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Article ; Online: Loneliness and Marital Quality as Predictors of Older Adults' Insomnia Symptoms.

Lawrence, Carly / Marini, Christina M

International journal of aging & human development

2023 Volume 98, Issue 2, Page(s) 243–262

Abstract: The current study examined associations between marital quality, loneliness, and sleep within a nationally representative sample of older adults who participated in Wave 2 of the National Social Life, Health, and Aging Project (NSHAP). Participants ( ...

Abstract	The current study examined associations between marital quality, loneliness, and sleep within a nationally representative sample of older adults who participated in Wave 2 of the National Social Life, Health, and Aging Project (NSHAP). Participants (
MeSH term(s)	Humans ; Aged ; Sleep Initiation and Maintenance Disorders/epidemiology ; Loneliness/psychology ; Sleep ; Aging/psychology ; Marriage/psychology
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	187072-5
ISSN	1541-3535 ; 0091-4150
ISSN (online)	1541-3535
ISSN	0091-4150
DOI	10.1177/00914150231208013
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Article ; Online: Older Adults' Social Profiles and Links to Functional and Biological Aging in the United States and Mexico.

Wilson, Stephanie J / Marini, Christina M

Psychosomatic medicine

2023

Abstract: Objective: Social stress-loneliness, isolation, and low relationship quality-increase risks for aging-related diseases. However, the ways in which they intersect to undermine healthy aging remain poorly understood. We utilized latent class analysis to ... ...

Abstract	Objective: Social stress-loneliness, isolation, and low relationship quality-increase risks for aging-related diseases. However, the ways in which they intersect to undermine healthy aging remain poorly understood. We utilized latent class analysis to identify groups of older adults based on their social stress in both the United States and Mexico. Thereafter, we examined their cross-sectional associations with markers of functional and biological aging. Method: Participants in the Health and Retirement Study (HRS, N = 8,316) and Mexican Health and Aging Study (MHAS, N = 15,001) reported their loneliness, isolation (i.e., living alone), and relationship quality with spouse, children, and friends. Outcomes included C-reactive protein (CRP), functional limitations, self-rated health, comorbidities, gait speed, and grip strength. Models controlled for demographics, health behaviors, and body mass index (BMI). Results: In both countries, five classes emerged, a Supported group and four with elevated social stress: (1) Strained, (2) Isolated, (3) Spousal Ambivalence, and (4) Unhappily Married. Compared to the others, Strained participants in both samples had greater functional limitations, poorer self-rated health, and more comorbidities, as well as slower gait in HRS and weaker grip in MHAS. Generally, Supported participants fared better than the other groups. In HRS, CRP levels differed between the Strained group and others, but these associations were explained by health behaviors and BMI. Conclusions: Older adults in both countries with strained relationships fared worst in their aging-related outcomes, revealing new insights about the links between toxic social stress and unhealthy aging.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000001248
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Article: The Days Add Up: Daily Marital Discord and Depressive Reactivity Linked to Past-Month Depressed Mood and Marital Risk across 10 Years.

Wilson, Stephanie J / Marini, Christina M

Journal of social and personal relationships

2022 Volume 40, Issue 4, Page(s) 1172–1193

Abstract: Marital discord fuels depression, according to decades of research. Most prior studies in this area have focused on macro-longitudinal change in depression over the course of years, and on global ratings of marital satisfaction. Less work has examined ... ...

Abstract	Marital discord fuels depression, according to decades of research. Most prior studies in this area have focused on macro-longitudinal change in depression over the course of years, and on global ratings of marital satisfaction. Less work has examined fluctuations in depressed mood and marital discord in daily life, and none has investigated associations of short-term patterns with longer-term depressed mood and marital outcomes. Using data from participants in the Midlife in the U.S. (MIDUS) project, the current study examined daily associations between marital discord and depressed mood, as well as their links to concurrent and prospective patterns of past-month depressed mood and marital risk. Results showed that, on average, depressed mood rose on days when individuals had an argument or tension with their spouse (i.e., marital discord). More frequent daily marital discord was also associated with greater past-month depressed mood and marital risk, above and beyond prior levels. Those with larger depressive mood responses to discord in daily life (i.e., greater reactivity) exhibited higher concurrent past-month depressed mood and greater 10-year increases in depressed mood. As the first study to link daily marital patterns to concurrent and prospective changes in depressed mood and marital outcomes, this investigation uncovered two novel processes-daily marital discord and depressive reactivity-as important for understanding long-term patterns of marital risk and depression.
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2023968-3
ISSN	1460-3608 ; 0265-4075
ISSN (online)	1460-3608
ISSN	0265-4075
DOI	10.1177/02654075221116277
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Article ; Online: The Social Context of Partnered Older Adults' Insomnia Symptoms.

Marini, Christina M / Zhaoyang, Ruixue / Martire, Lynn M / Buxton, Orfeu M

International journal of aging & human development

2022 Volume 97, Issue 1, Page(s) 18–34

Abstract: The current study included an examination of social factors that mitigate or exacerbate insomnia symptoms among older adults who are married or living with a partner. We first examined the unique effects of spousal support and strain on insomnia symptoms ...

Abstract	The current study included an examination of social factors that mitigate or exacerbate insomnia symptoms among older adults who are married or living with a partner. We first examined the unique effects of spousal support and strain on insomnia symptoms and then evaluated the degree to which extramarital social factors (e.g., friend support) moderated spousal influences. Data came from Waves 2 and 3 of the National Social Life, Health, and Aging Project. Our sample consisted of 495 participants who were either married or cohabitating with a partner (
MeSH term(s)	Humans ; Aged ; Sleep Initiation and Maintenance Disorders/epidemiology ; Marriage ; Marital Status ; Aging ; Social Environment
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	187072-5
ISSN	1541-3535 ; 0091-4150
ISSN (online)	1541-3535
ISSN	0091-4150
DOI	10.1177/00914150221128973
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Article: Dyadic Links Between Health Changes and Well-Being: The Role of Non-Spousal Confidants.

Martire, Lynn M / Zhaoyang, Ruixue / Marini, Christina M / Nah, Suyoung

Journal of social and personal relationships

2022 Volume 39, Issue 8, Page(s) 2617–2638

Abstract: Although the marital relationship is often the primary source of emotional support in adulthood, sole reliance on the spouse to discuss health-related issues may be harmful to the well-being of both partners. The first aim of this study was to examine ... ...

Abstract	Although the marital relationship is often the primary source of emotional support in adulthood, sole reliance on the spouse to discuss health-related issues may be harmful to the well-being of both partners. The first aim of this study was to examine whether declines in health during later life would be associated with poorer psychological well-being in self and partner. We further investigated whether declining health would have a stronger impact on own and partner psychological well-being in the absence of non-spousal health confidants. Longitudinal actor-partner interdependence models (APIMs) were used to test both hypotheses with dyadic data from Wave 2 (2010-2011) and Wave 3 (2015-2016) of the National Social Life, Health, and Aging Project (NSHAP). Contrary to prediction, increased anxiety following spousal declines in gait speed and cognitive function occurred for those whose spouse
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2023968-3
ISSN	1460-3608 ; 0265-4075
ISSN (online)	1460-3608
ISSN	0265-4075
DOI	10.1177/02654075221086509
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Article ; Online: Marital Quality and Loneliness Among Aging Vietnam-Era Combat Veterans: The Moderating Role of PTSD Symptom Severity.

Marini, Christina M / Yorgason, Jeremy B / Pless Kaiser, Anica / Erickson, Lance D

Clinical gerontologist

2023 , Page(s) 1–15

Abstract: ... from 269 Vietnam-Era combat veterans who had a spouse/partner (M age = 60.50). Utilizing two waves of data ...

Abstract	Objectives: We examined links between marital quality and loneliness among aging veterans and explored whether veterans' PTSD symptom severity moderated these associations. Methods: Data came from 269 Vietnam-Era combat veterans who had a spouse/partner (M age = 60.50). Utilizing two waves of data spanning six years, we estimated multiple regression models that included positive and negative marital quality, PTSD symptom severity, and loneliness in 2010 as predictors of loneliness in 2016. Results: Facets of positive (but not negative) marital quality were associated with veterans' loneliness. Companionship - spousal affection and understanding - was associated with lower subsequent loneliness among veterans with low/moderate - but not high - PTSD symptom severity. Conversely, sociability - the degree to which one's marriage promotes socializing with others - was associated with lower subsequent loneliness regardless of PTSD symptom severity. Conclusions: Companionship and sociability were each associated with veterans' subsequent loneliness. Whereas benefits of companionship were attenuated at higher levels of PTSD symptom severity, benefits of sociability were not. Clinical implications: For veterans with higher PTSD symptoms, recommending mental health treatment to decrease symptom severity may help them to reap the benefits of close/intimate relationships. However, bolstering veterans' social participation more broadly may provide an additional means of reducing their loneliness.
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2023.2274052
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Article: The

Marini, Simone / Boucher, Christina / Noyes, Noelle / Prosperi, Mattia

Frontiers in microbiology

2023 Volume 14, Page(s) 1060891

Abstract: Characterization of antibiotic resistance genes (ARGs) from high-throughput sequencing data of metagenomics and cultured bacterial samples is a challenging task, with the need to account for both computational (e.g., string algorithms) and biological (e ... ...

Abstract	Characterization of antibiotic resistance genes (ARGs) from high-throughput sequencing data of metagenomics and cultured bacterial samples is a challenging task, with the need to account for both computational (e.g., string algorithms) and biological (e.g., gene transfers, rearrangements) aspects. Curated ARG databases exist together with assorted ARG classification approaches (e.g., database alignment, machine learning). Besides ARGs that naturally occur in bacterial strains or are acquired through mobile elements, there are chromosomal genes that can render a bacterium resistant to antibiotics through point mutations, i.e., ARG variants (ARGVs). While ARG repositories also collect ARGVs, there are only a few tools that are able to identify ARGVs from metagenomics and high throughput sequencing data, with a number of limitations (e.g., pre-assembly,
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1060891
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Article ; Online: Assessing putative bias in prediction of anti-microbial resistance from real-world genotyping data under explicit causal assumptions.

Prosperi, Mattia / Boucher, Christina / Bian, Jiang / Marini, Simone

Artificial intelligence in medicine

2022 Volume 130, Page(s) 102326

Abstract: Whole genome sequencing (WGS) is quickly becoming the customary means for identification of antimicrobial resistance (AMR) due to its ability to obtain high resolution information about the genes and mechanisms that are causing resistance and driving ... ...

Abstract	Whole genome sequencing (WGS) is quickly becoming the customary means for identification of antimicrobial resistance (AMR) due to its ability to obtain high resolution information about the genes and mechanisms that are causing resistance and driving pathogen mobility. By contrast, traditional phenotypic (antibiogram) testing cannot easily elucidate such information. Yet development of AMR prediction tools from genotype-phenotype data can be biased, since sampling is non-randomized. Sample provenience, period of collection, and species representation can confound the association of genetic traits with AMR. Thus, prediction models can perform poorly on new data with sampling distribution shifts. In this work -under an explicit set of causal assumptions- we evaluate the effectiveness of propensity-based rebalancing and confounding adjustment on antibiotic resistance prediction using genotype-phenotype AMR data from the Pathosystems Resource Integration Center (PATRIC). We select bacterial genotypes (encoded as k-mer signatures, i.e., DNA fragments of length k), country, year, species, and AMR phenotypes for the tetracycline drug class, preparing test data with recent genomes coming from a single country. We test boosted logistic regression (BLR) and random forests (RF) with/without bias-handling. On 10,936 instances, we find evidence of species, location and year imbalance with respect to the AMR phenotype. The crude versus bias-adjusted change in effect of genetic signatures on AMR varies but only moderately (selecting the top 20,000 out of 40+ million k-mers). The area under the receiver operating characteristic (AUROC) of the RF (0.95) is comparable to that of BLR (0.94) on both out-of-bag samples from bootstrap and the external test (n = 1085), where AUROCs do not decrease. We observe a 1 %-5 % gain in AUROC with bias-handling compared to the sole use of genetic signatures. In conclusion, we recommend using causally-informed prediction methods for modeling real-world AMR data; however, traditional adjustment or propensity-based methods may not provide advantage in all use cases and further methodological development should be sought.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Genome, Bacterial ; Genotype ; Microbial Sensitivity Tests ; Whole Genome Sequencing/methods
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-06-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	645179-2
ISSN	1873-2860 ; 0933-3657
ISSN (online)	1873-2860
ISSN	0933-3657
DOI	10.1016/j.artmed.2022.102326
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Article ; Online: Military couples' experiences in the aftermath of a cancelled deployment.

Marini, Christina M / Basinger, Erin D / Monk, James K / McCall, Christine E / MacDermid Wadsworth, Shelley M

Family process

2022 Volume 61, Issue 4, Page(s) 1577–1592

Abstract: Deployment requires considerable preparation for military families and changes to these plans may create notable stress. The current study leveraged data from a sample of military couples who experienced the cancellation of an overseas deployment to ... ...

Abstract	Deployment requires considerable preparation for military families and changes to these plans may create notable stress. The current study leveraged data from a sample of military couples who experienced the cancellation of an overseas deployment to learn more about their experiences as they adjusted to this change. Guided by family stress and anticipatory stress perspectives, we analyzed qualitative data from 28 service members and their significant others (i.e., spouses or cohabitating partners) to understand their overall reactions to the deployment cancellation. We identified three overall reactions (positive, negative, and ambivalent) that were based on participants' appraisals of-and preparations for-deployment, as well as ambiguity about family roles and relationships. Further, participants across groups experienced uncertainty about whether or not the deployment would occur, and altered timelines for other life events. Together, our findings highlight the post-cancellation period as a significant time of stress and transition for military families. However, our findings also signify the need to help all military families cope with uncertainty about when or if deployments will occur given that the military's priorities are often in flux. We therefore describe coping efforts that may be particularly adaptive for families to engage in as they prepare for uncertain, anticipated stressors.
MeSH term(s)	Humans ; Military Family ; Spouses ; Marital Status ; Social Group
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	212740-4
ISSN	1545-5300 ; 0014-7370
ISSN (online)	1545-5300
ISSN	0014-7370
DOI	10.1111/famp.12747
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Article ; Online: Naloxone protection, social support, network characteristics, and overdose experiences among a cohort of people who use illicit opioids in New York City.

Bennett, Alex S / Scheidell, Joy / Bowles, Jeanette M / Khan, Maria / Roth, Alexis / Hoff, Lee / Marini, Christina / Elliott, Luther

Harm reduction journal

2022 Volume 19, Issue 1, Page(s) 20

Abstract: Background: Despite increased availability of take-home naloxone, many people who use opioids do so in unprotected contexts, with no other person who might administer naloxone present, increasing the likelihood that an overdose will result in death. ... ...

Abstract	Background: Despite increased availability of take-home naloxone, many people who use opioids do so in unprotected contexts, with no other person who might administer naloxone present, increasing the likelihood that an overdose will result in death. Thus, there is a social nature to being "protected" from overdose mortality, which highlights the importance of identifying background factors that promote access to protective social networks among people who use opioids. Methods: We used respondent-driven sampling to recruit adults residing in New York City who reported recent (past 3-day) nonmedical opioid use (n = 575). Participants completed a baseline assessment that included past 30-day measures of substance use, overdose experiences, and number of "protected" opioid use events, defined as involving naloxone and the presence of another person who could administer it, as well as measures of network characteristics and social support. We used modified Poisson regression with robust variance to estimate unadjusted and adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). Results: 66% of participants had ever been trained to administer naloxone, 18% had used it in the past three months, and 32% had experienced a recent overdose (past 30 days). During recent opioid use events, 64% reported never having naloxone and a person to administer present. This was more common among those: aged ≥ 50 years (PR: 1.18 (CI 1.03, 1.34); who identified as non-Hispanic Black (PR: 1.27 (CI 1.05, 1.53); experienced higher levels of stigma consciousness (PR: 1.13 (CI 1.00, 1.28); and with small social networks (< 5 persons) (APR: 1.14 (CI 0.98, 1.31). Having a recent overdose experience was associated with severe opioid use disorder (PR: 2.45 (CI 1.49, 4.04), suicidality (PR: 1.72 (CI 1.19, 2.49), depression (PR: 1.54 (CI 1.20, 1.98) and positive urinalysis result for benzodiazepines (PR: 1.56 (CI 1.23, 1.96), but not with network size. Conclusions: Results show considerable gaps in naloxone protection among people who use opioids, with more vulnerable and historically disadvantaged subpopulations less likely to be protected. Larger social networks of people who use opioids may be an important resource to curtail overdose mortality, but more effort is needed to harness the protective aspects of social networks.
MeSH term(s)	Adult ; Analgesics, Opioid/therapeutic use ; Drug Overdose/drug therapy ; Humans ; Middle Aged ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; New York City/epidemiology ; Opioid-Related Disorders/drug therapy ; Public Policy ; Social Networking ; Social Support
Chemical Substances	Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-022-00604-w
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