: Extended-release trazodone displayed good antidepressant properties in MDD + AUD patients, ameliorating overall symptomatology, functioning, and quality of life, with a good safety/ tolerability profile. Further, it significantly improved sleep disturbances and craving symptoms, which are associated with drinking relapse and worse outcomes. Therefore, trazodone might represent a promising pharmacological option for MDD + AUD patients.
MeSH term(s)	Adult ; Humans ; Trazodone/therapeutic use ; Trazodone/pharmacology ; Alcoholism/complications ; Alcoholism/drug therapy ; Depressive Disorder, Major/complications ; Depressive Disorder, Major/drug therapy ; Quality of Life ; Retrospective Studies ; Antidepressive Agents/therapeutic use ; Comorbidity
Chemical Substances	Trazodone (YBK48BXK30) ; Antidepressive Agents
Language	English
Publishing date	2023-03-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X21666230403080624
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Article: Deep-Dwelling Populations of Mediterranean

Carugati, Laura / Moccia, Davide / Bramanti, Lorenzo / Cannas, Rita / Follesa, Maria Cristina / Salvadori, Susanna / Cau, Alessandro

Biology

2022 Volume 11, Issue 2

Abstract: Corallium ... ...

Abstract	Corallium rubrum
Language	English
Publishing date	2022-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11020333
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Article: What Came First, Mania or Depression? Polarity at Onset in Bipolar I and II: Temperament and Clinical Course.

Janiri, Delfina / Simonetti, Alessio / Moccia, Lorenzo / Hirsch, Daniele / Montanari, Silvia / Mazza, Marianna / Di Nicola, Marco / Kotzalidis, Georgios D / Sani, Gabriele

Brain sciences

2023 Volume 14, Issue 1

Abstract: 1) Background: Bipolar disorder (BD) is divided into type I (BD-I) and type II (BD-II). Polarity at onset (PO) is a proposal to specify the clinical course of BD, based on the type of the first episode at disorder onset-depressive (D-PO) or manic (M-PO). ...

Abstract	(1) Background: Bipolar disorder (BD) is divided into type I (BD-I) and type II (BD-II). Polarity at onset (PO) is a proposal to specify the clinical course of BD, based on the type of the first episode at disorder onset-depressive (D-PO) or manic (M-PO). At the same time, affective temperaments represent preexisting variants of the spectrum of affective disorders. Our objectives were to investigate the hypothesis that temperament may exert an influence on PO, and that this factor can serve as an indicator of the forthcoming course of the disorder, carrying significant therapeutic implications. (2) Methods: We included 191 patients with BD and examined clinical variables and temperament; the latter was assessed using the short version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A-39-SV). We tested the associations between these variables and PO using standard univariate/bivariate methods followed by multivariate logistic regression models. (3) Results: 52.9% of the sample had D-PO and 47.1% had M-PO. D-PO and M-PO patients scored higher for dysthymic and hyperthymic temperaments, respectively (
Language	English
Publishing date	2023-12-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14010017
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Article: Functional Movement Disorders during COVID-19: Psychological Distress, Affective Temperament and Emotional Dysregulation.

Janiri, Delfina / Petracca, Martina / Moccia, Lorenzo / Solito, Marcella / Lo Monaco, Maria Rita / Cerbarano, Maria Luana / Piano, Carla / Imbimbo, Isabella / Di Nicola, Marco / Simonetti, Alessio / Sani, Gabriele / Bentivoglio, Anna Rita

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Background and ... ...

Abstract	Background and objective
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020175
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Article ; Online: Heartbeat Detection by Laser Doppler Vibrometry and Machine Learning.

Antognoli, Luca / Moccia, Sara / Migliorelli, Lucia / Casaccia, Sara / Scalise, Lorenzo / Frontoni, Emanuele

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 18

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Electrocardiography ; Heart Rate ; Humans ; Lasers ; Machine Learning ; Support Vector Machine ; Vibration
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20185362
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Article ; Online: Examining the relationship between the environmental impact of diet and child growth from a co-benefit perspective.

Maritano, Silvia / Moirano, Giovenale / Isaevska, Elena / Pizzi, Costanza / Ponzo, Valentina / Moccia, Chiara / Maule, Milena / Lastrucci, Vieri / Alderotti, Giorgia / Ronfani, Luca / Brumatti, Liza Vecchi / Rusconi, Franca / Gagliardi, Luigi / Brescianini, Sonia / Nisticò, Lorenza / De Sario, Manuela / Culasso, Martina / Richiardi, Lorenzo

Environmental research

2024 Volume 250, Page(s) 118496

Abstract: The adoption of diets that minimize both their environmental impacts and weight excess in children would be a major co-benefit for climate change mitigation. We evaluated the relationship between child diet-related environmental impact and anthropometric ...

Abstract	The adoption of diets that minimize both their environmental impacts and weight excess in children would be a major co-benefit for climate change mitigation. We evaluated the relationship between child diet-related environmental impact and anthropometric characteristics in an Italian birth cohort. The study involved 2127 children of the Piccolipiù birth cohort. At 4 years, their diet in the previous two months was assessed through a questionnaire, from which we derived individual: (i) diet-related daily greenhouse gas emissions (GHGE), (ii) land use (LU), (iii) adherence to the Mediterranean Diet (MD) and (iv) red meat consumption. We related these variables with overweight and obesity, waist circumference, and height at 4 years using regression models adjusted for a priori selected confounders. Diet-related GHGE and LU had a positive weak association with overweight and obesity, with an odds ratio (OR) for the fourth vs. second quartile of 1.30 for both GHGE (95% confidence intervals -CI-: 0.96; 1.77) and LU (95% CI: 0.96-1.76). Both OR estimates increased after adjustment for energy intake. GHGE and LU were not associated with height, with the exception of shorter children in the first quartile. A high vs. low MD adherence was associated with an increase in height Z-score of 0.11 (95% CI 0.01; 0.21). No association was found for red meat consumption. These results suggest that lowering the impact of high environmental impact diets may have, if anything, beneficial effects on child obesity, overweight, and height, with pro-MD patterns playing an important role.
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118496
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Article: COVID-19 and New-Onset Psychosis: A Comprehensive Review.

Moccia, Lorenzo / Kotzalidis, Georgios D / Bartolucci, Giovanni / Ruggiero, Sara / Monti, Laura / Biscosi, Marco / Terenzi, Beatrice / Ferrara, Ottavia M / Mazza, Marianna / Di Nicola, Marco / Janiri, Delfina / Simonetti, Alessio / Caroppo, Emanuele / Janiri, Luigi / Sani, Gabriele

Journal of personalized medicine

2023 Volume 13, Issue 1

Abstract: Psychosis is a multifactorial condition that typically involves delusions, hallucinations, and disorganized thought, speech or behavior. The observation of an association between infectious epidemics and acute psychosis dates back to the last century. ... ...

Abstract	Psychosis is a multifactorial condition that typically involves delusions, hallucinations, and disorganized thought, speech or behavior. The observation of an association between infectious epidemics and acute psychosis dates back to the last century. Recently, concerns have been expressed regarding COVID-19 and the risk for the development of new-onset psychosis. This article reviewed the current evidence of a possible link between SARS-CoV-2 and risk of psychosis as an acute or post-infectious manifestation of COVID-19. We here discuss potential neurobiological and environmental factors as well as a number of challenges in ascribing a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis.
Language	English
Publishing date	2023-01-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13010104
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Article: The Nrf2 Pathway in Depressive Disorders: A Systematic Review of Animal and Human Studies.

Sani, Gabriele / Margoni, Stella / Brugnami, Andrea / Ferrara, Ottavia Marianna / Bernardi, Evelina / Simonetti, Alessio / Monti, Laura / Mazza, Marianna / Janiri, Delfina / Moccia, Lorenzo / Kotzalidis, Georgios D / Chieffo, Daniela Pia Rosaria / Janiri, Luigi

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: There is increasing interest in the involvement of antioxidative systems in protecting from depression. Among these, Nrf2 occupies a central place. We aimed to review the role of Nrf2 in depression. For this reason, we conducted a PubMed search using as ... ...

Abstract	There is increasing interest in the involvement of antioxidative systems in protecting from depression. Among these, Nrf2 occupies a central place. We aimed to review the role of Nrf2 in depression. For this reason, we conducted a PubMed search using as search strategy (psychiatr[ti] OR schizo[ti] OR psychot[ti] OR psychos[ti] OR depress[ti] OR MDD[ti] OR BD[ti] OR bipolar[ti] OR Anxiety[ti] OR antidepress[ti] OR panic[ti] OR obsess[ti] OR compulsio[ti] OR "mood disord"[ti] OR phobi[ti] OR agoraphob[ti] OR anorex[ti] OR anorect[ti] OR bulimi[ti] OR "eating disorder"[ti] OR neurodevelopm[ti] OR retardation[ti] OR autism[ti] OR autistic[ti] OR ASM[ti] OR adhd[ti] OR "attention-deficit"[ti]) AND nrf2, which on the 9th of March produced 208 results of which 89 were eligible for our purposes. Eligible articles were studies reporting data of Nrf2 manipulations or content by any treatment in human patients or animals with any animal model of depression. Most studies were on mice only (N = 58), 20 on rats only, and three on both rats and mice. There were two studies on cell lines (
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12040817
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Article ; Online: Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children.

Moccia, Chiara / Pizzi, Costanza / Moirano, Giovenale / Popovic, Maja / Zugna, Daniela / d'Errico, Antonio / Isaevska, Elena / Fossati, Serena / Nieuwenhuijsen, Mark J / Fariselli, Piero / Sanavia, Tiziana / Richiardi, Lorenzo / Maule, Milena

Environment international

2023 Volume 173, Page(s) 107864

Abstract: Background: The exposome drivers are less studied than its consequences but may be crucial in identifying population subgroups with unfavourable exposures.: Objectives: We used three approaches to study the socioeconomic position (SEP) as a driver of ...

Abstract	Background: The exposome drivers are less studied than its consequences but may be crucial in identifying population subgroups with unfavourable exposures. Objectives: We used three approaches to study the socioeconomic position (SEP) as a driver of the early-life exposome in Turin children of the NINFEA cohort (Italy). Methods: Forty-two environmental exposures, collected at 18 months of age (N = 1989), were classified in 5 groups (lifestyle, diet, meteoclimatic, traffic-related, built environment). We performed cluster analysis to identify subjects sharing similar exposures, and intra-exposome-group Principal Component Analysis (PCA) to reduce the dimensionality. SEP at childbirth was measured through the Equivalised Household Income Indicator. SEP-exposome association was evaluated using: 1) an Exposome Wide Association Study (ExWAS), a one-exposure (SEP) one-outcome (exposome) approach; 2) multinomial regression of cluster membership on SEP; 3) regressions of each intra-exposome-group PC on SEP. Results: In the ExWAS, medium/low SEP children were more exposed to greenness, pet ownership, passive smoking, TV screen and sugar; less exposed to NO Conclusions: The three approaches provided consistent and complementary results, suggesting that children with lower SEP are less exposed to urbanization factors and more exposed to unhealthy lifestyles and diet. The simplest method, the ExWAS, conveys most of the information and is more replicable in other populations. Clustering and PCA may facilitate results interpretation and communication.
MeSH term(s)	Humans ; Child ; Exposome ; Birth Cohort ; Environmental Exposure/analysis ; Air Pollution ; Socioeconomic Factors
Language	English
Publishing date	2023-03-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107864
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