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  1. Article ; Online: Videolaryngoscopy in neonatal clinical care.

    Kirolos, Sandy / Edwards, Gemma / O'Shea, Joyce

    Seminars in fetal & neonatal medicine

    2023  Volume 28, Issue 5, Page(s) 101486

    Abstract: Endotracheal intubation is a life-saving procedure for many newborns. Historically, it has been achieved by obtaining an airway view through the mouth via direct laryngoscopy. It is a skill that takes time and practice to achieve proficiency. Increasing ... ...

    Abstract Endotracheal intubation is a life-saving procedure for many newborns. Historically, it has been achieved by obtaining an airway view through the mouth via direct laryngoscopy. It is a skill that takes time and practice to achieve proficiency. Increasing evidence for the benefit of videolaryngoscopy in adults and the new development of technology has allowed videolaryngoscopy to become a reality in neonatal care. Studies have examined its use as both a technique to improve intubation safety and success, and as a training tool for those learning the skill in this vulnerable population. We present the current evidence for videolaryngoscopy in neonates in different settings where intubation may be required, in addition to exploring the challenges and practicalities of implementing this technique into clinical practice.
    MeSH term(s) Adult ; Infant, Newborn ; Humans ; Laryngoscopy/education ; Laryngoscopy/methods ; Laryngoscopes ; Intubation, Intratracheal/methods
    Language English
    Publishing date 2023-11-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2023.101486
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4798: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects.

    O'Shea, Donagh G / Hodgkinson, Tom / Curtin, Caroline M / O'Brien, Fergal J

    Biofabrication

    2023  Volume 16, Issue 1

    Abstract: Current treatments for repairing articular cartilage defects are limited. However, pro-chondrogenic hydrogels formulated using articular cartilage matrix components (such as hyaluronic acid (HA) and collagen type II (Col II)), offer a potential solution ... ...

    Abstract Current treatments for repairing articular cartilage defects are limited. However, pro-chondrogenic hydrogels formulated using articular cartilage matrix components (such as hyaluronic acid (HA) and collagen type II (Col II)), offer a potential solution if they could be injected into the defect via minimally invasive arthroscopic procedures, or used as bioinks to 3D print patient-specific customised regenerative scaffolds-potentially combined with cells. However, HA and Col II are difficult to incorporate into injectable/3D printable hydrogels due to poor physicochemical properties. This study aimed to overcome this by developing an articular cartilage matrix-inspired pro-chondrogenic hydrogel with improved physicochemical properties for both injectable and 3D printing (3DP) applications. To achieve this, HA was methacrylated to improve mechanical properties and mixed in a 1:1 ratio with Col I, a Col I/Col II blend or Col II. Col I possesses superior mechanical properties to Col II and so was hypothesised to enhance hydrogel mechanical properties. Rheological analysis showed that the pre-gels had viscoelastic and shear thinning properties. Subsequent physicochemical analysis of the crosslinked hydrogels showed that Col II inclusion resulted in a more swollen and softer polymer network, without affecting degradation time. While all hydrogels exhibited exemplary injectability, only the Col I-containing hydrogels had sufficient mechanical stability for 3DP applications. To facilitate 3DP of multi-layered scaffolds using methacrylated HA (MeHA)-Col I and MeHA-Col I/Col II, additional mechanical support in the form of a gelatin slurry support bath freeform reversible embedding of suspended hydrogels was utilised. Biological analysis revealed that Col II inclusion enhanced hydrogel-embedded MSC chondrogenesis, thus MeHA-Col II was selected as the optimal injectable hydrogel, and MeHA-Col I/Col II as the preferred bioink. In summary, this study demonstrates how tailoring biomaterial composition and physicochemical properties enables development of pro-chondrogenic hydrogels with potential for minimally invasive delivery to injured articular joints or 3DP of customised regenerative implants for cartilage repair.
    MeSH term(s) Humans ; Hyaluronic Acid/chemistry ; Cartilage, Articular/metabolism ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Collagen Type II/metabolism ; Chondrogenesis ; Tissue Engineering
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Hydrogels ; Collagen Type II
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/ad047a
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  3. Article ; Online: Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering.

    O'Shea, Donagh G / Curtin, Caroline M / O'Brien, Fergal J

    Biomaterials science

    2022  Volume 10, Issue 10, Page(s) 2462–2483

    Abstract: In the human body, articular cartilage facilitates the frictionless movement of synovial joints. However, due to its avascular and aneural nature, it has a limited ability to self-repair when damaged due to injury or wear and tear over time. Current ... ...

    Abstract In the human body, articular cartilage facilitates the frictionless movement of synovial joints. However, due to its avascular and aneural nature, it has a limited ability to self-repair when damaged due to injury or wear and tear over time. Current surgical treatment options for cartilage defects often lead to the formation of fibrous, non-durable tissue and thus a new solution is required. Nature is the best innovator and so recent advances in the field of tissue engineering have aimed to recreate the microenvironment of native articular cartilage using biomaterial scaffolds. However, the inability to mirror the complexity of native tissue has hindered the clinical translation of many products thus far. Fortunately, the advent of 3D printing has provided a potential solution. 3D printed scaffolds, fabricated using biomimetic biomaterials, can be designed to mimic the complex zonal architecture and composition of articular cartilage. The bioinks used to fabricate these scaffolds can also be further functionalised with cells and/or bioactive factors or gene therapeutics to mirror the cellular composition of the native tissue. Thus, this review investigates how the architecture and composition of native articular cartilage is inspiring the design of biomimetic bioinks for 3D printing of scaffolds for cartilage repair. Subsequently, we discuss how these 3D printed scaffolds can be further functionalised with cells and bioactive factors, as well as looking at future prospects in this field.
    MeSH term(s) Biocompatible Materials/pharmacology ; Biomimetics ; Cartilage, Articular ; Humans ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm01540k
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  4. Article ; Online: Advances in radiological staging of colorectal cancer.

    Goiffon, R J / O'Shea, A / Harisinghani, M G

    Clinical radiology

    2021  Volume 76, Issue 12, Page(s) 879–888

    Abstract: The role of imaging in clinically staging colorectal cancer has grown substantially in the ... ...

    Abstract The role of imaging in clinically staging colorectal cancer has grown substantially in the 21
    MeSH term(s) Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/pathology ; Humans ; Magnetic Resonance Imaging ; Multimodal Imaging ; Neoplasm Staging ; Positron-Emission Tomography ; Tomography, X-Ray Computed ; Whole Body Imaging
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2021.06.005
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    Ue I Zs.201: Show issues Location:
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  5. Article ; Online: Use of telemedicine in general practice in Europe since the COVID-19 pandemic: A scoping review of patient and practitioner perspectives.

    Walley, David / McCombe, Geoff / Broughan, John / O'Shea, Conor / Crowley, Des / Quinlan, Diarmuid / Wann, Catherine / Crowley, Tadhg / Cullen, Walter

    PLOS digital health

    2024  Volume 3, Issue 2, Page(s) e0000427

    Abstract: General practice is generally the first point of contact for patients presenting with COVID-19. Since the start of the COVID-19 pandemic general practitioners (GPs) across Europe have had to adopt to using telemedicine consultations in order to minimise ... ...

    Abstract General practice is generally the first point of contact for patients presenting with COVID-19. Since the start of the COVID-19 pandemic general practitioners (GPs) across Europe have had to adopt to using telemedicine consultations in order to minimise the number of social contacts made. GPs had to balance two needs: preventing the spread of COVID-19, while providing their patients with regular care for other health issues. The aim of this study was to conduct a scoping review of the literature examining the use of telemedicine for delivering routine general practice care since the start of the pandemic from the perspectives of patients and practitioners. The six-stage framework developed by Arksey and O'Malley, with recommendations by Levac et al was used to review the existing literature. The study selection process was conducted according to the PRISMA Extension for Scoping Reviews guidelines. Braun and Clarke's' Thematic Analysis' approach was used to interpret data. A total of eighteen studies across nine countries were included in the review. Thirteen studies explored the practitioner perspective of the use of telemedicine in general practice since the COVID-19 pandemic, while five studies looked at the patient perspective. The types of studies included were: qualitative studies, literature reviews, a systematic review, observational studies, quantitative studies, Critical incident technique study, and surveys employing both closed and open styled questions. Key themes identified related to the patient/ practitioner experience and knowledge of using telemedicine, patient/ practitioner levels of satisfaction, GP collaboration, nature of workload, and suitability of consultations for telemedicine. The nature of general practice was radically changed during the COVID-19 pandemic. Certain patient groups and areas of clinical and administrative work were identified as having performed well, if not better, by using telemedicine. Our findings suggest a level of acceptability and satisfaction of telemedicine by GPs and patients during the pandemic; however, further research is warranted in this area.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3170
    ISSN (online) 2767-3170
    DOI 10.1371/journal.pdig.0000427
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  6. Article ; Online: Conventional versus ultra-low dose computed tomogram in Crohn's disease: Do morphomics correlate with clinical data?

    O'Mahony, A T / Waldron, M G / O'Shea, S / Mulryan, P / O'Connor, O J / Maher, M M

    Radiography (London, England : 1995)

    2023  Volume 29, Issue 4, Page(s) 712–720

    Abstract: Background: Cross-sectional study to assess the body composition of patients with Crohn's disease (CD) on standard (SDCT) and low dose CT (LDCT) protocols for the abdomen and pelvis (CTAP). We aimed to assess if a low dose CT protocol reconstructed with ...

    Abstract Background: Cross-sectional study to assess the body composition of patients with Crohn's disease (CD) on standard (SDCT) and low dose CT (LDCT) protocols for the abdomen and pelvis (CTAP). We aimed to assess if a low dose CT protocol reconstructed with model-based iterative reconstruction (IR) could evaluate body morphometric data comparable to standard dose examination.
    Methods: The CTAP images of 49 patients who underwent a low dose CT scan (20% of standard dose) and a second at standard dose minus 20% were assessed retrospectively. Images were collected from the PACS system, deidentified and analysed using a web-based semi-automated threshold-based segmentation tool (CoreSlicer), capable of identifying tissue type based on differences in attenuation co-efficient. The cross-sectional area (CSA) and Hounsfield units (HU) of each tissue was recorded.
    Results: Muscle and fat CSA is well preserved on comparing these derived metrics from low dose and standard dose CT scans of abdomen and pelvic in CD ((LDCT:SDCT mean CSA (cm
    Conclusion: We found comparable CSA across all tissues (muscle and fat) on both protocols with a strong positive correlation. A marginally lower muscle attenuation suggestive of less dense muscle was highlighted on SDCT. This study augments previous studies suggesting that comparable and reliable morphomic data may be generated from low dose and standard dose CT images.
    Implications for practice: Threshold-based segmental tools can be used to quantify body morphomics on standard and low dose computed tomogram protocols.
    MeSH term(s) Humans ; Radiation Dosage ; Crohn Disease/diagnostic imaging ; Retrospective Studies ; Cross-Sectional Studies ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2023-05-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2023.04.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4438: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Healthcare Utilization Differences Among Primary Care Patients Using Telemedicine in the Veterans Health Administration: a Retrospective Cohort Study.

    O'Shea, Amy M J / Mulligan, Kailey / Carlson, Paige / Haraldsson, Bjarni / Augustine, Matthew R / Kaboli, Peter J / Shimada, Stephanie L

    Journal of general internal medicine

    2024  Volume 39, Issue Suppl 1, Page(s) 109–117

    Abstract: ... telemedicine versus in-person only use adjusted for patient characteristics (e.g., age, gender, race ...

    Abstract Background: The COVID-19 pandemic encouraged telemedicine expansion. Research regarding follow-up healthcare utilization and primary care (PC) telemedicine is lacking.
    Objective: To evaluate whether healthcare utilization differed across PC populations using telemedicine.
    Design: Retrospective observational cohort study using administrative data from veterans with minimally one PC visit before the COVID-19 pandemic (March 1, 2019-February 28, 2020) and after in-person restrictions were lifted (October 1, 2020-September 30, 2021).
    Participants: All veterans receiving VHA PC services during study period.
    Main measures: Veterans' exposure to telemedicine was categorized as (1) in-person only, (2) telephone telemedicine (≥ 1 telephone visit with or without in-person visits), or (3) video telemedicine (≥ 1 video visit with or without telephone and/or in-person visits). Healthcare utilization 7 days after index PC visit were compared. Generalized estimating equations estimated odds ratios for telephone or video telemedicine versus in-person only use adjusted for patient characteristics (e.g., age, gender, race, residential rurality, ethnicity), area deprivation index, comorbidity risk, and intermediate PC visits within the follow-up window.
    Key results: Over the 2-year study, 3.4 million veterans had 12.9 million PC visits, where 1.7 million (50.7%), 1.0 million (30.3%), and 649,936 (19.0%) veterans were categorized as in-person only, telephone telemedicine, or video telemedicine. Compared to in-person only users, video telemedicine users experienced higher rates per 1000 patients of emergent care (15.1 vs 11.2; p < 0.001) and inpatient admissions (4.2 vs 3.3; p < 0.001). In adjusted analyses, video versus in-person only users experienced greater odds of emergent care (OR [95% CI]:1.18 [1.16, 1.19]) inpatient (OR [95% CI]: 1.29 [1.25, 1.32]), and ambulatory care sensitive condition admission (OR [95% CI]: 1.30 [1.27, 1.34]).
    Conclusions: Telemedicine potentially in combination with in-person care was associated with higher follow-up healthcare utilization rates compared to in-person only PC. Factors contributing to utilization differences between groups need further evaluation.
    MeSH term(s) Humans ; Retrospective Studies ; Pandemics ; Veterans Health ; Telemedicine ; Inpatients ; COVID-19 ; Patient Acceptance of Health Care ; Primary Health Care
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08472-1
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    Zs.A 2205: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Bipolar Patient-Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor.

    Dow, Rachel / DeLong, Cindy / Jiang, Guihua / Attili, Durga / Creech, Jeffery / Kraan, Rachel / Campbell, Katherine / Saraithong, Prakaimuk / O'Shea, Sue / Monteiro da Rocha, Andre / McInnis, Melvin G / Herron, Todd J

    Biological psychiatry global open science

    2024  Volume 4, Issue 3, Page(s) 100296

    Abstract: A common genetic risk factor for bipolar disorder ... ...

    Abstract A common genetic risk factor for bipolar disorder is
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2024.100296
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  9. Book ; Online: Computer Vision for Carriers

    Goodman, Ari / Singh, Gurpreet / Hing, James / O'Shea, Ryan

    PATRIOT

    2023  

    Abstract: Deck tracking performed on carriers currently involves a team of sailors manually identifying aircraft and updating a digital user interface called the Ouija Board. Improvements to the deck tracking process would result in increased Sortie Generation ... ...

    Abstract Deck tracking performed on carriers currently involves a team of sailors manually identifying aircraft and updating a digital user interface called the Ouija Board. Improvements to the deck tracking process would result in increased Sortie Generation Rates, and therefore applying automation is seen as a critical method to improve deck tracking. However, the requirements on a carrier ship do not allow for the installation of hardware-based location sensing technologies like Global Positioning System (GPS) sensors. PATRIOT (Panoramic Asset Tracking of Real-Time Information for the Ouija Tabletop) is a research effort and proposed solution to performing deck tracking with passive sensing and without the need for GPS sensors. PATRIOT is a prototype system which takes existing camera feeds, calculates aircraft poses, and updates a virtual Ouija board interface with the current status of the assets. PATRIOT would allow for faster, more accurate, and less laborious asset tracking for aircraft, people, and support equipment. PATRIOT is anticipated to benefit the warfighter by reducing cognitive workload, reducing manning requirements, collecting data to improve logistics, and enabling an automation gateway for future efforts to improve efficiency and safety. The authors have developed and tested algorithms to perform pose estimations of assets in real-time including OpenPifPaf, High-Resolution Network (HRNet), HigherHRNet (HHRNet), Faster R-CNN, and in-house developed encoder-decoder network. The software was tested with synthetic and real-world data and was able to accurately extract the pose of assets. Fusion, tracking, and real-world generality are planned to be improved to ensure a successful transition to the fleet.

    Comment: 8 pages, 18 figures. Published in the Proceedings of the ASNE 2023 Technology, Systems & Ships Symposium. Reproduced with permission from the American Society of Naval Engineers. Distribution Statement A: Approved for public release; distribution is unlimited, as submitted under NAVAIR ...
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 600
    Publishing date 2023-11-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes.

    Fernando, Nilisha / Sciumè, Giuseppe / O'Shea, John J / Shih, Han-Yu

    Frontiers in immunology

    2021  Volume 12, Page(s) 655590

    Abstract: The precise control of cytokine production by innate lymphoid cells (ILCs) and their T cell adaptive system counterparts is critical to mounting a proper host defense immune response without inducing collateral damage and autoimmunity. Unlike T cells ... ...

    Abstract The precise control of cytokine production by innate lymphoid cells (ILCs) and their T cell adaptive system counterparts is critical to mounting a proper host defense immune response without inducing collateral damage and autoimmunity. Unlike T cells that differentiate into functionally divergent subsets upon antigen recognition, ILCs are developmentally programmed to rapidly respond to environmental signals in a polarized manner, without the need of T cell receptor (TCR) signaling. The specification of cytokine production relies on dynamic regulation of cis-regulatory elements that involve multi-dimensional epigenetic mechanisms, including DNA methylation, transcription factor binding, histone modification and DNA-DNA interactions that form chromatin loops. How these different layers of gene regulation coordinate with each other to fine tune cytokine production, and whether ILCs and their T cell analogs utilize the same regulatory strategy, remain largely unknown. Herein, we review the molecular mechanisms that underlie cell identity and functionality of helper T cells and ILCs, focusing on networks of transcription factors and cis-regulatory elements. We discuss how higher-order chromatin architecture orchestrates these components to construct lineage- and state-specific regulomes that support ordered immunoregulation.
    MeSH term(s) Adaptive Immunity ; Animals ; Chromatin/genetics ; Chromatin/metabolism ; Enhancer Elements, Genetic ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Lymphocytes/immunology ; Lymphocytes/metabolism ; RNA, Untranslated/genetics ; Transcription Factors/metabolism ; Transcriptome
    Chemical Substances Chromatin ; RNA, Untranslated ; Transcription Factors
    Language English
    Publishing date 2021-03-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.655590
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