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  1. Article ; Online: HRT in a new light: Thanks UK.

    Gambacciani, Marco / Cagnacci, Angelo

    Maturitas

    2022  Volume 164, Page(s) 98–99

    MeSH term(s) Estrogen Replacement Therapy/adverse effects ; Female ; Hormone Replacement Therapy ; Humans ; Menopause ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-08-19
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2022.08.004
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    Zs.A 1432: Show issues Location:
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    Zs.MO 575: Show issues

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  2. Article ; Online: Hormone therapy in endometrial cancer survivors: time for a change.

    Cagnacci, Angelo / Londero, Ambrogio P

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2022  Volume 38, Issue 10, Page(s) 795–796

    MeSH term(s) Female ; Humans ; Endometrial Neoplasms ; Survivors ; Cancer Survivors ; Hormones
    Chemical Substances Hormones
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2022.2128105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2284: Show issues Location:
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    Zs.MO 608: Show issues

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  3. Article ; Online: Explaining the Potential Role of Hormone Replacement Therapy in Covid-19 Infection Among Postmenopausal Women. Reply.

    Cagnacci, Angelo / Xholli, Anjeza

    Menopause (New York, N.Y.)

    2022  Volume 29, Issue 5, Page(s) 636–637

    MeSH term(s) COVID-19 ; Female ; Hormone Replacement Therapy ; Humans ; Postmenopause
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000001971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4111: Show issues Location:
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  4. Article ; Online: COVID-19 and hormonal contraception.

    Cagnacci, Angelo / Londero, Ambrogio Pietro / Xholli, Anjeza

    Case reports in women's health

    2022  Volume 34, Page(s) e00389

    Language English
    Publishing date 2022-01-25
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2022.e00389
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  5. Article ; Online: Reappraising 21 years of the WHI study: Putting the findings in context for clinical practice.

    Stute, Petra / Marsden, Jo / Salih, Noor / Cagnacci, Angelo

    Maturitas

    2023  Volume 174, Page(s) 8–13

    Abstract: Menopausal hormone treatment (MHT) is recommended for the management of menopause symptoms. The Women's Health Initiative (WHI) placebo-controlled randomised study examined the effects of continuous combined or estrogen-only MHT on the risk of non- ... ...

    Abstract Menopausal hormone treatment (MHT) is recommended for the management of menopause symptoms. The Women's Health Initiative (WHI) placebo-controlled randomised study examined the effects of continuous combined or estrogen-only MHT on the risk of non-communicable diseases (NCDs) in post-menopausal women. The study was terminated prematurely after an interim analysis showed an increased risk of breast cancer diagnosis, which led to a rapid decrease in MHT use worldwide. Subsequently, limitations of the study design and its interpretation in the context of other clinical studies has contributed to a more nuanced appreciation of the risk-benefit profile of differing MHT regimens regarding risk associated with the class of progestogen prescribed, its pattern of prescription, duration of use and timing of initiation related to menopause onset. This review provides a contextual interpretation of the WHI placebo-controlled study and evaluates the impact of bioidentical MHT, with a focus on combined therapies containing micronised progesterone, on the risk of chronic NCDs in post-menopausal women.
    MeSH term(s) Female ; Humans ; Estrogen Replacement Therapy/adverse effects ; Women's Health ; Menopause ; Breast Neoplasms/chemically induced ; Risk Assessment ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-05-11
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2023.04.271
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    Zs.A 1432: Show issues Location:
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  6. Article ; Online: How often is oral contraception used for contraception? The need of benefit's formalisation.

    Cagnacci, Angelo / Bruni, Vincenzina / Di Carlo, Costantino / Fruzzetti, Franca

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

    2023  Volume 28, Issue 2, Page(s) 81–82

    MeSH term(s) Humans ; Contraception ; Contraceptives, Oral
    Chemical Substances Contraceptives, Oral
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Editorial
    ZDB-ID 1397560-2
    ISSN 1473-0782 ; 1362-5187
    ISSN (online) 1473-0782
    ISSN 1362-5187
    DOI 10.1080/13625187.2023.2170711
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    Zs.A 4819: Show issues Location:
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  7. Article ; Online: Hormonal contraception: venous and arterial disease.

    Cagnacci, Angelo

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

    2017  Volume 22, Issue 3, Page(s) 191–199

    Abstract: Objectives: The aim of this review was to evaluate whether the biological and epidemiological evidence is concordant in suggesting that levonorgestrel (LNG)-based hormonal contraceptives (HCs) are safer than newer formulations with regard to their ... ...

    Abstract Objectives: The aim of this review was to evaluate whether the biological and epidemiological evidence is concordant in suggesting that levonorgestrel (LNG)-based hormonal contraceptives (HCs) are safer than newer formulations with regard to their effect on the cardiovascular system.
    Methods: A narrative review was carried out of the modification of risk factors for venous thromboembolism (VTE) and arterial diseases induced by different HCs. Limits and concordance with epidemiological data were addressed.
    Results: The data indicate general concordance between modifications of risk factors and epidemiology of VTE, with LNG-based HCs showing lower risk compared with most new formulations. Evidence for drospirenone (DRSP)-containing HCs is conflicting. LNG-based HCs are less favourable than HCs containing non-androgenic progestins, particularly DRSP, on risk factors for arterial events. Epidemiological studies do not consistently show a difference in arterial disease outcomes between different HCs; however, by evaluating women up to the age of 50, they do not take into consideration the time lag necessary for atherosclerosis to develop.
    Conclusions: As a consequence of the different risk factors involved, and the different time lags between HC use and the manifestation of VTE or arterial diseases, the available epidemiological data do not give a reliable estimate of the cardiovascular risk associated with the use of different HCs. LNG-based HCs are safer than newer HCs as regards VTE risk, but biological data indicate that they are less favourable, particularly than HCs containing DRSP, on risk factors for atherosclerosis. Because of the limits of actual epidemiological evidence regarding arterial disease, modifications of arterial risk factors should be taken into consideration when considering individual long-term safety of HC use.
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397560-2
    ISSN 1473-0782 ; 1362-5187
    ISSN (online) 1473-0782
    ISSN 1362-5187
    DOI 10.1080/13625187.2017.1305349
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    Zs.A 4819: Show issues Location:
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  8. Article ; Online: Is the multinational, surveillance PRO-E2 study informative for all countries? The Italian data on VTE and contraceptive effectiveness.

    Fruzzetti, Franca / Cagnacci, Angelo / Boolell, Mitra / Di Carlo, Costantino / Bruni, Vincenzina

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

    2024  Volume 29, Issue 1, Page(s) 1–7

    Abstract: Purpose: To evaluate whether the thromboembolic risk and contraceptive effectiveness of NOMAC-E2 observed in the PRO-E2 study can be extended to each participating country, as lifestyle, cardiovascular risk factors and prescribing habits may differ ... ...

    Abstract Purpose: To evaluate whether the thromboembolic risk and contraceptive effectiveness of NOMAC-E2 observed in the PRO-E2 study can be extended to each participating country, as lifestyle, cardiovascular risk factors and prescribing habits may differ geographically. This analysis was performed on the PRO-E2 Italian subpopulation, where smoking habit and women over 35 years were more prevalent compared with the overall study population.
    Materials and methods: Data from NOMAC-E2 or levonorgestrel-containing COCs (COC
    Results: Overall, 11,179 NOMAC-E2 and 8,504 COC
    Conclusion: Despite the higher age and tobacco use, findings from the Italian subpopulation were broadly consistent with overall PRO-E2 results, confirming a similar low thromboembolic risk and high contraceptive effectiveness of NOMAC-E2 and COC
    Short condensation: This subgroup analysis of the PRO-E2 study provides comprehensive epidemiological data on the use of combined oral contraceptives in a large Italian cohort, with a higher prevalence of women over 35 years and smokers. The study confirms the low thromboembolic risk and high contraceptive effectiveness of NOMAC-E2 pill.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Ethinyl Estradiol/adverse effects ; Estradiol/adverse effects ; Megestrol/adverse effects ; Contraceptive Effectiveness ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/epidemiology ; Contraceptives, Oral, Combined/adverse effects ; Italy/epidemiology
    Chemical Substances Ethinyl Estradiol (423D2T571U) ; Estradiol (4TI98Z838E) ; Megestrol (EA6LD1M70M) ; Contraceptives, Oral, Combined
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397560-2
    ISSN 1473-0782 ; 1362-5187
    ISSN (online) 1473-0782
    ISSN 1362-5187
    DOI 10.1080/13625187.2023.2284085
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    Zs.A 4819: Show issues Location:
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  9. Article ; Online: Timing of cesarean delivery for fetal heart rate abnormalities in hypertensive pregnancies induced with oral misoprostol or Foley catheter: Secondary analysis of a randomized clinical trial.

    Londero, Ambrogio P / Fichera, Anna / Orabona, Rossana / Cagnacci, Angelo / Prefumo, Federico

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  

    Abstract: Objective: The study aims to assess how oral misoprostol for cervical ripening affects the time of cesarean delivery (CD) for fetal heart rate (FHR) abnormalities in pre-eclampsia patients. Secondary goals include determining the role of uterine ... ...

    Abstract Objective: The study aims to assess how oral misoprostol for cervical ripening affects the time of cesarean delivery (CD) for fetal heart rate (FHR) abnormalities in pre-eclampsia patients. Secondary goals include determining the role of uterine hyperstimulation, comparing misoprostol with Foley catheter, and identifying risk factors for FHR abnormalities associated with CD.
    Methods: A previously published randomized clinical trial was subjected to a secondary analysis (NCT01801410). We conducted a time-dependent analysis, stratifying the population based on the final mode of induction used (low-dose oral misoprostol vs Foley catheter).
    Results: There was no CD for FHR abnormalities within 2 h of starting misoprostol. At 5 h, the cumulative incidence of CD for FHR abnormalities in the misoprostol group was 2.10%, while it was 1.00% in the Foley group (P = 0.565). After 25 h, the CD risk for FHR abnormalities remained constant in both groups at 21.00% (95% confidence interval [CI] 15.00%-28.00%). Within 5 h of misoprostol induction, the risk of uterine hyperstimulation was similar in both groups (0.33% in misoprostol vs 0.34% in Foley group, P = 0.161). The risk of CD for FHR abnormalities was unaffected by newborn weight centiles.
    Conclusion: There was no significant difference in CD risk for FHR abnormalities between misoprostol and Foley catheter induction. Nonetheless, the cumulative incidence of CD for FHR abnormalities increased faster in the misoprostol group, indicating that FHR monitoring timing should be tailored to the induction method.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15375
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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  10. Article ; Online: IMPROVE lifestyle in polycystic ovary syndrome: a systematic strategy.

    Del Pup, Lino / Cagnacci, Angelo

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2021  Volume 37, Issue 10, Page(s) 875–878

    Abstract: Lifestyle change is the first-line of treatment for the management of women with PCOS, however obtaining long-term adherence is challenging. In order to improve adherence to advice on lifestyle, we propose a strategic systematic approach that could be ... ...

    Abstract Lifestyle change is the first-line of treatment for the management of women with PCOS, however obtaining long-term adherence is challenging. In order to improve adherence to advice on lifestyle, we propose a strategic systematic approach that could be easily remembered with the acronym I.M.P.R.O.V.E.: Inform, Motivate, Prescribe, Reward, Oversee, Visualize, Empower. Besides giving information and recommendations, it emphasizes the need to listen to PCOS patients in order to better motivate and to encourage to increase those physical activities they like the most. The reduction of calorie intake more than macronutrient changes may also be proposed. In the second phase the strategy aims to assess lifestyle changes, trying to visualize and quantify them so as to reinforce adherence and motivation or to find new motivations and rewards. The final goal is to empower the patient in order to maintain long term self-adherence. Lifestyle approach is not an alternative to pharmacological treatment of PCOS, but it is synergic with it as it can counterbalance some side effects or risks.
    MeSH term(s) Behavior Therapy/methods ; Energy Intake ; Exercise ; Female ; Healthy Lifestyle ; Humans ; Motivation ; Patient Compliance/psychology ; Patient Participation/psychology ; Patient Preference ; Polycystic Ovary Syndrome/psychology ; Polycystic Ovary Syndrome/therapy ; Reward
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2021.1871892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 608: Show issues

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