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  1. Article ; Online: Artificial Intelligence Poised to Improve Retinopathy of Prematurity Screening.

    Moshfeghi, Darius M

    Ophthalmology. Retina

    2023  Volume 8, Issue 1, Page(s) 1–2

    MeSH term(s) Infant, Newborn ; Humans ; Artificial Intelligence ; Retinopathy of Prematurity/diagnosis
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Editorial
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of Icteric Vitreous, Retinal Opacification, and Atypical Retinopathy of Prematurity.

    Meyer, Carlotta / Moshfeghi, Darius M

    Ophthalmic surgery, lasers & imaging retina

    2024  Volume 55, Issue 3, Page(s) 164–167

    Abstract: A dichorionic, diamniotic twin born at 24-0/7 weeks and 740 g developed hyperbilirubinemia, necrotizing enterocolitis, and sepsis. Photographic imaging documented vitreous opacification, which was absent in the fellow twin. Retinal opacification was ... ...

    Abstract A dichorionic, diamniotic twin born at 24-0/7 weeks and 740 g developed hyperbilirubinemia, necrotizing enterocolitis, and sepsis. Photographic imaging documented vitreous opacification, which was absent in the fellow twin. Retinal opacification was presumed secondary to embolic sepsis and responded to systemic antibiotics. Subsequent dropout of vascularized retina corresponded to areas of retinal opacification. Type 1 retinopathy of prematurity (ROP)-Zone I, Stage 3 ROP bilateral-demonstrated a rapid and durable response to off-label intravitreal bevacizumab 0.625 mg. Retinal opacification resolved between 39 and 40 weeks postmenstrual age. Systemic comorbidities may alter the appearance, course, and management of ROP.
    MeSH term(s) Infant, Newborn ; Humans ; Angiogenesis Inhibitors/therapeutic use ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/drug therapy ; Vascular Endothelial Growth Factor A ; Gestational Age ; Bevacizumab/therapeutic use ; Retina ; Sepsis/drug therapy ; Intravitreal Injections ; Retrospective Studies
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20231206-03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Retinal Arterial Tortuosity in Marfan and Loeys-Dietz Syndromes.

    Ghoraba, Hashem H / Moshfeghi, Darius M

    Ophthalmology. Retina

    2023  Volume 7, Issue 6, Page(s) 554–557

    MeSH term(s) Humans ; Marfan Syndrome/complications ; Marfan Syndrome/diagnosis ; Loeys-Dietz Syndrome/complications ; Loeys-Dietz Syndrome/diagnosis ; Vascular Malformations/diagnosis ; Arteries
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.02.014
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  4. Article ; Online: Photographic Gel Artifact Simulating International Classification of Retinopathy of Prematurity Notch: Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) Report no. 16.

    Wai, Karen M / Moshfeghi, Darius M

    Ophthalmology. Retina

    2023  Volume 7, Issue 8, Page(s) 732–736

    Abstract: Purpose: To report a series of fundus photographs taken for retinopathy of prematurity (ROP) screening that contain artifacts with imaging characteristics mimicking a notch, a recently refined classification metric in the International Classification of ...

    Abstract Purpose: To report a series of fundus photographs taken for retinopathy of prematurity (ROP) screening that contain artifacts with imaging characteristics mimicking a notch, a recently refined classification metric in the International Classification of Retinopathy of Prematurity, third edition.
    Design: Retrospective case series.
    Participants: Infants requiring ROP screening in neonatal intensive care units from the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) and TeleROP telemedicine screening programs.
    Methods: Preterm infants meeting ROP examination criteria were screened with 130° wide-angle imaging systems. The images were taken by a trained nurse in the neonatal intensive care unit and transferred to an ROP specialist using a Health Insurance Portability and Accountability Act-compliant picture archiving and communication system for interpretation.
    Main outcome measures: Presence of an artifact that appeared consistent with a notch.
    Results: We identified a total of 17 cases in ROP screening with artifact findings that had imaging characteristics similar to a notch. The artifactual appearance of the pseudo-notch was created by the camera illumination system within the gel-lens interface when the lens was not well apposed to the cornea. In telemedicine screening for ROP, we present fundus images of eyes with a pseudo-notch appearance; review of overlapping images can help differentiate between notch and artifact.
    Conclusions: Pediatric retinal specialists need to be aware that artifacts play a confounding role in screening for ROP, that can be mitigated through the use of overlapping and redundant images.
    Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.
    MeSH term(s) United States ; Infant ; Child ; Infant, Newborn ; Humans ; Infant, Premature ; Retinopathy of Prematurity/diagnosis ; Artifacts ; Retrospective Studies ; Universities ; Gestational Age ; Ophthalmoscopy/methods ; Sensitivity and Specificity ; Neonatal Screening/methods
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unilateral Retinopathy in a Preterm Infant With 4q Duplication: Description and Management.

    Brant, Arthur / Meyer, Carlotta / Moshfeghi, Darius M

    Ophthalmic surgery, lasers & imaging retina

    2024  Volume 55, Issue 4, Page(s) 228–230

    Abstract: A 33-5/7, 1570 g dichorionic diamniotic twin presented with cryptorchidism, failed hearing examination (both ears), poor feeding, profound hypoglycemia, coagulopathy, conjugated hyper-bilirubinemia, hydronephrosis, and hypotension. Microarray sent with ... ...

    Abstract A 33-5/7, 1570 g dichorionic diamniotic twin presented with cryptorchidism, failed hearing examination (both ears), poor feeding, profound hypoglycemia, coagulopathy, conjugated hyper-bilirubinemia, hydronephrosis, and hypotension. Microarray sent with results of whole genome SNP microgray analysis detected an interstitial duplication of the chromosomal segment 4q35 1q35.2. On this basis, telemedicine screening was performed to evaluate for ocular abnormalities in association with abnormal gene testing. Unilateral advanced retinopathy was noted affecting the right eye, with mature vascularization in the left eye. This infant was managed in concordance with retinopathy of prematurity guidelines, despite not making screening criteria. Off-label intravitreal bevacizumab injection (0.625 mg in 0.025 mL) resulted in full vascular maturation assessed by fluorescein angiography 6 months later. This represents the first description and management of retinopathy in 4q duplication syndrome.
    MeSH term(s) Humans ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/drug therapy ; Infant, Newborn ; Male ; Angiogenesis Inhibitors/therapeutic use ; Angiogenesis Inhibitors/administration & dosage ; Fluorescein Angiography/methods ; Bevacizumab/therapeutic use ; Bevacizumab/administration & dosage ; Intravitreal Injections ; Infant, Premature ; Chromosome Duplication/genetics
    Chemical Substances Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Case Reports
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20240117-02
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    Zs.A 756: Show issues Location:
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  6. Article ; Online: Retinal arterial tortuosity in Ehlers-Danlos syndromes.

    Ghoraba, Hashem H / Moshfeghi, Darius M

    Eye (London, England)

    2022  Volume 37, Issue 9, Page(s) 1936–1941

    Abstract: Purpose: To report a novel finding of retinal arterial tortuosity (RAT) associated with Ehlers-Danlos syndromes (EDS).: Methods: We queried the STAnford Research Repository (STARR) database to identify patients diagnosed with EDS. We included ... ...

    Abstract Purpose: To report a novel finding of retinal arterial tortuosity (RAT) associated with Ehlers-Danlos syndromes (EDS).
    Methods: We queried the STAnford Research Repository (STARR) database to identify patients diagnosed with EDS. We included patients with a confirmed diagnosis of any subtype of EDS who had any form of readable retinal imaging including colour fundus photos, autofluorescence, red-free photos, red-free optical coherence tomography photos and fluorescein angiography. Patients who had no retinal imaging and those with no confirmed EDS diagnosis were excluded. Retinal images were reviewed for RAT and were graded into no, possible and definite RAT. Eyes with definite RAT were further graded into mild, moderate and severe. Eyes with definite RAT were again subclassified according to the type of involved vessels into first-order arteriolar, macular and arteriovenous.
    Results: A total of 307 patients were identified using the STARR tool and 142 patients were included. Mean age was 40.9 ± 18.1 years and 87% were female. Underlying EDS subtypes were hypermobile EDS (69.7%), classical EDS (2.8%), vascular EDS (2.1%), myopathic EDS (0.7%) and not specified (24.6%). We graded 37.3% of patients with definite RAT, 10.6% with possible RAT and 52.1% with no RAT. In patients with definite RAT, we graded 39.2% of eyes with mild RAT, 40.2% with moderate RAT and 20.6% with severe RAT. In all, 84.9% showed involvement of first-order retinal arterioles, 35.8% showed involvement of macular arterioles and 1.9% showed arteriovenous involvement.
    Conclusions: Variable degrees of RAT are associated with EDS.
    MeSH term(s) Female ; Male ; Humans ; Ehlers-Danlos Syndrome/complications ; Ehlers-Danlos Syndrome/diagnosis ; Skin Diseases, Genetic/complications ; Vascular Malformations ; Joint Instability/complications
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02278-x
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  7. Article ; Online: Rapid Improvement in Lipid Maculopathy Following Faricimab Therapy in Recalcitrant Familial Exudative Vitreoretinopathy.

    Ghoraba, Hashem H / DeBoer, Charles / Moshfeghi, Darius M

    Ophthalmic surgery, lasers & imaging retina

    2023  Volume 54, Issue 7, Page(s) 426–428

    Abstract: A monocular 22-year-old man with recalcitrant familial exudative vitreoretinopathy presented with progressive subretinal lipid exudation and lipid maculopathy that responded poorly to repeated aflibercept injections. The subretinal exudation started ... ...

    Abstract A monocular 22-year-old man with recalcitrant familial exudative vitreoretinopathy presented with progressive subretinal lipid exudation and lipid maculopathy that responded poorly to repeated aflibercept injections. The subretinal exudation started temporally and gradually progressed, involving the macula and the retinal periphery in all 4 quadrants. At the 22-month follow-up visit, macular and peripheral subretinal exudation persisted despite a total of 29 injections. Faricimab was then injected once every 2 weeks for a total of 3 injections, which resulted in rapid dramatic resolution of the macular and most of the peripheral subretinal exudation. No ocular or systemic adverse events were noted.
    MeSH term(s) Male ; Humans ; Young Adult ; Adult ; Familial Exudative Vitreoretinopathies ; Retinal Diseases ; Macular Degeneration ; Retina ; Lipids
    Chemical Substances faricimab ; Lipids
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20230609-01
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  8. Article ; Online: Reducing Blindness Resulting from Retinopathy of Prematurity Using Deep Learning.

    Moshfeghi, Darius M / Trese, Michael T

    Ophthalmology

    2021  Volume 128, Issue 7, Page(s) 1077–1078

    MeSH term(s) Blindness/etiology ; Blindness/prevention & control ; Deep Learning ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Retinopathy of Prematurity/complications ; Retinopathy of Prematurity/diagnosis
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2021.04.028
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  9. Article ; Online: Correction to: Differences in anterior peripheral pathologic myopia and macular pathologic myopia by age and gender.

    Ludwig, Cassie A / Boucher, Nick / Saroj, Namrata / Moshfeghi, Darius M

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2023  Volume 261, Issue 9, Page(s) 2727

    Language English
    Publishing date 2023-04-04
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06053-w
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  10. Article ; Online: Introduction.

    Moshfeghi, Darius M

    Ophthalmic surgery, lasers & imaging retina

    2018  Volume 49, Issue 7, Page(s) S4

    MeSH term(s) Consensus Development Conferences as Topic ; Diabetic Retinopathy/drug therapy ; Expert Testimony ; Glucocorticoids/therapeutic use ; Humans ; Macular Edema/drug therapy ; Ophthalmology/organization & administration ; Precision Medicine
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2018-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20180523-01
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