LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2202

Search options

  1. Book ; Online ; E-Book: Analysis of a model for epilepsy

    Kent, Candace M. / Chan, David M.

    application of a max-type difference equation to mesial temporal lobe epilepsy

    (Chapman and Hall/CRC Monographs and Research Notes in Mathematics)

    2022  

    Author's details Candace M. Kent, David M. Chan
    Series title Chapman and Hall/CRC Monographs and Research Notes in Mathematics
    Keywords Temporal lobe epilepsy/Mathematical models
    Subject code 616.853
    Language English
    Size 1 online resource (172 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-328538-4 ; 1-003-28538-4 ; 1-000-59437-8 ; 1-03-225538-2 ; 978-1-00-328538-0 ; 978-1-003-28538-0 ; 978-1-000-59437-9 ; 978-1-03-225538-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Overall average treatment effects from clinical trials, one-variable-at-a-time subgroup analyses and predictive approaches to heterogeneous treatment effects: Toward a more patient-centered evidence-based medicine.

    Kent, David M

    Clinical trials (London, England)

    2023  Volume 20, Issue 4, Page(s) 328–337

    Abstract: Despite the predominance of the evidence-based medicine paradigm, a fundamental incongruity remains: Evidence is derived from groups of people, yet medical decisions are made by and for individuals. Randomization ensures the comparability of treatment ... ...

    Abstract Despite the predominance of the evidence-based medicine paradigm, a fundamental incongruity remains: Evidence is derived from groups of people, yet medical decisions are made by and for individuals. Randomization ensures the comparability of treatment groups within a clinical trial, which allows for unbiased estimation of average treatment effects. If we treated groups of patients instead of individuals, or if patients with the same disease were identical to one another in all factors that determined the harms and the benefits of therapy, then these group-level averages would make a perfectly sound foundation for medical decision-making. But patients differ from one another in many ways that determine the likelihood of an outcome, both with and without a treatment. Nevertheless, popular approaches to evidence-based medicine have encouraged a reliance on the average treatment effects estimated from clinical trials and meta-analysis as guides to decision-making for individuals. Here, we discuss the limitations of this approach as well as limitations of conventional, one-variable-at-a-time subgroup analysis; finally, we discuss the rationale for "predictive" approaches to heterogeneous treatment effects. Predictive approaches to heterogeneous treatment effects combine methods for causal inference (e.g. randomization) with methods for prediction that permit inferences about which patients are likely to benefit and which are not, taking into account multiple relevant variables simultaneously to yield "personalized" estimates of benefit-harm trade-offs. We focus on risk modeling approaches, which rely on the mathematical dependence of the absolute treatment effect with the baseline risk, which varies substantially "across patients" in most trials. While there are a number of examples of risk modeling approaches that have been practice-changing, risk modeling does not provide ideal estimates of individual treatment effects, since risk modeling does not account for how individual variables might modify the effects of therapy. In "effect modeling," prediction models are developed directly on clinical trial data, including terms for treatment and treatment effect interactions. These more flexible approaches may better uncover individualized treatment effects, but are also prone to overfitting when dimensionality is high, power is low, and there is limited prior knowledge about effect modifiers.
    MeSH term(s) Humans ; Causality ; Evidence-Based Medicine ; Patient-Centered Care ; Clinical Trials as Topic
    Language English
    Publishing date 2023-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2138796-5
    ISSN 1740-7753 ; 1740-7745
    ISSN (online) 1740-7753
    ISSN 1740-7745
    DOI 10.1177/17407745231171897
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Is Incidentally Discovered Covert Cerebrovascular Disease Ignorable?

    Meinel, Thomas R / Wardlaw, Joanna M / Kent, David M

    JAMA neurology

    2024  

    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.5456
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.191: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Measuring the performance of prediction models to personalize treatment choice: Defining observed and predicted pairwise treatment effects.

    van Klaveren, David / Maas, Carolien C H M / Kent, David M

    Statistics in medicine

    2023  Volume 42, Issue 24, Page(s) 4514–4515

    MeSH term(s) Humans ; Patient Selection ; Precision Medicine
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Letter
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9719
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Machine learning to deal with missing disability status: Ascertainment and imputation of outcomes should be distinguished.

    Kent, David M / Steyerberg, Ewout W

    Multiple sclerosis journal - experimental, translational and clinical

    2022  Volume 8, Issue 4, Page(s) 20552173221128874

    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173221128874
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Treatment Effects in Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale-Reply.

    Kent, David M / Saver, Jeffrey L / Thaler, David E

    JAMA

    2022  Volume 327, Issue 14, Page(s) 1403

    MeSH term(s) Cardiac Catheterization ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/surgery ; Humans ; Randomized Controlled Trials as Topic ; Risk Factors ; Secondary Prevention ; Septal Occluder Device ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.2661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Retrospective analysis of high-intensity focused electromagnetic procedure synchronized with radiofrequency energy for visceral fat reduction.

    Kent, David E / Jacob, Carolyn / Kinney, Brian M

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 9, Page(s) 2485–2491

    Abstract: Background: Visceral adipose tissue (VAT), present in the abdominal cavity, oftentimes contributes to an unpleasant aesthetic appearance and can be correlated with serious health issues. High-intensity focused electromagnetic field (HIFEM) technology ... ...

    Abstract Background: Visceral adipose tissue (VAT), present in the abdominal cavity, oftentimes contributes to an unpleasant aesthetic appearance and can be correlated with serious health issues. High-intensity focused electromagnetic field (HIFEM) technology with synchronized radiofrequency (RF) was recently used for abdominal body shaping through subcutaneous fat reduction and muscle growth.
    Aim: This study aimed to assess the effect of HIFEM + RF technology on VAT tissue.
    Methods: Data of 16 men and 24 women (22-62 years, 21.2-34.3 kg/cm
    Results: By thoughtful review of the subject's post-treatment MRI scans, no other changes in the abdominal cavity were found except for VAT. The evaluation showed a VAT reduction of 17.8% (p < 0.001) on average at 3-month follow-up, maintaining the results up to 6 months (-17.3%). Averaging the values obtained from both measured levels, the VAT, occupied an area of 100.2 ± 73.3 cm
    Conclusion: This retrospective analysis of MRI images objectively documented the effect of HIFEM + RF abdominal therapy on VAT. The data indicates considerable VAT reduction without serious adverse events following the HIFEM + RF procedure.
    MeSH term(s) Male ; Humans ; Female ; Retrospective Studies ; Intra-Abdominal Fat/diagnostic imaging ; Subcutaneous Fat ; Abdomen ; Radio Waves/adverse effects
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15784
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The effect of high-intensity focused electromagnetic procedure on visceral adipose tissue: Retrospective assessment of computed tomography scans.

    Kent, David E / Kinney, Brian M

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 3, Page(s) 757–762

    Abstract: ... scans of 22 subjects (47.3 ± 8.4 years, BMI of 23.5 ± 3.5 kg/m: Results: Analysis of the CSA revealed ...

    Abstract Background: High levels of visceral adipose tissue (VAT) are associated with abdominal obesity and increased risk of metabolic deterioration. Recent studies showed that intensive physical exercise results in the reduction of subcutaneous and visceral fat.
    Aims: This study investigates the effect of supramaximal muscle contractions induced by a HIFEM procedure for abdominal VAT changes.
    Methods: Computed tomography (CT) scans of 22 subjects (47.3 ± 8.4 years, BMI of 23.5 ± 3.5 kg/m
    Results: Analysis of the CSA revealed a significant (P = .004) and uniform reduction of the abdominal VAT area by 14.3% (-16.7 cm
    Conclusions: The outcomes indicate that HIFEM technology has a positive effect on VAT. However, further studies are necessary to validate these outcomes and to clarify the exact mechanism of a VAT reduction. Based on our results, the HIFEM procedure may be a beneficial treatment option for patients with high VAT deposits.
    MeSH term(s) Adipose Tissue ; Electromagnetic Phenomena ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Obesity, Abdominal/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13952
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The interaction of O

    Mashaheet, Alsayed M / Burkey, Kent O / Marshall, David S

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 334, Page(s) 122122

    Abstract: Wheat rusts, elevated ozone ( ... ...

    Abstract Wheat rusts, elevated ozone (O
    MeSH term(s) Triticum ; Carbon Dioxide/pharmacology ; Plant Leaves ; Ozone/toxicity ; Seasons
    Chemical Substances Carbon Dioxide (142M471B3J) ; Ozone (66H7ZZK23N)
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122122
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: All-cause mortality as the primary endpoint for the GRAIL/National Health Service England multi-cancer screening trial.

    Carr, David / Kent, David M / Welch, H Gilbert

    Journal of medical screening

    2021  Volume 29, Issue 1, Page(s) 3–6

    Abstract: A randomized trial of the GRAIL ... ...

    Abstract A randomized trial of the GRAIL Galleri
    MeSH term(s) Early Detection of Cancer ; England/epidemiology ; Humans ; Mass Screening ; Neoplasms/diagnosis ; State Medicine
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1235253-6
    ISSN 1475-5793 ; 0969-1413
    ISSN (online) 1475-5793
    ISSN 0969-1413
    DOI 10.1177/09691413211059638
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top