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  1. Article ; Online: Search for a Charged Higgs Boson Produced in the Vector-Boson Fusion Mode with Decay H(±)→W(±)Z using pp Collisions at √s=8  TeV with the ATLAS Experiment.

    Aad, G / Abbott, B / Abdallah, J / Abdinov, O / Aben, R / Abolins, M / AbouZeid, O S / Abramowicz, H / Abreu, H / Abreu, R / Abulaiti, Y / Acharya, B S / Adamczyk, L / Adams, D L / Adelman, J / Adomeit, S / Adye, T / Affolder, A A / Agatonovic-Jovin, T /
    Aguilar-Saavedra, J A / Ahlen, S P / Ahmadov, F / Aielli, G / Akerstedt, H / Åkesson, T P A / Akimoto, G / Akimov, A V / Alberghi, G L / Albert, J / Albrand, S / Alconada Verzini, M J / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexander, G / Alexopoulos, T / Alhroob, M / Alimonti, G / Alio, L / Alison, J / Alkire, S P / Allbrooke, B M M / Allport, P P / Aloisio, A / Alonso, A / Alonso, F / Alpigiani, C / Altheimer, A / Alvarez Gonzalez, B / Álvarez Piqueras, D / Alviggi, M G / Amadio, B T / Amako, K / Amaral Coutinho, Y / Amelung, C / Amidei, D / Amor Dos Santos, S P / Amorim, A / Amoroso, S / Amram, N / Amundsen, G / Anastopoulos, C / Ancu, L S / Andari, N / Andeen, T / Anders, C F / Anders, G / Anders, J K / Anderson, K J / Andreazza, A / Andrei, V / Angelidakis, S / Angelozzi, I / Anger, P / Angerami, A / Anghinolfi, F / Anisenkov, A V / Anjos, N / Annovi, A / Antonelli, M / Antonov, A / Antos, J / Anulli, F / Aoki, M / Aperio Bella, L / Arabidze, G / Arai, Y / Araque, J P / Arce, A T H / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arik, M / Armbruster, A J / Arnaez, O / Arnal, V / Arnold, H / Arratia, M / Arslan, O / Artamonov, A / Artoni, G / Asai, S / Asbah, N / Ashkenazi, A / Åsman, B / Asquith, L / Assamagan, K / Astalos, R / Atkinson, M / Atlay, N B / Auerbach, B / Augsten, K / Aurousseau, M / Avolio, G / Axen, B / Ayoub, M K / Azuelos, G / Baak, M A / Baas, A E / Bacci, C / Bachacou, H / Bachas, K / Backes, M / Backhaus, M / Badescu, E / Bagiacchi, P / Bagnaia, P / Bai, Y / Bain, T / Baines, J T / Baker, O K / Balek, P / Balestri, T / Balli, F / Banas, E / Banerjee, Sw / Bannoura, A A E / Bansil, H S / Barak, L / Baranov, S P / Barberio, E L / Barberis, D / Barbero, M / Barillari, T / Barisonzi, M / Barklow, T / Barlow, N / Barnes, S L / Barnett, B M / Barnett, R M / Barnovska, Z / Baroncelli, A / Barone, G / Barr, A J / Barreiro, F / Barreiro Guimarães da Costa, J / Bartoldus, R / Barton, A E / Bartos, P / Bassalat, A / Basye, A / Bates, R L / Batista, S J / Batley, J R / Battaglia, M / Bauce, M / Bauer, F / Bawa, H S / Beacham, J B / Beattie, M D / Beau, T / Beauchemin, P H / Beccherle, R / Bechtle, P / Beck, H P / Becker, K / Becker, M / Becker, S / Beckingham, M / Becot, C / Beddall, A J / Beddall, A / Bednyakov, V A / Bee, C P / Beemster, L J / Beermann, T A / Begel, M / Behr, J K / Belanger-Champagne, C / Bell, P J / Bell, W H / Bella, G / Bellagamba, L / Bellerive, A / Bellomo, M / Belotskiy, K / Beltramello, O / Benary, O / Benchekroun, D / Bender, M / Bendtz, K / Benekos, N / Benhammou, Y / Benhar Noccioli, E / Benitez Garcia, J A / Benjamin, D P / Bensinger, J R / Bentvelsen, S / Beresford, L / Beretta, M / Berge, D / Bergeaas Kuutmann, E / Berger, N / Berghaus, F / Beringer, J / Bernard, C / Bernard, N R / Bernius, C / Bernlochner, F U / Berry, T / Berta, P / Bertella, C / Bertoli, G / Bertolucci, F / Bertsche, C / Bertsche, D / Besana, M I / Besjes, G J / Bessidskaia Bylund, O / Bessner, M / Besson, N / Betancourt, C / Bethke, S / Bevan, A J / Bhimji, W / Bianchi, R M / Bianchini, L / Bianco, M / Biebel, O / Bieniek, S P / Biglietti, M / Bilbao De Mendizabal, J / Bilokon, H / Bindi, M / Binet, S / Bingul, A / Bini, C / Black, C W / Black, J E / Black, K M / Blackburn, D / Blair, R E / Blanchard, J-B / Blanco, J E / Blazek, T / Bloch, I / Blocker, C / Blum, W / Blumenschein, U / Bobbink, G J / Bobrovnikov, V S / Bocchetta, S S / Bocci, A / Bock, C / Boehler, M / Bogaerts, J A / Bogdanchikov, A G / Bohm, C / Boisvert, V / Bold, T / Boldea, V / Boldyrev, A S / Bomben, M / Bona, M / Boonekamp, M / Borisov, A / Borissov, G / Borroni, S / Bortfeldt, J / Bortolotto, V / Bos, K / Boscherini, D / Bosman, M / Boudreau, J / Bouffard, J / Bouhova-Thacker, E V / Boumediene, D / Bourdarios, C / Bousson, N / Boveia, A / Boyd, J / Boyko, I R / Bozic, I / Bracinik, J / Brandt, A / Brandt, G / Brandt, O / Bratzler, U / Brau, B / Brau, J E / Braun, H M / Brazzale, S F / Brendlinger, K / Brennan, A J / Brenner, L / Brenner, R / Bressler, S / Bristow, K / Bristow, T M / Britton, D / Britzger, D / Brochu, F M / Brock, I / Brock, R / Bronner, J / Brooijmans, G / Brooks, T / Brooks, W K / Brosamer, J / Brost, E / Brown, J / Bruckman de Renstrom, P A / Bruncko, D / Bruneliere, R / Bruni, A / Bruni, G / Bruschi, M / Bryngemark, L / Buanes, T / Buat, Q / Buchholz, P / Buckley, A G / Buda, S I / Budagov, I A / Buehrer, F / Bugge, L / Bugge, M K / Bulekov, O / Burckhart, H / Burdin, S / Burghgrave, B / Burke, S / Burmeister, I / Busato, E / Büscher, D / Büscher, V / Bussey, P / Buszello, C P / Butler, J M / Butt, A I / Buttar, C M / Butterworth, J M / Butti, P / Buttinger, W / Buzatu, A / Buzykaev, R / Cabrera Urbán, S / Caforio, D / Cairo, V M / Cakir, O / Calafiura, P / Calandri, A / Calderini, G / Calfayan, P / Caloba, L P / Calvet, D / Calvet, S / Camacho Toro, R / Camarda, S / Camarri, P / Cameron, D / Caminada, L M / Caminal Armadans, R / Campana, S / Campanelli, M / Campoverde, A / Canale, V / Canepa, A / Cano Bret, M / Cantero, J / Cantrill, R / Cao, T / Capeans Garrido, M D M / Caprini, I / Caprini, M / Capua, M / Caputo, R / Cardarelli, R / Carli, T / Carlino, G / Carminati, L / Caron, S / Carquin, E / Carrillo-Montoya, G D / Carter, J R / Carvalho, J / Casadei, D / Casado, M P / Casolino, M / Castaneda-Miranda, E / Castelli, A / Castillo Gimenez, V / Castro, N F / Catastini, P / Catinaccio, A / Catmore, J R / Cattai, A / Caudron, J / Cavaliere, V / Cavalli, D / Cavalli-Sforza, M / Cavasinni, V / Ceradini, F / Cerio, B C / Cerny, K / Cerqueira, A S / Cerri, A / Cerrito, L / Cerutti, F / Cerv, M / Cervelli, A / Cetin, S A / Chafaq, A / Chakraborty, D / Chalupkova, I / Chang, P / Chapleau, B / Chapman, J D / Charlton, D G / Chau, C C / Chavez Barajas, C A / Cheatham, S / Chegwidden, A / Chekanov, S / Chekulaev, S V / Chelkov, G A / Chelstowska, M A / Chen, C / Chen, H / Chen, K / Chen, L / Chen, S / Chen, X / Chen, Y / Cheng, H C / Cheng, Y / Cheplakov, A / Cheremushkina, E / Cherkaoui El Moursli, R / Chernyatin, V / Cheu, E / Chevalier, L / Chiarella, V / Childers, J T / Chiodini, G / Chisholm, A S / Chislett, R T / Chitan, A / Chizhov, M V / Choi, K / Chouridou, S / Chow, B K B / Christodoulou, V / Chromek-Burckhart, D / Chu, M L / Chudoba, J / Chuinard, A J / Chwastowski, J J / Chytka, L / Ciapetti, G / Ciftci, A K / Cinca, D / Cindro, V / Cioara, I A / Ciocio, A / Citron, Z H / Ciubancan, M / Clark, A / Clark, B L / Clark, P J / Clarke, R N / Cleland, W / Clement, C / Coadou, Y / Cobal, M / Coccaro, A / Cochran, J / Coffey, L / Cogan, J G / Cole, B / Cole, S / Colijn, A P / Collot, J / Colombo, T / Compostella, G / Conde Muiño, P / Coniavitis, E / Connell, S H / Connelly, I A / Consonni, S M / Consorti, V / Constantinescu, S / Conta, C / Conti, G / Conventi, F / Cooke, M / Cooper, B D / Cooper-Sarkar, A M / Cornelissen, T / Corradi, M / Corriveau, F / Corso-Radu, A / Cortes-Gonzalez, A / Cortiana, G / Costa, G / Costa, M J / Costanzo, D / Côté, D / Cottin, G / Cowan, G / Cox, B E / Cranmer, K / Cree, G / Crépé-Renaudin, S / Crescioli, F / Cribbs, W A / Crispin Ortuzar, M / Cristinziani, M / Croft, V / Crosetti, G / Cuhadar Donszelmann, T / Cummings, J / Curatolo, M / Cuthbert, C / Czirr, H / Czodrowski, P / D'Auria, S / D'Onofrio, M / Da Cunha Sargedas De Sousa, M J / Da Via, C / Dabrowski, W / Dafinca, A / Dai, T / Dale, O / Dallaire, F / Dallapiccola, C / Dam, M / Dandoy, J R / Dang, N P / Daniells, A C / Danninger, M / Dano Hoffmann, M / Dao, V / Darbo, G / Darmora, S / Dassoulas, J / Dattagupta, A / Davey, W / David, C / Davidek, T / Davies, E / Davies, M / Davison, P / Davygora, Y / Dawe, E / Dawson, I / Daya-Ishmukhametova, R K / De, K / de Asmundis, R / De Castro, S / De Cecco, S / De Groot, N / de Jong, P / De la Torre, H / De Lorenzi, F / De Nooij, L / De Pedis, D / De Salvo, A / De Sanctis, U / De Santo, A / De Vivie De Regie, J B / Dearnaley, W J / Debbe, R / Debenedetti, C / Dedovich, D V / Deigaard, I / Del Peso, J / Del Prete, T / Delgove, D / Deliot, F / Delitzsch, C M / Deliyergiyev, M / Dell'Acqua, A / Dell'Asta, L / Dell'Orso, M / Della Pietra, M / della Volpe, D / Delmastro, M / Delsart, P A / Deluca, C / DeMarco, D A / Demers, S / Demichev, M / Demilly, A / Denisov, S P / Derendarz, D / Derkaoui, J E / Derue, F / Dervan, P / Desch, K / Deterre, C / Deviveiros, P O / Dewhurst, A / Dhaliwal, S / Di Ciaccio, A / Di Ciaccio, L / Di Domenico, A / Di Donato, C / Di Girolamo, A / Di Girolamo, B / Di Mattia, A / Di Micco, B / Di Nardo, R / Di Simone, A / Di Sipio, R / Di Valentino, D / Diaconu, C / Diamond, M / Dias, F A / Diaz, M A / Diehl, E B / Dietrich, J / Diglio, S / Dimitrievska, A / Dingfelder, J / Dittus, F / Djama, F / Djobava, T / Djuvsland, J I / do Vale, M A B / Dobos, D / Dobre, M / Doglioni, C / Dohmae, T / Dolejsi, J / Dolezal, Z / Dolgoshein, B A / Donadelli, M / Donati, S / Dondero, P / Donini, J / Dopke, J / Doria, A / Dova, M T / Doyle, A T / Drechsler, E / Dris, M / Dubreuil, E / Duchovni, E / Duckeck, G / Ducu, O A / Duda, D / Dudarev, A / Duflot, L / Duguid, L / Dührssen, M / Dunford, M / Duran Yildiz, H / Düren, M / Durglishvili, A / Duschinger, D / Dyndal, M / Eckardt, C / Ecker, K M / Edgar, R C / Edson, W / Edwards, N C / Ehrenfeld, W / Eifert, T / Eigen, G / Einsweiler, K / Ekelof, T / El Kacimi, M / Ellert, M / Elles, S / Ellinghaus, F / Elliot, A A / Ellis, N / Elmsheuser, J / Elsing, M / Emeliyanov, D / Enari, Y / Endner, O C / Endo, M / Engelmann, R / Erdmann, J / Ereditato, A / Ernis, G / Ernst, J / Ernst, M / Errede, S / Ertel, E / Escalier, M / Esch, H / Escobar, C / Esposito, B / Etienvre, A I / Etzion, E / Evans, H / Ezhilov, A / Fabbri, L / Facini, G / Fakhrutdinov, R M / Falciano, S / Falla, R J / Faltova, J / Fang, Y / Fanti, M / Farbin, A / Farilla, A / Farooque, T / Farrell, S / Farrington, S M / Farthouat, P / Fassi, F / Fassnacht, P / Fassouliotis, D / Faucci Giannelli, M / Favareto, A / Fayard, L / Federic, P / Fedin, O L / Fedorko, W / Feigl, S / Feligioni, L / Feng, C / Feng, E J / Feng, H / Fenyuk, A B / Fernandez Martinez, P / Fernandez Perez, S / Ferrag, S / Ferrando, J / Ferrari, A / Ferrari, P / Ferrari, R / Ferreira de Lima, D E / Ferrer, A / Ferrere, D / Ferretti, C / Ferretto Parodi, A / Fiascaris, M / Fiedler, F / Filipčič, A / Filipuzzi, M / Filthaut, F / Fincke-Keeler, M / Finelli, K D / Fiolhais, M C N / Fiorini, L / Firan, A / Fischer, A / Fischer, C / Fischer, J / Fisher, W C / Fitzgerald, E A / Flechl, M / Fleck, I / Fleischmann, P / Fleischmann, S / Fletcher, G T / Fletcher, G / Flick, T / Floderus, A / Flores Castillo, L R / Flowerdew, M J / Formica, A / Forti, A / Fournier, D / Fox, H / Fracchia, S / Francavilla, P / Franchini, M / Francis, D / Franconi, L / Franklin, M / Fraternali, M / Freeborn, D / French, S T / Friedrich, F / Froidevaux, D / Frost, J A / Fukunaga, C / Fullana Torregrosa, E / Fulsom, B G / Fuster, J / Gabaldon, C / Gabizon, O / Gabrielli, A / Gadatsch, S / Gadomski, S / Gagliardi, G / Gagnon, P / Galea, C / Galhardo, B / Gallas, E J / Gallop, B J / Gallus, P / Galster, G / Gan, K K / Gao, J / Gao, Y / Gao, Y S / Garay Walls, F M / Garberson, F / García, C / García Navarro, J E / Garcia-Sciveres, M / Gardner, R W / Garelli, N / Garonne, V / Gatti, C / Gaudiello, A / Gaudio, G / Gaur, B / Gauthier, L / Gauzzi, P / Gavrilenko, I L / Gay, C / Gaycken, G / Gazis, E N / Ge, P / Gecse, Z / Gee, C N P / Geerts, D A A / Geich-Gimbel, Ch / Geisler, M P / Gemme, C / Genest, M H / Gentile, S / George, M / George, S / Gerbaudo, D / Gershon, A / Ghazlane, H / Giacobbe, B / Giagu, S / Giangiobbe, V / Giannetti, P / Gibbard, B / Gibson, S M / Gilchriese, M / Gillam, T P S / Gillberg, D / Gilles, G / Gingrich, D M / Giokaris, N / Giordani, M P / Giorgi, F M / Giraud, P F / Giromini, P / Giugni, D / Giuliani, C / Giulini, M / Gjelsten, B K / Gkaitatzis, S / Gkialas, I / Gkougkousis, E L / Gladilin, L K / Glasman, C / Glatzer, J / Glaysher, P C F / Glazov, A / Goblirsch-Kolb, M / Goddard, J R / Godlewski, J / Goldfarb, S / Golling, T / Golubkov, D / Gomes, A / Gonçalo, R / Goncalves Pinto Firmino Da Costa, J / Gonella, L / González de la Hoz, S / Gonzalez Parra, G / Gonzalez-Sevilla, S / Goossens, L / Gorbounov, P A / Gordon, H A / Gorelov, I / Gorini, B / Gorini, E / Gorišek, A / Gornicki, E / Goshaw, A T / Gössling, C / Gostkin, M I / Goujdami, D / Goussiou, A G / Govender, N / Grabas, H M X / Graber, L / Grabowska-Bold, I / Grafström, P / Grahn, K-J / Gramling, J / Gramstad, E / Grancagnolo, S / Grassi, V / Gratchev, V / Gray, H M / Graziani, E / Greenwood, Z D / Gregersen, K / Gregor, I M / Grenier, P / Griffiths, J / Grillo, A A / Grimm, K / Grinstein, S / Gris, Ph / Grivaz, J-F / Grohs, J P / Grohsjean, A / Gross, E / Grosse-Knetter, J / Grossi, G C / Grout, Z J / Guan, L / Guenther, J / Guescini, F / Guest, D / Gueta, O / Guido, E / Guillemin, T / Guindon, S / Gul, U / Gumpert, C / Guo, J / Gupta, S / Gutierrez, P / Gutierrez Ortiz, N G / Gutschow, C / Guyot, C / Gwenlan, C / Gwilliam, C B / Haas, A / Haber, C / Hadavand, H K / Haddad, N / Haefner, P / Hageböck, S / Hajduk, Z / Hakobyan, H / Haleem, M / Haley, J / Hall, D / Halladjian, G / Hallewell, G D / Hamacher, K / Hamal, P / Hamano, K / Hamer, M / Hamilton, A / Hamilton, S / Hamity, G N / Hamnett, P G / Han, L / Hanagaki, K / Hanawa, K / Hance, M / Hanke, P / Hanna, R / Hansen, J B / Hansen, J D / Hansen, M C / Hansen, P H / Hara, K / Hard, A S / Harenberg, T / Hariri, F / Harkusha, S / Harrington, R D / Harrison, P F / Hartjes, F / Hasegawa, M / Hasegawa, S / Hasegawa, Y / Hasib, A / Hassani, S / Haug, S / Hauser, R / Hauswald, L / Havranek, M / Hawkes, C M / Hawkings, R J / Hawkins, A D / Hayashi, T / Hayden, D / Hays, C P / Hays, J M / Hayward, H S / Haywood, S J / Head, S J / Heck, T / Hedberg, V / Heelan, L / Heim, S / Heim, T / Heinemann, B / Heinrich, L / Hejbal, J / Helary, L / Hellman, S / Hellmich, D / Helsens, C / Henderson, J / Henderson, R C W / Heng, Y / Hengler, C / Henrichs, A / Henriques Correia, A M / Henrot-Versille, S / Herbert, G H / Hernández Jiménez, Y / Herrberg-Schubert, R / Herten, G / Hertenberger, R / Hervas, L / Hesketh, G G / Hessey, N P / Hetherly, J W / Hickling, R / Higón-Rodriguez, E / Hill, E / Hill, J C / Hiller, K H / Hillier, S J / Hinchliffe, I / Hines, E / Hinman, R R / Hirose, M / Hirschbuehl, D / Hobbs, J / Hod, N / Hodgkinson, M C / Hodgson, P / Hoecker, A / Hoeferkamp, M R / Hoenig, F / Hohlfeld, M / Hohn, D / Holmes, T R / Hong, T M / Hooft van Huysduynen, L / Hopkins, W H / Horii, Y / Horton, A J / Hostachy, J-Y / Hou, S / Hoummada, A / Howard, J / Howarth, J / Hrabovsky, M / Hristova, I / Hrivnac, J / Hryn'ova, T / Hrynevich, A / Hsu, C / Hsu, P J / Hsu, S-C / Hu, D / Hu, Q / Hu, X / Huang, Y / Hubacek, Z / Hubaut, F / Huegging, F / Huffman, T B / Hughes, E W / Hughes, G / Huhtinen, M / Hülsing, T A / Huseynov, N / Huston, J / Huth, J / Iacobucci, G / Iakovidis, G / Ibragimov, I / Iconomidou-Fayard, L / Ideal, E / Idrissi, Z / Iengo, P / Igonkina, O / Iizawa, T / Ikegami, Y / Ikematsu, K / Ikeno, M / Ilchenko, Y / Iliadis, D / Ilic, N / Inamaru, Y / Ince, T / Ioannou, P / Iodice, M / Iordanidou, K / Ippolito, V / Irles Quiles, A / Isaksson, C / Ishino, M / Ishitsuka, M / Ishmukhametov, R / Issever, C / Istin, S / Iturbe Ponce, J M / Iuppa, R / Ivarsson, J / Iwanski, W / Iwasaki, H / Izen, J M / Izzo, V / Jabbar, S / Jackson, B / Jackson, M / Jackson, P / Jaekel, M R / Jain, V / Jakobs, K / Jakobsen, S / Jakoubek, T / Jakubek, J / Jamin, D O / Jana, D K / Jansen, E / Jansky, R W / Janssen, J / Janus, M / Jarlskog, G / Javadov, N / Javůrek, T / Jeanty, L / Jejelava, J / Jeng, G-Y / Jennens, D / Jenni, P / Jentzsch, J / Jeske, C / Jézéquel, S / Ji, H / Jia, J / Jiang, Y / Jiggins, S / Jimenez Pena, J / Jin, S / Jinaru, A / Jinnouchi, O / Joergensen, M D / Johansson, P / Johns, K A / Jon-And, K / Jones, G / Jones, R W L / Jones, T J / Jongmanns, J / Jorge, P M / Joshi, K D / Jovicevic, J / Ju, X / Jung, C A / Jussel, P / Juste Rozas, A / Kaci, M / Kaczmarska, A / Kado, M / Kagan, H / Kagan, M / Kahn, S J / Kajomovitz, E / Kalderon, C W / Kama, S / Kamenshchikov, A / Kanaya, N / Kaneda, M / Kaneti, S / Kantserov, V A / Kanzaki, J / Kaplan, B / Kapliy, A / Kar, D / Karakostas, K / Karamaoun, A / Karastathis, N / Kareem, M J / Karnevskiy, M / Karpov, S N / Karpova, Z M / Karthik, K / Kartvelishvili, V / Karyukhin, A N / Kashif, L / Kass, R D / Kastanas, A / Kataoka, Y / Katre, A / Katzy, J / Kawagoe, K / Kawamoto, T / Kawamura, G / Kazama, S / Kazanin, V F / Kazarinov, M Y / Keeler, R / Kehoe, R / Keller, J S / Kempster, J J / Keoshkerian, H / Kepka, O / Kerševan, B P / Kersten, S / Keyes, R A / Khalil-zada, F / Khandanyan, H / Khanov, A / Kharlamov, A G / Khoo, T J / Khovanskiy, V / Khramov, E / Khubua, J / Kim, H Y / Kim, H / Kim, S H / Kim, Y / Kimura, N / Kind, O M / King, B T / King, M / King, R S B / King, S B / Kirk, J / Kiryunin, A E / Kishimoto, T / Kisielewska, D / Kiss, F / Kiuchi, K / Kivernyk, O / Kladiva, E / Klein, M H / Klein, M / Klein, U / Kleinknecht, K / Klimek, P / Klimentov, A / Klingenberg, R / Klinger, J A / Klioutchnikova, T / Klok, P F / Kluge, E-E / Kluit, P / Kluth, S / Kneringer, E / Knoops, E B F G / Knue, A / Kobayashi, A / Kobayashi, D / Kobayashi, T / Kobel, M / Kocian, M / Kodys, P / Koffas, T / Koffeman, E / Kogan, L A / Kohlmann, S / Kohout, Z / Kohriki, T / Koi, T / Kolanoski, H / Koletsou, I / Komar, A A / Komori, Y / Kondo, T / Kondrashova, N / Köneke, K / König, A C / König, S / Kono, T / Konoplich, R / Konstantinidis, N / Kopeliansky, R / Koperny, S / Köpke, L / Kopp, A K / Korcyl, K / Kordas, K / Korn, A / Korol, A A / Korolkov, I / Korolkova, E V / Kortner, O / Kortner, S / Kosek, T / Kostyukhin, V V / Kotov, V M / Kotwal, A / Kourkoumeli-Charalampidi, A / Kourkoumelis, C / Kouskoura, V / Koutsman, A / Kowalewski, R / Kowalski, T Z / Kozanecki, W / Kozhin, A S / Kramarenko, V A / 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Spalla, M / Spanò, F / Spearman, W R / Spettel, F / Spighi, R / Spigo, G / Spiller, L A / Spousta, M / Spreitzer, T / St Denis, R D / Staerz, S / Stahlman, J / Stamen, R / Stamm, S / Stanecka, E / Stanescu, C / Stanescu-Bellu, M / Stanitzki, M M / Stapnes, S / Starchenko, E A / Stark, J / Staroba, P / Starovoitov, P / Staszewski, R / Stavina, P / Steinberg, P / Stelzer, B / Stelzer, H J / Stelzer-Chilton, O / Stenzel, H / Stern, S / Stewart, G A / Stillings, J A / Stockton, M C / Stoebe, M / Stoicea, G / Stolte, P / Stonjek, S / Stradling, A R / Straessner, A / Stramaglia, M E / Strandberg, J / Strandberg, S / Strandlie, A / Strauss, E / Strauss, M / Strizenec, P / Ströhmer, R / Strom, D M / Stroynowski, R / Strubig, A / Stucci, S A / Stugu, B / Styles, N A / Su, D / Su, J / Subramaniam, R / Succurro, A / Sugaya, Y / Suhr, C / Suk, M / Sulin, V V / Sultansoy, S / Sumida, T / Sun, S / Sun, X / Sundermann, J E / Suruliz, K / Susinno, G / Sutton, M R / Suzuki, S / Suzuki, Y / Svatos, M / Swedish, S / Swiatlowski, M / Sykora, I / Sykora, T / Ta, D / Taccini, C / Tackmann, K / Taenzer, J / Taffard, A / Tafirout, R / Taiblum, N / Takai, H / Takashima, R / Takeda, H / Takeshita, T / Takubo, Y / Talby, M / Talyshev, A A / Tam, J Y C / Tan, K G / Tanaka, J / Tanaka, R / Tanaka, S / Tannenwald, B B / Tannoury, N / Tapprogge, S / Tarem, S / Tarrade, F / Tartarelli, G F / Tas, P / Tasevsky, M / Tashiro, T / Tassi, E / Tavares Delgado, A / Tayalati, Y / Taylor, F E / Taylor, G N / Taylor, W / Teischinger, F A / Teixeira Dias Castanheira, M / Teixeira-Dias, P / Temming, K K / Ten Kate, H / Teng, P K / Teoh, J J / Tepel, F / Terada, S / Terashi, K / Terron, J / Terzo, S / Testa, M / Teuscher, R J / Therhaag, J / Theveneaux-Pelzer, T / Thomas, J P / Thomas-Wilsker, J / Thompson, E N / Thompson, P D / Thompson, R J / Thompson, A S / Thomsen, L A / Thomson, E / Thomson, M / Thun, R P / Tibbetts, M J / Ticse Torres, R E / Tikhomirov, V O / Tikhonov, Yu A / Timoshenko, S / Tiouchichine, E / Tipton, P / Tisserant, S / Todorov, T / Todorova-Nova, S / Tojo, J / Tokár, S / Tokushuku, K / Tollefson, K / Tolley, E / Tomlinson, L / Tomoto, M / Tompkins, L / Toms, K / Torrence, E / Torres, H / Torró Pastor, E / Toth, J / Touchard, F / Tovey, D R / Trefzger, T / Tremblet, L / Tricoli, A / Trigger, I M / Trincaz-Duvoid, S / Tripiana, M F / Trischuk, W / Trocmé, B / Troncon, C / Trottier-McDonald, M / Trovatelli, M / True, P / Truong, L / Trzebinski, M / Trzupek, A / Tsarouchas, C / Tseng, J C-L / Tsiareshka, P V / Tsionou, D / Tsipolitis, G / Tsirintanis, N / Tsiskaridze, S / Tsiskaridze, V / Tskhadadze, E G / Tsukerman, I I / Tsulaia, V / Tsuno, S / Tsybychev, D / Tudorache, A / Tudorache, V / Tuna, A N / Tupputi, S A / Turchikhin, S / Turecek, D / Turra, R / Turvey, A J / Tuts, P M / Tykhonov, A / Tylmad, M / Tyndel, M / Ueda, I / Ueno, R / Ughetto, M / Ugland, M / Uhlenbrock, M / Ukegawa, F / Unal, G / Undrus, A / Unel, G / Ungaro, F C / Unno, Y / Unverdorben, 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    Physical review letters

    2015  Volume 114, Issue 23, Page(s) 231801

    Abstract: A search for a charged Higgs boson, H(±), decaying to a W(±) boson and a Z boson is presented ... production of an H(±) boson times its branching fraction to W(±)Z. The limits are compared with predictions ... recorded with the ATLAS detector at the LHC. The H(±) boson is assumed to be produced via vector-boson ...

    Abstract A search for a charged Higgs boson, H(±), decaying to a W(±) boson and a Z boson is presented. The search is based on 20.3  fb(-1) of proton-proton collision data at a center-of-mass energy of 8 TeV recorded with the ATLAS detector at the LHC. The H(±) boson is assumed to be produced via vector-boson fusion and the decays W(±)→qq' and Z→e(+)e(-)/μ(+)μ(-) are considered. The search is performed in a range of charged Higgs boson masses from 200 to 1000 GeV. No evidence for the production of an H(±) boson is observed. Upper limits of 31-1020 fb at 95% C.L. are placed on the cross section for vector-boson fusion production of an H(±) boson times its branching fraction to W(±)Z. The limits are compared with predictions from the Georgi-Machacek Higgs triplet model.
    Language English
    Publishing date 2015-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.114.231801
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  2. Article ; Online: Industry payments to academic neurosurgeons in 2021: an open payments cross-sectional analysis.

    Debs, Luca H / Mansouri, Seena / Ledford, W Luke / Woodall, William / Vale, Fernando L

    Journal of neurosurgery

    2024  , Page(s) 1–7

    Abstract: Objective: The Open Payments Program (OPP) was a database started in 2013 by the US government to report payments made by the medical device and pharmaceutical industry to physicians. Neurosurgery is a technologically advanced field that relies heavily ... ...

    Abstract Objective: The Open Payments Program (OPP) was a database started in 2013 by the US government to report payments made by the medical device and pharmaceutical industry to physicians. Neurosurgery is a technologically advanced field that relies heavily on the latest innovations for complex treatment of its patient population. This study sought to explore the financial relationship between academic neurosurgeons and the industry.
    Methods: OPP data were reviewed for the year 2021 of all faculty neurosurgeons affiliated with a neurosurgery residency program. Trends related to general payments, research payments, associated research funding, ownership and investment interest, name of the companies making payments, monetary amount of payments per company, and number of payments per company were analyzed.
    Results: Industry payments to 1151 US academic neurosurgeons were reviewed. These neurosurgeons received $121.4 million in payments. Three hundred thirty-two companies made 18,466 payments. The average payment per neurosurgeon was approximately six-fold higher than that of all other physicians. Vascular and spine subspecialties received the highest payments. A higher proportion of research money was allocated to the Pacific division, while all other categories (including total amount) were higher in the Eastern US. Most financial contributions were made by a small number of companies.
    Conclusions: Neurosurgery has been rated by many as a field fueled by research, innovation, and technology. In 2021, academic neurosurgeons had a strong relationship with the medical device and pharmaceutical industry as reflected in the OPP data. While the true impact on patient care cannot be directly measured, the advancement of the field relies heavily on these collaborations.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2024.1.JNS232321
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  3. Article ; Online: Predictive accuracy of risk prediction models for recurrence, metastasis and survival for early-stage cutaneous melanoma: a systematic review.

    Kunonga, Tafadzwa Patience / Kenny, R P W / Astin, Margaret / Bryant, Andrew / Kontogiannis, Vasileios / Coughlan, Diarmuid / Richmond, Catherine / Eastaugh, Claire H / Beyer, Fiona R / Pearson, Fiona / Craig, Dawn / Lovat, Penny / Vale, Luke / Ellis, Robert

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e073306

    Abstract: Objectives: To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.: ... ...

    Abstract Objectives: To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.
    Design: Systematic review and narrative synthesis.
    Data sources: Searched MEDLINE, Embase, CINAHL, Cochrane Library, Science Citation Index and grey literature sources including cancer and guideline websites from 2000 to September 2021.
    Eligibility criteria: Included studies on risk prediction models for stage I and II melanoma in adults ≥18 years. Outcomes included OS, recurrence, metastases and model performance. No language or country of publication restrictions were applied.
    Data extraction and synthesis: Two pairs of reviewers independently screened studies, extracted data and assessed the risk of bias using the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies checklist and the Prediction study Risk of Bias Assessment Tool. Heterogeneous predictors prevented statistical synthesis.
    Results: From 28 967 records, 15 studies reporting 20 models were included; 8 (stage I), 2 (stage II), 7 (stages I-II) and 7 (stages not reported), but were clearly applicable to early stages. Clinicopathological predictors per model ranged from 3-10. The most common were: ulceration, Breslow thickness/depth, sociodemographic status and site. Where reported, discriminatory values were ≥0.7. Calibration measures showed good matches between predicted and observed rates. None of the studies assessed clinical usefulness of the models. Risk of bias was high in eight models, unclear in nine and low in three. Seven models were internally and externally cross-validated, six models were externally validated and eight models were internally validated.
    Conclusions: All models are effective in their predictive performance, however the low quality of the evidence raises concern as to whether current follow-up recommendations following surgical treatment is adequate. Future models should incorporate biomarkers for improved accuracy.
    Prospero registration number: CRD42018086784.
    MeSH term(s) Adult ; Humans ; Melanoma ; Prognosis ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073306
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  4. Article: Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis.

    Paul, Blessy / Merta, Holly / Ugrankar-Banerjee, Rupali / Hensley, Monica / Tran, Son / Dias do Vale, Goncalo / McDonald, Jeffrey G / Farber, Steven A / Henne, W Mike

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality control. Using multi- ... ...

    Abstract Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality control. Using multi-organismal profiling featuring
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.26.577049
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  5. Article ; Online: Clinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study.

    Peterson, Daniel / Van Poppel, Mark / Boling, Warren / Santos, Perry / Schwalb, Jason / Eisenberg, Howard / Mehta, Ashesh / Spader, Heather / Botros, James / Vrionis, Frank D / Ko, Andrew / Adelson, P David / Lega, Bradley / Konrad, Peter / Calle, Guillermo / Vale, Fernando L / Bucholz, Richard / Richardson, R Mark

    Bioelectronic medicine

    2024  Volume 10, Issue 1, Page(s) 8

    Abstract: Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of the vagus nerve activates the ... ...

    Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of the vagus nerve activates the inflammatory reflex and has been shown to inhibit the production and release of inflammatory cytokines and decrease clinical signs and symptoms in RA. The RESET-RA study was designed to determine the safety and efficacy of an active implantable device for treating RA.
    Methods: The RESET-RA study is a randomized, double-blind, sham-controlled, multi-center, two-stage pivotal trial that enrolled patients with moderate-to-severe RA who were incomplete responders or intolerant to at least one biologic or targeted synthetic disease-modifying anti-rheumatic drug. A neuroimmune modulation device (SetPoint Medical, Valencia, CA) was implanted on the left cervical vagus nerve within the carotid sheath in all patients. Following post-surgical clearance, patients were randomly assigned (1:1) to active stimulation or non-active (control) stimulation for 1 min once per day. A predefined blinded interim analysis was performed in patients enrolled in the study's initial stage (Stage 1) that included demographics, enrollment rates, device implantation rates, and safety of the surgical procedure, device, and stimulation over 12 weeks of treatment.
    Results: Sixty patients were implanted during Stage 1 of the study. All device implant procedures were completed without intraoperative complications, infections, or surgical revisions. No unanticipated adverse events were reported during the perioperative period and at the end of 12 weeks of follow-up. No study discontinuations were due to adverse events, and no serious adverse events were related to the device or stimulation. Two serious adverse events were related to the implantation procedure: vocal cord paresis and prolonged hoarseness. These were reported in two patients and are known complications of surgical implantation procedures with vagus nerve stimulation devices. The adverse event of vocal cord paresis resolved after vocal cord augmentation injections with filler and speech therapy. The prolonged hoarseness had improved with speech therapy, but mild hoarseness persists.
    Conclusions: The surgical procedures for implantation of the novel neuroimmune modulation device for the treatment of RA were safe, and the device and its use were well tolerated.
    Trial registration: NCT04539964; August 31, 2020.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-023-00138-x
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  6. Article ; Online: Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high-intensity treadmill training.

    Knych, Heather K / Wilson, W David / Vale, Alina / Kass, Philip H / Steffey, Eugene P / Jones, James H / Arthur, Rick M

    Journal of veterinary pharmacology and therapeutics

    2020  Volume 43, Issue 6, Page(s) 565–576

    Abstract: Although controversial, due to its reported effectiveness in attenuating bleeding associated with exercise-induced pulmonary hemorrhage (EIPH), furosemide is currently a permitted race day medication in most North American racing jurisdictions. The ... ...

    Abstract Although controversial, due to its reported effectiveness in attenuating bleeding associated with exercise-induced pulmonary hemorrhage (EIPH), furosemide is currently a permitted race day medication in most North American racing jurisdictions. The objective of this study was to assess the efficacy of furosemide in reducing the presence and severity of EIPH when administered 24 hr prior to strenuous treadmill exercise. Eight exercised Thoroughbred horses received saline or 250 mg of furosemide either 4 or 24 hr prior to high-speed treadmill exercise in a balanced 3-way cross-over design. Blood samples were collected for determination of furosemide, lactate, hemoglobin, blood gas, and electrolyte concentrations. Heart rate and pulmonary arterial pressure were measured throughout the run and endoscopic examination and bronchoalveolar lavage (BAL) performed. Horses were assigned an EIPH score and the number of red blood cells in BAL fluid determined. Although not significantly different, endoscopic EIPH scores were lower in the 4-hr versus the 24-hr and saline groups. RBC counts were not significantly different between the treatment groups. Pulmonary arterial pressures were significantly increased at higher speeds; however, there were no significant differences between dose groups when controlling for speed. A small sample size and unknown bleeding history warrant a larger-scale study.
    MeSH term(s) Animals ; Blood Pressure/drug effects ; Cross-Over Studies ; Diuretics/administration & dosage ; Diuretics/pharmacology ; Drug Administration Schedule ; Female ; Furosemide/administration & dosage ; Furosemide/pharmacology ; Horses ; Lactic Acid/blood ; Male ; Physical Conditioning, Animal ; Water Deprivation
    Chemical Substances Diuretics ; Lactic Acid (33X04XA5AT) ; Furosemide (7LXU5N7ZO5)
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial, Veterinary
    ZDB-ID 435216-6
    ISSN 1365-2885 ; 0140-7783
    ISSN (online) 1365-2885
    ISSN 0140-7783
    DOI 10.1111/jvp.12881
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  7. Article ; Online: Predictive accuracy of risk prediction models for recurrence, metastasis and survival for early-stage cutaneous melanoma

    Andrew Bryant / Fiona Pearson / Luke Vale / Dawn Craig / Diarmuid Coughlan / Catherine Richmond / Tafadzwa Patience Kunonga / Robert Ellis / Fiona R Beyer / R P W Kenny / Margaret Astin / Vasileios Kontogiannis / Claire H Eastaugh / Penny Lovat

    BMJ Open, Vol 13, Iss

    a systematic review

    2023  Volume 9

    Abstract: Objectives To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.Design ... ...

    Abstract Objectives To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.Design Systematic review and narrative synthesis.Data sources Searched MEDLINE, Embase, CINAHL, Cochrane Library, Science Citation Index and grey literature sources including cancer and guideline websites from 2000 to September 2021.Eligibility criteria Included studies on risk prediction models for stage I and II melanoma in adults ≥18 years. Outcomes included OS, recurrence, metastases and model performance. No language or country of publication restrictions were applied.Data extraction and synthesis Two pairs of reviewers independently screened studies, extracted data and assessed the risk of bias using the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies checklist and the Prediction study Risk of Bias Assessment Tool. Heterogeneous predictors prevented statistical synthesis.Results From 28 967 records, 15 studies reporting 20 models were included; 8 (stage I), 2 (stage II), 7 (stages I–II) and 7 (stages not reported), but were clearly applicable to early stages. Clinicopathological predictors per model ranged from 3–10. The most common were: ulceration, Breslow thickness/depth, sociodemographic status and site. Where reported, discriminatory values were ≥0.7. Calibration measures showed good matches between predicted and observed rates. None of the studies assessed clinical usefulness of the models. Risk of bias was high in eight models, unclear in nine and low in three. Seven models were internally and externally cross-validated, six models were externally validated and eight models were internally validated.Conclusions All models are effective in their predictive performance, however the low quality of the evidence raises concern as to whether current follow-up recommendations following surgical treatment is ...
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Which patients with metastatic hormone-sensitive prostate cancer benefit from docetaxel: a systematic review and meta-analysis of individual participant data from randomised trials.

    Vale, Claire L / Fisher, David J / Godolphin, Peter J / Rydzewska, Larysa H / Boher, Jean-Marie / Burdett, Sarah / Chen, Yu-Hui / Clarke, Noel W / Fizazi, Karim / Gravis, Gwenaelle / James, Nicholas D / Liu, Glenn / Matheson, David / Murphy, Laura / Oldroyd, Robert E / Parmar, Mahesh K B / Rogozinska, Ewelina / Sfumato, Patrick / Sweeney, Christopher J /
    Sydes, Matthew R / Tombal, Bertrand / White, Ian R / Tierney, Jayne F

    The Lancet. Oncology

    2023  Volume 24, Issue 7, Page(s) 783–797

    Abstract: Background: Adding docetaxel to androgen deprivation therapy (ADT) improves survival in patients with metastatic, hormone-sensitive prostate cancer, but uncertainty remains about who benefits most. We therefore aimed to obtain up-to-date estimates of ... ...

    Abstract Background: Adding docetaxel to androgen deprivation therapy (ADT) improves survival in patients with metastatic, hormone-sensitive prostate cancer, but uncertainty remains about who benefits most. We therefore aimed to obtain up-to-date estimates of the overall effects of docetaxel and to assess whether these effects varied according to prespecified characteristics of the patients or their tumours.
    Methods: The STOPCAP M1 collaboration conducted a systematic review and meta-analysis of individual participant data. We searched MEDLINE (from database inception to March 31, 2022), Embase (from database inception to March 31, 2022), the Cochrane Central Register of Controlled Trials (from database inception to March 31, 2022), proceedings of relevant conferences (from Jan 1, 1990, to Dec 31, 2022), and ClinicalTrials.gov (from database inception to March 28, 2023) to identify eligible randomised trials that assessed docetaxel plus ADT compared with ADT alone in patients with metastatic, hormone-sensitive prostate cancer. Detailed and updated individual participant data were requested directly from study investigators or through relevant repositories. The primary outcome was overall survival. Secondary outcomes were progression-free survival and failure-free survival. Overall pooled effects were estimated using an adjusted, intention-to-treat, two-stage, fixed-effect meta-analysis, with one-stage and random-effects sensitivity analyses. Missing covariate values were imputed. Differences in effect by participant characteristics were estimated using adjusted two-stage, fixed-effect meta-analysis of within-trial interactions on the basis of progression-free survival to maximise power. Identified effect modifiers were also assessed on the basis of overall survival. To explore multiple subgroup interactions and derive subgroup-specific absolute treatment effects we used one-stage flexible parametric modelling and regression standardisation. We assessed the risk of bias using the Cochrane Risk of Bias 2 tool. This study is registered with PROSPERO, CRD42019140591.
    Findings: We obtained individual participant data from 2261 patients (98% of those randomised) from three eligible trials (GETUG-AFU15, CHAARTED, and STAMPEDE trials), with a median follow-up of 72 months (IQR 55-85). Individual participant data were not obtained from two additional small trials. Based on all included trials and patients, there were clear benefits of docetaxel on overall survival (hazard ratio [HR] 0·79, 95% CI 0·70 to 0·88; p<0·0001), progression-free survival (0·70, 0·63 to 0·77; p<0·0001), and failure-free survival (0·64, 0·58 to 0·71; p<0·0001), representing 5-year absolute improvements of around 9-11%. The overall risk of bias was assessed to be low, and there was no strong evidence of differences in effect between trials for all three main outcomes. The relative effect of docetaxel on progression-free survival appeared to be greater with increasing clinical T stage (p
    Interpretation: The addition of docetaxel to hormone therapy is best suited to patients with poorer prognosis for metastatic, hormone-sensitive prostate cancer based on a high volume of disease and potentially the bulkiness of the primary tumour. There is no evidence of meaningful benefit for patients with metachronous, low-volume disease who should therefore be managed differently. These results will better characterise patients most and, importantly, least likely to gain benefit from docetaxel, potentially changing international practice, guiding clinical decision making, better informing treatment policy, and improving patient outcomes.
    Funding: UK Medical Research Council and Prostate Cancer UK.
    MeSH term(s) Male ; Humans ; Docetaxel ; Prostatic Neoplasms/pathology ; Androgen Antagonists ; Disease-Free Survival ; Hormones/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Randomized Controlled Trials as Topic
    Chemical Substances Docetaxel (15H5577CQD) ; Androgen Antagonists ; Hormones
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00230-9
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  9. Article ; Online: Large-scale two-photon calcium imaging in freely moving mice.

    Zong, Weijian / Obenhaus, Horst A / Skytøen, Emilie R / Eneqvist, Hanna / de Jong, Nienke L / Vale, Ruben / Jorge, Marina R / Moser, May-Britt / Moser, Edvard I

    Cell

    2022  Volume 185, Issue 7, Page(s) 1240–1256.e30

    Abstract: We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible connection cable, MINI2P ... ...

    Abstract We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible connection cable, MINI2P allowed stable imaging with no impediment of behavior in a variety of assays compared to untethered, unimplanted animals. The improved cell yield was achieved through a optical system design featuring an enlarged field of view (FOV) and a microtunable lens with increased z-scanning range and speed that allows fast and stable imaging of multiple interleaved planes, as well as 3D functional imaging. Successive imaging across multiple, adjacent FOVs enabled recordings from more than 10,000 neurons in the same animal. Large-scale proof-of-principle data were obtained from cell populations in visual cortex, medial entorhinal cortex, and hippocampus, revealing spatial tuning of cells in all areas.
    MeSH term(s) Animals ; Calcium ; Entorhinal Cortex ; Hippocampus ; Mice ; Microscopy ; Neurons/physiology ; Visual Cortex
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.02.017
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  10. Article ; Online: Effectiveness of furosemide in attenuating exercise-induced pulmonary haemorrhage in horses when administered at 4- and 24-h prior to high-speed training.

    Knych, H K / Wilson, W D / Vale, A / Kass, P H / Arthur, R M / Jones, J H

    Equine veterinary journal

    2017  Volume 50, Issue 3, Page(s) 350–355

    Abstract: ... on the horse's health, furosemide administration is permitted up to 4-h prior to post time in most North American ... racing jurisdictions. Anecdotal reports suggest that administration of furosemide 24-h prior to strenuous ... the efficacy of furosemide in reducing the presence and severity of EIPH when administered 4- or 24-h prior ...

    Abstract Background: Due to the high prevalence of EIPH in racehorses and its potential impact on the horse's health, furosemide administration is permitted up to 4-h prior to post time in most North American racing jurisdictions. Anecdotal reports suggest that administration of furosemide 24-h prior to strenuous exercise may be equally effective in decreasing the severity of EIPH.
    Objectives: To 1) compare the efficacy of furosemide in reducing the presence and severity of EIPH when administered 4- or 24-h prior to strenuous exercise 2) characterise electrolyte and blood parameters following administration of furosemide at 4- and 24-h prior to exercise.
    Study design: 3-way crossover.
    Methods: Fifteen Thoroughbred racehorses received 5 mL of 0.9% NaCl or 250 mg of furosemide either 4- or 24-h prior to a 5-furlong simulated race. Blood samples were collected prior to and post-run for determination of furosemide, lactate, haemoglobin and electrolyte concentrations. One-hour post-race, an endoscopic exam and bronchoalveolar lavage (BAL) were performed. Horses were assigned an EIPH score based on predetermined criteria and the number of red blood cells in BAL fluid was determined.
    Results: Endoscopic EIPH scores were lower in the 4-h vs. the 24-h (P = 0.03) furosemide groups. RBC counts in BAL fluid were lower in the 4-h furosemide vs. saline treatment groups (P = 0.01) but no difference was noted between the saline and 24-h furosemide groups (P = 0.3), nor between the 4- and 24-h groups (P = 0.5).
    Main limitations: Small sample size and large range of running times for the 5-furlong work.
    Conclusions: While none of the treatments prevented EIPH, endoscopic scores and RBC counts in BAL fluid support the efficacy of furosemide in reducing the severity of EIPH. Endoscopic scores were lower in the 4-h furosemide group compared with 24-h administration. Red blood cell counts were lower in the 4-h furosemide group compared with saline treatment.
    MeSH term(s) Animals ; Bronchoalveolar Lavage Fluid ; Cross-Over Studies ; Diuretics/pharmacology ; Female ; Furosemide/pharmacology ; Hemorrhage/prevention & control ; Hemorrhage/veterinary ; Horse Diseases/etiology ; Horse Diseases/prevention & control ; Horses ; Lung Diseases/etiology ; Lung Diseases/prevention & control ; Lung Diseases/veterinary ; Male ; Physical Conditioning, Animal/adverse effects ; Physical Exertion ; Running
    Chemical Substances Diuretics ; Furosemide (7LXU5N7ZO5)
    Language English
    Publishing date 2017-11-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 41606-x
    ISSN 2042-3306 ; 0425-1644
    ISSN (online) 2042-3306
    ISSN 0425-1644
    DOI 10.1111/evj.12760
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