LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 12

Search options

  1. Article ; Online: Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials.

    Burstein, Summer

    The AAPS journal

    2005  Volume 7, Issue 1, Page(s) E143–8

    Abstract: Ajulemic acid (CT-3, IP-751, 1',1'-dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid) (AJA) has a cannabinoid-derived structure; however, there is no evidence that it produces psychotropic actions when given at therapeutic doses. In a variety of ... ...

    Abstract Ajulemic acid (CT-3, IP-751, 1',1'-dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid) (AJA) has a cannabinoid-derived structure; however, there is no evidence that it produces psychotropic actions when given at therapeutic doses. In a variety of animal assays, AJA shows efficacy in models for pain and inflammation. Furthermore, in the rat adjuvant arthritis model, it displayed a remarkable action in preventing the destruction of inflamed joints. A phase-2 human trial with chronic, neuropathic pain patients suggested that AJA could become a useful drug for treating this condition. Its low toxicity, particularly its lack of ulcerogenicity, further suggests that it will have a highly favorable therapeutic index and may replace some of the current anti-inflammatory/analgesic medications. Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects.
    MeSH term(s) Adult ; Analgesics/adverse effects ; Analgesics/chemical synthesis ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Analgesics/toxicity ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Apoptosis/drug effects ; Arthritis, Experimental/drug therapy ; Cannabinoids/chemistry ; Cell Line, Tumor/drug effects ; Clinical Trials, Phase II as Topic ; Cytokines/physiology ; Double-Blind Method ; Dronabinol/adverse effects ; Dronabinol/analogs & derivatives ; Dronabinol/chemical synthesis ; Dronabinol/chemistry ; Dronabinol/pharmacology ; Dronabinol/therapeutic use ; Dronabinol/toxicity ; Drug Evaluation, Preclinical ; Edema/drug therapy ; Female ; Gastritis/chemically induced ; Humans ; Male ; Mice ; Middle Aged ; Molecular Structure ; Neuralgia/drug therapy ; Randomized Controlled Trials as Topic ; Rats
    Chemical Substances Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Cannabinoids ; Cytokines ; Dronabinol (7J8897W37S) ; lenabasum (OGN7X90BT8)
    Language English
    Publishing date 2005-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
    ISSN 1550-7416
    ISSN (online) 1550-7416
    DOI 10.1208/aapsj070115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book: The shape of good nutrition

    Burstein, John

    the food pyramid

    (Slim goodbody's lighten up!)

    2008  

    Abstract: This summer Simon is working as an assistant cook at Whispering Pines Camp. Join him as he learns ...

    Author's details John Burstein
    Series title Slim goodbody's lighten up!
    Abstract This summer Simon is working as an assistant cook at Whispering Pines Camp. Join him as he learns about nutrition, eating well and living a health lifestyle.
    Keywords Nutrition
    Language English
    Size 32 p. :, col. ill. ;, 28 cm.
    Publisher Crabtree Pub. Co
    Publishing place New York, NY
    Document type Book
    ISBN 9780778739197 ; 0778739198 ; 9780778739371 ; 0778739376
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Big fat lies

    Burstein, John

    advertising tricks

    (Slim Goodbody's lighten up! series)

    2008  

    Abstract: Martina is a high school student. This summer she worked as an intern at an advertising agency ...

    Author's details John Burstein
    Series title Slim Goodbody's lighten up! series
    Abstract Martina is a high school student. This summer she worked as an intern at an advertising agency. She is going to give us an inside look at the world of advertising. We will learn about the ways advertisements influence our decisions to buy things. She will also share what she learned about making good choices and setting goals for a healthier lifestyle.
    Keywords Advertising/Food
    Language English
    Size 32 p. :, col. ill. ;, 28 cm.
    Publisher Crabtree Pub
    Publishing place St. Catherines, Ont ; New York
    Document type Book
    ISBN 9780778739135 ; 0778739139 ; 9780778739319 ; 0778739317
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book: Grocery shopping

    Burstein, John

    it's in the bag

    (Slim Goodbody's lighten up!)

    2008  

    Abstract: ... this summer. To save enough money for camp, Mandy is working After school at her local grocery store. Join ...

    Author's details John Burstein
    Series title Slim Goodbody's lighten up!
    Abstract Mandy is known at her high school as a talented artist, and she's hoping to attend art camp this summer. To save enough money for camp, Mandy is working After school at her local grocery store. Join her as she learns about nutrition and becoming a smart shopper.
    Keywords Grocery shopping ; Nutrition
    Language English
    Size 32 p. :, col. ill. ;, 29 cm.
    Publisher Crabtree Pub
    Publishing place New York
    Document type Book
    ISBN 9780778739166 ; 0778739163 ; 9780778739340 ; 0778739341
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Seasonal variations in the muscarinic regulation of acetylcholine release from Torpedo electric organ nerve terminals.

    Pinchasi, I / Burstein, M / Moldovan, M / Michaelson, D M

    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

    1985  Volume 81, Issue 2, Page(s) 439–444

    Abstract: ... in the fall and spring, and no effect is observed during the summer. These variations are accompanied ...

    Abstract The cholinergic nerve endings of the electric organs of Torpedo ocellata contains presynaptic muscarinic acetylcholine receptors (mAChR) which regulate acetylcholine (ACh) release by negative feedback. The efficiency of this muscarinic regulation varies circannually: maximal inhibition is observed in the winter, much smaller effects in the fall and spring, and no effect is observed during the summer. These variations are accompanied by seasonal changes in the ability of the mAChR to trigger the synthesis of its second messenger (a prostaglandin E-like substance) and in the ability of exogenous prostaglandin E2 to inhibit ACh release. No seasonal changes were found in the number of presynaptic mAChRs. These findings suggest that the observed seasonal variations are due to changes in both the metabolism of prostaglandins in the electric organ and the sensitivity of the ACh-releasing apparatus to the muscarinic second messenger.
    MeSH term(s) Acetylcholine/metabolism ; Animals ; Calcium/pharmacology ; Dinoprostone ; Electric Organ/drug effects ; Electric Organ/innervation ; Electric Organ/metabolism ; In Vitro Techniques ; Kinetics ; Neurons/metabolism ; Oxotremorine/pharmacology ; Prostaglandins E/biosynthesis ; Prostaglandins E/metabolism ; Receptors, Muscarinic/physiology ; Seasons ; Torpedo
    Chemical Substances Prostaglandins E ; Receptors, Muscarinic ; Oxotremorine (5RY0UWH1JL) ; Dinoprostone (K7Q1JQR04M) ; Acetylcholine (N9YNS0M02X) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1985
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 189285-x
    ISSN 0742-8413 ; 0306-4492 ; 1532-0456
    ISSN 0742-8413 ; 0306-4492 ; 1532-0456
    DOI 10.1016/0742-8413(85)90034-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 44/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Energy expenditure variations in soldiers performing military activities under cold and hot climate conditions.

    Burstein, R / Coward, A W / Askew, W E / Carmel, K / Irving, C / Shpilberg, O / Moran, D / Pikarsky, A / Ginot, G / Sawyer, M / Golan, R / Epstein, Y

    Military medicine

    1996  Volume 161, Issue 12, Page(s) 750–754

    Abstract: ... phase and group B (n = 12) in the summer phase. Energy expenditure (EE) was measured by the doubly ... Mean (+/- SE) daily EE was 4,281 +/- 170 and 3,937 +/- 159 kcal/day for the winter and summer groups ...

    Abstract This study assessed the energetic status of soldiers exposed to intense physical activities in cold and warm weather. Thirty subjects participated in a two-phase study group A (n = 18) in the winter phase and group B (n = 12) in the summer phase. Energy expenditure (EE) was measured by the doubly labeled water technique; after a single, oral dosing of 2H(2)18O, daily urine samples were collected for 12 successive days. Energy intake (EI) was assessed from detailed food records analyzed by computerized food charts. Energy balance was calculated as the difference between EI and EE for each subject. Mean (+/- SE) daily EE was 4,281 +/- 170 and 3,937 +/- 159 kcal/day for the winter and summer groups, respectively. Daily EI was 2,792 +/- 124 kcal/day in group A and almost identical in group B. A negative energy balance of 1,422 +/- 163 kcal/day and 924 +/- 232 kcal/day (not significant) was calculated for groups A and B, respectively. Energy expenditure is primarily determined by the level of activity rather than by climate conditions; EI is insufficient to offset the high energy requirements under these conditions.
    MeSH term(s) Adult ; Climate ; Cold Climate ; Energy Intake ; Energy Metabolism ; Hot Temperature ; Humans ; Israel ; Male ; Military Personnel ; Physical Exertion
    Language English
    Publishing date 1996-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.546: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

    Vos, Theo / Flaxman, Abraham D / Naghavi, Mohsen / Lozano, Rafael / Michaud, Catherine / Ezzati, Majid / Shibuya, Kenji / Salomon, Joshua A / Abdalla, Safa / Aboyans, Victor / Abraham, Jerry / Ackerman, Ilana / Aggarwal, Rakesh / Ahn, Stephanie Y / Ali, Mohammed K / Alvarado, Miriam / Anderson, H Ross / Anderson, Laurie M / Andrews, Kathryn G /
    Atkinson, Charles / Baddour, Larry M / Bahalim, Adil N / Barker-Collo, Suzanne / Barrero, Lope H / Bartels, David H / Basáñez, Maria-Gloria / Baxter, Amanda / Bell, Michelle L / Benjamin, Emelia J / Bennett, Derrick / Bernabé, Eduardo / Bhalla, Kavi / Bhandari, Bishal / Bikbov, Boris / Bin Abdulhak, Aref / Birbeck, Gretchen / Black, James A / Blencowe, Hannah / Blore, Jed D / Blyth, Fiona / Bolliger, Ian / Bonaventure, Audrey / Boufous, Soufiane / Bourne, Rupert / Boussinesq, Michel / Braithwaite, Tasanee / Brayne, Carol / Bridgett, Lisa / Brooker, Simon / Brooks, Peter / Brugha, Traolach S / Bryan-Hancock, Claire / Bucello, Chiara / Buchbinder, Rachelle / Buckle, Geoffrey / Budke, Christine M / Burch, Michael / Burney, Peter / Burstein, Roy / Calabria, Bianca / Campbell, Benjamin / Canter, Charles E / Carabin, Hélène / Carapetis, Jonathan / Carmona, Loreto / Cella, Claudia / Charlson, Fiona / Chen, Honglei / Cheng, Andrew Tai-Ann / Chou, David / Chugh, Sumeet S / Coffeng, Luc E / Colan, Steven D / Colquhoun, Samantha / Colson, K Ellicott / Condon, John / Connor, Myles D / Cooper, Leslie T / Corriere, Matthew / Cortinovis, Monica / de Vaccaro, Karen Courville / Couser, William / Cowie, Benjamin C / Criqui, Michael H / Cross, Marita / Dabhadkar, Kaustubh C / Dahiya, Manu / Dahodwala, Nabila / Damsere-Derry, James / Danaei, Goodarz / Davis, Adrian / De Leo, Diego / Degenhardt, Louisa / Dellavalle, Robert / Delossantos, Allyne / Denenberg, Julie / Derrett, Sarah / Des Jarlais, Don C / Dharmaratne, Samath D / Dherani, Mukesh / Diaz-Torne, Cesar / Dolk, Helen / Dorsey, E Ray / Driscoll, Tim / Duber, Herbert / Ebel, Beth / Edmond, Karen / Elbaz, Alexis / Ali, Suad Eltahir / Erskine, Holly / Erwin, Patricia J / Espindola, Patricia / Ewoigbokhan, Stalin E / Farzadfar, Farshad / Feigin, Valery / Felson, David T / Ferrari, Alize / Ferri, Cleusa P / Fèvre, Eric M / Finucane, Mariel M / Flaxman, Seth / Flood, Louise / Foreman, Kyle / Forouzanfar, Mohammad H / Fowkes, Francis Gerry R / Franklin, Richard / Fransen, Marlene / Freeman, Michael K / Gabbe, Belinda J / Gabriel, Sherine E / Gakidou, Emmanuela / Ganatra, Hammad A / Garcia, Bianca / Gaspari, Flavio / Gillum, Richard F / Gmel, Gerhard / Gosselin, Richard / Grainger, Rebecca / Groeger, Justina / Guillemin, Francis / Gunnell, David / Gupta, Ramyani / Haagsma, Juanita / Hagan, Holly / Halasa, Yara A / Hall, Wayne / Haring, Diana / Haro, Josep Maria / Harrison, James E / Havmoeller, Rasmus / Hay, Roderick J / Higashi, Hideki / Hill, Catherine / Hoen, Bruno / Hoffman, Howard / Hotez, Peter J / Hoy, Damian / Huang, John J / Ibeanusi, Sydney E / Jacobsen, Kathryn H / James, Spencer L / Jarvis, Deborah / Jasrasaria, Rashmi / Jayaraman, Sudha / Johns, Nicole / Jonas, Jost B / Karthikeyan, Ganesan / Kassebaum, Nicholas / Kawakami, Norito / Keren, Andre / Khoo, Jon-Paul / King, Charles H / Knowlton, Lisa Marie / Kobusingye, Olive / Koranteng, Adofo / Krishnamurthi, Rita / Lalloo, Ratilal / Laslett, Laura L / Lathlean, Tim / Leasher, Janet L / Lee, Yong Yi / Leigh, James / Lim, Stephen S / Limb, Elizabeth / Lin, John Kent / Lipnick, Michael / Lipshultz, Steven E / Liu, Wei / Loane, Maria / Ohno, Summer Lockett / Lyons, Ronan / Ma, Jixiang / Mabweijano, Jacqueline / MacIntyre, Michael F / Malekzadeh, Reza / Mallinger, Leslie / Manivannan, Sivabalan / Marcenes, Wagner / March, Lyn / Margolis, David J / Marks, Guy B / Marks, Robin / Matsumori, Akira / Matzopoulos, Richard / Mayosi, Bongani M / McAnulty, John H / McDermott, Mary M / McGill, Neil / McGrath, John / Medina-Mora, Maria Elena / Meltzer, Michele / Mensah, George A / Merriman, Tony R / Meyer, Ana-Claire / Miglioli, Valeria / Miller, Matthew / Miller, Ted R / Mitchell, Philip B / Mocumbi, Ana Olga / Moffitt, Terrie E / Mokdad, Ali A / Monasta, Lorenzo / Montico, Marcella / Moradi-Lakeh, Maziar / Moran, Andrew / Morawska, Lidia / Mori, Rintaro / Murdoch, Michele E / Mwaniki, Michael K / Naidoo, Kovin / Nair, M Nathan / Naldi, Luigi / Narayan, K M Venkat / Nelson, Paul K / Nelson, Robert G / Nevitt, Michael C / Newton, Charles R / Nolte, Sandra / Norman, Paul / Norman, Rosana / O'Donnell, Martin / O'Hanlon, Simon / Olives, Casey / Omer, Saad B / Ortblad, Katrina / Osborne, Richard / Ozgediz, Doruk / Page, Andrew / Pahari, Bishnu / Pandian, Jeyaraj Durai / Rivero, Andrea Panozo / Patten, Scott B / Pearce, Neil / Padilla, Rogelio Perez / Perez-Ruiz, Fernando / Perico, Norberto / Pesudovs, Konrad / Phillips, David / Phillips, Michael R / Pierce, Kelsey / Pion, Sébastien / Polanczyk, Guilherme V / Polinder, Suzanne / Pope, C Arden / Popova, Svetlana / Porrini, Esteban / Pourmalek, Farshad / Prince, Martin / Pullan, Rachel L / Ramaiah, Kapa D / Ranganathan, Dharani / Razavi, Homie / Regan, Mathilda / Rehm, Jürgen T / Rein, David B / Remuzzi, Guiseppe / Richardson, Kathryn / Rivara, Frederick P / Roberts, Thomas / Robinson, Carolyn / De Leòn, Felipe Rodriguez / Ronfani, Luca / Room, Robin / Rosenfeld, Lisa C / Rushton, Lesley / Sacco, Ralph L / Saha, Sukanta / Sampson, Uchechukwu / Sanchez-Riera, Lidia / Sanman, Ella / Schwebel, David C / Scott, James Graham / Segui-Gomez, Maria / Shahraz, Saeid / Shepard, Donald S / Shin, Hwashin / Shivakoti, Rupak / Singh, David / Singh, Gitanjali M / Singh, Jasvinder A / Singleton, Jessica / Sleet, David A / Sliwa, Karen / Smith, Emma / Smith, Jennifer L / Stapelberg, Nicolas J C / Steer, Andrew / Steiner, Timothy / Stolk, Wilma A / Stovner, Lars Jacob / Sudfeld, Christopher / Syed, Sana / Tamburlini, Giorgio / Tavakkoli, Mohammad / Taylor, Hugh R / Taylor, Jennifer A / Taylor, William J / Thomas, Bernadette / Thomson, W Murray / Thurston, George D / Tleyjeh, Imad M / Tonelli, Marcello / Towbin, Jeffrey A / Truelsen, Thomas / Tsilimbaris, Miltiadis K / Ubeda, Clotilde / Undurraga, Eduardo A / van der Werf, Marieke J / van Os, Jim / Vavilala, Monica S / Venketasubramanian, N / Wang, Mengru / Wang, Wenzhi / Watt, Kerrianne / Weatherall, David J / Weinstock, Martin A / Weintraub, Robert / Weisskopf, Marc G / Weissman, Myrna M / White, Richard A / Whiteford, Harvey / Wiersma, Steven T / Wilkinson, James D / Williams, Hywel C / Williams, Sean R M / Witt, Emma / Wolfe, Frederick / Woolf, Anthony D / Wulf, Sarah / Yeh, Pon-Hsiu / Zaidi, Anita K M / Zheng, Zhi-Jie / Zonies, David / Lopez, Alan D / Murray, Christopher J L / AlMazroa, Mohammad A / Memish, Ziad A

    Lancet (London, England)

    2012  Volume 380, Issue 9859, Page(s) 2163–2196

    Abstract: Background: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies ...

    Abstract Background: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).
    Methods: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.
    Findings: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.
    Interpretation: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.
    Funding: Bill & Melinda Gates Foundation.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Global Health/statistics & numerical data ; Health Status ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prevalence ; Quality-Adjusted Life Years ; Sex Factors ; Wounds and Injuries/epidemiology ; Young Adult
    Language English
    Publishing date 2012-12-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(12)61729-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

    Murray, Christopher J L / Vos, Theo / Lozano, Rafael / Naghavi, Mohsen / Flaxman, Abraham D / Michaud, Catherine / Ezzati, Majid / Shibuya, Kenji / Salomon, Joshua A / Abdalla, Safa / Aboyans, Victor / Abraham, Jerry / Ackerman, Ilana / Aggarwal, Rakesh / Ahn, Stephanie Y / Ali, Mohammed K / Alvarado, Miriam / Anderson, H Ross / Anderson, Laurie M /
    Andrews, Kathryn G / Atkinson, Charles / Baddour, Larry M / Bahalim, Adil N / Barker-Collo, Suzanne / Barrero, Lope H / Bartels, David H / Basáñez, Maria-Gloria / Baxter, Amanda / Bell, Michelle L / Benjamin, Emelia J / Bennett, Derrick / Bernabé, Eduardo / Bhalla, Kavi / Bhandari, Bishal / Bikbov, Boris / Bin Abdulhak, Aref / Birbeck, Gretchen / Black, James A / Blencowe, Hannah / Blore, Jed D / Blyth, Fiona / Bolliger, Ian / Bonaventure, Audrey / Boufous, Soufiane / Bourne, Rupert / Boussinesq, Michel / Braithwaite, Tasanee / Brayne, Carol / Bridgett, Lisa / Brooker, Simon / Brooks, Peter / Brugha, Traolach S / Bryan-Hancock, Claire / Bucello, Chiara / Buchbinder, Rachelle / Buckle, Geoffrey / Budke, Christine M / Burch, Michael / Burney, Peter / Burstein, Roy / Calabria, Bianca / Campbell, Benjamin / Canter, Charles E / Carabin, Hélène / Carapetis, Jonathan / Carmona, Loreto / Cella, Claudia / Charlson, Fiona / Chen, Honglei / Cheng, Andrew Tai-Ann / Chou, David / Chugh, Sumeet S / Coffeng, Luc E / Colan, Steven D / Colquhoun, Samantha / Colson, K Ellicott / Condon, John / Connor, Myles D / Cooper, Leslie T / Corriere, Matthew / Cortinovis, Monica / de Vaccaro, Karen Courville / Couser, William / Cowie, Benjamin C / Criqui, Michael H / Cross, Marita / Dabhadkar, Kaustubh C / Dahiya, Manu / Dahodwala, Nabila / Damsere-Derry, James / Danaei, Goodarz / Davis, Adrian / De Leo, Diego / Degenhardt, Louisa / Dellavalle, Robert / Delossantos, Allyne / Denenberg, Julie / Derrett, Sarah / Des Jarlais, Don C / Dharmaratne, Samath D / Dherani, Mukesh / Diaz-Torne, Cesar / Dolk, Helen / Dorsey, E Ray / Driscoll, Tim / Duber, Herbert / Ebel, Beth / Edmond, Karen / Elbaz, Alexis / Ali, Suad Eltahir / Erskine, Holly / Erwin, Patricia J / Espindola, Patricia / Ewoigbokhan, Stalin E / Farzadfar, Farshad / Feigin, Valery / Felson, David T / Ferrari, Alize / Ferri, Cleusa P / Fèvre, Eric M / Finucane, Mariel M / Flaxman, Seth / Flood, Louise / Foreman, Kyle / Forouzanfar, Mohammad H / Fowkes, Francis Gerry R / Fransen, Marlene / Freeman, Michael K / Gabbe, Belinda J / Gabriel, Sherine E / Gakidou, Emmanuela / Ganatra, Hammad A / Garcia, Bianca / Gaspari, Flavio / Gillum, Richard F / Gmel, Gerhard / Gonzalez-Medina, Diego / Gosselin, Richard / Grainger, Rebecca / Grant, Bridget / Groeger, Justina / Guillemin, Francis / Gunnell, David / Gupta, Ramyani / Haagsma, Juanita / Hagan, Holly / Halasa, Yara A / Hall, Wayne / Haring, Diana / Haro, Josep Maria / Harrison, James E / Havmoeller, Rasmus / Hay, Roderick J / Higashi, Hideki / Hill, Catherine / Hoen, Bruno / Hoffman, Howard / Hotez, Peter J / Hoy, Damian / Huang, John J / Ibeanusi, Sydney E / Jacobsen, Kathryn H / James, Spencer L / Jarvis, Deborah / Jasrasaria, Rashmi / Jayaraman, Sudha / Johns, Nicole / Jonas, Jost B / Karthikeyan, Ganesan / Kassebaum, Nicholas / Kawakami, Norito / Keren, Andre / Khoo, Jon-Paul / King, Charles H / Knowlton, Lisa Marie / Kobusingye, Olive / Koranteng, Adofo / Krishnamurthi, Rita / Laden, Francine / Lalloo, Ratilal / Laslett, Laura L / Lathlean, Tim / Leasher, Janet L / Lee, Yong Yi / Leigh, James / Levinson, Daphna / Lim, Stephen S / Limb, Elizabeth / Lin, John Kent / Lipnick, Michael / Lipshultz, Steven E / Liu, Wei / Loane, Maria / Ohno, Summer Lockett / Lyons, Ronan / Mabweijano, Jacqueline / MacIntyre, Michael F / Malekzadeh, Reza / Mallinger, Leslie / Manivannan, Sivabalan / Marcenes, Wagner / March, Lyn / Margolis, David J / Marks, Guy B / Marks, Robin / Matsumori, Akira / Matzopoulos, Richard / Mayosi, Bongani M / McAnulty, John H / McDermott, Mary M / McGill, Neil / McGrath, John / Medina-Mora, Maria Elena / Meltzer, Michele / Mensah, George A / Merriman, Tony R / Meyer, Ana-Claire / Miglioli, Valeria / Miller, Matthew / Miller, Ted R / Mitchell, Philip B / Mock, Charles / Mocumbi, Ana Olga / Moffitt, Terrie E / Mokdad, Ali A / Monasta, Lorenzo / Montico, Marcella / Moradi-Lakeh, Maziar / Moran, Andrew / Morawska, Lidia / Mori, Rintaro / Murdoch, Michele E / Mwaniki, Michael K / Naidoo, Kovin / Nair, M Nathan / Naldi, Luigi / Narayan, K M Venkat / Nelson, Paul K / Nelson, Robert G / Nevitt, Michael C / Newton, Charles R / Nolte, Sandra / Norman, Paul / Norman, Rosana / O'Donnell, Martin / O'Hanlon, Simon / Olives, Casey / Omer, Saad B / Ortblad, Katrina / Osborne, Richard / Ozgediz, Doruk / Page, Andrew / Pahari, Bishnu / Pandian, Jeyaraj Durai / Rivero, Andrea Panozo / Patten, Scott B / Pearce, Neil / Padilla, Rogelio Perez / Perez-Ruiz, Fernando / Perico, Norberto / Pesudovs, Konrad / Phillips, David / Phillips, Michael R / Pierce, Kelsey / Pion, Sébastien / Polanczyk, Guilherme V / Polinder, Suzanne / Pope, C Arden / Popova, Svetlana / Porrini, Esteban / Pourmalek, Farshad / Prince, Martin / Pullan, Rachel L / Ramaiah, Kapa D / Ranganathan, Dharani / Razavi, Homie / Regan, Mathilda / Rehm, Jürgen T / Rein, David B / Remuzzi, Guiseppe / Richardson, Kathryn / Rivara, Frederick P / Roberts, Thomas / Robinson, Carolyn / De Leòn, Felipe Rodriguez / Ronfani, Luca / Room, Robin / Rosenfeld, Lisa C / Rushton, Lesley / Sacco, Ralph L / Saha, Sukanta / Sampson, Uchechukwu / Sanchez-Riera, Lidia / Sanman, Ella / Schwebel, David C / Scott, James Graham / Segui-Gomez, Maria / Shahraz, Saeid / Shepard, Donald S / Shin, Hwashin / Shivakoti, Rupak / Singh, David / Singh, Gitanjali M / Singh, Jasvinder A / Singleton, Jessica / Sleet, David A / Sliwa, Karen / Smith, Emma / Smith, Jennifer L / Stapelberg, Nicolas J C / Steer, Andrew / Steiner, Timothy / Stolk, Wilma A / Stovner, Lars Jacob / Sudfeld, Christopher / Syed, Sana / Tamburlini, Giorgio / Tavakkoli, Mohammad / Taylor, Hugh R / Taylor, Jennifer A / Taylor, William J / Thomas, Bernadette / Thomson, W Murray / Thurston, George D / Tleyjeh, Imad M / Tonelli, Marcello / Towbin, Jeffrey A / Truelsen, Thomas / Tsilimbaris, Miltiadis K / Ubeda, Clotilde / Undurraga, Eduardo A / van der Werf, Marieke J / van Os, Jim / Vavilala, Monica S / Venketasubramanian, N / Wang, Mengru / Wang, Wenzhi / Watt, Kerrianne / Weatherall, David J / Weinstock, Martin A / Weintraub, Robert / Weisskopf, Marc G / Weissman, Myrna M / White, Richard A / Whiteford, Harvey / Wiebe, Natasha / Wiersma, Steven T / Wilkinson, James D / Williams, Hywel C / Williams, Sean R M / Witt, Emma / Wolfe, Frederick / Woolf, Anthony D / Wulf, Sarah / Yeh, Pon-Hsiu / Zaidi, Anita K M / Zheng, Zhi-Jie / Zonies, David / Lopez, Alan D / AlMazroa, Mohammad A / Memish, Ziad A

    Lancet (London, England)

    2012  Volume 380, Issue 9859, Page(s) 2197–2223

    Abstract: Background: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life ... ...

    Abstract Background: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
    Methods: We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights.
    Findings: Global DALYs remained stable from 1990 (2·503 billion) to 2010 (2·490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions.
    Interpretation: Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.
    Funding: Bill & Melinda Gates Foundation.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Global Health/statistics & numerical data ; Health Status ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prevalence ; Quality-Adjusted Life Years ; Sex Factors ; Wounds and Injuries/epidemiology ; Young Adult
    Language English
    Publishing date 2012-12-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(12)61689-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

    Vos, Theo / Flaxman, Abraham D / Naghavi, Mohsen / Lozano, Rafael / Michaud, Catherine / Ezzati, Majid / Shibuya, Kenji / Salomon, Joshua A / Abdalla, Safa / Aboyans, Victor / Abraham, Jerry / Ackerman, Ilana / Aggarwal, Rakesh / Ahn, Stephanie Y / Ali, Mohammed K / AlMazroa, Mohammad A / Alvarado, Miriam / Anderson, H Ross / Anderson, Laurie M /
    Andrews, Kathryn G / Atkinson, Charles / Baddour, Larry M / Bahalim, Adil N / Barker-Collo, Suzanne / Barrero, Lope H / Bartels, David H / Basáñez, Maria-Gloria / Baxter, Amanda / Bell, Michelle L / Benjamin, Emelia J / Bennett, Derrick / Bernabé, Eduardo / Bhalla, Kavi / Bhandari, Bishal / Bikbov, Boris / Abdulhak, Aref Bin / Birbeck, Gretchen / Black, James A / Blencowe, Hannah / Blore, Jed D / Blyth, Fiona / Bolliger, Ian / Bonaventure, Audrey / Boufous, Soufiane / Bourne, Rupert / Boussinesq, Michel / Braithwaite, Tasanee / Brayne, Carol / Bridgett, Lisa / Brooker, Simon / Brooks, Peter / Brugha, Traolach S / Bryan-Hancock, Claire / Bucello, Chiara / Buchbinder, Rachelle / Buckle, Geoffrey / Budke, Christine M / Burch, Michael / Burney, Peter / Burstein, Roy / Calabria, Bianca / Campbell, Benjamin / Canter, Charles E / Carabin, Hélène / Carapetis, Jonathan / Carmona, Loreto / Cella, Claudia / Charlson, Fiona / Chen, Honglei / Cheng, Andrew Tai-Ann / Chou, David / Chugh, Sumeet S / Coffeng, Luc E / Colan, Steven D / Colquhoun, Samantha / Colson, K Ellicott / Condon, John / Connor, Myles D / Cooper, Leslie T / Corriere, Matthew / Cortinovis, Monica / de Vaccaro, Karen Courville / Couser, William / Cowie, Benjamin C / Criqui, Michael H / Cross, Marita / Dabhadkar, Kaustubh C / Dahiya, Manu / Dahodwala, Nabila / Damsere-Derry, James / Danaei, Goodarz / Davis, Adrian / De Leo, Diego / Degenhardt, Louisa / Dellavalle, Robert / Delossantos, Allyne / Denenberg, Julie / Derrett, Sarah / Des Jarlais, Don C / Dharmaratne, Samath D / Dherani, Mukesh / Diaz-Torne, Cesar / Dolk, Helen / Dorsey, E Ray / Driscoll, Tim / Duber, Herbert / Ebel, Beth / Edmond, Karen / Elbaz, Alexis / Ali, Suad Eltahir / Erskine, Holly / Erwin, Patricia J / Espindola, Patricia / Ewoigbokhan, Stalin E / Farzadfar, Farshad / Feigin, Valery / Felson, David T / Ferrari, Alize / Ferri, Cleusa P / Fèvre, Eric M / Finucane, Mariel M / Flaxman, Seth / Flood, Louise / Foreman, Kyle / Forouzanfar, Mohammad H / Fowkes, Francis Gerry R / Franklin, Richard / Fransen, Marlene / Freeman, Michael K / Gabbe, Belinda J / Gabriel, Sherine E / Gakidou, Emmanuela / Ganatra, Hammad A / Garcia, Bianca / Gaspari, Flavio / Gillum, Richard F / Gmel, Gerhard / Gosselin, Richard / Grainger, Rebecca / Groeger, Justina / Guillemin, Francis / Gunnell, David / Gupta, Ramyani / Haagsma, Juanita / Hagan, Holly / Halasa, Yara A / Hall, Wayne / Haring, Diana / Haro, Josep Maria / Harrison, James E / Havmoeller, Rasmus / Hay, Roderick J / Higashi, Hideki / Hill, Catherine / Hoen, Bruno / Hoffman, Howard / Hotez, Peter J / Hoy, Damian / Huang, John J / Ibeanusi, Sydney E / Jacobsen, Kathryn H / James, Spencer L / Jarvis, Deborah / Jasrasaria, Rashmi / Jayaraman, Sudha / Johns, Nicole / Jonas, Jost B / Karthikeyan, Ganesan / Kassebaum, Nicholas / Kawakami, Norito / Keren, Andre / Khoo, Jon-Paul / King, Charles H / Knowlton, Lisa Marie / Kobusingye, Olive / Koranteng, Adofo / Krishnamurthi, Rita / Lalloo, Ratilal / Laslett, Laura L / Lathlean, Tim / Leasher, Janet L / Lee, Yong Yi / Leigh, James / Lim, Stephen S / Limb, Elizabeth / Lin, John Kent / Lipnick, Michael / Lipshultz, Steven E / Liu, Wei / Loane, Maria / Ohno, Summer Lockett / Lyons, Ronan / Ma, Jixiang / Mabweijano, Jacqueline / MacIntyre, Michael F / Malekzadeh, Reza / Mallinger, Leslie / Manivannan, Sivabalan / Marcenes, Wagner / March, Lyn / Margolis, David J / Marks, Guy B / Marks, Robin / Matsumori, Akira / Matzopoulos, Richard / Mayosi, Bongani M / McAnulty, John H / McDermott, Mary M / McGill, Neil / McGrath, John / Medina-Mora, Maria Elena / Meltzer, Michele / Memish, Ziad A / Mensah, George A / Merriman, Tony R / Meyer, Ana-Claire / Miglioli, Valeria / Miller, Matthew / Miller, Ted R / Mitchell, Philip B / Mocumbi, Ana Olga / Moffitt, Terrie E / Mokdad, Ali A / Monasta, Lorenzo / Montico, Marcella / Moradi-Lakeh, Maziar / Moran, Andrew / Morawska, Lidia / Mori, Rintaro / Murdoch, Michele E / Mwaniki, Michael K / Naidoo, Kovin / Nair, M Nathan / Naldi, Luigi / Narayan, KM Venkat / Nelson, Paul K / Nelson, Robert G / Nevitt, Michael C / Newton, Charles R / Nolte, Sandra / Norman, Paul / Norman, Rosana / O'Donnell, Martin / O'Hanlon, Simon / Olives, Casey / Omer, Saad B / Ortblad, Katrina / Osborne, Richard / Ozgediz, Doruk / Page, Andrew / Pahari, Bishnu / Pandian, Jeyaraj Durai / Rivero, Andrea Panozo / Patten, Scott B / Pearce, Neil / Padilla, Rogelio Perez / Perez-Ruiz, Fernando / Perico, Norberto / Pesudovs, Konrad / Phillips, David / Phillips, Michael R / Pierce, Kelsey / Pion, Sébastien / Polanczyk, Guilherme V / Polinder, Suzanne / Pope, C Arden, III / Popova, Svetlana / Porrini, Esteban / Pourmalek, Farshad / Prince, Martin / Pullan, Rachel L / Ramaiah, Kapa D / Ranganathan, Dharani / Razavi, Homie / Regan, Mathilda / Rehm, Jürgen T / Rein, David B / Remuzzi, Guiseppe / Richardson, Kathryn / Rivara, Frederick P / Roberts, Thomas / Robinson, Carolyn / De Leòn, Felipe Rodriguez / Ronfani, Luca / Room, Robin / Rosenfeld, Lisa C / Rushton, Lesley / Sacco, Ralph L / Saha, Sukanta / Sampson, Uchechukwu / Sanchez-Riera, Lidia / Sanman, Ella / Schwebel, David C / Scott, James Graham / Segui-Gomez, Maria / Shahraz, Saeid / Shepard, Donald S / Shin, Hwashin / Shivakoti, Rupak / Singh, David / Singh, Gitanjali M / Singh, Jasvinder A / Singleton, Jessica / Sleet, David A / Sliwa, Karen / Smith, Emma / Smith, Jennifer L / Stapelberg, Nicolas JC / Steer, Andrew / Steiner, Timothy / Stolk, Wilma A / Stovner, Lars Jacob / Sudfeld, Christopher / Syed, Sana / Tamburlini, Giorgio / Tavakkoli, Mohammad / Taylor, Hugh R / Taylor, Jennifer A / Taylor, William J / Thomas, Bernadette / Thomson, W Murray / Thurston, George D / Tleyjeh, Imad M / Tonelli, Marcello / Towbin, Jeffrey A / Truelsen, Thomas / Tsilimbaris, Miltiadis K / Ubeda, Clotilde / Undurraga, Eduardo A / van der Werf, Marieke J / van Os, Jim / Vavilala, Monica S / Venketasubramanian, N / Wang, Mengru / Wang, Wenzhi / Watt, Kerrianne / Weatherall, David J / Weinstock, Martin A / Weintraub, Robert / Weisskopf, Marc G / Weissman, Myrna M / White, Richard A / Whiteford, Harvey / Wiersma, Steven T / Wilkinson, James D / Williams, Hywel C / Williams, Sean RM / Witt, Emma / Wolfe, Frederick / Woolf, Anthony D / Wulf, Sarah / Yeh, Pon-Hsiu / Zaidi, Anita KM / Zheng, Zhi-Jie / Zonies, David / Lopez, Alan D / Murray, Christopher JL

    lancet. 2013 Dec. 15, v. 380, no. 9859

    2013  

    Abstract: BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies ... ...

    Abstract BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. INTERPRETATION: Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. FUNDING: Bill & Melinda Gates Foundation.
    Keywords anxiety ; behavior disorders ; cohort studies ; comorbidity ; complications (disease) ; correlation ; diabetes ; disability weights ; disability-adjusted life year ; household surveys ; iron deficiency anemia ; malaria ; migraine ; models ; monitoring ; mortality ; musculoskeletal diseases ; natural history ; neck ; pain ; people ; population growth ; remission ; tuberculosis ; uncertainty ; Sub-Saharan Africa
    Language English
    Dates of publication 2013-1215
    Size p. 2163-2196.
    Publishing place Elsevier Ltd.
    Document type Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(12)61729-2
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 62/103: Show issues
    Z70.00 LA01: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

    Murray, Christopher J L / Vos, Theo / Lozano, Rafael / Naghavi, Mohsen / Flaxman, Abraham D / Michaud, Catherine / Ezzati, Majid / Shibuya, Kenji / Salomon, Joshua A / Abdalla, Safa / Aboyans, Victor / Abraham, Jerry / Ackerman, Ilana / Aggarwal, Rakesh / Ahn, Stephanie Y / Ali, Mohammed K / AlMazroa, Mohammad A / Alvarado, Miriam / Anderson, H Ross /
    Anderson, Laurie M / Andrews, Kathryn G / Atkinson, Charles / Baddour, Larry M / Bahalim, Adil N / Barker-Collo, Suzanne / Barrero, Lope H / Bartels, David H / Basáñez, Maria-Gloria / Baxter, Amanda / Bell, Michelle L / Benjamin, Emelia J / Bennett, Derrick / Bernabé, Eduardo / Bhalla, Kavi / Bhandari, Bishal / Bikbov, Boris / Abdulhak, Aref Bin / Birbeck, Gretchen / Black, James A / Blencowe, Hannah / Blore, Jed D / Blyth, Fiona / Bolliger, Ian / Bonaventure, Audrey / Boufous, Soufiane / Bourne, Rupert / Boussinesq, Michel / Braithwaite, Tasanee / Brayne, Carol / Bridgett, Lisa / Brooker, Simon / Brooks, Peter / Brugha, Traolach S / Bryan-Hancock, Claire / Bucello, Chiara / Buchbinder, Rachelle / Buckle, Geoffrey / Budke, Christine M / Burch, Michael / Burney, Peter / Burstein, Roy / Calabria, Bianca / Campbell, Benjamin / Canter, Charles E / Carabin, Hélène / Carapetis, Jonathan / Carmona, Loreto / Cella, Claudia / Charlson, Fiona / Chen, Honglei / Cheng, Andrew Tai-Ann / Chou, David / Chugh, Sumeet S / Coffeng, Luc E / Colan, Steven D / Colquhoun, Samantha / Colson, K Ellicott / Condon, John / Connor, Myles D / Cooper, Leslie T / Corriere, Matthew / Cortinovis, Monica / de Vaccaro, Karen Courville / Couser, William / Cowie, Benjamin C / Criqui, Michael H / Cross, Marita / Dabhadkar, Kaustubh C / Dahiya, Manu / Dahodwala, Nabila / Damsere-Derry, James / Danaei, Goodarz / Davis, Adrian / Leo, Diego De / Degenhardt, Louisa / Dellavalle, Robert / Delossantos, Allyne / Denenberg, Julie / Derrett, Sarah / Des Jarlais, Don C / Dharmaratne, Samath D / Dherani, Mukesh / Diaz-Torne, Cesar / Dolk, Helen / Dorsey, E Ray / Driscoll, Tim / Duber, Herbert / Ebel, Beth / Edmond, Karen / Elbaz, Alexis / Ali, Suad Eltahir / Erskine, Holly / Erwin, Patricia J / Espindola, Patricia / Ewoigbokhan, Stalin E / Farzadfar, Farshad / Feigin, Valery / Felson, David T / Ferrari, Alize / Ferri, Cleusa P / Fèvre, Eric M / Finucane, Mariel M / Flaxman, Seth / Flood, Louise / Foreman, Kyle / Forouzanfar, Mohammad H / Fowkes, Francis Gerry R / Fransen, Marlene / Freeman, Michael K / Gabbe, Belinda J / Gabriel, Sherine E / Gakidou, Emmanuela / Ganatra, Hammad A / Garcia, Bianca / Gaspari, Flavio / Gillum, Richard F / Gmel, Gerhard / Gonzalez-Medina, Diego / Gosselin, Richard / Grainger, Rebecca / Grant, Bridget / Groeger, Justina / Guillemin, Francis / Gunnell, David / Gupta, Ramyani / Haagsma, Juanita / Hagan, Holly / Halasa, Yara A / Hall, Wayne / Haring, Diana / Haro, Josep Maria / Harrison, James E / Havmoeller, Rasmus / Hay, Roderick J / Higashi, Hideki / Hill, Catherine / Hoen, Bruno / Hoffman, Howard / Hotez, Peter J / Hoy, Damian / Huang, John J / Ibeanusi, Sydney E / Jacobsen, Kathryn H / James, Spencer L / Jarvis, Deborah / Jasrasaria, Rashmi / Jayaraman, Sudha / Johns, Nicole / Jonas, Jost B / Karthikeyan, Ganesan / Kassebaum, Nicholas / Kawakami, Norito / Keren, Andre / Khoo, Jon-Paul / King, Charles H / Knowlton, Lisa Marie / Kobusingye, Olive / Koranteng, Adofo / Krishnamurthi, Rita / Laden, Francine / Lalloo, Ratilal / Laslett, Laura L / Lathlean, Tim / Leasher, Janet L / Lee, Yong Yi / Leigh, James / Levinson, Daphna / Lim, Stephen S / Limb, Elizabeth / Lin, John Kent / Lipnick, Michael / Lipshultz, Steven E / Liu, Wei / Loane, Maria / Ohno, Summer Lockett / Lyons, Ronan / Mabweijano, Jacqueline / MacIntyre, Michael F / Malekzadeh, Reza / Mallinger, Leslie / Manivannan, Sivabalan / Marcenes, Wagner / March, Lyn / Margolis, David J / Marks, Guy B / Marks, Robin / Matsumori, Akira / Matzopoulos, Richard / Mayosi, Bongani M / McAnulty, John H / McDermott, Mary M / McGill, Neil / McGrath, John / Medina-Mora, Maria Elena / Meltzer, Michele / Memish, Ziad A / Mensah, George A / Merriman, Tony R / Meyer, Ana-Claire / Miglioli, Valeria / Miller, Matthew / Miller, Ted R / Mitchell, Philip B / Mock, Charles / Mocumbi, Ana Olga / Moffitt, Terrie E / Mokdad, Ali A / Monasta, Lorenzo / Montico, Marcella / Moradi-Lakeh, Maziar / Moran, Andrew / Morawska, Lidia / Mori, Rintaro / Murdoch, Michele E / Mwaniki, Michael K / Naidoo, Kovin / Nair, M Nathan / Naldi, Luigi / Narayan, K M Venkat / Nelson, Paul K / Nelson, Robert G / Nevitt, Michael C / Newton, Charles R / Nolte, Sandra / Norman, Paul / Norman, Rosana / O'Donnell, Martin / O'Hanlon, Simon / Olives, Casey / Omer, Saad B / Ortblad, Katrina / Osborne, Richard / Ozgediz, Doruk / Page, Andrew / Pahari, Bishnu / Pandian, Jeyaraj Durai / Rivero, Andrea Panozo / Patten, Scott B / Pearce, Neil / Padilla, Rogelio Perez / Perez-Ruiz, Fernando / Perico, Norberto / Pesudovs, Konrad / Phillips, David / Phillips, Michael R / Pierce, Kelsey / Pion, Sébastien / Polanczyk, Guilherme V / Polinder, Suzanne / Pope, C Arden, III / Popova, Svetlana / Porrini, Esteban / Pourmalek, Farshad / Prince, Martin / Pullan, Rachel L / Ramaiah, Kapa D / Ranganathan, Dharani / Razavi, Homie / Regan, Mathilda / Rehm, Jürgen T / Rein, David B / Remuzzi, Guiseppe / Richardson, Kathryn / Rivara, Frederick P / Roberts, Thomas / Robinson, Carolyn / De Leòn, Felipe Rodriguez / Ronfani, Luca / Room, Robin / Rosenfeld, Lisa C / Rushton, Lesley / Sacco, Ralph L / Saha, Sukanta / Sampson, Uchechukwu / Sanchez-Riera, Lidia / Sanman, Ella / Schwebel, David C / Scott, James Graham / Segui-Gomez, Maria / Shahraz, Saeid / Shepard, Donald S / Shin, Hwashin / Shivakoti, Rupak / Singh, David / Singh, Gitanjali M / Singh, Jasvinder A / Singleton, Jessica / Sleet, David A / Sliwa, Karen / Smith, Emma / Smith, Jennifer L / Stapelberg, Nicolas JC / Steer, Andrew / Steiner, Timothy / Stolk, Wilma A / Stovner, Lars Jacob / Sudfeld, Christopher / Syed, Sana / Tamburlini, Giorgio / Tavakkoli, Mohammad / Taylor, Hugh R / Taylor, Jennifer A / Taylor, William J / Thomas, Bernadette / Thomson, W Murray / Thurston, George D / Tleyjeh, Imad M / Tonelli, Marcello / Towbin, Jeffrey A / Truelsen, Thomas / Tsilimbaris, Miltiadis K / Ubeda, Clotilde / Undurraga, Eduardo A / van der Werf, Marieke J / van Os, Jim / Vavilala, Monica S / Venketasubramanian, N / Wang, Mengru / Wang, Wenzhi / Watt, Kerrianne / Weatherall, David J / Weinstock, Martin A / Weintraub, Robert / Weisskopf, Marc G / Weissman, Myrna M / White, Richard A / Whiteford, Harvey / Wiebe, Natasha / Wiersma, Steven T / Wilkinson, James D / Williams, Hywel C / Williams, Sean RM / Witt, Emma / Wolfe, Frederick / Woolf, Anthony D / Wulf, Sarah / Yeh, Pon-Hsiu / Zaidi, Anita KM / Zheng, Zhi-Jie / Zonies, David / Lopez, Alan D

    lancet. 2013 Dec. 15, v. 380, no. 9859

    2013  

    Abstract: BACKGROUND: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life ... ...

    Abstract BACKGROUND: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. METHODS: We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights. FINDINGS: Global DALYs remained stable from 1990 (2·503 billion) to 2010 (2·490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions. INTERPRETATION: Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results. FUNDING: Bill & Melinda Gates Foundation.
    Keywords behavior disorders ; children ; complications (disease) ; death ; diabetes ; diet-related diseases ; disability weights ; disability-adjusted life year ; longevity ; mortality ; musculoskeletal diseases ; myocardial ischemia ; stroke ; uncertainty ; Asia ; Australasian region ; North America ; Sub-Saharan Africa ; Western European region
    Language English
    Dates of publication 2013-1215
    Size p. 2197-2223.
    Publishing place Elsevier Ltd.
    Document type Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(12)61689-4
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 62/103: Show issues
    Z70.00 LA01: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top