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  1. Article ; Online: Increasing Understanding of SARS-CoV-2 Infection in Young Children-Would They Benefit From Immunization?

    Heald-Sargent, Taylor

    JAMA network open

    2022  Volume 5, Issue 6, Page(s) e2218801

    MeSH term(s) COVID-19/prevention & control ; Child ; Child, Preschool ; Humans ; Immunization ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.18801
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  2. Article ; Online: Pre-Transplantation Strategies for Infectious Disease Mitigation and Prevention.

    Heald-Sargent, Taylor / Michaels, Marian G / Ardura, Monica I

    Journal of the Pediatric Infectious Diseases Society

    2024  Volume 13, Issue Supplement_1, Page(s) S3–S13

    Abstract: Pediatric Infectious Disease (ID) clinicians play a critical role in helping prevent and mitigate infectious risks in children peri- and post-transplantation. Prevention starts during the pre-transplant evaluation and persists throughout the solid organ ... ...

    Abstract Pediatric Infectious Disease (ID) clinicians play a critical role in helping prevent and mitigate infectious risks in children peri- and post-transplantation. Prevention starts during the pre-transplant evaluation and persists throughout the solid organ transplant and hematopoietic cell transplant continuum. The pre-transplant evaluation is an opportunity to screen for latent infections, plan preventative strategies, optimize immunizations, and discuss risk mitigation practices. An ideal pre-transplant evaluation establishes a relationship with the family that further promotes post-transplant infectious risk reduction. This manuscript builds on shared pediatric ID prevention strategies, introduces updated ID testing recommendations for transplant donors/candidates, highlights emerging data, and identifies ongoing knowledge gaps that are potential areas of research.
    MeSH term(s) Child ; Humans ; Hematopoietic Stem Cell Transplantation ; Communicable Diseases ; Organ Transplantation ; Immunization ; Infections
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pediatric solid organ transplant recipients positive for severe acute respiratory syndrome coronavirus 2 pre-transplant.

    Heald-Sargent, Taylor / Morrison, Adam / Verghese, Priya S / Chapin, Catherine A / Li, Caitlin Naureckas

    Transplant infectious disease : an official journal of the Transplantation Society

    2024  , Page(s) e14284

    Language English
    Publishing date 2024-04-22
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14284
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  4. Article ; Online: Understanding the State of Quality Improvement Education for Pediatric Infectious Diseases Trainees.

    Naureckas Li, Caitlin / Heald-Sargent, Taylor / Mithal, Leena B

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue 4, Page(s) 252–253

    MeSH term(s) Child ; Humans ; Quality Improvement ; Communicable Diseases ; Curriculum ; Educational Status ; Infectious Disease Medicine
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Letter
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad012
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  5. Article ; Online: Viral Loads of SARS-CoV-2 in Young Children-Reply.

    Heald-Sargent, Taylor / Muller, William J / Kociolek, Larry K

    JAMA pediatrics

    2021  Volume 175, Issue 5, Page(s) 530–531

    MeSH term(s) COVID-19 ; Child ; Child, Preschool ; Humans ; Nasopharynx ; RNA, Viral ; SARS-CoV-2 ; Viral Load
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.5551
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  6. Article ; Online: Caution With COVID-19: Infant With Fever and Hepatosplenomegaly.

    Takabatake, Yuri / Swigart, Lindsey / Koressel, Lindsay / Weinstein, Joanna / Heald-Sargent, Taylor

    Clinical pediatrics

    2022  Volume 61, Issue 4, Page(s) 320–324

    MeSH term(s) COVID-19 ; Fever/etiology ; Hepatomegaly/etiology ; Humans ; Infant ; Splenomegaly/etiology
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228221075093
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    Zs.A 454: Show issues Location:
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  7. Article ; Online: A pilot recruitment strategy to enhance ethical and equitable access to Covid-19 pediatric vaccine trials.

    Muller, William J / Jhaveri, Ravi / Heald-Sargent, Taylor / Macy, Michelle L / Heard-Garris, Nia / Shah, Seema / Paquette, Erin

    Clinical trials (London, England)

    2023  , Page(s) 17407745231217299

    Abstract: Background/aims: The SARS-CoV-2 pandemic disproportionately impacted communities with lower access to health care in the United States, particularly before vaccines were widely available. These same communities are often underrepresented in clinical ... ...

    Abstract Background/aims: The SARS-CoV-2 pandemic disproportionately impacted communities with lower access to health care in the United States, particularly before vaccines were widely available. These same communities are often underrepresented in clinical trials. Efforts to ensure equitable enrollment of participants in trials related to treatment and prevention of Covid-19 can raise concerns about exploitation if communities with lower access to health care are targeted for recruitment.
    Methods: To enhance equity while avoiding exploitation, our site developed and implemented a three-part recruitment strategy for pediatric Covid-19 vaccine studies. First, we publicized a registry for potentially interested participants. Next, we applied public health community and social vulnerability indices to categorize the residence of families who had signed up for the registry into three levels to reflect the relative impact of the pandemic on their community: high, medium, and low. Finally, we preferentially offered study participation to interested families living in areas categorized by these indices as having high impact of the Covid-19 pandemic on their community.
    Results: This approach allowed us to meet goals for study recruitment based on public health metrics related to disease burden, which contributed to a racially diverse study population that mirrored the surrounding community demographics. While this three-part recruitment strategy improved representation of minoritized groups from areas heavily impacted by the Covid-19 pandemic, important limitations were identified that would benefit from further study.
    Conclusion: Future use of this approach to enhance equitable access to research while avoiding exploitation should test different methods to build trust and communicate with underserved communities more effectively.
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2138796-5
    ISSN 1740-7753 ; 1740-7745
    ISSN (online) 1740-7753
    ISSN 1740-7745
    DOI 10.1177/17407745231217299
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    Zs.A 5831: Show issues Location:
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  8. Article ; Online: Zika Virus: A Review for Pediatricians.

    Heald-Sargent, Taylor / Muller, William

    Pediatric annals

    2017  Volume 46, Issue 11, Page(s) e428–e432

    Abstract: For the past several years, the Zika virus has been a topic of conversation among pediatric health care providers in many settings. This article provides current answers to many questions that may be posed to pediatricians, including inquiries about ... ...

    Abstract For the past several years, the Zika virus has been a topic of conversation among pediatric health care providers in many settings. This article provides current answers to many questions that may be posed to pediatricians, including inquiries about clinical presentation, testing, and prevention. Although infants born with congenital Zika syndrome often have microcephaly, there are other characteristic features, such as eye abnormalities, that one should recognize. Additionally, testing for the syndrome must be considered in all infants at risk for infection, including those who are asymptomatic at birth. Maternal travel to an endemic region or sexual intercourse with an exposed person shortly before or during pregnancy may put an infant at risk for infection. [Pediatr Ann. 2017;46(11):e428-e432.].
    Language English
    Publishing date 2017-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20171025-01
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    Zs.A 1347: Show issues Location:
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  9. Article ; Online: Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient.

    Alisoltani, Arghavan / Simons, Lacy M / Agnes, Maria Francesca Reyes / Heald-Sargent, Taylor A / Muller, William J / Kociolek, Larry K / Hultquist, Judd F / Lorenzo-Redondo, Ramon / Ozer, Egon A

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 246

    Abstract: Background: Persistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural selection and viral recombination in cases of viral co-infection or superinfection. However, there are ... ...

    Abstract Background: Persistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural selection and viral recombination in cases of viral co-infection or superinfection. However, there are limited data on the longitudinal intra-host population dynamics of SARS-CoV-2 co-infection/superinfection, especially in pediatric populations. Here, we report a case of Delta-Omicron superinfection in a hospitalized, immunocompromised pediatric patient.
    Methods: We conducted Illumina whole genome sequencing (WGS) for longitudinal specimens to investigate intra-host dynamics of SARS-CoV-2 strains. Topoisomerase PCR cloning of Spike open-reading frame and Sanger sequencing of samples was performed for four specimens to validate the findings. Analysis of publicly available SARS-CoV-2 sequence data was performed to investigate the co-circulation and persistence of SARS-CoV-2 variants.
    Results: Results of WGS indicate the patient was initially infected with the SARS-CoV-2 Delta variant before developing a SARS-CoV-2 Omicron variant superinfection, which became predominant. Shortly thereafter, viral loads decreased below the level of detection before resurgence of the original Delta variant with no residual trace of Omicron. After 54 days of persistent infection, the patient tested negative for SARS-CoV-2 but ultimately succumbed to a COVID-19-related death. Despite protracted treatment with remdesivir, no antiviral resistance mutations emerged. These results indicate a unique case of persistent SARS-CoV-2 infection with the Delta variant interposed by a transient superinfection with the Omicron variant. Analysis of publicly available sequence data suggests the persistence and ongoing evolution of Delta subvariants despite the global predominance of Omicron, potentially indicative of continued transmission in an unknown population or niche.
    Conclusion: A better understanding of SARS-CoV-2 intra-host population dynamics, persistence, and evolution during co-infections and/or superinfections will be required to continue optimizing patient care and to better predict the emergence of new variants of concern.
    MeSH term(s) Humans ; Child ; SARS-CoV-2/genetics ; COVID-19 ; Superinfection ; Coinfection ; Immunocompromised Host
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-02186-w
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  10. Article ; Online: Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence.

    Heald-Sargent, Taylor / Gallagher, Tom

    Viruses

    2012  Volume 4, Issue 4, Page(s) 557–580

    Abstract: Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes. This review ... ...

    Abstract Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes. This review describes our current understanding of the S proteins, their interactions with and their responses to these entry triggers. We focus on receptors and proteases in prompting entry and highlight the type II transmembrane serine proteases (TTSPs) known to activate several virus fusion proteins. These and other proteases are essential cofactors permitting coronavirus infection, conceivably being in proximity to cell-surface receptors and thus poised to split entering spike proteins into the fragments that refold to mediate membrane fusion. The review concludes by noting how understanding of coronavirus entry informs antiviral therapies.
    MeSH term(s) Coronavirus/physiology ; Humans ; Membrane Glycoproteins/metabolism ; Serine Proteases/metabolism ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins/metabolism ; Virus Internalization
    Chemical Substances Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; Serine Proteases (EC 3.4.-)
    Keywords covid19
    Language English
    Publishing date 2012-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v4040557
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