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  1. AU=Babajanyan S G
  2. AU="Haruhara, Kotaro"
  3. AU="Wang, Che-Wei"
  4. AU="Eisenberg, Marcia"
  5. AU="Ufnalska, Sylwia"
  6. AU="Leroux, Dominique"
  7. AU="Gallagher, Timothy J"
  8. AU=Baggish Aaron
  9. AU="Bush, Ashley I"
  10. AU="Carr, Kenneth D."
  11. AU="Spiro, Stephen"
  12. AU="Roberts, William Clifford"
  13. AU="Park, Hyungjong"
  14. AU="Das, Debasish"
  15. AU="Sanz-Magro, Adrián"
  16. AU="Fan, Shanhui"
  17. AU="Ellonen, Pekka"
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  1. Article: Age-structured SIR model and resource growth dynamics: a COVID-19 study.

    Babajanyan, S G / Cheong, Kang Hao

    Nonlinear dynamics

    2021  Volume 104, Issue 3, Page(s) 2853–2864

    Abstract: In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be ... ...

    Abstract In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be infected again. Available resource dynamics is governed by the well-known logistic growth model, in which the reproduction coefficient depends on the disease outbreak spreading dynamics. We further investigate the feedback interaction of the disease spread dynamics and resource growth dynamics with the premise that the quality of treatment depends on the current economic situation. The very inclusion of mortality rates and economic considerations in the same model may be incongruous under certain positions, but in this model, we take a "realpolitik" approach by exploring all of these factors together as it is done in reality.
    Language English
    Publishing date 2021-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012600-1
    ISSN 1573-269X ; 0924-090X
    ISSN (online) 1573-269X
    ISSN 0924-090X
    DOI 10.1007/s11071-021-06384-5
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  2. Article: Thermodynamic selection: mechanisms and scenarios.

    Babajanyan, S G / Koonin, E V / Allahverdyan, A E

    New journal of physics

    2022  Volume 24, Issue 5

    Abstract: ... The agents can apply different work-extracting, game-theoretical strategies, e.g. the maximum power or ...

    Abstract Thermodynamic selection is an indirect competition between agents feeding on the same energy resource and obeying the laws of thermodynamics. We examine scenarios of this selection, where the agent is modeled as a heat-engine coupled to two thermal baths and extracting work from the high-temperature bath. The agents can apply different work-extracting, game-theoretical strategies, e.g. the maximum power or the maximum efficiency. They can also have a fixed structure or be adaptive. Depending on whether the resource (i.e. the high-temperature bath) is infinite or finite, the fitness of the agent relates to the work-power or the total extracted work. These two selection scenarios lead to increasing or decreasing efficiencies of the work-extraction, respectively. The scenarios are illustrated via plant competition for sunlight, and the competition between different ATP production pathways. We also show that certain general concepts of game-theory and ecology-the prisoner's dilemma and the maximal power principle-emerge from the thermodynamics of competing agents. We emphasize the role of adaptation in developing efficient work-extraction mechanisms.
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464444-7
    ISSN 1367-2630
    ISSN 1367-2630
    DOI 10.1088/1367-2630/ac6531
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  3. Article ; Online: Next-Generation Sequencing Trends among Adult Patients with Select Advanced Tumor Types: A Real-World Evidence Evaluation.

    Ferreira-Gonzalez, Andrea / Hocum, Brian / Ko, Gilbert / Shuvo, Sohul / Appukkuttan, Sreevalsa / Babajanyan, Svetlana

    The Journal of molecular diagnostics : JMD

    2024  Volume 26, Issue 4, Page(s) 292–303

    Abstract: There are limited data on the prevalence of next-generation sequencing (NGS) in the United States, especially in light of the increasing importance of identifying actionable oncogenic variants due to molecular biomarker-based therapy approvals. This ... ...

    Abstract There are limited data on the prevalence of next-generation sequencing (NGS) in the United States, especially in light of the increasing importance of identifying actionable oncogenic variants due to molecular biomarker-based therapy approvals. This retrospective study of adult patients with select metastatic solid tumors and central nervous system tumors from the Optum Clinformatics Data Mart US health care claims database (January 1, 2014, to June 30, 2021; N = 63,209) examined NGS use trends over time. A modest increase in NGS was observed across tumor types from 2015 (0.0% to 1.5%) to 2021 (2.1% to 17.4%). A similar increase in NGS rates was also observed across key periods; however, rates in the final key period remained <10% for patients with breast, colorectal, head and neck, soft tissue sarcoma, and thyroid cancers, as well as central nervous system tumors. The median time to NGS from diagnosis was shortest among patients with non-small-cell lung cancer and longest for patients with breast cancer. Predictors of NGS varied by tumor type; test rates for minorities in select tumor types appeared comparable to the White population. Despite improving payer policies to expand coverage of NGS and molecular biomarker-based therapy approvals, NGS rates remained low across tumor types. Given the potential for improved patient outcomes with molecular biomarker-based therapy, further efforts to improve NGS rates are warranted.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms/diagnosis ; Retrospective Studies ; Central Nervous System Neoplasms ; Biomarkers ; High-Throughput Nucleotide Sequencing ; Mutation
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2000060-1
    ISSN 1943-7811 ; 1525-1578
    ISSN (online) 1943-7811
    ISSN 1525-1578
    DOI 10.1016/j.jmoldx.2024.01.005
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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Real-world practice patterns and outcomes for RAI-refractory differentiated thyroid cancer.

    Gianoukakis, Andrew G / Choe, Jennifer H / Bowles, Daniel W / Brose, Marcia S / Wirth, Lori J / Owonikoko, Taofeek / Babajanyan, Svetlana / Worden, Francis P

    European thyroid journal

    2024  Volume 13, Issue 1

    Abstract: Background: The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes in ... ...

    Abstract Background: The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes in asymptomatic patients with progressive RAI-R DTC (≥1 lesion ≥1 cm in diameter) in the USA (US population) and outside the USA (non-US population).
    Methods: In this prospective, non-interventional, open-label study, eligible patients were chosen by treating physicians to receive MKI therapy (cohort 1) or undergo active surveillance (cohort 2) at study entry. Cohort 2 patients were allowed to transition to MKI therapy later. The primary endpoint was time to symptomatic progression (TTSP) from study entry. Data were compared descriptively. When endpoints were inestimable, 36-month rates were calculated.
    Results: Of the 647 patients, 478 underwent active surveillance (cohort 2) and 169 received MKI treatment (cohort 1). Patients underwent surveillance at a higher rate in the US (92.6%) vs the non-US (66.9%) populations. Half of US and non-US patients who qualified for MKI treatment had initial American Thyroid Association (ATA) low-to-intermediate-risk disease. In cohort 2, the 36-month TTSP rates from study entry were 65.6% and 66.5% in the US and non-US populations, respectively. Cohort 2 patients treated later demonstrated 36-month TTSP rates of 30.8% and 55.8% in the US and non-US populations, respectively.
    Conclusions: Active surveillance is a viable option for asymptomatic patients with progressive RAI-R DTC. However, early intervention with MKI therapy may be more suitable for others. Further research is needed to identify patients who are optimal for active surveillance.
    Registration: NCT02303444.
    MeSH term(s) Humans ; Thyroid Neoplasms/drug therapy ; Treatment Outcome ; Iodine Radioisotopes/therapeutic use ; Prospective Studies ; Adenocarcinoma/chemically induced
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2659767-6
    ISSN 2235-0802 ; 2235-0640
    ISSN (online) 2235-0802
    ISSN 2235-0640
    DOI 10.1530/ETJ-23-0039
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  5. Book ; Online: Thermodynamic selection

    Babajanyan, S. G. / Koonin, E. V. / Allahverdyan, A. E.

    mechanisms and scenarios

    2022  

    Abstract: ... The agents can apply different work-extracting, game-theoretical strategies, e.g. the maximum power or ...

    Abstract Thermodynamic selection is an indirect competition between agents feeding on the same energy resource and obeying the laws of thermodynamics. We examine scenarios of this selection, where the agent is modeled as a heat-engine coupled to two thermal baths and extracting work from the high-temperature bath. The agents can apply different work-extracting, game-theoretical strategies, e.g. the maximum power or the maximum efficiency. They can also have a fixed structure or be adaptive. Depending on whether the resource (i.e. the high-temperature bath) is infinite or finite, the fitness of the agent relates to the work-power or the total extracted work. These two selection scenarios lead to increasing or decreasing efficiencies of the work-extraction, respectively. The scenarios are illustrated via plant competition for sunlight, and the competition between different ATP production pathways. We also show that certain general concepts of game-theory and ecology--the prisoner's dilemma and the maximal power principle--emerge from the thermodynamics of competing agents. We emphasize the role of adaptation in developing efficient work-extraction mechanisms.

    Comment: 14+10 pages, several figures
    Keywords Condensed Matter - Statistical Mechanics ; Physics - Biological Physics ; Quantitative Biology - Populations and Evolution
    Subject code 612
    Publishing date 2022-03-19
    Publishing country us
    Document type Book ; Online
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  6. Article ; Online: Age-structured SIR model and resource growth dynamics: A preliminary COVID-19 study

    Babajanyan, S. G. / Cheong, Kang Hao

    medRxiv

    Abstract: In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be ... ...

    Abstract In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be infected again. Available resource dynamics is governed by the well-known logistic growth model, in which the reproduction coefficient depends on the disease outbreak spreading dynamics. We further investigate the feedback interaction of the disease spread dynamics and resource growth dynamics with the premise that the quality of treatment depends on the current economic situation. The very inclusion of mortality rates and economic considerations in the same model may be incongruous under certain positions, but in this model, we take a 9realpolitik9 approach by exploring all of these factors together as it is done in reality.
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.07.20184887
    Database COVID19

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  7. Article ; Online: Age-structured SIR model and resource growth dynamics: A preliminary COVID-19 study

    Babajanyan, S. G. / Cheong, K. H.

    Abstract: In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be ... ...

    Abstract In this paper, we discuss three different response strategies to a disease outbreak and their economic implications in an age-structured population. We have utilized the classical age structured SIR-model, thus assuming that recovered people will not be infected again. Available resource dynamics is governed by the well-known logistic growth model, in which the reproduction coefficient depends on the disease outbreak spreading dynamics. We further investigate the feedback interaction of the disease spread dynamics and resource growth dynamics with the premise that the quality of treatment depends on the current economic situation. The very inclusion of mortality rates and economic considerations in the same model may be incongruous under certain positions, but in this model, we take a 'realpolitik' approach by exploring all of these factors together as it is done in reality.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.09.07.20184887
    Database COVID19

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  8. Article: Cooperate or Not Cooperate in Predictable but Periodically Varying Situations? Cooperation in Fast Oscillating Environment.

    Babajanyan, S G / Lin, Wayne / Cheong, Kang Hao

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 21, Page(s) 2001995

    Abstract: In this work, the cooperation problem between two populations in a periodically varying environment is discussed. In particular, the two-population prisoner's dilemma game with periodically oscillating payoffs is discussed, such that the time-average of ... ...

    Abstract In this work, the cooperation problem between two populations in a periodically varying environment is discussed. In particular, the two-population prisoner's dilemma game with periodically oscillating payoffs is discussed, such that the time-average of these oscillations over the period of environmental variations vanishes. The possible overlaps of these oscillations generate completely new dynamical effects that drastically change the phase space structure of the two-population evolutionary dynamics. Due to these effects, the emergence of some level of cooperators in both populations is possible under certain conditions on the environmental variations. In the domain of stable coexistence the dynamics of cooperators in each population form stable cycles. Thus, the cooperators in each population promote the existence of cooperators in the other population. However, the survival of cooperators in both populations is not guaranteed by a large initial fraction of them.
    Language English
    Publishing date 2020-09-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202001995
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  9. Article: Can Environmental Manipulation Help Suppress Cancer? Non-Linear Competition Among Tumor Cells in Periodically Changing Conditions.

    Babajanyan, S G / Koonin, Eugene V / Cheong, Kang Hao

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 16, Page(s) 2000340

    Abstract: It has been shown that the tumor population growth dynamics in a periodically varying environment can drastically differ from the one in a fixed environment. Thus, the environment of a tumor can potentially be manipulated to suppress cancer progression. ... ...

    Abstract It has been shown that the tumor population growth dynamics in a periodically varying environment can drastically differ from the one in a fixed environment. Thus, the environment of a tumor can potentially be manipulated to suppress cancer progression. Diverse evolutionary processes play vital roles in cancer progression and accordingly, understanding the interplay between these processes is essential in optimizing the treatment strategy. Somatic evolution and genetic instability result in intra-tumor cell heterogeneity. Various models have been developed to analyze the interactions between different types of tumor cells. Here, models of density-dependent interaction between different types of tumor cells under fast periodical environmental changes are examined. It is illustrated that tumor population densities, which vary on a slow time scale, are affected by fast environmental variations. Finally, the intriguing density-dependent interactions in metastatic castration-resistant prostate cancer (mCRPC) in which the different types of tumor cells are defined with respect to the production of and dependence on testosterone are discussed.
    Language English
    Publishing date 2020-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202000340
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  10. Article ; Online: Cooperate or Not Cooperate in Predictable but Periodically Varying Situations? Cooperation in Fast Oscillating Environment

    S. G. Babajanyan / Wayne Lin / Kang Hao Cheong

    Advanced Science, Vol 7, Iss 21, Pp n/a-n/a (2020)

    2020  

    Abstract: Abstract In this work, the cooperation problem between two populations in a periodically varying environment is discussed. In particular, the two‐population prisoner's dilemma game with periodically oscillating payoffs is discussed, such that the time‐ ... ...

    Abstract Abstract In this work, the cooperation problem between two populations in a periodically varying environment is discussed. In particular, the two‐population prisoner's dilemma game with periodically oscillating payoffs is discussed, such that the time‐average of these oscillations over the period of environmental variations vanishes. The possible overlaps of these oscillations generate completely new dynamical effects that drastically change the phase space structure of the two‐population evolutionary dynamics. Due to these effects, the emergence of some level of cooperators in both populations is possible under certain conditions on the environmental variations. In the domain of stable coexistence the dynamics of cooperators in each population form stable cycles. Thus, the cooperators in each population promote the existence of cooperators in the other population. However, the survival of cooperators in both populations is not guaranteed by a large initial fraction of them.
    Keywords dynamical systems ; game theory ; nonlinear dynamics ; population dynamics ; prisoner's dilemma ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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