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  1. Article ; Online: Learning human liver biology in humanized mice.

    Lehrich, Brandon M / Monga, Satdarshan P

    Cell research

    2024  Volume 34, Issue 1, Page(s) 9–10

    MeSH term(s) Humans ; Mice ; Animals ; Liver ; Hepatocytes ; Biology
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00877-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
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  2. Article ; Online: Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives.

    Lehrich, Brandon M / Delgado, Evan R

    Organogenesis

    2024  Volume 20, Issue 1, Page(s) 2313696

    Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current ... ...

    Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including immune checkpoint inhibitors and combinations, have achieved limited objective response rates for the majority of patients. Thus, a precision medicine approach is needed to tailor specific treatment options for molecular subsets of HCC patients. Lipid nanovesicle platforms, either liposome- (synthetic) or extracellular vesicle (natural)-derived present are improved drug delivery vehicles which may be modified to contain specific cargos for targeting specific tumor sites, with a natural affinity for liver with limited toxicity. This mini-review provides updates on the applications of novel lipid nanovesicle-based therapeutics for HCC precision medicine and the challenges associated with translating this therapeutic subclass from preclinical models to the clinic.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; Precision Medicine ; Extracellular Vesicles/pathology ; Lipids/therapeutic use ; Tumor Microenvironment
    Chemical Substances Lipids
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1555-8592
    ISSN (online) 1555-8592
    ISSN 1555-8592
    DOI 10.1080/15476278.2024.2313696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic drivers in craniopharyngiomas: Analysis of the AACR project GENIE database.

    Lehrich, M Brandon / Tong, C L Charles / Hsu, P K Frank / Kuan, C Edward

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2024  

    Abstract: Purpose: Craniopharyngiomas are rare tumors originating in the sellar region, with limited information on their somatic mutational landscape. In this study, we utilized a publicly available genomic database to profile the somatic mutational landscape of ...

    Abstract Purpose: Craniopharyngiomas are rare tumors originating in the sellar region, with limited information on their somatic mutational landscape. In this study, we utilized a publicly available genomic database to profile the somatic mutational landscape of craniopharyngioma patients and interrogate differences based on histologic subtype.
    Methods: We utilized the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE)
    Results: Of the 336 patients with sellar tumors, 51 (15.2%) had craniopharyngiomas. Of these 51 patients, 42 (82.4%) were adamantinomatous subtype and 9 (17.6%) were papillary subtype. In this cohort, 32 (62.7%) patients were pediatric, while 19 (37.3%) were adult. The top mutations in the cohort were: CTNNB1 (n = 37; 73%), BRAF (n = 7; 14%), ARID1B (n = 5; 10%), KMT2D (n = 4; 8%), FANCA (n = 4; 8%), ATM (n = 4; 8%), and TERT (n = 3; 8%). Of the 37 patients with CTNNB1 mutations, 8 (21.6%) had S33X, 9 (24.3%) had S37X, 7 (18.9%) had T41X, and 5 (13.5%) had D32X. In this cohort, CTNNB1 mutations tended to co-occur with ATM (n = 4; 10.8%), KMT2C (n = 4; 10.8%), TERT (n = 3; 8.1%), BLM (n = 3; 8.1%), and ERBB2/3 (n = 3; 8.1%), suggesting CTNNB1 mutations tended to co-occur with mutations in genes important in cell growth and survival, chromatin accessibility, and DNA damage response pathways.
    Conclusions: CTNNB1 mutations account for a large proportion of somatic mutations in craniopharyngiomas. Identification of specific point mutations and secondary drivers may advance development of novel craniopharyngioma preclinical models for targeted therapy testing.
    Language English
    Publishing date 2024-02-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-024-06320-z
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    Zs.A 2036: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Battle of the biopsies: Role of tissue and liquid biopsy in hepatocellular carcinoma.

    Lehrich, Brandon M / Zhang, Josephine / Monga, Satdarshan P / Dhanasekaran, Renumathy

    Journal of hepatology

    2023  Volume 80, Issue 3, Page(s) 515–530

    Abstract: The diagnosis and management of hepatocellular carcinoma (HCC) have improved significantly in recent years. With the introduction of immunotherapy-based combination therapy, there has been a notable expansion in treatment options for patients with ... ...

    Abstract The diagnosis and management of hepatocellular carcinoma (HCC) have improved significantly in recent years. With the introduction of immunotherapy-based combination therapy, there has been a notable expansion in treatment options for patients with unresectable HCC. Simultaneously, innovative molecular tests for early detection and management of HCC are emerging. This progress prompts a key question: as liquid biopsy techniques rise in prominence, will they replace traditional tissue biopsies, or will both techniques remain relevant? Given the ongoing challenges of early HCC detection, including issues with ultrasound sensitivity, accessibility, and patient adherence to surveillance, the evolution of diagnostic techniques is more relevant than ever. Furthermore, the accurate stratification of HCC is limited by the absence of reliable biomarkers which can predict response to therapies. While the advantages of molecular diagnostics are evident, their potential has not yet been fully harnessed, largely because tissue biopsies are not routinely performed for HCC. Liquid biopsies, analysing components such as circulating tumour cells, DNA, and extracellular vesicles, provide a promising alternative, though they are still associated with challenges related to sensitivity, cost, and accessibility. The early results from multi-analyte liquid biopsy panels are promising and suggest they could play a transformative role in HCC detection and management; however, comprehensive clinical validation is still ongoing. In this review, we explore the challenges and potential of both tissue and liquid biopsy, highlighting that these diagnostic methods, while distinct in their approaches, are set to jointly reshape the future of HCC management.
    MeSH term(s) Humans ; Biomarkers, Tumor ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/genetics ; Liquid Biopsy/methods ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Liver Neoplasms/genetics ; Neoplastic Cells, Circulating
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-12-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.11.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Foetal bovine serum influence on in vitro extracellular vesicle analyses.

    Lehrich, Brandon M / Liang, Yaxuan / Fiandaca, Massimo S

    Journal of extracellular vesicles

    2021  Volume 10, Issue 3, Page(s) e12061

    MeSH term(s) Cell Culture Techniques/methods ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/metabolism ; Serum Albumin, Bovine/pharmacology
    Chemical Substances Serum Albumin, Bovine (27432CM55Q)
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2683797-3
    ISSN 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mutational landscape and predictors of survival in head and neck mucosal melanoma.

    Lehrich, Brandon M / Abiri, Arash / Nguyen, Theodore V / Bitner, Benjamin F / Tong, Charles C L / Kuan, Edward C

    International forum of allergy & rhinology

    2023  Volume 14, Issue 4, Page(s) 858–861

    Abstract: Key points: Head and neck mucosal melanomas have a diverse mutational landscape with low mutational burden. A molecular subset (∼13%) has ROS1 mutations, which is an actionable driver mutation. ROS1-mutated patients have improved overall survival likely ...

    Abstract Key points: Head and neck mucosal melanomas have a diverse mutational landscape with low mutational burden. A molecular subset (∼13%) has ROS1 mutations, which is an actionable driver mutation. ROS1-mutated patients have improved overall survival likely due to high mutational burden.
    MeSH term(s) Humans ; Melanoma/genetics ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Mutation ; DNA Mutational Analysis
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6927: Show issues Location:
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  7. Article: Response to "Technical approaches to reduce interference of Fetal calf serum derived RNA in the analysis of extracellular vesicle RNA from cultured cells".

    Lehrich, Brandon M / Liang, Yaxuan / Fiandaca, Massimo S

    Journal of extracellular vesicles

    2019  Volume 8, Issue 1, Page(s) 1599681

    Language English
    Publishing date 2019-04-14
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2683797-3
    ISSN 2001-3078
    ISSN 2001-3078
    DOI 10.1080/20013078.2019.1599681
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  8. Article: Emerging methods in biomarker identification for extracellular vesicle-based liquid biopsy.

    Liang, Yaxuan / Lehrich, Brandon M / Zheng, Siyang / Lu, Mengrou

    Journal of extracellular vesicles

    2021  Volume 10, Issue 7, Page(s) e12090

    Abstract: Extracellular vesicles (EVs) are released by many cell types and distributed within various biofluids. EVs have a lipid membrane-confined structure that allows for carrying unique molecular information originating from their parent cells. The species and ...

    Abstract Extracellular vesicles (EVs) are released by many cell types and distributed within various biofluids. EVs have a lipid membrane-confined structure that allows for carrying unique molecular information originating from their parent cells. The species and quantity of EV cargo molecules, including nucleic acids, proteins, lipids, and metabolites, may vary largely owing to their parent cell types and the pathophysiologic status. Such heterogeneity in EV populations provides immense challenges to researchers, yet allows for the possibility to prognosticate the pathogenesis of a particular tissue from unique molecular signatures of dispersing EVs within biofluids. However, the inherent nature of EV's small size requires advanced methods for EV purification and evaluation from the complex biofluid. Recently, the interdisciplinary significance of EV research has attracted growing interests, and the EV analytical platforms for their diagnostic prospect have markedly progressed. This review summarizes the recent advances in these EV detection techniques and methods with the intention of translating an EV-based liquid biopsy into clinical practice. This article aims to present an overview of current EV assessment techniques, with a focus on their progress and limitations, as well as an outlook on the clinical translation of an EV-based liquid biopsy that may augment current paradigms for the diagnosis, prognosis, and monitoring the response to therapy in a variety of disease settings.
    MeSH term(s) Biomarkers/analysis ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/metabolism ; Humans ; Lipids ; Liquid Biopsy/methods ; Liquid Biopsy/trends ; Nucleic Acids/metabolism ; Prognosis ; Proteins/metabolism
    Chemical Substances Biomarkers ; Lipids ; Nucleic Acids ; Proteins
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2683797-3
    ISSN 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The association of frailty, age, and ASA classification with postoperative outcomes in endoscopic sinus surgery.

    Goshtasbi, Khodayar / Birkenbeuel, Jack L / Abiri, Arash / Lehrich, Brandon M / Kuan, Edward C

    International forum of allergy & rhinology

    2021  Volume 11, Issue 11, Page(s) 1596–1598

    MeSH term(s) Endoscopy ; Frailty ; Humans ; Postoperative Complications/epidemiology ; Postoperative Period ; Risk Factors
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6927: Show issues Location:
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  10. Article ; Online: Peer-to-Peer Contact Tracing: Development of a Privacy-Preserving Smartphone App.

    Yasaka, Tyler M / Lehrich, Brandon M / Sahyouni, Ronald

    JMIR mHealth and uHealth

    2020  Volume 8, Issue 4, Page(s) e18936

    Abstract: Background: The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any ... ...

    Abstract Background: The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any intervention or response. Contact tracing using smartphone technology is a powerful tool that may be employed to limit disease transmission during an epidemic or pandemic; yet, contact tracing apps present significant privacy concerns regarding the collection of personal data such as location.
    Objective: The aim of this study is to develop an effective contact tracing smartphone app that respects user privacy by not collecting location information or other personal data.
    Methods: We propose the use of an anonymized graph of interpersonal interactions to conduct a novel form of contact tracing and have developed a proof-of-concept smartphone app that implements this approach. Additionally, we developed a computer simulation model that demonstrates the impact of our proposal on epidemic or pandemic outbreak trajectories across multiple rates of adoption.
    Results: Our proof-of-concept smartphone app allows users to create "checkpoints" for contact tracing, check their risk level based on their past interactions, and anonymously self-report a positive status to their peer network. Our simulation results suggest that higher adoption rates of such an app may result in a better controlled epidemic or pandemic outbreak.
    Conclusions: Our proposed smartphone-based contact tracing method presents a novel solution that preserves privacy while demonstrating the potential to suppress an epidemic or pandemic outbreak. This app could potentially be applied to the current COVID-19 pandemic as well as other epidemics or pandemics in the future to achieve a middle ground between drastic isolation measures and unmitigated disease spread.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Computer Simulation ; Contact Tracing/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Humans ; Interpersonal Relations ; Mobile Applications ; Pandemics ; Peer Group ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Privacy ; Public Health ; Risk Assessment ; SARS-CoV-2 ; Self Report ; Smartphone
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719220-9
    ISSN 2291-5222 ; 2291-5222
    ISSN (online) 2291-5222
    ISSN 2291-5222
    DOI 10.2196/18936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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