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  1. Article ; Online: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19.

    de Castro-Hamoy, Leniza / de Castro, Leonardo D

    Asian bioethics review

    2020  Volume 12, Issue 3, Page(s) 331–340

    Abstract: A patient's age serves as a very useful guide to physicians in deciding what disease manifestations to anticipate, what treatment to offer for certain conditions, and how to prepare for possible emergencies. In the context of the COVID-19 pandemic, ... ...

    Abstract A patient's age serves as a very useful guide to physicians in deciding what disease manifestations to anticipate, what treatment to offer for certain conditions, and how to prepare for possible emergencies. In the context of the COVID-19 pandemic, determining treatment options on the basis of a patient's chronological age can easily give rise to unjustified discrimination. This is of particular significance in situations where the allocation of scarce critical care resources could have a direct impact on who will live and who will die. This paper examines the fairness of recommendations contained in resource allocation guidelines in the Philippines that have implications for the way elderly patients could be treated or excluded from some forms of critical care treatment in the context of the ongoing Corona virus emergency.
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2602378-7
    ISSN 1793-9453 ; 1793-8759
    ISSN (online) 1793-9453
    ISSN 1793-8759
    DOI 10.1007/s41649-020-00130-6
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  2. Article ; Online: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19

    de Castro-Hamoy, Leniza / de Castro, Leonardo D.

    Asian Bioethics Review

    2020  Volume 12, Issue 3, Page(s) 331–340

    Keywords Philosophy ; Health Policy ; Health(social science) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2602378-7
    ISSN 1793-9453 ; 1793-8759
    ISSN (online) 1793-9453
    ISSN 1793-8759
    DOI 10.1007/s41649-020-00130-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Attitudes of Filipino parents of children with Down syndrome on noninvasive prenatal testing.

    de Castro-Hamoy, Leniza G / Tumulak, Ma-Am Joy R / Cagayan, Maria Stephanie Fay S / Sy, Peter A / Mira, Nona Rachel C / Laurino, Mercy Y

    Journal of community genetics

    2022  Volume 13, Issue 4, Page(s) 411–425

    Abstract: Globally, there has been an increasing uptake of noninvasive prenatal testing (NIPT). In the Philippines, the test is currently available through private laboratories and can be availed by families who can afford the out-of-pocket cost. In a country ... ...

    Abstract Globally, there has been an increasing uptake of noninvasive prenatal testing (NIPT). In the Philippines, the test is currently available through private laboratories and can be availed by families who can afford the out-of-pocket cost. In a country where elective termination of pregnancy is not an option, the question arises as to the relevance of this testing, even among health professionals. This is an exploratory qualitative study that explored the attitudes of Filipino parents of children with Down syndrome (DS) toward NIPT using thematic analysis of in-depth interviews. Study participants acknowledged the value of NIPT in providing early diagnosis and, subsequently, emotional, mental, spiritual, and financial preparation. This said, they also emphasized that such early detection may cause anxiety and even thoughts of termination for some, despite abortion being against the law and predominant religious beliefs. For those undergoing NIPT and receiving positive results, study participants highlighted the need to receive proper and nonbiased counseling from both health professionals and parents who have children with DS.
    Language English
    Publishing date 2022-06-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543127-4
    ISSN 1868-6001 ; 1868-310X
    ISSN (online) 1868-6001
    ISSN 1868-310X
    DOI 10.1007/s12687-022-00597-w
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  4. Article: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19

    de Castro-Hamoy, Leniza / de Castro, Leonardo D

    Asian Bioeth Rev

    Abstract: A patient's age serves as a very useful guide to physicians in deciding what disease manifestations to anticipate, what treatment to offer for certain conditions, and how to prepare for possible emergencies. In the context of the COVID-19 pandemic, ... ...

    Abstract A patient's age serves as a very useful guide to physicians in deciding what disease manifestations to anticipate, what treatment to offer for certain conditions, and how to prepare for possible emergencies. In the context of the COVID-19 pandemic, determining treatment options on the basis of a patient's chronological age can easily give rise to unjustified discrimination. This is of particular significance in situations where the allocation of scarce critical care resources could have a direct impact on who will live and who will die. This paper examines the fairness of recommendations contained in resource allocation guidelines in the Philippines that have implications for the way elderly patients could be treated or excluded from some forms of critical care treatment in the context of the ongoing Corona virus emergency.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #602164
    Database COVID19

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  5. Article ; Online: Landscape of genetic counseling in the Philippines.

    Abad, Peter James / Tumulak, Ma-Am Joy / Guerbo, Romer / de Castro-Hamoy, Leniza / Bautista, Niecy Grace / Nuique, Ramonito / Jacalan, Frances Isabelle / Talapian, Gay Luz / Felipe-Dimog, Eva Belingon / Lagarde, John Benedict / Plaga, Starlene Joy / Jover, Edbert Jasper / Morales, Kristine Dawn / Canoy, Graciel Mae / Laurino, Mercy Y

    Journal of genetic counseling

    2023  

    Abstract: In this paper, we report on the professional development of genetic counselors in the Philippines as we discuss the status of genetic counseling training and research, along with the roles and scope of practice of genetic counselors. The development of a ...

    Abstract In this paper, we report on the professional development of genetic counselors in the Philippines as we discuss the status of genetic counseling training and research, along with the roles and scope of practice of genetic counselors. The development of a master's level training program for non-physician genetic counselors in the Philippines initiated in 2011 was in response to the increasing demand for genetic counseling services. There are currently 18 locally trained genetic counselors who are practicing in various fields including newborn screening, pediatrics, cancer, prenatal and preconception, neurology, and research. Despite the success of the genetic counseling training program, various professional challenges hinder maximizing the impact of genetic counselors in the health system. The challenges discussed in this paper include the limited number of genetic counselors, the lack of government positions officially recognizing the 'genetic counselor' title, and the absence of a regulatory framework. These issues require thorough discussion with appropriate government agencies and collaboration with other healthcare professional organizations with the ultimate goal of ensuring quality genetic counseling services nationwide.
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1804
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4263: Show issues Location:
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  6. Article ; Online: Maple syrup urine disease associated with nephrotic syndrome in a Filipino child.

    Maceda, Ebner Bon G / Abadingo, Michelle E / Magbanua-Calalo, Cheryll J / Dator, Melissa A / Resontoc, Lourdes Paula R / Castro-Hamoy, Leniza De / Abacan, Mary Ann R / Chiong, Mary Anne D / Estrada, Sylvia C

    BMJ case reports

    2021  Volume 14, Issue 7

    Abstract: A 22-month-old female child with maple syrup urine disease (MSUD) presented with generalised oedema. Diagnostic evaluation revealed nephrotic range proteinuria, hypoalbuminaemia and dyslipidaemia supporting the diagnosis of nephrotic syndrome (NS). Diet, ...

    Abstract A 22-month-old female child with maple syrup urine disease (MSUD) presented with generalised oedema. Diagnostic evaluation revealed nephrotic range proteinuria, hypoalbuminaemia and dyslipidaemia supporting the diagnosis of nephrotic syndrome (NS). Diet, being at the core of the management plan for both MSUD and NS, necessitated regular monitoring and evaluation via dried blood spot collection of leucine. The opposing requirement for total protein for both disorders (that is protein restriction in MSUD and protein supplementation in NS) prompted a careful balancing act of the dietary management. The monitoring, which revealed normal leucine levels on multiple determinations, allowed an eventual increase in dietary protein and daily administration of albumin to address the NS. Dietary protein increase, both in total protein (3.5 g/kg/day) and natural protein (1 g/kg/day) levels, was instituted. It was observed that NS does not trigger leucinosis and allowed easing of protein restriction in MSUD.
    MeSH term(s) Child ; Diet ; Dietary Proteins ; Female ; Humans ; Infant ; Leucine ; Maple Syrup Urine Disease/complications ; Maple Syrup Urine Disease/diagnosis ; Nephrotic Syndrome/complications
    Chemical Substances Dietary Proteins ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-242689
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  7. Article: Challenges in the management of patients with maple syrup urine disease diagnosed by newborn screening in a developing country.

    De Castro-Hamoy, Leniza G / Chiong, Mary Anne D / Estrada, Sylvia C / Cordero, Cynthia P

    Journal of community genetics

    2016  Volume 8, Issue 1, Page(s) 9–15

    Abstract: Maple syrup urine disease (MSUD) is a rare inborn error of metabolism resulting from a deficiency in the branched-chain alpha-ketoacid dehydrogenase complex. MSUD has been reported to be the most common inborn error of metabolism in the Philippines. We ... ...

    Abstract Maple syrup urine disease (MSUD) is a rare inborn error of metabolism resulting from a deficiency in the branched-chain alpha-ketoacid dehydrogenase complex. MSUD has been reported to be the most common inborn error of metabolism in the Philippines. We described all patients with maple syrup urine disease patients diagnosed through newborn screening during its first 2 years of implementation and the challenges encountered during their medical management. There were 24 patients diagnosed with maple syrup urine disease for the 2-year period. All patients needed hospital admission. The most common complication during hospital admission was infection, needing intravenous antibiotics which were given to 21 of the patients. Out of the 24 diagnosed, 16 patients are alive, while eight have died. Several neurologic and non-neurologic complications have been observed during the follow-up of the patients. The common challenges of MSUD management in a low-resource setting identified in this study were late diagnosis, lack of access to metabolic specialists and medical supplies, nosocomial septicemia, and protein deficiency. Aside from early properly timed collection, improvement in other logistical concerns will also help in earlier diagnosis. Mechanisms of transfer of critically ill patients must be improved. Hospitals in difficult-to-reach areas must be equipped to handle critical metabolic cases when transfers are not possible. Newborn screening has been proven to improve outcome in patients with MSUD but the success of the program in preventing disability is also dependent on improvements in other aspects of healthcare.
    Language English
    Publishing date 2016-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543127-4
    ISSN 1868-6001 ; 1868-310X
    ISSN (online) 1868-6001
    ISSN 1868-310X
    DOI 10.1007/s12687-016-0281-5
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