LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: Estimating Children's Soil/Dust Ingestion Rates through Retrospective Analyses of Blood Lead Biomonitoring from the Bunker Hill Superfund Site in Idaho.

von Lindern, Ian / Spalinger, Susan / Stifelman, Marc L / Stanek, Lindsay Wichers / Bartrem, Casey

2016 Volume 124, Issue 9, Page(s) 1462–1470

Abstract: ... Lindern I, Spalinger S, Stifelman ML, Stanek LW, Bartrem C. 2016. Estimating children's soil/dust ...

Abstract	Background: Soil/dust ingestion rates are important variables in assessing children's health risks in contaminated environments. Current estimates are based largely on soil tracer methodology, which is limited by analytical uncertainty, small sample size, and short study duration. Objectives: The objective was to estimate site-specific soil/dust ingestion rates through reevaluation of the lead absorption dose-response relationship using new bioavailability data from the Bunker Hill Mining and Metallurgical Complex Superfund Site (BHSS) in Idaho, USA. Methods: The U.S. Environmental Protection Agency (EPA) in vitro bioavailability methodology was applied to archived BHSS soil and dust samples. Using age-specific biokinetic slope factors, we related bioavailable lead from these sources to children's blood lead levels (BLLs) monitored during cleanup from 1988 through 2002. Quantitative regression analyses and exposure assessment guidance were used to develop candidate soil/dust source partition scenarios estimating lead intake, allowing estimation of age-specific soil/dust ingestion rates. These ingestion rate and bioavailability estimates were simultaneously applied to the U.S. EPA Integrated Exposure Uptake Biokinetic Model for Lead in Children to determine those combinations best approximating observed BLLs. Results: Absolute soil and house dust bioavailability averaged 33% (SD ± 4%) and 28% (SD ± 6%), respectively. Estimated BHSS age-specific soil/dust ingestion rates are 86-94 mg/day for 6-month- to 2-year-old children and 51-67 mg/day for 2- to 9-year-old children. Conclusions: Soil/dust ingestion rate estimates for 1- to 9-year-old children at the BHSS are lower than those commonly used in human health risk assessment. A substantial component of children's exposure comes from sources beyond the immediate home environment. Citation: von Lindern I, Spalinger S, Stifelman ML, Stanek LW, Bartrem C. 2016. Estimating children's soil/dust ingestion rates through retrospective analyses of blood lead biomonitoring from the Bunker Hill Superfund Site in Idaho. Environ Health Perspect 124:1462-1470; http://dx.doi.org/10.1289/ehp.1510144.
MeSH term(s)	Absorption, Physiological ; Adolescent ; Biological Availability ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Dust/analysis ; Environmental Exposure ; Environmental Monitoring ; Environmental Pollutants/blood ; Environmental Pollutants/pharmacokinetics ; Humans ; Idaho ; Infant ; Infant, Newborn ; Lead/blood ; Lead/pharmacokinetics ; Retrospective Studies ; Soil Pollutants/blood ; Soil Pollutants/pharmacokinetics
Chemical Substances	Dust ; Environmental Pollutants ; Soil Pollutants ; Lead (2P299V784P)
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.1510144
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Air pollution toxicology--a brief review of the role of the science in shaping the current understanding of air pollution health risks.

Stanek, Lindsay Wichers / Brown, James S / Stanek, John / Gift, Jeff / Costa, Daniel L

Toxicological sciences : an official journal of the Society of Toxicology

2011 Volume 120 Suppl 1, Page(s) S8–27

Abstract: Human and animal toxicology has had a profound impact on our historical and current understanding of air pollution health effects. Early animal toxicological studies of air pollution had distinctively military or workplace themes. With the discovery that ...

Abstract	Human and animal toxicology has had a profound impact on our historical and current understanding of air pollution health effects. Early animal toxicological studies of air pollution had distinctively military or workplace themes. With the discovery that ambient air pollution episodes led to excess illness and death, there became an emergence of toxicological studies that focused on industrial air pollution encountered by the general public. Not only did the pollutants investigated evolve from ambient mixtures to individual pollutants but also the endpoints and outcomes evaluated became more sophisticated, resulting in our present state of the science. Currently, a large toxicological database exists for the effects of particulate matter and ozone, and we provide a focused review of some of the major contributions to the biological understanding for these two "criteria" air pollutants. A limited discussion of the toxicological advancements in the scientific knowledge of two hazardous air pollutants, formaldehyde and phosgene, is also included. Moving forward, the future challenge of air pollution toxicology lies in the health assessment of complex mixtures and their interactions, given the projected impacts of climate change and altered emissions on ambient conditions. In the coming years, the toxicologist will need to be flexible and forward thinking in order to dissect the complexity of the biological system itself, as well as that of air pollution in all its varied forms.
MeSH term(s)	Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/legislation & jurisprudence ; Animals ; Biomedical Research ; Humans ; Ozone/adverse effects ; Ozone/analysis ; Particle Size ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Research Design ; Risk Assessment
Chemical Substances	Air Pollutants ; Particulate Matter ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfq367
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1709: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Attributing health effects to apportioned components and sources of particulate matter: An evaluation of collective results

Stanek, Lindsay Wichers / Sacks, Jason D / Dutton, Steven J / Dubois, Jean-Jacques B

Atmospheric environment. 2011 Oct., v. 45, no. 32

2011

Abstract: It has been hypothesized that the composition of particulate matter (PM) may be a better predictor of health effects than PM mass alone. The regional differences in PM composition and the heterogeneity in PM risk estimates in large multi-city ... ...

Abstract	It has been hypothesized that the composition of particulate matter (PM) may be a better predictor of health effects than PM mass alone. The regional differences in PM composition and the heterogeneity in PM risk estimates in large multi-city epidemiologic studies are consistent with this hypothesis. Since 2005, efforts have been made to relate apportioned components and sources of PM with human health outcomes in epidemiology, controlled human exposure and toxicology studies. We reviewed published studies that: 1) focused on short-term exposure to PM; 2) included at least five components of PM; 3) grouped them into factors or sources; and 4) used quantitative methods to examine the relationship between the factors or sources and health effects. We then examined whether specific groups of PM components or sources of PM are consistently linked to specific health effects across studies. Collectively, these studies suggest that cardiovascular effects may be associated with PM₂.₅ from crustal or combustion sources, including traffic, but at this time, no consistent relationships have emerged. Fewer studies evaluated respiratory health effects, and the evidence for associations was limited. Apportionment methods have linked a variety of health effects to multiple groups of PM components and sources of PM, but the collective evidence has not yet isolated factors or sources that would be closely and unequivocally related to specific health outcomes.
Keywords	atmospheric chemistry ; combustion ; epidemiological studies ; human health ; humans ; particulates ; quantitative analysis ; risk estimate ; toxicology ; traffic
Language	English
Dates of publication	2011-10
Size	p. 5655-5663.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2011.07.023
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.B 783: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Particulate matter-induced health effects: who is susceptible?

Sacks, Jason D / Stanek, Lindsay Wichers / Luben, Thomas J / Johns, Douglas O / Buckley, Barbara J / Brown, James S / Ross, Mary

Environmental health perspectives

2010 Volume 119, Issue 4, Page(s) 446–454

Abstract: Background: Epidemiological, controlled human exposure, and toxicological studies have demonstrated a variety of health effects in response to particulate matter (PM) exposure with some of these studies indicating that populations with certain ... ...

Abstract	Background: Epidemiological, controlled human exposure, and toxicological studies have demonstrated a variety of health effects in response to particulate matter (PM) exposure with some of these studies indicating that populations with certain characteristics may be disproportionately affected. Objective: To identify populations potentially at greatest risk for PM-related health effects, we evaluated epidemiological studies that examined various characteristics that may influence susceptibility, while using results from controlled human exposure and toxicological studies as supporting evidence. Additionally, we formulated a definition of susceptibility, building from the varied and inconsistent definitions of susceptibility and vulnerability used throughout the literature. Data synthesis: We evaluated recent epidemiological studies to identify characteristics of populations potentially susceptible to PM-related health effects. Additionally, we evaluated controlled human exposure and toxicological studies to provide supporting evidence. We conducted a comprehensive review of epidemiological studies that presented stratified results (e.g., < 65 vs. ≥ 65 years of age), controlled human exposure studies that examined individuals with underlying disease, and toxicological studies that used animal models of disease. We evaluated results for consistency across studies, coherence across disciplines, and biological plausibility to assess the potential for increased susceptibility to PM-related health effects in a specific population or life stage. Conclusions: We identified a diverse group of characteristics that can lead to increased risk of PM-related health effects, including life stage (i.e., children and older adults), preexisting cardiovascular or respiratory diseases, genetic polymorphisms, and low-socioeconomic status. In addition, we crafted a comprehensive definition of susceptibility that can be used to encompass all populations potentially at increased risk of adverse health effects as a consequence of exposure to an air pollutant.
MeSH term(s)	Aged ; Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/statistics & numerical data ; Cardiovascular Diseases/epidemiology ; Demography ; Disease Susceptibility/epidemiology ; Humans ; Middle Aged ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Respiratory Tract Diseases/epidemiology ; Risk Assessment ; Socioeconomic Factors
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2010-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.1002255
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Practical advancement of multipollutant scientific and risk assessment approaches for ambient air pollution.

Johns, Douglas O / Stanek, Lindsay Wichers / Walker, Katherine / Benromdhane, Souad / Hubbell, Bryan / Ross, Mary / Devlin, Robert B / Costa, Daniel L / Greenbaum, Daniel S

Environmental health perspectives

2012 Volume 120, Issue 9, Page(s) 1238–1242

Abstract: Objectives: The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can ... ...

Abstract	Objectives: The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can then be used for future scientific and risk assessments. Data sources: A public workshop was held in Chapel Hill, North Carolina, 22-24 February 2011, to discuss scientific issues and data gaps related to adopting multipollutant science and risk assessment approaches, with a particular focus on the criteria air pollutants. Expert panelists in the fields of epidemiology, toxicology, and atmospheric and exposure sciences led open discussions to encourage workshop participants to think broadly about available and emerging scientific evidence related to multipollutant approaches to evaluating the health effects of air pollution. Synthesis: Although there is clearly a need for novel research and analytical approaches to better characterize the health effects of multipollutant exposures, much progress can be made by using existing scientific information and statistical methods to evaluate the effects of single pollutants in a multipollutant context. This work will have a direct impact on the development of a multipollutant science assessment and a conceptual framework for conducting multipollutant risk assessments. Conclusions: Transitioning to a multipollutant paradigm can be aided through the adoption of a framework for multipollutant science and risk assessment that encompasses well-studied and ubiquitous air pollutants. Successfully advancing methods for conducting these assessments will require collaborative and parallel efforts between the scientific and environmental regulatory and policy communities.
MeSH term(s)	Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/adverse effects ; Air Pollution/analysis ; Environmental Exposure ; Environmental Health ; Environmental Monitoring ; Humans ; Risk Assessment ; United States ; United States Environmental Protection Agency
Chemical Substances	Air Pollutants
Language	English
Publishing date	2012-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.1204939
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Comparison of Risk Estimates for the Effect of Short-Term Exposure to PM, NO2 and CO on Cardiovascular Hospitalizations and Emergency Department Visits

Lindsay Wichers Stanek / Thomas J. Luben / Genee Smith / Thomas C. Long / Dennis Kotchmar / Doug Johns / Allen Davis / Mary Ross / Barbara Buckley / David Svendsgaard / Ellen Kirrane

Atmosphere, Vol 2, Iss 4, Pp 688-

Effect Size Modeling of Study Findings

2011 Volume 701

Abstract: Although particulate matter (PM), nitrogen dioxide (NO2) and carbon monoxide (CO) typically exist as part of a complex air pollution mixture, the evidence linking these pollutants to health effects is evaluated separately in the scientific and policy ... ...

Abstract	Although particulate matter (PM), nitrogen dioxide (NO2) and carbon monoxide (CO) typically exist as part of a complex air pollution mixture, the evidence linking these pollutants to health effects is evaluated separately in the scientific and policy reviews of the National Ambient Air Quality Standards (NAAQS). The objective of this analysis was to use meta-regression methods to model effect estimates for several individual yet correlated NAAQS pollutants in an effort to identify factors that explain differences in the effect sizes across studies and across pollutants. We expected that our consideration of the evidence for several correlated pollutants in parallel could lead to insights regarding exposure to the pollutant mixture. We focused on studies of hospital admissions for congestive heart failure (CHF) and ischemic heart disease (IHD), which have played an important role in the evaluation of the scientific evidence communicated in the PM, NO2, and CO Integrated Science Assessments (ISAs). Of the studies evaluated, 11 CHF studies and 21 IHD studies met our inclusion requirements. The size of the risk estimates was explained by factors related to the pollution mixture, study methods, and monitoring network characteristics. Our findings suggest that additional analyses focusing on understanding differences in effect sizes across geographic areas with different pollution mixtures and monitor network designs may improve our understanding of the independent and combined effects of correlated pollutants.
Keywords	hospital admissions ; air pollution ; PM ; NO2 ; CO ; Meteorology. Climatology ; QC851-999 ; Physics ; QC1-999 ; Science ; Q ; DOAJ:Meteorology and Climatology ; DOAJ:Earth and Environmental Sciences
Subject code	333
Language	English
Publishing date	2011-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Attributing health effects to apportioned components and sources of particulate matter: An evaluation of collective results

Stanek, Lindsay Wichers / Sacks, Jason D. / Dutton, Steven J. / Dubois, Jean-Jacques B.

Atmospheric environment

Volume v. 45,, Issue no. 3

Abstract	It has been hypothesized that the composition of particulate matter (PM) may be a better predictor of health effects than PM mass alone. The regional differences in PM composition and the heterogeneity in PM risk estimates in large multi-city epidemiologic studies are consistent with this hypothesis. Since 2005, efforts have been made to relate apportioned components and sources of PM with human health outcomes in epidemiology, controlled human exposure and toxicology studies. We reviewed published studies that: 1) focused on short-term exposure to PM; 2) included at least five components of PM; 3) grouped them into factors or sources; and 4) used quantitative methods to examine the relationship between the factors or sources and health effects. We then examined whether specific groups of PM components or sources of PM are consistently linked to specific health effects across studies. Collectively, these studies suggest that cardiovascular effects may be associated with PM₂.₅ from crustal or combustion sources, including traffic, but at this time, no consistent relationships have emerged. Fewer studies evaluated respiratory health effects, and the evidence for associations was limited. Apportionment methods have linked a variety of health effects to multiple groups of PM components and sources of PM, but the collective evidence has not yet isolated factors or sources that would be closely and unequivocally related to specific health outcomes.
Keywords	human health ; traffic ; risk estimate ; quantitative analysis ; toxicology ; humans ; atmospheric chemistry ; epidemiological studies ; combustion ; particulates
Language	English
Document type	Article
ISSN	1352-2310
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A Comparison of Risk Estimates for the Effect of Short-Term Exposure to PM, NO2 and CO on Cardiovascular Hospitalizations and Emergency Department Visits: Effect Size Modeling of Study Findings

Ellen Kirrane / David Svendsgaard / Mary Ross / Barbara Buckley / Allen Davis / Doug Johns / Dennis Kotchmar / Thomas C. Long / Thomas J. Luben / Genee Smith / Lindsay Wichers Stanek

Atmosphere

Issue (4)

Abstract	Although particulate matter (PM), nitrogen dioxide (NO2) and carbon monoxide (CO) typically exist as part of a complex air pollution mixture, the evidence linking these pollutants to health effects is evaluated separately in the scientific and policy reviews of the National Ambient Air Quality Standards (NAAQS). The objective of this analysis was to use meta-regression methods to model effect estimates for several individual yet correlated NAAQS pollutants in an effort to identify factors that explain differences in the effect sizes across studies and across pollutants. We expected that our consideration of the evidence for several correlated pollutants in parallel could lead to insights regarding exposure to the pollutant mixture. We focused on studies of hospital admissions for congestive heart failure (CHF) and ischemic heart disease (IHD), which have played an important role in the evaluation of the scientific evidence communicated in the PM, NO2, and CO Integrated Science Assessments (ISAs). Of the studies evaluated, 11 CHF studies and 21 IHD studies met our inclusion requirements. The size of the risk estimates was explained by factors related to the pollution mixture, study methods, and monitoring network characteristics. Our findings suggest that additional analyses focusing on understanding differences in effect sizes across geographic areas with different pollution mixtures and monitor network designs may improve our understanding of the independent and combined effects of correlated pollutants.
Language	English
Document type	Article
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED