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  1. Article: Putting evo-devo into focus. An interview with Scott F. Gilbert. Interview by Alexander T. Mikhailov.

    Gilbert, Scott F

    The International journal of developmental biology

    2005  Volume 49, Issue 1, Page(s) 9–16

    Abstract: This article announces Dr. Scott F. Gilbert as the winner of the Alexander Kowavelsky international ... prize (2004) and briefly reviews his achievements in developmental biology and evo-devo. Dr. Gilbert ...

    Abstract This article announces Dr. Scott F. Gilbert as the winner of the Alexander Kowavelsky international prize (2004) and briefly reviews his achievements in developmental biology and evo-devo. Dr. Gilbert replies to the interviewer's questions concerning his personal interest in evo-devo and current controversies within the field. His thoughts and comments represent a unique blend of research talents and skills, curiosity and creativity.
    MeSH term(s) Awards and Prizes ; Biological Evolution ; Developmental Biology
    Language English
    Publishing date 2005
    Publishing country Spain
    Document type Interview
    ZDB-ID 1036070-0
    ISSN 1696-3547 ; 0214-6282
    ISSN (online) 1696-3547
    ISSN 0214-6282
    DOI 10.1387/ijdb.041972am
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online ; E-Book: Evolutionary developmental biology

    Gilbert, Scott F.

    2021  

    Author's details edited by Scott F. Gilbert
    Keywords Evolutionary developmental biology
    Subject code 571.8
    Language English
    Size 1 online resource (454 pages) :, illustrations
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-814969-8 ; 0-12-814968-X ; 978-0-12-814969-0 ; 978-0-12-814968-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Prelude to molecularization: The double gradient model of Sulo Toivonen and Lauri Saxén.

    Gilbert, Scott F

    Cells & development

    2023  Volume 177, Page(s) 203884

    Abstract: The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most prominent of these ... ...

    Abstract The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most prominent of these connections is the dual gradient model for anterior-posterior and dorsal-ventral polarity. This paper will discuss some of the history of how transplantation experiments provided data that could be interpreted in terms of two gradients of biologically active materials. It will highlight how the attempts to discover the elusive Induktionsstoffen gave rise to the double gradient model of Sulo Toivonen and Lauri Saxén in the 1950s and 1960s. This paper will also document how this research into the identity of these molecules gave rise to the developmental genetics that eventually would find the molecules responsible for primary embryonic induction.
    MeSH term(s) Organizers, Embryonic ; Embryonic Induction
    Language English
    Publishing date 2023-11-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2667-2901
    ISSN (online) 2667-2901
    DOI 10.1016/j.cdev.2023.203884
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  4. Article ; Online: Preface.

    Gilbert, Scott F

    Current topics in developmental biology

    2021  Volume 141, Page(s) xiii–xxiii

    MeSH term(s) Animals ; Biological Evolution ; Chordata ; Decapodiformes ; Developmental Biology ; Gene Regulatory Networks ; Genetics, Population ; Hydra ; Neural Crest ; Sea Urchins ; Vertebrates/embryology ; Wings, Animal
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/S0070-2153(21)00011-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Systemic racism, systemic sexism, and the embryological enterprise.

    Gilbert, Scott F

    Developmental biology

    2021  Volume 473, Page(s) 97–104

    Abstract: The core of systemic racism and sexism is not merely an emphasis about human differences and thinking that another group of people is inferior to one's own. Rather, the institutional nature of racism or sexism establishes a permanent group hierarchy that ...

    Abstract The core of systemic racism and sexism is not merely an emphasis about human differences and thinking that another group of people is inferior to one's own. Rather, the institutional nature of racism or sexism establishes a permanent group hierarchy that is believed to reflect the laws of nature or the decrees of God. It thus becomes the norm of a culture to think and behave according to these rules. Notions of hierarchy became solidified into the Great Chain of Being during the Middle Ages, as did views concerning hereditary racial and gender superiority. During the Enlightenment, such classifications became established by philosophy and science. Starting in the 1800s, embryology and anthropology were used to provide evidence for the unilinear progression of species and races. The first evolutionary schemes were not "branching trees." In these schemes, women and non-white races were seen as embryonic or juvenile forms of the adult white male, and they were often depicted as intermediaries between the fully human and the animals. Such linear schemes of evolution remain part of popular culture and even some science, promoting the racism and sexism associated with them.
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 508: Show issues Location:
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  6. Article ; Online: Evolutionary developmental biology and sustainability: A biology of resilience.

    Gilbert, Scott F

    Evolution & development

    2021  Volume 23, Issue 4, Page(s) 273–291

    Abstract: Evolutionary developmental biology, and especially ecological developmental biology, is essential for discussions of sustainability and the responses to global climate change. First, this paper explores examples of animals that have successfully altered ... ...

    Abstract Evolutionary developmental biology, and especially ecological developmental biology, is essential for discussions of sustainability and the responses to global climate change. First, this paper explores examples of animals that have successfully altered their development to accommodate human-made changes to their environments. We next document the ability of global warming to disrupt the development of those organisms with temperature-dependent sex-determination or with phenologies coordinating that organism's development with those of other species. The thermotolerance of Homo sapiens is also related to key developmental factors concerning brain development and maintenance, and the development of corals, the keystone organisms of tropical reefs, is discussed in relation to global warming as well as to other anthropogenic changes. While teratogenic and endocrine-disrupting compounds are not discussed in this essay, the ability of glyphosate herbicides to block insect development is highlighted. Last, the paper discusses the need to creatively integrate developmental biology with ecological, political, religious, and economic perspectives, as the flourishing of contemporary species may require altering the ways that Western science has considered the categories of nature, culture, and self.
    MeSH term(s) Animals ; Anthozoa ; Biological Evolution ; Biology ; Developmental Biology ; Temperature
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020288-X
    ISSN 1525-142X ; 1520-541X
    ISSN (online) 1525-142X
    ISSN 1520-541X
    DOI 10.1111/ede.12366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Symbiosis of disciplines: how can developmental biologists join conservationists in sustaining and restoring earth's biodiversity?

    Gilbert, Scott F / Hadfield, Michael G

    Development (Cambridge, England)

    2022  Volume 149, Issue 13

    Abstract: What can developmental biology contribute toward mitigating the consequences of anthropogenic assaults on the environment and climate change? In this Spotlight article, we advocate a developmental biology that takes seriously Lynn Margulis' claim that ' ... ...

    Abstract What can developmental biology contribute toward mitigating the consequences of anthropogenic assaults on the environment and climate change? In this Spotlight article, we advocate a developmental biology that takes seriously Lynn Margulis' claim that 'the environment is part of the body'. We believe this to be a pre-condition for developmental biology playing important roles in conservation and environmental restoration. We need to forge a developmental biology of the holobiont - the multi-genomic physiologically integrated organism that is also a functional biome. To this end, we highlight how developmental biology needs to explore more deeply the interactions between developing organisms, and their chemical, physical and biotic environments.
    MeSH term(s) Biodiversity ; Ecosystem ; Genomics ; Symbiosis
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.199960
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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Evolutionary transitions revisited: Holobiont evo-devo.

    Gilbert, Scott F

    Journal of experimental zoology. Part B, Molecular and developmental evolution

    2019  Volume 332, Issue 8, Page(s) 307–314

    Abstract: John T. Bonner lists four essential transformations in the evolution of life: the emergence of the eukaryotic cell, meiosis, multicellularity, and the nervous system. This paper analyses the mechanisms for those transitions in light of three of Dr. ... ...

    Abstract John T. Bonner lists four essential transformations in the evolution of life: the emergence of the eukaryotic cell, meiosis, multicellularity, and the nervous system. This paper analyses the mechanisms for those transitions in light of three of Dr. Bonner's earlier hypotheses: (a) that the organism is its life cycle, (b) that evolution consists of alterations of the life cycle, and (c) that development extends beyond the body and into interactions with other organisms. Using the notion of the holobiont life cycle, this paper attempts to show that these evolutionary transitions can be accomplished through various means of symbiosis. Perceiving the organism both as an interspecies consortium and as a life cycle supports a twofold redefinition of the organism as a holobiont constructed by integrating together the life cycles of several species. These findings highlight the importance of symbiosis and the holobiont development in analyses of evolution.
    MeSH term(s) Animals ; Biological Evolution ; Developmental Biology ; Host Microbial Interactions ; Life Cycle Stages ; Microbiota ; Symbiosis
    Language English
    Publishing date 2019-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2103823-5
    ISSN 1552-5015 ; 0022-104X ; 1552-5007
    ISSN (online) 1552-5015
    ISSN 0022-104X ; 1552-5007
    DOI 10.1002/jez.b.22903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2003/701: Show issues

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  9. Article ; Online: Developmental symbiosis facilitates the multiple origins of herbivory.

    Gilbert, Scott F

    Evolution & development

    2019  Volume 22, Issue 1-2, Page(s) 154–164

    Abstract: Developmental bias toward particular evolutionary trajectories can be facilitated through symbiosis. Organisms are holobionts, consisting of zygote-derived cells and a consortia of microbes, and the development, physiology, and immunity of animals are ... ...

    Abstract Developmental bias toward particular evolutionary trajectories can be facilitated through symbiosis. Organisms are holobionts, consisting of zygote-derived cells and a consortia of microbes, and the development, physiology, and immunity of animals are properties of complex interactions between the zygote-derived cells and microbial symbionts. Such symbionts can be agents of developmental plasticity, allowing an organism to develop in particular directions. This plasticity can lead to genetic assimilation either through the incorporation of microbial genes into host genomes or through the direct maternal transmission of the microbes. Such plasticity can lead to niche construction, enabling the microbes to remodel host anatomy and/or physiology. In this article, I will focus on the ability of symbionts to bias development toward the evolution of herbivory. I will posit that the behavioral and morphological manifestations of herbivorous phenotypes must be preceded by the successful establishment of a community of symbiotic microbes that can digest cell walls and detoxify plant poisons. The ability of holobionts to digest plant materials can range from being a plastic trait, dependent on the transient incorporation of environmental microbes, to becoming a heritable trait of the holobiont organism, transmitted through the maternal propagation of symbionts or their genes.
    MeSH term(s) Animals ; Biological Evolution ; Herbivory ; Invertebrates/growth & development ; Life History Traits ; Phenotype ; Symbiosis ; Vertebrates/growth & development
    Language English
    Publishing date 2019-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2020288-X
    ISSN 1525-142X ; 1520-541X
    ISSN (online) 1525-142X
    ISSN 1520-541X
    DOI 10.1111/ede.12291
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  10. Article ; Online: Platinum(IV) Prodrugs Incorporating an Indole-Based Derivative, 5-Benzyloxyindole-3-Acetic Acid in the Axial Position Exhibit Prominent Anticancer Activity.

    Aputen, Angelico D / Elias, Maria George / Gilbert, Jayne / Sakoff, Jennette A / Gordon, Christopher P / Scott, Kieran F / Aldrich-Wright, Janice R

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Kinetically inert platinum(IV) complexes are a chemical strategy to overcome the impediments of standard platinum(II) antineoplastic drugs like cisplatin, oxaliplatin and carboplatin. In this study, we reported the syntheses and structural ... ...

    Abstract Kinetically inert platinum(IV) complexes are a chemical strategy to overcome the impediments of standard platinum(II) antineoplastic drugs like cisplatin, oxaliplatin and carboplatin. In this study, we reported the syntheses and structural characterisation of three platinum(IV) complexes that incorporate 5-benzyloxyindole-3-acetic acid, a bioactive ligand that integrates an indole pharmacophore. The purity and chemical structures of the resultant complexes,
    MeSH term(s) Humans ; Cisplatin/pharmacology ; Platinum/chemistry ; Oxaliplatin/pharmacology ; Carboplatin/pharmacology ; Carboplatin/chemistry ; Prodrugs/chemistry ; Cell Line, Tumor ; Antineoplastic Agents/chemistry ; Hydroxyindoleacetic Acid/analogs & derivatives
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Platinum (49DFR088MY) ; Oxaliplatin (04ZR38536J) ; Carboplatin (BG3F62OND5) ; 5-benzyloxyindole-3-acetic acid (4382-53-0) ; Prodrugs ; Antineoplastic Agents ; Hydroxyindoleacetic Acid (54-16-0)
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042181
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