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Article ; Online: Opportunistic Elizabethkingia miricola Infections in Intensive Care Unit, Spain.

Soler-Iborte, Eva / Rivera-Izquierdo, Mario / Valero-Ubierna, Carmen

2024 Volume 30, Issue 4, Page(s) 834–837

Abstract: In 2021, we identified a cluster of Elizabethkingia miricola cases in an intensive care unit in Spain. Because E. miricola is not considered a special surveillance agent in Spain, whole-genome sequencing was not performed. The bacterial source was not ... ...

Abstract	In 2021, we identified a cluster of Elizabethkingia miricola cases in an intensive care unit in Spain. Because E. miricola is not considered a special surveillance agent in Spain, whole-genome sequencing was not performed. The bacterial source was not identified. All Elizabethkingia species should be listed as special surveillance bacteria.
MeSH term(s)	Humans ; Spain/epidemiology ; Intensive Care Units ; Opportunistic Infections ; Whole Genome Sequencing ; Flavobacteriaceae
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3004.231491
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Article ; Online: Benefits for cardiovascular system, bone density, and quality of life of a long-term hormone therapy in hysterectomized women: a 20-year follow-up study.

Lorite, Maria Isabel / Cuadros, Angela Maria / Rivera-Izquierdo, Mario / Sanchez-Martin, Victoria / Cuadros, Marta

Menopause (New York, N.Y.)

2023 Volume 30, Issue 10, Page(s) 995–1001

Abstract: Objective: The safety, consequences, and dosage of long-term hormone therapy (HT) for postmenopausal women remain unclear. Our aim was to analyze the effects of HT after 20 years of therapy in women after hysterectomy, focusing on the symptoms of ... ...

Abstract	Objective: The safety, consequences, and dosage of long-term hormone therapy (HT) for postmenopausal women remain unclear. Our aim was to analyze the effects of HT after 20 years of therapy in women after hysterectomy, focusing on the symptoms of menopause, blood pressure, lipid profiles, and bone density. Methods: A prospective observational longitudinal study was designed. The initial transdermal estradiol dose was reduced in half (0.025 mg/d) at 60 years of age. Different parameters including demographic, cardiovascular, bone density, and metabolic variables, as well as quality of life characteristics, were analyzed using bivariate analyses. Multivariate generalized estimating equations for longitudinal data were fitted for differences over time and between doses (<60 vs ≥60 y) using the R package geepack. Results: After 20 years of HT, the mean age of 56 studied hysterectomized women was 67.1 years. The mean Kupperman index score decreased from 26.7 to 12.0 ( P < 0.001). A trend with total and low-density lipoprotein cholesterol reduction and high-density lipoprotein cholesterol increase was observed over time. A decrease in very-low-density lipoprotein cholesterol ( P = 0.05) and an increase in T score vertebral densitometry ( P = 0.014) were detected after HT. No changes in health outcome were detected in women older than 60 years with the reduced dose of HT. Breast cancer was the reason for dropouts in 0.02% women. Conclusions: HT for up to 20 years after hysterectomy may be beneficial for bone and cardiovascular health and for the overall quality of life. Our data suggest the importance of evaluating the dose and the timing of HT.
MeSH term(s)	Female ; Humans ; Middle Aged ; Male ; Bone Density ; Follow-Up Studies ; Quality of Life ; Longitudinal Studies ; Cardiovascular System ; Cholesterol, HDL ; Estradiol
Chemical Substances	Cholesterol, HDL ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000002239
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Zs.A 4111: Show issues

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Article ; Online: Recommendations on Weight Loss and Healthy Lifestyle in Prostate Cancer Clinical Guidelines: A Systematic Review.

Rivera-Izquierdo, Mario / Martínez-Ruiz, Virginia / Jiménez-Moleón, José Juan

International journal of environmental research and public health

2022 Volume 19, Issue 3

Abstract: Obesity is associated with negative prostate cancer outcomes (e.g., specific mortality, all-cause mortality, biochemical recurrence, etc.), according to the current scientific literature. Nevertheless, recommendations on weight loss and healthy ... ...

Abstract	Obesity is associated with negative prostate cancer outcomes (e.g., specific mortality, all-cause mortality, biochemical recurrence, etc.), according to the current scientific literature. Nevertheless, recommendations on weight loss and healthy lifestyles are poorly covered by clinicians. We aimed at identifying these recommendations from clinical practice guidelines (CPGs) for prostate cancer. We systematically searched MEDLINE, EMBASE, Web of Science, Scopus, guideline databases and online sources for CPGs updated from January 2015 to August 2021. The searches were independently conducted by two researchers, without language restrictions. A total of 97 prostate cancer guidelines, including 84 (86.6%) CPGs and 13 (13.4%) consensus statements, were included. Recommendations on reaching and maintaining a healthy weight or healthy lifestyles were provided by 7 (7.2%) and 13 (13.4%) documents, respectively. No differences regarding recommendations were found by type of document, year of publication or country. Our results suggest that professional societies and governments should update prostate cancer guidelines to include these recommendations for improving prostate cancer prognosis.
MeSH term(s)	Consensus ; Databases, Factual ; Healthy Lifestyle ; Humans ; Male ; Prostatic Neoplasms/prevention & control ; Weight Loss
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19031452
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Article ; Online: Recommendations on Weight Loss and Healthy Lifestyle in Prostate Cancer Clinical Guidelines

Mario Rivera-Izquierdo / Virginia Martínez-Ruiz / José Juan Jiménez-Moleón

International Journal of Environmental Research and Public Health, Vol 19, Iss 1452, p

A Systematic Review

2022 Volume 1452

Abstract	Obesity is associated with negative prostate cancer outcomes (e.g., specific mortality, all-cause mortality, biochemical recurrence, etc.), according to the current scientific literature. Nevertheless, recommendations on weight loss and healthy lifestyles are poorly covered by clinicians. We aimed at identifying these recommendations from clinical practice guidelines (CPGs) for prostate cancer. We systematically searched MEDLINE, EMBASE, Web of Science, Scopus, guideline databases and online sources for CPGs updated from January 2015 to August 2021. The searches were independently conducted by two researchers, without language restrictions. A total of 97 prostate cancer guidelines, including 84 (86.6%) CPGs and 13 (13.4%) consensus statements, were included. Recommendations on reaching and maintaining a healthy weight or healthy lifestyles were provided by 7 (7.2%) and 13 (13.4%) documents, respectively. No differences regarding recommendations were found by type of document, year of publication or country. Our results suggest that professional societies and governments should update prostate cancer guidelines to include these recommendations for improving prostate cancer prognosis.
Keywords	clinical guidelines ; consensus statement ; prostate cancer ; obesity ; mortality ; body weight ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Nosocomial Bacteraemia Caused by Acinetobacter ursingii in Neonatology Critical Care Unit in Spain: A Rising Challenge.

Rivera-Izquierdo, Mario / Valero-Ubierna, Carmen / Masso-Guijarro, Paloma

The Pediatric infectious disease journal

2020 Volume 39, Issue 3, Page(s) e28–e29

MeSH term(s)	Acinetobacter ; Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology ; Communicable Diseases, Emerging ; Critical Care/methods ; Critical Care/statistics & numerical data ; Cross Infection ; Humans ; Infant ; Infant, Newborn ; Intensive Care, Neonatal/methods ; Intensive Care, Neonatal/statistics & numerical data ; Premature Birth ; Spain/epidemiology
Language	English
Publishing date	2020-02-06
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002562
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Zs.A 1852: Show issues

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Article ; Online: Cycling area can be a confounder and effect modifier of the association between helmet use and cyclists' risk of death after a crash.

Molina-Soberanes, Daniel / Martínez-Ruiz, Virginia / Gordo, Daniel Águila / Martín-delosReyes, Luis Miguel / Rivera-Izquierdo, Mario / Lardelli-Claret, Pablo

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3157

Abstract: The effect of helmet use on reducing the risk of death in cyclists appears to be distorted by some variables (potential confounders, effect modifiers, or both). Our aim was to provide evidence for or against the hypothesis that cycling area may act as a ... ...

Abstract	The effect of helmet use on reducing the risk of death in cyclists appears to be distorted by some variables (potential confounders, effect modifiers, or both). Our aim was to provide evidence for or against the hypothesis that cycling area may act as a confounder and effect modifier of the association between helmet use and risk of death of cyclists involved in road crashes. Data were analysed for 24,605 cyclists involved in road crashes in Spain. A multiple imputation procedure was used to mitigate the effect of missing values. We used multilevel Poisson regression with province as the group level to estimate the crude association between helmet use and risk of death, and also three adjusted analyses: (1) for cycling area only, (2) for the remaining variables which may act as confounders, and (3) for all variables. Incidence-density ratios (IDR) and their 95% confidence intervals were calculated. Crude IDR was 1.10, but stratifying by cycling area disclosed a protective, differential effect of helmet use: IDR = 0.67 in urban areas, IDR = 0.34 on open roads. Adjusting for all variables except cycling area yielded similar results in both strata, albeit with a smaller difference between them. Adjusting for cycling area only yielded a strong association (IDR = 0.42), which was slightly lower in the adjusted analysis for all variables (IDR = 0.45). Cycling area can act as a confounder and also appears to act as an effect modifier (albeit to a lesser extent) of the risk of cyclists' death after a crash.
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07135-1
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Article ; Online: Addressing the association between driving with an expired vehicle inspection certificate and injury severity after a crash.

Martín-delosReyes, Luis Miguel / Martínez-Ruiz, Virginia / Rivera-Izquierdo, Mario / Jiménez-Mejías, Eladio / Pulido-Manzanero, José / Lardelli-Claret, Pablo

Traffic injury prevention

2022 Volume 23, Issue 4, Page(s) 159–162

Abstract: Objectives: The aim of this study was to quantify the association between driving a vehicle with an expired vehicle inspection certificate (DEVIC) and the severity of injuries sustained by drivers involved in collisions.: Methods: A cohort study was ... ...

Abstract	Objectives: The aim of this study was to quantify the association between driving a vehicle with an expired vehicle inspection certificate (DEVIC) and the severity of injuries sustained by drivers involved in collisions. Methods: A cohort study was designed to compare the incidence of minor injuries, major injuries, and deaths between DEVIC and non-DEVIC drivers involved in collisions. We selected all 51,305 non-responsible drivers (i.e., drivers who did not commit an error or infraction) involved in clean collisions (those in which only one driver in multivehicle collisions committed a traffic infraction or error) from the population of drivers of four-wheeled motor vehicles involved in crashes recorded in the National Register for Road Traffic Accident Victims in Spain from 2014 to 2017. Results: DEVIC was not related with a greater severity of drivers' injuries. The adjusted estimates for the association between DEVIC and major injuries or death yielded an odds ratio of 0.91 (0.66-1.25), compared to no injuries or minor injuries, and a relative risk ratio of 0.90 (0.65-1.24) compared to no injuries. Conclusions: Although we have not found an association between DEVIC and drivers' injury severity, the study limitations does not allow us to discard the usefulness of periodic vehicle inspection in reducing the risk of more severe injury among drivers involved in road crashes.
MeSH term(s)	Accidents, Traffic ; Automobile Driving ; Cohort Studies ; Humans ; Motor Vehicles ; Risk Factors ; Spain/epidemiology ; Wounds and Injuries/epidemiology
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2022.2045587
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Zs.A 6253: Show issues

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Article ; Online: Obesity and biochemical recurrence in clinically localised prostate cancer: a systematic review and meta-analysis of 86,490 patients.

Rivera-Izquierdo, Mario / Pérez de Rojas, Javier / Martínez-Ruiz, Virginia / Arrabal-Polo, Miguel Ángel / Pérez-Gómez, Beatriz / Jiménez-Moleón, José Juan

Prostate cancer and prostatic diseases

2022 Volume 25, Issue 3, Page(s) 411–421

Abstract: Background: The association of obesity with biochemical recurrence (BCR) after treatment of clinically localised prostate cancer (PC) shows inconsistent results. Our aim was to systematically review all evidence evaluating obesity as a prognostic factor ...

Abstract	Background: The association of obesity with biochemical recurrence (BCR) after treatment of clinically localised prostate cancer (PC) shows inconsistent results. Our aim was to systematically review all evidence evaluating obesity as a prognostic factor for BCR. Methods: We searched PubMed, Web of Science and Scopus, from inception to June 1, 2021. Cohort studies reporting BCR among PC patients stratified by body mass index (BMI) were included. To assess the quality of the selected studies, we used the Newcastle-Ottawa scale (NOS). Risk of BCR among obese patients (BMI ≥ 30 kg/m Results: We identified 46 cohort studies including 86,490 PC patients. A total of 14,719 (17.1%) patients developed BCR. There was no consistent definition of BCR. Obesity was associated with BCR (HR: 1.25, 95% CI: 1.11-1.39, I Conclusions: Obesity showed a moderate, consistent relationship with biochemical recurrence after radical prostatectomy. Measurement of BMI and BCR was variable, highlighting the need for standardised clinical guidelines. Preventive weight control programs may have a role in reducing BCR for clinically localised PC patients.
MeSH term(s)	Body Mass Index ; Humans ; Male ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/etiology ; Obesity/complications ; Obesity/epidemiology ; Proportional Hazards Models ; Prostatectomy/methods ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy
Language	English
Publishing date	2022-01-06
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-021-00481-7
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Zs.A 5277: Show issues

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Article ; Online: Prevalence and Risk Factors Associated with Tumors and Other Structural Anomalies in Brain MRI Performed to Rule out Secondary Headache: A Multicenter Observational Study.

Martínez Barbero, José Pablo / Láinez Ramos-Bossini, Antonio Jesús / Rivera-Izquierdo, Mario / Sendra-Portero, Francisco / Benítez-Sánchez, José Manuel / Cervilla, Jorge A

International journal of environmental research and public health

2022 Volume 19, Issue 6

Abstract: Headache disorders (HDs) are among the most common conditions of the central nervous system, with an estimated prevalence of 50% in adult population. The aim of this work is to analyze the prevalence of structural anomalies that may explain HDs in MRI ... ...

Abstract	Headache disorders (HDs) are among the most common conditions of the central nervous system, with an estimated prevalence of 50% in adult population. The aim of this work is to analyze the prevalence of structural anomalies that may explain HDs in MRI exams performed to rule out secondary headache in real-world practice, as well as risk factors associated with these lesions. We conducted a retrospective observational study based on a consecutive case series of all patients that underwent brain MRI due to headache from 1 January 2019 to 31 May 2019. We included patients from six MRI diagnostic centers accounting for four provinces of Andalusia (southern Spain). Bivariate and multivariate logistical regression models were performed to identify risk factors associated with the outcomes (1) presence of a structural finding potentially explaining headache, (2) presence of intracranial space-occupying lesions (SOLs), and (3) presence of intracranial tumors (ITs). Of the analyzed sample (1041 patients), a structural finding that could explain headache was found in 224 (21.5%) patients. SOLs were found in 50 (6.8%) patients and ITs in 12 (1.5%) patients. The main factors associated with structural abnormalities were female sex (OR, 1.35; 95% CI, 1.02-1.85), accompanying symptoms (OR, 1.34; 95% CI, 1.05-1.89), use of gadolinium-based contrast agents (OR, 1.89; 95% CI, 1.31-2.72) and previously known conditions potentially explaining headache (OR, 2.44; 95% CI, 1.55-3.84). Female sex (
MeSH term(s)	Adult ; Brain/diagnostic imaging ; Brain/pathology ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/epidemiology ; Female ; Headache/complications ; Headache/etiology ; Humans ; Magnetic Resonance Imaging/adverse effects ; Male ; Prevalence ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19063521
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Article ; Online: Improvement of intermediate vision with new monofocal intraocular lenses: A systematic review and meta-analysis.

Redruello-Guerrero, Pablo / Rivera-Izquierdo, Mario / Jiménez-Gutiérrez, Carmen / Láinez-Ramos-Bossini, Antonio Jesús / Yela, Rubén / López-Marín, Ignacio

European journal of ophthalmology

2022 Volume 33, Issue 3, Page(s) 1308–1319

Abstract: Purpose: Monofocal intraocular lenses (IOLs) used in cataract surgery are designed to improve visual acuity (VA). The available evidence of new monofocal IOLs" functional benefits is limited. The aim of this meta-analysis was to analyze the improvement ... ...

Abstract	Purpose: Monofocal intraocular lenses (IOLs) used in cataract surgery are designed to improve visual acuity (VA). The available evidence of new monofocal IOLs" functional benefits is limited. The aim of this meta-analysis was to analyze the improvement in VA using Tecnis Eyhance monofocal IOLs compared to standard monofocal IOLs Tecnis ZCB00. Methods: MEDLINE, Web of Science and Scopus were searched for studies assessing improvement in intermediate VA using Tecnis Eyhance IOLs versus Tecnis ZCB00 IOLs. Studies evaluating post-operative VA in patients who underwent cataract surgery were selected. This meta-analysis followed PRISMA guidelines and was registered in PROSPERO. The Cochrane Risk of Bias Tool 2.0. was used to assess the methodological quality of the included studies, risk of selection bias and comparability of cohorts and outcomes. Results: The search resulted in 1153 articles. Five studies met the inclusion criteria and were included in the meta-analysis. A total of 604 eyes were evaluated, of which 309 received Tecnis Eyhance IOLs and 295 were implanted with Tecnis ZCB00 IOLs. Mean binocular distant-corrected intermediate VA with Tecnis Eyhance IOLs at 2 weeks-1 month showed a significant difference of -0,21 logMAR, p < 0.001; and mean binocular distance-corrected intermediate VA with Tecnis Eyhance IOLs at 6 months showed a significant difference of -0,11 logMAR, p < 0.001. Conclusion: Near VA could not be assessed in this meta-analysis as it was measured in very few studies. Preliminary pooled evidence indicates that intermediate VA improved with Tecnis Eyhance IOLs. Further studies evaluating near VA and with longer follow-up are still necessary.
MeSH term(s)	Humans ; Prosthesis Design ; Lenses, Intraocular ; Vision, Ocular ; Cataract Extraction ; Cataract ; Phacoemulsification ; Patient Satisfaction
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221127075
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