Article ; Online: Senescent T cells: Beneficial and detrimental roles.
2023 Volume 316, Issue 1, Page(s) 160–175
Abstract: As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells ... ...
Abstract | As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments. |
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MeSH term(s) | Humans ; Adult ; T-Lymphocytes ; Cellular Senescence ; Aging ; Cell Differentiation ; Antigens ; CD8-Positive T-Lymphocytes |
Chemical Substances | Antigens |
Language | English |
Publishing date | 2023-04-25 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 391796-4 |
ISSN | 1600-065X ; 0105-2896 |
ISSN (online) | 1600-065X |
ISSN | 0105-2896 |
DOI | 10.1111/imr.13206 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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