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  1. Article: Lateral force separation of biopolymers using an atomic force microscope.

    Anderson, Mark S

    Biomicrofluidics

    2023  Volume 17, Issue 3, Page(s) 34102

    Abstract: The lateral force separation of long chain biomolecules is demonstrated using an atomic force microscope (AFM). This is achieved by using an AFM tip to pull molecules away from the edge of a nanofluidic solution. By monitoring the torsion on the AFM ... ...

    Abstract The lateral force separation of long chain biomolecules is demonstrated using an atomic force microscope (AFM). This is achieved by using an AFM tip to pull molecules away from the edge of a nanofluidic solution. By monitoring the torsion on the AFM cantilever, a characteristic force-distance signal is produced when long chain molecules separate and detach from the solvent edge. This lateral force separation using AFM (LFS-AFM) is demonstrated on egg albumin proteins and synthetic DNA strands. The detected length of the protein and nucleotide biopolymers was consistent with their calculated molecular contour length. LFS AFM provides separation and detection of single polymer strands that has potential applications in biochemical analysis, paleontology, and life detection.
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 1932-1058
    ISSN 1932-1058
    DOI 10.1063/5.0153116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Concurrent surface enhanced infrared and Raman spectroscopy with single molecule sensitivity.

    Anderson, Mark S

    The Review of scientific instruments

    2023  Volume 94, Issue 2, Page(s) 25103

    Abstract: Surface enhanced infrared absorption (SEIRA) and surface enhanced Raman Spectroscopy (SERS) were simultaneously measured from the same location on plasmonically active substrates. The spectra were acquired using an optical photothermal infrared ... ...

    Abstract Surface enhanced infrared absorption (SEIRA) and surface enhanced Raman Spectroscopy (SERS) were simultaneously measured from the same location on plasmonically active substrates. The spectra were acquired using an optical photothermal infrared spectrometer coupled with a Raman spectrometer. The sensitivity of this approach enables exceptionally small quantities of molecules to be interrogated while providing complementary information from both infrared and Raman spectroscopy. This arrangement provides additional improvement of SEIRA through the enhancement of both the optical photothermal detector signal and the infrared absorption. The plasmonic substrates tested were silver nanospheres and a gold coated atomic force microscope tip. The concurrent acquisition of SEIRA and SERS is further demonstrated by nano-sampling material onto an atomic force microscope tip. The analytes, Buckminsterfullerene and 1,2-bis(4-pyridyl) ethylene, were analyzed individually and as mixtures. The concurrent acquisition of SERIA and SERS is a unique approach. It has general applications in trace surface analysis and for the analysis of returned planetary samples.
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0136908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.

    Casanova, Jean-Laurent / Anderson, Mark S

    The Journal of clinical investigation

    2023  Volume 133, Issue 3

    Abstract: Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)-driven T cell tolerance were ... ...

    Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)-driven T cell tolerance were discovered in 2006, but not initially linked to any viral disease. These two lines of clinical investigation converged in 2020, with the discovery that inherited and/or autoimmune deficiencies of type I IFN immunity accounted for approximately 15%-20% of cases of critical COVID-19 pneumonia in unvaccinated individuals. Thus, insufficient type I IFN immunity at the onset of SARS-CoV-2 infection may be a general determinant of life-threatening COVID-19. These findings illustrate the unpredictable, but considerable, contribution of the study of rare human genetic diseases to basic biology and public health.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Interferon Type I/genetics ; Virus Diseases ; Autoantibodies
    Chemical Substances Interferon Type I ; Autoantibodies
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI166283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aire in Autoimmunity.

    Miller, Corey N / Waterfield, Michael R / Gardner, James M / Anderson, Mark S

    Annual review of immunology

    2024  

    Abstract: The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced ... ...

    Abstract The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced single-cell genomics. We briefly describe the role of human genetics in the discovery of Aire, as well as insights into its function gained from genotype-phenotype correlations and the spectrum of Aire-associated autoimmunity-including insights from patients with Aire mutations with broad and diverse implications for human health. We then highlight emerging trends in Aire biology, focusing on three topic areas. First, we discuss medullary thymic epithelial diversity and the role of Aire in thymic epithelial development. Second, we highlight recent developments regarding the molecular mechanisms of Aire and its binding partners. Finally, we describe the rapidly evolving biology of the identity and function of extrathymic Aire-expressing cells (eTACs), and a novel eTAC subset called Janus cells, as well as their potential roles in immune homeostasis. Expected final online publication date for the
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-090222-101050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exemplifying practice-based research: the influence of age on myopia progression.

    Berkow, David / Dunne, Mark / Logan, Nicola S / Anderson, Stephen J

    Clinical & experimental optometry

    2024  , Page(s) 1–5

    Abstract: Clinical relevance: The electronic storage of patient records and modern-day search engines present private practitioners with a unique opportunity to extract valuable data for investigative research purposes. However, practitioners seldom harness this ... ...

    Abstract Clinical relevance: The electronic storage of patient records and modern-day search engines present private practitioners with a unique opportunity to extract valuable data for investigative research purposes. However, practitioners seldom harness this resource and consequently a vast repository of clinical data remains largely unexplored.
    Background: This study, based on real-world data from an optometric practice, stands as an example of how clinicians can actively contribute to research. In doing so it underscores the role played by age in determining the rate of natural myopia progression.
    Methods: A retrospective data analysis of the refractive status, age and optical correction type of participants, was conducted over six years. Forty-four participants were recruited (25 contact lens and 19 spectacle wearers), with a presenting age varying from 5 to 20 years (median, 11 years). Non-cycloplegic, monocular foveal refractions were completed using a ShinNippon open-field autorefractor, corroborated with subjective refraction. The mean spherical equivalent refractive error was calculated for the participants' initial visit (baseline measure) and for a six-year follow-up visit (progression measure), with myopia progression defined as the difference between these measures. Statistical analyses were computed using Decision Tree Analysis, with a significance level set at 95%.
    Results: The participant age at first visit exerted a significant influence on natural myopia progression over the assessment period (F 1,42 = 17.11,
    Conclusions: Utilizing the advantage of small real-world data samples, the benefit of research by private practitioners was demonstrated, providing evidence that the age at which a child first presents for an eye examination is highly influential in determining their rate of myopia progression.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2024.2309219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3168: Show issues Location:
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  6. Article ; Online: Nanofluidic chromatography using a vibrating atomic force microscope tip.

    Anderson, Mark S

    The Review of scientific instruments

    2019  Volume 90, Issue 9, Page(s) 93701

    Abstract: The separation of liquid mixtures is demonstrated using the vibrating tip of an Atomic Force Microscope (AFM). Fluid is collected onto the tip from a liquid surface while under tapping mode operation. This suppresses bulk capillary flow and enhances ... ...

    Abstract The separation of liquid mixtures is demonstrated using the vibrating tip of an Atomic Force Microscope (AFM). Fluid is collected onto the tip from a liquid surface while under tapping mode operation. This suppresses bulk capillary flow and enhances partitioning based on molecular affinity to the tip. AFM tapping mode separation was tested on liquid films consisting of binary and complex mixtures. The separated components were analyzed using tip enhanced infrared spectroscopy and direct analysis in real time mass spectrometry. The results demonstrate nanometer scale chemical separation for ultratrace analysis and nanofluidic applications.
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/1.5097592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/112: Show issues

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  7. Article ; Online: Celebrating 20 years of FOCIS.

    Roncarolo, Maria Grazia / Anderson, Mark S

    Science immunology

    2020  Volume 5, Issue 52

    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Editorial
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abe8102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

    Jean-Laurent Casanova / Mark S. Anderson

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 3

    Abstract: Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were ... ...

    Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not initially linked to any viral disease. These two lines of clinical investigation converged in 2020, with the discovery that inherited and/or autoimmune deficiencies of type I IFN immunity accounted for approximately 15%–20% of cases of critical COVID-19 pneumonia in unvaccinated individuals. Thus, insufficient type I IFN immunity at the onset of SARS-CoV-2 infection may be a general determinant of life-threatening COVID-19. These findings illustrate the unpredictable, but considerable, contribution of the study of rare human genetic diseases to basic biology and public health.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Hypertension and mild cognitive impairment: state-of-the-art review.

    Shajahan, Sultana / Peters, Ruth / Carcel, Cheryl / Woodward, Mark / Harris, Katie / Anderson, Craig S

    American journal of hypertension

    2024  

    Abstract: Background: Mid-life hypertension is associated with cognitive decline and dementia in later life. Reducing high blood pressure (BP) with antihypertensive agents is a well-researched strategy to prevent dementia and mild cognitive impairment (MCI). ... ...

    Abstract Background: Mid-life hypertension is associated with cognitive decline and dementia in later life. Reducing high blood pressure (BP) with antihypertensive agents is a well-researched strategy to prevent dementia and mild cognitive impairment (MCI). However, there is still limited direct evidence to support the approach, and particularly for the treatment of the very old and those with existing MCI.
    Methods: This review presents an overview of the current evidence for the relationship between MCI and hypertension, and of the potential pathophysiological mechanisms related to cognitive decline and incidence dementia in relation to aging.
    Results: Although observational data are near consistent in showing an association between mid-life hypertension and MCI and/or dementia, the evidence in relation to hypertension in younger adults and the very old (age >80 years) is much more limited. Most of the commonly available antihypertensive agents appear to provide beneficial effects in reducing the risk dementia, but there is limited evidence to support such treatment in those with existing MCI.
    Conclusions: Further studies are needed to determine the optimal levels of BP control across different age groups, especially in adults with MCI, and which class(es) of antihypertensive agents and duration of treatment best preserve cognitive function in those at risk of, or with established, MCI.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpae007
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    Zs.A 2329: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Exploring Working Memory Capacity and Efficiency Processes to Understand Working Memory Training Outcomes in Primary School Children.

    Tan, Alexandra S L / Lau, Regine C / Anderson, Peter J / Gathercole, Susan / Bellgrove, Mark A / Wiley, Joshua F / Spencer-Smith, Megan M

    Journal of cognition

    2024  Volume 7, Issue 1, Page(s) 23

    Abstract: Despite the abundance of research evaluating working memory training outcomes in children, few studies have examined the underlying cognitive mechanisms. This study aimed to contribute understanding by exploring ... ...

    Abstract Despite the abundance of research evaluating working memory training outcomes in children, few studies have examined the underlying cognitive mechanisms. This study aimed to contribute understanding by exploring whether
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ISSN 2514-4820
    ISSN (online) 2514-4820
    DOI 10.5334/joc.348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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