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  1. Article ; Online: Age is just a number - and so is frailty: Strategies to inform resource allocation during the COVID-19 pandemic.

    Boreskie, Kevin F / Boreskie, Patrick E / Melady, Don

    CJEM

    2020  Volume 22, Issue 4, Page(s) 411–413

    MeSH term(s) Age Factors ; Ageism ; Betacoronavirus ; COVID-19 ; Canada/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Decision Making ; Frailty ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Resource Allocation ; SARS-CoV-2 ; Triage
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Journal Article
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1017/cem.2020.358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Frailty-aware care: giving value to frailty assessment across different healthcare settings.

    Boreskie, Kevin F / Hay, Jacqueline L / Boreskie, Patrick E / Arora, Rakesh C / Duhamel, Todd A

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 13

    Abstract: Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health outcomes. ... ...

    Abstract Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health outcomes. Furthermore, frailty assessments offer an opportunity to optimize patient care in various healthcare settings. While the vast number of frailty assessment tools available can be a source of confusion for clinicians, each tool has features adaptable to the constraints and goals of different healthcare settings. This review discusses and compares barriers, facilitators, and the application of frailty assessments in primary care, the emergency department/intensive care unit and surgical care to cover a breadth of settings with different frailty assessment considerations. The implementation of frailty-aware care across healthcare settings potentiates better healthcare outcomes for older adults.
    MeSH term(s) Aged ; Aging ; Delivery of Health Care ; Emergency Service, Hospital ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Primary Health Care
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-021-02722-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commentary: Presurgical frailty assessment can predict adverse outcomes in patients undergoing cardiac surgery… but where do we go from here?

    Hay, Jacqueline L / Boreskie, Kevin F / Arora, Rakesh C / Duhamel, Todd A

    JTCVS open

    2022  Volume 10, Page(s) 264–265

    Language English
    Publishing date 2022-02-23
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2021.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Age is just a number – and so is frailty

    Boreskie, Kevin F. / Boreskie, Patrick E. / Melady, Don

    CJEM

    Strategies to inform resource allocation during the COVID-19 pandemic

    2020  Volume 22, Issue 4, Page(s) 411–413

    Keywords Emergency Medicine ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2059217-6
    ISSN 1481-8035 ; 1488-1543
    ISSN (online) 1481-8035
    ISSN 1488-1543
    DOI 10.1017/cem.2020.358
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Frailty-aware care

    Kevin F. Boreskie / Jacqueline L. Hay / Patrick E. Boreskie / Rakesh C. Arora / Todd A. Duhamel

    BMC Geriatrics, Vol 22, Iss 1, Pp 1-

    giving value to frailty assessment across different healthcare settings

    2022  Volume 12

    Abstract: Abstract Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health ... ...

    Abstract Abstract Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health outcomes. Furthermore, frailty assessments offer an opportunity to optimize patient care in various healthcare settings. While the vast number of frailty assessment tools available can be a source of confusion for clinicians, each tool has features adaptable to the constraints and goals of different healthcare settings. This review discusses and compares barriers, facilitators, and the application of frailty assessments in primary care, the emergency department/intensive care unit and surgical care to cover a breadth of settings with different frailty assessment considerations. The implementation of frailty-aware care across healthcare settings potentiates better healthcare outcomes for older adults.
    Keywords Frailty ; Emergency Medicine ; Critical Care ; Primary Care ; Perioperative Care ; Geriatrics ; RC952-954.6
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article: Risk versus Benefit of Using Hydroxychloroquine to Treat Patients with COVID-19.

    Zhanel, George G / Zhanel, Michael A / Boreskie, Kevin F / Lynch, Joseph P / Karlowsky, James A

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2021  Volume 2021, Page(s) 5942366

    Abstract: Hydroxychloroquine (HCQ), also known by its trade name Plaquenil®, has been used for over 50 years as a treatment for malaria, systemic lupus erythematosus, and rheumatoid arthritis. As the COVID-19 pandemic emerged in the United States and globally in ... ...

    Abstract Hydroxychloroquine (HCQ), also known by its trade name Plaquenil®, has been used for over 50 years as a treatment for malaria, systemic lupus erythematosus, and rheumatoid arthritis. As the COVID-19 pandemic emerged in the United States and globally in early 2020, HCQ began to garner attention as a potential treatment and as prophylaxis against COVID-19. Preliminary data indicated that HCQ as well as chloroquine (CQ) possessed in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early clinical data from China and France reported that HCQ and CQ were associated with viral load reduction and clinical improvement in patients with COVID-19 compared to control groups; however, an overwhelming number of randomized controlled trials, meta-analyses, and systematic reviews have since concluded that HCQ used alone, or in combination with azithromycin (AZ), provides no mortality or time-to-recovery benefit in hospitalized patients with COVID-19. Additionally, these same trials reported adverse events including cardiac, neuropsychiatric, hematologic, and hepatobiliary manifestations in patients with COVID-19 whom had been treated with HCQ. This review article summarizes the available data pertaining to the adverse events associated with HCQ use, alone or in combination with azithromycin, in patients with COVID-19 in order to fully assess the risk versus benefit of treating COVID-19 patients with these agents. The results of this review lead us to conclude that the risks of adverse events associated with HCQ use (with or without AZ) outweigh the potential clinical benefits and thus recommend against its use in the treatment or prevention of COVID-19.
    Language English
    Publishing date 2021-09-15
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2021/5942366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Protocol for the WARM Hearts study: examining cardiovascular disease risk in middle-aged and older women - a prospective, observational cohort study.

    Rose, Alexandra V / Boreskie, Kevin F / Hay, Jacqueline L / Thompson, Liam / Arora, Rakesh C / Duhamel, Todd A

    BMJ open

    2021  Volume 11, Issue 5, Page(s) e044227

    Abstract: Introduction: Cardiovascular disease (CVD) is a leading cause of death in women. Novel approaches to detect early signs of elevated CVD risk in women are needed. Enhancement of traditional CVD risk assessment approaches through the addition of ... ...

    Abstract Introduction: Cardiovascular disease (CVD) is a leading cause of death in women. Novel approaches to detect early signs of elevated CVD risk in women are needed. Enhancement of traditional CVD risk assessment approaches through the addition of procedures to assess physical function or frailty as well as novel biomarkers of cardiovascular, gut and muscle health could improve early identification. The Women's Advanced Risk-assessment in Manitoba (WARM) Hearts study will examine the use of novel non-invasive assessments and biomarkers to identify women who are at elevated risk for adverse cardiovascular events.
    Methods and analysis: One thousand women 55 years of age or older will be recruited and screened by the WARM Hearts observational, cohort study. The two screening appointments will include assessments of medical history, gender variables, body composition, cognition, frailty status, functional fitness, physical activity levels, nutritional status, quality of life questionnaires, sleep behaviour, resting blood pressure (BP), BP response to moderate-intensity exercise, a non-invasive measure of arterial stiffness and heart rate variability. Blood sample analysis will be used to assess lipid and novel biomarker profiles and stool samples will support the characterisation of gut microbiota. The incidence of the adverse cardiovascular outcomes will be assessed 5 years after screening to compare WARM Hearts approaches to the Framingham Risk Score, the current clinical standard of assessing CVD risk in Canada.
    Ethics and dissemination: The University of Manitoba Health Research Ethics Board (7 October 2019) and the St Boniface Hospital Research Review Committee (7 October 2019) approved the trial (Ethics Number HS22576 (H2019:063)). Recruitment started 10 October 2020. Data gathered from the WARM Hearts study will be published in peer-reviewed journals and presented at national and international conferences. Knowledge translation strategies will be created to share our findings with stakeholders who are positioned to implement evidence-informed CVD risk assessment programming.
    Trial registration number: NCT03938155.
    MeSH term(s) Aged ; Canada ; Cardiovascular Diseases/epidemiology ; Clinical Trial Protocols as Topic ; Cohort Studies ; Female ; Humans ; Manitoba/epidemiology ; Middle Aged ; Observational Studies as Topic ; Prospective Studies ; Quality of Life ; Risk Assessment
    Language English
    Publishing date 2021-05-25
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-044227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Self-compassion and responses to health information in middle-aged and older women: An observational cohort study.

    Semenchuk, Brittany N / Boreskie, Kevin F / Hay, Jacqueline L / Miller, Cindy / Duhamel, Todd A / Strachan, Shaelyn M

    Journal of health psychology

    2020  Volume 26, Issue 12, Page(s) 2231–2247

    Abstract: The aim of this study was to determine whether self-compassion-orientation to care for oneself during challenges-helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This ... ...

    Abstract The aim of this study was to determine whether self-compassion-orientation to care for oneself during challenges-helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This observational study recruited women (
    MeSH term(s) Adaptation, Psychological ; Aged ; Cohort Studies ; Emotions ; Empathy ; Female ; Health Behavior ; Humans ; Middle Aged
    Language English
    Publishing date 2020-03-07
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/1359105320909860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Association Between Route of Post-menopausal Estrogen Administration and Blood Pressure and Arterial Stiffness in Community-Dwelling Women.

    Kalenga, Cindy Z / Hay, Jacqueline L / Boreskie, Kevin F / Duhamel, Todd A / MacRae, Jennifer M / Metcalfe, Amy / Nerenberg, Kara A / Robert, Magali / Ahmed, Sofia B

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 913609

    Abstract: Background: Postmenopausal hormone therapy (HT) is associated with increased cardiovascular risk. Although the route of estrogen administration may play a role in mediating risk, previous studies have not controlled for concomitant progestin use.: ... ...

    Abstract Background: Postmenopausal hormone therapy (HT) is associated with increased cardiovascular risk. Although the route of estrogen administration may play a role in mediating risk, previous studies have not controlled for concomitant progestin use.
    Objective: To investigate the association between the route of estrogen therapy (oral or non-oral) HT use, without concomitant progestin, and blood pressure and arterial stiffness in postmenopausal women.
    Methods: Systolic blood pressure [SBP], diastolic blood pressure [DBP]), arterial stiffness (aortic pulse wave velocity [aPWV] and augmentation index at 75 beats per minute [AIx]) were measured using a validated automated brachial cuff-based oscillometric approach (Mobil-O-Graph) in a community-dwelling sample of 328 women.
    Results: Fifty-five participants (16.8%) were ever users (current and past use) of estrogen-only HT (oral [
    Conclusion: Ever use of oral estrogen was associated with increased SBP and DBP compared to non-oral estrogen use and no use. Given the cardiovascular risk associated with both menopause and increased blood pressure, further studies are required exploring the potential benefits of non-oral estrogen in postmenopausal women.
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.913609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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