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Article ; Online: A personal journey with matrix metalloproteinases.

Nagase, Hideaki

2016 Volume 397, Issue 9, Page(s) 805–813

Abstract: I was given the honor of delivering the 2015 Lifetime Membership Award lecture at the International Proteolysis Society's annual meeting held in Penang, Malaysia in October 2015. It gave me an opportunity to look back on how I started my research on ... ...

Abstract	I was given the honor of delivering the 2015 Lifetime Membership Award lecture at the International Proteolysis Society's annual meeting held in Penang, Malaysia in October 2015. It gave me an opportunity to look back on how I started my research on matrix metalloproteinases (MMPs) and how I continued to work on these proteinases for the next 42 years. This is a series of sketches from the personal journey that I took with MMPs, starting from the purification of metalloproteinases, cloning, structural studies, then to a more recent encounter, endocytic regulation of matrix-degrading metalloproteinases.
MeSH term(s)	Biochemistry/history ; Cartilage/enzymology ; Cloning, Molecular ; DNA, Complementary/genetics ; History, 20th Century ; History, 21st Century ; Humans ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinases/chemistry ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism
Chemical Substances	DNA, Complementary ; Matrix Metalloproteinase Inhibitors ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2016-09-01
Publishing country	Germany
Document type	Historical Article ; Journal Article
ZDB-ID	1334659-3
ISSN	1437-4315 ; 1431-6730 ; 1432-0355
ISSN (online)	1437-4315
ISSN	1431-6730 ; 1432-0355
DOI	10.1515/hsz-2016-0169
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Article ; Online: Frozen shoulder. An overview of pathology and biology with hopes to novel drug therapies.

Tamai, Kazuya / Hamada, Junichiro / Nagase, Yuichi / Morishige, Masahiko / Naito, Masashi / Asai, Hideaki / Tanaka, Sakae

Modern rheumatology

2023 Volume 34, Issue 3, Page(s) 439–443

Abstract: Frozen shoulder (FS) is a common disorder characterized by spontaneous onset of shoulder pain accompanied by progressive loss of range-of-motions. The cause of FS is still unclear, and radical therapy has not been established. With the final aim of ... ...

Abstract	Frozen shoulder (FS) is a common disorder characterized by spontaneous onset of shoulder pain accompanied by progressive loss of range-of-motions. The cause of FS is still unclear, and radical therapy has not been established. With the final aim of preventing or curing FS at an earlier stage, we reviewed the pathological and biological features of this disease. Many studies indicate that the main pathology of FS is inflammation initially and fibrosis later. There are inflammatory cytokines, immune cells, fibrotic growth factors, and type-III collagen in the synovium and the joint capsule. The immune cell landscape switches from the macrophages to T cells. Activated fibroblasts seem to regulate the inflammatory and fibrotic processes. The imbalance between matrix metalloproteinases and tissue inhibitors of metalloproteases might promote fibrosis. Additionally, advanced glycation end-products are noted in the FS synovium. Diabetes mellitus and hypothyroidism are closely related to the development of FS. In terms of nonsurgical treatment, oral or intra-articular glucocorticoids are the only drugs that provide early benefit. Some other anti-inflammatory or antifibrotic drugs may potentially control the FS, but have not been proven effective in the clinical setting. Future studies should be targeted to develop steroid-sparing agents that inhibit biological events in FS.
MeSH term(s)	Humans ; Bursitis/drug therapy ; Bursitis/metabolism ; Cytokines/metabolism ; Inflammation/pathology ; Fibrosis ; Biology ; Shoulder Joint/pathology
Chemical Substances	Cytokines
Language	English
Publishing date	2023-08-26
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/road087
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Article ; Online: Measurement of Protease Activities Using Fluorogenic Substrates.

Santamaria, Salvatore / Nagase, Hideaki

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1731, Page(s) 107–122

Abstract: Matrix metalloproteinases and the related metalloproteases are implicated in cancer progression. They are endopeptidases that require several defined amino acid residues in both N-terminal and C-terminal sides of the scissile bond. Fluorogenic Förster ... ...

Abstract	Matrix metalloproteinases and the related metalloproteases are implicated in cancer progression. They are endopeptidases that require several defined amino acid residues in both N-terminal and C-terminal sides of the scissile bond. Fluorogenic Förster resonance energy transfer (FRET) substrates that harbor a fluorophore and a quencher on opposite sides of the scissile bond are conveniently used to measure their activities. In this chapter, we describe the principle of FRET substrates and how to use them to measure activities and kinetic parameters of endopeptidases.
MeSH term(s)	ADAMTS4 Protein/analysis ; ADAMTS4 Protein/genetics ; ADAMTS4 Protein/metabolism ; Amino Acid Sequence ; Enzyme Assays/instrumentation ; Enzyme Assays/methods ; Fluorescence Resonance Energy Transfer/instrumentation ; Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Kinetics ; Mutation ; Proteolysis ; Recombinant Proteins/analysis ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity
Chemical Substances	Fluorescent Dyes ; Recombinant Proteins ; ADAMTS4 Protein (EC 3.4.24.82) ; ADAMTS4 protein, human (EC 3.4.24.82)
Language	English
Publishing date	2018-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7595-2_11
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Article ; Online: Retinal damage alters gene expression profile in lacrimal glands of mice.

Ohno, Yuta / Yako, Tomohiro / Satoh, Keitaro / Nagase, Haruna / Shitara, Akiko / Hara, Hideaki / Kashimata, Masanori

Journal of pharmacological sciences

2022 Volume 149, Issue 1, Page(s) 20–26

Abstract: Early detection of such retinal diseases as glaucoma and age-related macular degeneration (AMD) is important to prevent blindness. There have been reports of changes in some components in the tears of glaucoma and AMD patients, suggesting tears' ... ...

Abstract	Early detection of such retinal diseases as glaucoma and age-related macular degeneration (AMD) is important to prevent blindness. There have been reports of changes in some components in the tears of glaucoma and AMD patients, suggesting tears' potential usefulness in screening for retinal diseases. We hypothesized that retinal damage might alter gene expression in the lacrimal gland, leading to those changes in tear components. We caused retinal damage in mice by intravitreal injection of N-methyl-d-aspartate (NMDA) or excessive light exposure. Hematoxylin and eosin staining showed no histological changes in the lacrimal glands of animals whose retinas had been damaged. However, RNA sequencing of lacrimal glands on the 3rd day after NMDA injection or light exposure revealed changes in the expression of 491 genes (268 up-regulated; 223 down-regulated) in the NMDA group and 531 genes (311 up-regulated; 220 down-regulated) in the light group. Further gene-set enrichment analysis indicated that both types of retinal damage activated the immune system in the lacrimal glands. This is the first demonstration that retinal damage can alter gene expression in the lacrimal glands, and it might lead to a novel non-invasive screening method for early detection of retinal diseases.
MeSH term(s)	Animals ; Humans ; Intravitreal Injections ; Lacrimal Apparatus/metabolism ; Mice ; Retina ; Retinal Diseases/metabolism ; Transcriptome
Language	English
Publishing date	2022-02-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2022.02.007
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Article ; Online: Anti-Inflammatory Effects of Japanese Herbal Medicine Hochuekkito in a Mouse Model of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Fukuda, Kensuke / Matsuzaki, Hirotaka / Hiraishi, Yoshihisa / Miyashita, Naoya / Ishii, Takashi / Yuki, Masaaki / Isago, Hideaki / Tamiya, Hiroyuki / Mitani, Akihisa / Saito, Akira / Jo, Taisuke / Nagase, Takahide

Pharmacology

2024 Volume 109, Issue 2, Page(s) 121–126

Abstract: Introduction: The traditional Japanese herbal medicine hochuekkito (TJ-41) has been reported to ameliorate systemic inflammation and malnutrition in patients with chronic obstructive pulmonary disease (COPD). TJ-41 has also been known to have preventive ...

Abstract	Introduction: The traditional Japanese herbal medicine hochuekkito (TJ-41) has been reported to ameliorate systemic inflammation and malnutrition in patients with chronic obstructive pulmonary disease (COPD). TJ-41 has also been known to have preventive effects against influenza virus infection. However, its role in the acute exacerbation of COPD (AECOPD) remains to be elucidated. Our previous study established a murine model of viral infection-associated AECOPD that was induced by intratracheal administration of porcine pancreatic elastase (PPE) and polyinosinic-polycytidylic acid [poly(I:C)]. Here, we used this model and investigated the effects of TJ-41 in AECOPD. Methods: Specific pathogen-free C57BL/6J mice were used. A COPD model was induced by treating mice intratracheally with PPE on day 0. To generate the murine model of AECOPD, poly(I:C) was administered intratracheally following PPE treatment on days 22-24. Mice were sacrificed and analyzed on day 25. Mice were fed a diet containing 2% TJ-41 or a control diet. Results: Daily oral intake of TJ-41 significantly decreased the numbers of neutrophils and lymphocytes in the bronchoalveolar lavage fluid (BALF), which was accompanied by decreased transcripts of CXC chemokines involved in neutrophil migration, viz., Cxcl1 and Cxcl2, in whole lung homogenates and reduced Cxcl2 concentration in BALF. Conclusion: This study demonstrates the anti-inflammatory effects of TJ-41 in a mouse model of AECOPD, suggesting the effectiveness of TJ-41 for the management of COPD. Clinical investigations evaluating the therapeutic efficacy of TJ-41 in AECOPD would be meaningful.
MeSH term(s)	Humans ; Mice ; Animals ; Swine ; Disease Models, Animal ; Japan ; Mice, Inbred C57BL ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/complications ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	bu-zhong-yi-qi-tang ; Drugs, Chinese Herbal ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	News
ZDB-ID	206671-3
ISSN	1423-0313 ; 0031-7012
ISSN (online)	1423-0313
ISSN	0031-7012
DOI	10.1159/000536348
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Article ; Online: Predictive correction of serum sodium concentration with formulas derived from the Edelman equation in patients with severe hyponatremia.

Nagase, Koya / Watanabe, Tsuyoshi / Nomura, Akihiro / Nagase, Fumika N / Iwasaki, Keita / Nakamura, Yoshihiro / Ikai, Hiroki / Yamamoto, Mari / Murai, Yukari / Yokoyama-Kokuryo, Waka / Takizawa, Naoho / Shimizu, Hideaki / Fujita, Yoshiro

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1783

Abstract: Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection can result in osmotic demyelination. This study investigated potential factors, including predictive ...

Abstract	Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection can result in osmotic demyelination. This study investigated potential factors, including predictive correction based on the Edelman equation, associated with appropriate correction in 221 patients with a serum sodium concentration ≤ 120 mEq/L who were admitted to a hospital in Nagoya, Japan. Appropriate correction was defined as an elevation in serum sodium concentration in the range of 4-10 mEq/L in the first 24 h and within 18 mEq/L in the first 48 h after the start of the correction. Appropriate corrections were made in 132 (59.7%) of the 221 patients. Multivariate analysis revealed that predictive correction with an infusate and fluid loss formula derived from the Edelman equation was associated with appropriate correction of serum sodium concentration (adjusted odds ratio, 7.84; 95% confidence interval, 2.97-20.64). Relative without its use, the predictive equation results in a lower proportion of undercorrection (14.3% vs. 48.0%, respectively) and overcorrection (1.0% vs. 12.2%, respectively). These results suggest that predictive correction of serum sodium concentrations using the formula derived from the Edelman equation can play an essential role in the appropriate management of patients with severe hyponatremia.
MeSH term(s)	Humans ; Behavior Therapy ; Brain Edema ; Hyponatremia/therapy ; Sodium
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28380-y
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Article ; Online: ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α

Kadurin, Ivan / Dahimene, Shehrazade / Page, Karen M / Ellaway, Joseph I J / Chaggar, Kanchan / Troeberg, Linda / Nagase, Hideaki / Dolphin, Annette C

Function (Oxford, England)

2022 Volume 3, Issue 3, Page(s) zqac013

Abstract: The auxiliary ... ...

Abstract	The auxiliary α
MeSH term(s)	Humans ; Tissue Inhibitor of Metalloproteinase-3/metabolism ; Calcium Channels, N-Type/genetics ; Proteolysis ; Calcium, Dietary/metabolism ; Neuralgia ; Peptide Hydrolases/metabolism ; ADAM17 Protein/genetics
Chemical Substances	Tissue Inhibitor of Metalloproteinase-3 ; Calcium Channels, N-Type ; Calcium, Dietary ; Peptide Hydrolases (EC 3.4.-) ; ADAM17 protein, human (EC 3.4.24.86) ; ADAM17 Protein (EC 3.4.24.86)
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2633-8823
ISSN (online)	2633-8823
DOI	10.1093/function/zqac013
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Article ; Online: Predictive correction of serum sodium concentration with formulas derived from the Edelman equation in patients with severe hyponatremia

Koya Nagase / Tsuyoshi Watanabe / Akihiro Nomura / Fumika N. Nagase / Keita Iwasaki / Yoshihiro Nakamura / Hiroki Ikai / Mari Yamamoto / Yukari Murai / Waka Yokoyama-Kokuryo / Naoho Takizawa / Hideaki Shimizu / Yoshiro Fujita

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection can result in osmotic demyelination. This study investigated potential factors, including ... ...

Abstract	Abstract Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection can result in osmotic demyelination. This study investigated potential factors, including predictive correction based on the Edelman equation, associated with appropriate correction in 221 patients with a serum sodium concentration ≤ 120 mEq/L who were admitted to a hospital in Nagoya, Japan. Appropriate correction was defined as an elevation in serum sodium concentration in the range of 4–10 mEq/L in the first 24 h and within 18 mEq/L in the first 48 h after the start of the correction. Appropriate corrections were made in 132 (59.7%) of the 221 patients. Multivariate analysis revealed that predictive correction with an infusate and fluid loss formula derived from the Edelman equation was associated with appropriate correction of serum sodium concentration (adjusted odds ratio, 7.84; 95% confidence interval, 2.97–20.64). Relative without its use, the predictive equation results in a lower proportion of undercorrection (14.3% vs. 48.0%, respectively) and overcorrection (1.0% vs. 12.2%, respectively). These results suggest that predictive correction of serum sodium concentrations using the formula derived from the Edelman equation can play an essential role in the appropriate management of patients with severe hyponatremia.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of cytokine levels in response to mitogen among HIV-1-infected blood cells and their relationships to the number of T cells.

Imoto, Sahoko / Suzukawa, Maho / Takeda, Keita / Asari, Isao / Watanabe, Shizuka / Tohma, Shigeto / Nagase, Takahide / Ohta, Ken / Teruya, Katsuji / Nagai, Hideaki

Cytokine

2022 Volume 153, Page(s) 155840

Abstract: Background: Human immunodeficiency virus-1 (HIV-1) infection causes loss and anergy of CD4: Methods: The number of CD4: Results: HIV-1-infected individuals (110) and control subjects (27) were enrolled. Interferon (IFN)-γ, interleukin-1 receptor ... ...

Abstract	Background: Human immunodeficiency virus-1 (HIV-1) infection causes loss and anergy of CD4 Methods: The number of CD4 Results: HIV-1-infected individuals (110) and control subjects (27) were enrolled. Interferon (IFN)-γ, interleukin-1 receptor antagonist (IL-1RA), IL-6, IL-8, and regulated on activation, normal T cell expressed and secreted (RANTES) values in Mit-Nil tubes showed a significant correlation with CD4 Conclusion: The functions of HIV-1-infected T cells and uninfected T cells, such as spontaneous and responsive cytokine production in response to Mit, were different. Our findings may be useful for developing new clinical tools for patients with low T cell counts. Additionally, the study provides new insights into the pathogenesis of HIV-1 infection.
MeSH term(s)	Blood Cells/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Chemokine CCL5 ; Chemokine CXCL10 ; Cytokines ; HIV Infections ; HIV-1 ; Humans ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Interleukin-8 ; Mitogens ; Tuberculosis
Chemical Substances	Chemokine CCL5 ; Chemokine CXCL10 ; Cytokines ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Interleukin-8 ; Mitogens
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.155840
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Article ; Online: Corrigendum to "Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor" [Allergol Int 68S (2019) S3-S8].

Watanabe, Kaoru / Suzukawa, Maho / Arakawa, Sayaka / Kobayashi, Koichi / Igarashi, Sayaka / Tashimo, Hiroyuki / Nagai, Hideaki / Tohma, Shigeto / Nagase, Takahide / Ohta, Ken

Allergology international : official journal of the Japanese Society of Allergology

2021 Volume 70, Issue 3, Page(s) 404

Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2021.04.005
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