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Book: Radiation Therapy of Benign Diseases

Donaldson, Sarah S. / Roberge, David

(Radiation Oncology)

2023

Author's details	David Roberge, MD completed medical school at the University of Montreal (1997) before completing a residency at McGill University (2002) and fellowships at St-Jude Children's Research Hospital (2002) and Stanford University (2003). He has authored over one hundred fifty peer-reviewed articles (H-index 43) and other scholarly works. He has a broad interest and expertise in radiation oncology (including radiotherapy of benign disease) but is best known for his work in the field of brain tumors. He is currently president elect of the Canadian Association of Radiation Oncology and a Full Professor of Radiology, Radiation Oncology and Nuclear Medicine at the University of Montreal. Sarah S. Donaldson, MD completed medical school at Harvard (1968) before completing a residency at Stanford University (1972), an internship at the University of Washington (1969) and fellowships at both MD Anderson Cancer Center (1971) and Institut Gustave-Roussy (1973). She has authored several hundred pe
Series title	Radiation Oncology
Keywords	benign tumors ; Radiotherapy ; anti-inflammatory ; infectious disease ; vascular disease ; Anti-proliferative ; Benign diseases ; Benign tumors ; Anti-inflammatory ; Vascular disease ; Infectious disease ; Radiation therapy of benign diseases
Language	English
Size	364 p.
Edition	3
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_22
Format	183 x 260 x 26
ISBN	9783031355165 ; 3031355164
Database	PDA

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Article: Getting the data--and the information--right: an interview with the IOM's Molla S. Donaldson. Interview by David Lansky.

Donaldson, M S

The Joint Commission journal on quality improvement

1994 Volume 20, Issue 4, Page(s) 208–214

MeSH term(s)	Computer Communication Networks/legislation & jurisprudence ; Computer Security/legislation & jurisprudence ; Confidentiality/legislation & jurisprudence ; Databases, Factual/legislation & jurisprudence ; Health Care Reform/legislation & jurisprudence ; Humans ; National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division ; Quality Assurance, Health Care/legislation & jurisprudence ; United States
Language	English
Publishing date	1994-04
Publishing country	United States
Document type	Interview
ZDB-ID	1189890-2
ISSN	1938-131X ; 1549-425X ; 1070-3241 ; 1553-7250 ; 1549-3741
ISSN (online)	1938-131X ; 1549-425X
ISSN	1070-3241 ; 1553-7250 ; 1549-3741
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Article ; Online: Aging-Related Impairments to M Cells in Peyer's Patches Coincide With Disturbances to Paneth Cells.

Donaldson, David S / Shih, Barbara B / Mabbott, Neil A

Frontiers in immunology

2021 Volume 12, Page(s) 761949

Abstract: The decline in mucosal immunity during aging increases susceptibility, morbidity and mortality to infections ... ...

Abstract	The decline in mucosal immunity during aging increases susceptibility, morbidity and mortality to infections acquired
MeSH term(s)	Animals ; COVID-19 ; Cell Differentiation/immunology ; Immunity, Mucosal/immunology ; Immunosenescence/immunology ; Mice ; Mice, Inbred C57BL ; Paneth Cells/immunology ; Peyer's Patches/immunology ; SARS-CoV-2
Language	English
Publishing date	2021-12-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.761949
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Article ; Online: Nucleus accumbens dopamine release reflects the selective nature of pair bonds.

Pierce, Anne F / Protter, David S W / Watanabe, Yurika L / Chapel, Gabriel D / Cameron, Ryan T / Donaldson, Zoe R

Current biology : CB

2024 Volume 34, Issue 3, Page(s) 519–530.e5

Abstract: In monogamous species, prosocial behaviors directed toward partners are dramatically different from those directed toward unknown individuals and potential threats. Dopamine release in the nucleus accumbens has a well-established role in social reward ... ...

Abstract	In monogamous species, prosocial behaviors directed toward partners are dramatically different from those directed toward unknown individuals and potential threats. Dopamine release in the nucleus accumbens has a well-established role in social reward and motivation, but how this mechanism may be engaged to drive the highly divergent social behaviors directed at a partner or unfamiliar conspecific remains unknown. Using monogamous prairie voles, we first employed receptor pharmacology in partner preference and social operant tasks to show that dopamine is critical for the appetitive drive for social interaction but not for low-effort, unconditioned consummatory behaviors. We then leveraged the subsecond temporal resolution of the fluorescent biosensor, GRAB
MeSH term(s)	Humans ; Animals ; Pair Bond ; Nucleus Accumbens ; Dopamine ; Social Behavior ; Motivation ; Arvicolinae
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.12.041
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Article ; Online: A novel, reverse-phase-shifting, thermoreversible foaming hydrogel containing antibiotics for the treatment of thermal burns in a swine model - A pilot study.

Donaldson, Ross I / Armstrong, Jonathan K / Buchanan, Oliver J / Graham, Todd L / Cambridge, John S / Cristerna, Nely N / Goldenberg, Diane / Tanen, Captain David A / Fisher, Timothy C / Tolles, Juliana / Burns, Christopher J / Ross, James D

Burns : journal of the International Society for Burn Injuries

2024

Abstract: Background: This study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence ... ...

Abstract	Background: This study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence of concomitant bacterial inoculation. Methods: Eight equal burn wounds were created on six Yorkshire swine. Half the wounds were randomized to post-burn bacterial inoculation. Wounds were subsequently randomized to three treatments groups: no intervention, CI-PRJ012, or silver sulfadiazine cream. At study end, a blinded pathologist evaluated wounds for necrosis and bacterial colonization. Results: When comparing CI-PRJ012 and silver sulfadiazine cream to no treatment, both agents significantly reduced the amount of necrosis and bacteria at 7 days after wound creation (p < 0.01, independently for both). Further, CI-PRJ012 was found to be significantly better than silver sulfadiazine (p < 0.02) in reducing bacterial colonization. For wound necrosis, no significant difference was found between silver sulfadiazine cream and CI-PRJ012 (p = 0.33). Conclusions: CI-PRJ012 decreases necrosis and bacterial colonization compared to no treatment in a swine model. CI-PRJ012 appeared to perform comparably to silver sulfadiazine. CI-PRJ012, which is easily removed with the application of room-temperature water, may provide clinical advantages over silver sulfadiazine.
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2024.03.018
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Article ; Online: Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure.

Schaeffer, Ericka A / LaCour, Ariyana / Donaldson, Tia N / Linsenbardt, David N / Davies, Suzy / Savage, Daniel D / Wallace, Douglas G / Clark, Benjamin J

Behavioral neuroscience

2024

Abstract: Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home ... ...

Abstract	Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest of the environment. Open-field behaviors are organized even under darkened test conditions, suggesting a role for self-motion cues (vestibular, motor, etc.). The impact of moderate prenatal alcohol exposure (mPAE) on the organization of spontaneous open-field behaviors under darkened conditions has not been investigated. Here we tested adult female and male rats with mPAE or saccharin control exposure in a circular open field for 30 min in a testing room that was made completely dark. While general locomotion, as measured by reductions in travel distance and increased stop duration, decreased across the test session, the organization of these behaviors, as measured by stop duration, home base establishment, home base stability, progression accuracy, and scaling of peak speeds with progression length, did not differ between mPAE and saccharin control rats. Together, the findings strongly suggest that spontaneous movement organization in relation to self-motion cues remains intact in adult mPAE rats. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	230159-3
ISSN	1939-0084 ; 0735-7044
ISSN (online)	1939-0084
ISSN	0735-7044
DOI	10.1037/bne0000589
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Article ; Online: Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase.

Donaldson, David S / Bradford, Barry M / Else, Kathryn J / Mabbott, Neil A

Scientific reports

2020 Volume 10, Issue 1, Page(s) 4554

Abstract: Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. Therefore, we used the gastrointestinal helminth pathogen Trichuris muris to ...

Abstract	Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. Therefore, we used the gastrointestinal helminth pathogen Trichuris muris to test the hypothesis that a chronic systemic inflammatory response to a gastrointestinal infection would similarly affect CNS prion disease pathogenesis. Mice were injected with prions directly into the CNS and subsequently orally co-infected with T. muris before the onset of clinical signs. We show that co-infection with a low dose of T. muris that leads to the development of a chronic T helper cell type 1-polarized systemic immune response accelerated the onset of clinical prion disease. In contrast, co-infection with a high dose of T. muris that induces a T helper cell type 2-polarized immune response did not affect prion disease pathogenesis. The reduced survival times in mice co-infected with a low dose of T. muris on d 105 after CNS prion infection coincided with enhanced astrocyte activation in the brain during the preclinical phase. These data aid our understanding of how systemic inflammation may augment the progression of neurodegeneration in the CNS.
MeSH term(s)	Animals ; Cell Polarity ; Central Nervous System/immunology ; Central Nervous System/pathology ; Coinfection ; Disease Models, Animal ; Disease Progression ; Female ; Gastrointestinal Diseases/immunology ; Gastrointestinal Diseases/parasitology ; Mice ; Prion Diseases/immunology ; Prion Diseases/parasitology ; Prion Diseases/pathology ; Th1 Cells/metabolism ; Th2 Cells/metabolism ; Trichuriasis/immunology ; Trichuriasis/parasitology
Language	English
Publishing date	2020-03-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-61483-4
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Article ; Online: The influence of the commensal and pathogenic gut microbiota on prion disease pathogenesis.

Donaldson, David S / Mabbott, Neil A

The Journal of general virology

2016 Volume 97, Issue 8, Page(s) 1725–1738

Abstract: Prion diseases are a unique group of transmissible, chronic, neurodegenerative disorders. Following peripheral exposure (e.g. oral), prions often accumulate first within the secondary lymphoid tissues before they infect the central nervous system (CNS). ... ...

Abstract	Prion diseases are a unique group of transmissible, chronic, neurodegenerative disorders. Following peripheral exposure (e.g. oral), prions often accumulate first within the secondary lymphoid tissues before they infect the central nervous system (CNS). Prion replication within secondary lymphoid tissues is crucial for the efficient spread of disease to the CNS. Once within the CNS, the responses of innate immune cells within it can have a significant influence on neurodegeneration and disease progression. Recently, there have been substantial advances in our understanding of how cross-talk between the host and the vast community of commensal microorganisms present at barrier surfaces such as the gut influences the development and regulation of the host's immune system. These effects are evident not only in the mucosal immune system in the gut, but also in the CNS. The actions of this microbial community (the microbiota) have many important beneficial effects on host health, from metabolism of nutrients and regulation of host development to protection from pathogen infection. However, the microbiota can also have detrimental effects in some circumstances. In this review we discuss the many and varied interactions between prions, the host and the gut microbiota. Particular emphasis is given to the ways by which changes to the composition of the commensal gut microbiota or congruent pathogen infection may influence prion disease pathogenesis and/or disease susceptibility. Understanding how these factors influence prion pathogenesis and disease susceptibility is important for assessing the risk to infection and the design of novel opportunities for therapeutic intervention.
MeSH term(s)	Animals ; Disease Susceptibility ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Prion Diseases/immunology ; Prion Diseases/pathology
Language	English
Publishing date	2016-05-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.000507
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Article ; Online: ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas.

Jiang, Baishan / Weinstock, David M / Donovan, Katherine A / Sun, Hong-Wei / Wolfe, Ashley / Amaka, Sam / Donaldson, Nicholas L / Wu, Gongwei / Jiang, Yuan / Wilcox, Ryan A / Fischer, Eric S / Gray, Nathanael S / Wu, Wenchao

Cell chemical biology

2023 Volume 30, Issue 4, Page(s) 383–393.e6

Abstract: Interleukin (IL)-2-inducible T cell kinase (ITK) is essential for T cell receptor (TCR) signaling and plays an integral role in T cell proliferation and differentiation. Unlike the ITK homolog BTK, no inhibitors of ITK are currently US Food and Drug ... ...

Abstract	Interleukin (IL)-2-inducible T cell kinase (ITK) is essential for T cell receptor (TCR) signaling and plays an integral role in T cell proliferation and differentiation. Unlike the ITK homolog BTK, no inhibitors of ITK are currently US Food and Drug Administration (FDA) approved. In addition, recent studies have identified mutations within BTK that confer resistance to both covalent and non-covalent inhibitors. Here, as an alternative strategy, we report the development of BSJ-05-037, a potent and selective heterobifunctional degrader of ITK. BSJ-05-037 displayed enhanced anti-proliferative effects relative to its parent inhibitor BMS-509744, blocked the activation of NF-kB/GATA-3 signaling, and increased the sensitivity of T cell lymphoma cells to cytotoxic chemotherapy both in vitro and in vivo. In summary, targeted degradation of ITK is a novel approach to modulate TCR signal strength that could have broad application for the investigation and treatment of T cell-mediated diseases.
MeSH term(s)	Humans ; Signal Transduction ; Receptors, Antigen, T-Cell/metabolism ; Drug Resistance, Neoplasm ; T-Lymphocytes ; Lymphoma, T-Cell/drug therapy
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2023.03.007
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Article: Initial response of young people with thyrotoxicosis to block and replace or dose titration thionamide.

Wood, Claire L / Morrison, Niamh / Cole, Michael / Donaldson, Malcolm / Dunger, David B / Wood, Ruth / Pearce, Simon H S / Cheetham, Timothy D

European thyroid journal

2022 Volume 11, Issue 1

Abstract: Objective: Patients with thyrotoxicosis are treated with anti-thyroid drug (ATD) using block and replace (BR) or a smaller, titrated dose of ATD (dose titration, DT).: Design: A multi-centre, phase III, open-label trial of newly diagnosed paediatric ... ...

Abstract	Objective: Patients with thyrotoxicosis are treated with anti-thyroid drug (ATD) using block and replace (BR) or a smaller, titrated dose of ATD (dose titration, DT). Design: A multi-centre, phase III, open-label trial of newly diagnosed paediatric thyrotoxicosis patients randomised to BR/DT. We compared the biochemical response to BR/DT in the first 6 months of therapy. Methods: Patients commenced 0.75 mg/kg carbimazole (CBZ) daily with randomisation to BR/DT. We examined baseline patient characteristics, CBZ dose, time to serum thyroid-stimulating hormone (TSH)/free thyroxine (FT4) normalisation and BMI Z-score change. Results: There were 80 patients (baseline) and 78 patients (61 female) at 6 months. Mean CBZ dose was 0.9 mg/kg/day (BR) and 0.5 mg/kg/day (DT). There was no difference in time to non-suppressed TSH concentration; 16 of 39 patients (BR) and 11 of 39 (DT) had suppressed TSH at 6 months. Patients with suppressed TSH had higher mean baseline FT4 levels (72.7 vs 51.7 pmol/L; 95% CI for difference 1.73, 31.7; P = 0.029). Time to normalise FT4 levels was reduced in DT (log-rank test, P = 0.049) with 50% attaining normal FT4 at 28 days (95% CI 25, 32) vs 35 days in BR (95% CI 28, 58). Mean BMI Z-score increased from 0.10 to 0.81 at 6 months (95% CI for difference 0.57, 0.86; P < 0.001) and was greatest in patients with higher baseline FT4 concentrations. Conclusions: DT-treated patients normalised FT4 concentrations more quickly than BR. Overall, 94% of patients have normal FT4 levels after 6 months, but 33% still have TSH suppression. Excessive weight gain occurs with both BR and DT therapy.
Language	English
Publishing date	2022-01-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2659767-6
ISSN	2235-0802 ; 2235-0640
ISSN (online)	2235-0802
ISSN	2235-0640
DOI	10.1530/ETJ-21-0043
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