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  1. Article ; Online: Letter concerning: Clewell (2019) incorporation of

    Kaltofen, Marco / Nachman, Keeve E / Hattis, Dale

    Inhalation toxicology

    2020  Volume 32, Issue 8, Page(s) 327

    MeSH term(s) Chloroprene ; Models, Biological ; Risk Assessment
    Chemical Substances Chloroprene (126-99-8)
    Language English
    Publishing date 2020-08-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1038809-6
    ISSN 1091-7691 ; 0895-8378
    ISSN (online) 1091-7691
    ISSN 0895-8378
    DOI 10.1080/08958378.2020.1806960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2618: Show issues Location:
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  2. Book: Use of biological markers and pharmacokinetics in human health risk assessment

    Hattis, Dale

    1989  

    Title variant Biomarkers and pharmacokinetics in risk assessment
    Author's details Dale Hattis
    Keywords Biological Markers ; Pharmacokinetics ; Environmental Exposure ; Neoplasms / chemically induced ; Nervous System / drug effects ; Acrylamides / toxicity ; Tetrachloroethylene / toxicity ; Ethylene Oxide / toxicity ; Butadienes / toxicity ; Infant, Low Birth Weight
    Language English
    Size 25, [12] Bl. : Ill., graph. Darst.
    Publisher MIT Center for Techn., Policy and Industrial Development
    Publishing place Cambridge, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT006238380
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 1730 order for loan Magazin

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  3. Article ; Online: High-throughput testing--the NRC vision, the challenge of modeling dynamic changes in biological systems, and the reality of low-throughput environmental health decision making.

    Hattis, Dale

    Risk analysis : an official publication of the Society for Risk Analysis

    2009  Volume 29, Issue 4, Page(s) 483–4; discussion 492–7

    MeSH term(s) Decision Making ; Environmental Health ; Humans ; Models, Biological ; Toxicity Tests/methods
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/j.1539-6924.2008.01167.x
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Distributional analyses for children's inhalation risk assessments.

    Hattis, Dale

    Journal of toxicology and environmental health. Part A

    2008  Volume 71, Issue 3, Page(s) 218–226

    Abstract: The discussion here is divided into three parts. First there is a generic introduction to variability and uncertainty and a discussion of some underappreciated features of these concepts that have nontrivial implications for structuring risk analyses. ... ...

    Abstract The discussion here is divided into three parts. First there is a generic introduction to variability and uncertainty and a discussion of some underappreciated features of these concepts that have nontrivial implications for structuring risk analyses. Next are some suggestions for a way forward to build a better quantitative understanding of relevant variability and uncertainty. The process involves building databases of putative analogous cases to represent the concerns that are now reflected in the various point-estimate "uncertainty factors" or "adjustment factors" in the formulas used to derive current reference doses and reference concentrations (RfDs and RfCs). The use of such databases is illustrated with some limited selections from our own databases where some preliminary comparisons between child and adult population variability in activity and respiratory response parameters are possible. A final section reflects on the current evolution of practice in estimating variability in risk assessments.
    MeSH term(s) Adult ; Child, Preschool ; Databases, Factual ; Dose-Response Relationship, Drug ; Female ; Humans ; Inhalation Exposure ; Male ; Models, Statistical ; Risk Assessment/methods ; Uncertainty
    Language English
    Publishing date 2008
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1413345-3
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    DOI 10.1080/15287390701598150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1268: Show issues Location:
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  5. Book: Analysis of dose time response relationships for chronic toxic effects

    Hattis, Dale / Shapiro, Karen

    the case of acrylamide

    (PB / [NTIS] ; 89-109581)

    1988  

    Title variant dose-time-response
    Author's details Dale Hattis ; Karen Shapiro
    Series title PB / [NTIS] ; 89-109581
    PB / National Technical Information Service
    Collection PB / National Technical Information Service
    Keywords Acrylamides / toxicity ; Dose-Response Relationship, Drug ; Nervous System / drug effects ; Time Factors
    Language English
    Size S-11, 56 Bl. : Ill.
    Publisher Center for Technology, Policy and Industrial Development, Massachusetts Inst. of Technology
    Publishing place Cambridge, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT007543160
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 201 -89-109581- verfügbar in Königswinter Königswinter

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  6. Book: Potential indirect mechanisms of carcinogenesis

    Hattis, Dale / Strauss, Harlee

    a preliminary taxonomy

    (PB ; 89-120513)

    1986  

    Author's details Dale Hattis ; Harlee Strauss
    Series title PB ; 89-120513
    PB / National Technical Information Service
    Collection PB / National Technical Information Service
    Keywords Neoplasms / chemically induced
    Size 91 S.
    Publishing place Springfield, Va
    Publishing country United States
    Document type Book
    HBZ-ID HT004421608
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 201 -89-120513- verfügbar in Königswinter Königswinter

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  7. Article: High-Throughput Testing--The NRC Vision, The Challenge of Modeling Dynamic Changes in Biological Systems, and the Reality of Low-Throughput Environmental Health Decision Making

    Hattis, Dale

    Risk analysis. 2009 Apr., v. 29, no. 4

    2009  

    Language English
    Dates of publication 2009-04
    Size p. 483-484.
    Publishing place Blackwell Publishing Inc
    Document type Article
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/j.1539-6924.2008.01167.x
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment.

    Varshavsky, Julia R / Rayasam, Swati D G / Sass, Jennifer B / Axelrad, Daniel A / Cranor, Carl F / Hattis, Dale / Hauser, Russ / Koman, Patricia D / Marquez, Emily C / Morello-Frosch, Rachel / Oksas, Catherine / Patton, Sharyle / Robinson, Joshua F / Sathyanarayana, Sheela / Shepard, Peggy M / Woodruff, Tracey J

    Environmental health : a global access science source

    2023  Volume 21, Issue Suppl 1, Page(s) 133

    Abstract: A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and ... ...

    Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence of wider variability. Experts and authoritative bodies support using advanced techniques to better account for human variability due to factors such as in utero or early life exposure and exposure to multiple environmental, social, and economic stressors.This review describes: 1) sources of human variability and susceptibility in dose-response assessment, 2) existing US frameworks for addressing response variability in risk assessment; 3) key scientific inadequacies necessitating updated methods; 4) improved approaches and opportunities for better use of science; and 5) specific and quantitative recommendations to address evidence and policy needs.Current default adjustment factors do not sufficiently capture human variability in dose-response and thus are inadequate to protect the entire population. Susceptible groups are not appropriately protected under current regulatory guidelines. Emerging tools and data sources that better account for human variability and susceptibility include probabilistic methods, genetically diverse in vivo and in vitro models, and the use of human data to capture underlying risk and/or assess combined effects from chemical and non-chemical stressors.We recommend using updated methods and data to improve consideration of human variability and susceptibility in risk assessment, including the use of increased default human variability factors and separate adjustment factors for capturing age/life stage of development and exposure to multiple chemical and non-chemical stressors. Updated methods would result in greater transparency and protection for susceptible groups, including children, infants, people who are pregnant or nursing, people with disabilities, and those burdened by additional environmental exposures and/or social factors such as poverty and racism.
    MeSH term(s) Infant ; Child ; Pregnancy ; Female ; Humans ; Environmental Exposure ; Risk Assessment/methods ; Poverty
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-022-00940-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Are conundrums with uncertainty factors an obstacle to developing probabilistic interpretations of noncancer risks from chemicals?

    Goble, Rob / Hattis, Dale

    Risk analysis : an official publication of the Society for Risk Analysis

    2010  Volume 30, Issue 3, Page(s) 340–5; author reply 353

    MeSH term(s) Humans ; Risk ; Uncertainty
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/j.1539-6924.2010.01364.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

    Julia R. Varshavsky / Swati D. G. Rayasam / Jennifer B. Sass / Daniel A. Axelrad / Carl F. Cranor / Dale Hattis / Russ Hauser / Patricia D. Koman / Emily C. Marquez / Rachel Morello-Frosch / Catherine Oksas / Sharyle Patton / Joshua F. Robinson / Sheela Sathyanarayana / Peggy M. Shepard / Tracey J. Woodruff

    Environmental Health, Vol 21, Iss S1, Pp 1-

    2023  Volume 20

    Abstract: Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average ( ... ...

    Abstract Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence of wider variability. Experts and authoritative bodies support using advanced techniques to better account for human variability due to factors such as in utero or early life exposure and exposure to multiple environmental, social, and economic stressors. This review describes: 1) sources of human variability and susceptibility in dose-response assessment, 2) existing US frameworks for addressing response variability in risk assessment; 3) key scientific inadequacies necessitating updated methods; 4) improved approaches and opportunities for better use of science; and 5) specific and quantitative recommendations to address evidence and policy needs. Current default adjustment factors do not sufficiently capture human variability in dose-response and thus are inadequate to protect the entire population. Susceptible groups are not appropriately protected under current regulatory guidelines. Emerging tools and data sources that better account for human variability and susceptibility include probabilistic methods, genetically diverse in vivo and in vitro models, and the use of human data to capture underlying risk and/or assess combined effects from chemical and non-chemical stressors. We recommend using updated methods and data to improve consideration of human variability and susceptibility in risk assessment, including the use of increased default human variability factors and separate adjustment factors for capturing age/life stage of development and exposure to multiple chemical and non-chemical stressors. Updated methods would result in greater transparency and protection for susceptible groups, including children, infants, people who are pregnant or nursing, people with disabilities, and those burdened by additional ...
    Keywords Adjustment factors ; Chemicals ; Cumulative risk ; Environmental justice ; EPA ; NAMs ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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