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  1. Article ; Online: Antibiotic prophylaxis for patients with acute brain injury.

    Klompas, Michael

    The Lancet. Respiratory medicine

    2024  

    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(24)00006-7
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    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Progress in preventing non-ventilator-associated hospital-acquired pneumonia.

    Klompas, Michael

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 7, Page(s) 769–771

    MeSH term(s) Humans ; Pneumonia, Ventilator-Associated/prevention & control ; Cross Infection/prevention & control ; Hospitals
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00867-2
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    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses.

    Klompas, Michael

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 2, Page(s) 295–303

    Abstract: A fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission ... ...

    Abstract A fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission and hospital-based clusters. Data from before the pandemic suggest the same can be true of influenza, respiratory syncytial virus, and other respiratory viruses. The pandemic has also helped clarify the primary mechanisms and risk factors for viral transmission. Respiratory viruses are primarily transmitted by respiratory aerosols that are routinely emitted when people exhale, talk, and cough. Labored breathing and coughing increase aerosol generation to a much greater extent than intubation, extubation, positive pressure ventilation, and other so-called aerosol-generating procedures. Transmission risk is proportional to the amount of viral exposure. Most transmissions take place over short distances because respiratory emissions are densest immediately adjacent to the source but then rapidly dilute and diffuse with distance leading to less viral exposure. The primary risk factors for transmission then are high viral loads, proximity, sustained exposure, and poor ventilation as these all increase net viral exposure. Poor ventilation increases the risk of long-distance transmission by allowing aerosol-borne viruses to accumulate over time leading to higher levels of exposure throughout an enclosed space. Surgical and procedural masks reduce viral exposure but do not eradicate it and thus lower but do not eliminate transmission risk. Most hospital-based clusters have been attributed to delayed diagnoses, transmission between roommates, and staff-to-patient infections. Strategies to prevent nosocomial respiratory viral infections include testing all patients upon admission, preventing healthcare providers from working while sick, assuring adequate ventilation, universal masking, and vaccinating both patients and healthcare workers.
    MeSH term(s) Aerosols ; COVID-19/prevention & control ; Hospitals ; Humans ; Pneumonia, Ventilator-Associated ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0041-1740582
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    Zs.A 1555: Show issues Location:
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  4. Article ; Online: Beyond Septic Shock: Who Else Requires Immediate Antibiotics?

    Klompas, Michael / Martin, Greg S

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 7, Page(s) 781–782

    MeSH term(s) Humans ; Shock, Septic/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Sepsis/drug therapy ; Time Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202401-0185ED
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    Uh II Zs.80: Show issues Location:
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  5. Article ; Online: Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination.

    Klompas, Michael

    JAMA

    2021  Volume 326, Issue 20, Page(s) 2018–2020

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.19063
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    Ua VI Zs.88: Show issues Location:
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  6. Article ; Online: Overuse of Broad-Spectrum Antibiotics for Pneumonia.

    Klompas, Michael

    JAMA internal medicine

    2020  Volume 180, Issue 4, Page(s) 485–486

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Humans ; Pneumonia/drug therapy ; Standard of Care
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2019.7251
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    Ua VI Zs.119: Show issues Location:
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  7. Article ; Online: The authors reply.

    Klompas, Michael / Goldberg, Scott A

    Critical care medicine

    2023  Volume 51, Issue 4, Page(s) e98–e99

    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005812
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    Zs.A 1261: Show issues Location:
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  8. Article: New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses

    Klompas, Michael

    Seminars in Respiratory and Critical Care Medicine

    (HAP and VAP after Guidelines)

    2022  Volume 43, Issue 02, Page(s) 295–303

    Abstract: A fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission ... ...

    Series title HAP and VAP after Guidelines
    Abstract A fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission and hospital-based clusters. Data from before the pandemic suggest the same can be true of influenza, respiratory syncytial virus, and other respiratory viruses. The pandemic has also helped clarify the primary mechanisms and risk factors for viral transmission. Respiratory viruses are primarily transmitted by respiratory aerosols that are routinely emitted when people exhale, talk, and cough. Labored breathing and coughing increase aerosol generation to a much greater extent than intubation, extubation, positive pressure ventilation, and other so-called aerosol-generating procedures. Transmission risk is proportional to the amount of viral exposure. Most transmissions take place over short distances because respiratory emissions are densest immediately adjacent to the source but then rapidly dilute and diffuse with distance leading to less viral exposure. The primary risk factors for transmission then are high viral loads, proximity, sustained exposure, and poor ventilation as these all increase net viral exposure. Poor ventilation increases the risk of long-distance transmission by allowing aerosol-borne viruses to accumulate over time leading to higher levels of exposure throughout an enclosed space. Surgical and procedural masks reduce viral exposure but do not eradicate it and thus lower but do not eliminate transmission risk. Most hospital-based clusters have been attributed to delayed diagnoses, transmission between roommates, and staff-to-patient infections. Strategies to prevent nosocomial respiratory viral infections include testing all patients upon admission, preventing healthcare providers from working while sick, assuring adequate ventilation, universal masking, and vaccinating both patients and healthcare workers.
    Keywords hospital-acquired pneumonia ; respiratory viruses ; nosocomial infection ; infection control ; masking ; ventilation
    Language English
    Publishing date 2022-01-18
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0041-1740582
    Database Thieme publisher's database

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  9. Article ; Online: Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible.

    Klompas, Michael

    Annals of internal medicine

    2020  Volume 172, Issue 9, Page(s) 619–620

    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Cross Infection/prevention & control ; Diagnosis, Differential ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis
    Keywords covid19
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-0751
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  10. Article ; Online: Is COVID-19 Care Better in Veterans Health Administration Hospitals, Ceteris Paribus?

    Klompas, Michael / Jones, Barbara E

    JAMA network open

    2023  Volume 6, Issue 5, Page(s) e2315829

    MeSH term(s) Humans ; Veterans Health ; COVID-19/epidemiology ; Hospitals
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.15829
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