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  1. Article: Regelwidrige Schädellagen in der Lehre. Hella R. Köster über Zeichen und Merkmale der RSL und die Kunst, das Wissen weiterzugeben

    Köster, Hella R.

    Deutsche Hebammen-Zeitschrift

    2022  Volume 74, Issue 2, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 80218-9
    ISSN 0012-026X
    Database Current Contents Medicine

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  2. Article ; Online: Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS.

    Johnson, Jeanette A I / Tsang, Ashley P / Mitchell, Jacob T / Zhou, David L / Bowden, Julia / Davis-Marcisak, Emily / Sherman, Thomas / Liefeld, Ted / Loth, Melanie / Goff, Loyal A / Zimmerman, Jacquelyn W / Kinny-Köster, Ben / Jaffee, Elizabeth M / Tamayo, Pablo / Mesirov, Jill P / Reich, Michael / Fertig, Elana J / Stein-O'Brien, Genevieve L

    Nature protocols

    2023  Volume 18, Issue 12, Page(s) 3690–3731

    Abstract: ... through the same single-cell NMF analysis using our R CoGAPS interface. The fourth introduces a beginner-friendly ... of data analysis but without a basic proficiency in the R or Python programming language. We also constructed ...

    Abstract Non-negative matrix factorization (NMF) is an unsupervised learning method well suited to high-throughput biology. However, inferring biological processes from an NMF result still requires additional post hoc statistics and annotation for interpretation of learned features. Here, we introduce a suite of computational tools that implement NMF and provide methods for accurate and clear biological interpretation and analysis. A generalized discussion of NMF covering its benefits, limitations and open questions is followed by four procedures for the Bayesian NMF algorithm Coordinated Gene Activity across Pattern Subsets (CoGAPS). Each procedure will demonstrate NMF analysis to quantify cell state transitions in a public domain single-cell RNA-sequencing dataset. The first demonstrates PyCoGAPS, our new Python implementation that enhances runtime for large datasets, and the second allows its deployment in Docker. The third procedure steps through the same single-cell NMF analysis using our R CoGAPS interface. The fourth introduces a beginner-friendly CoGAPS platform using GenePattern Notebook, aimed at users with a working conceptual knowledge of data analysis but without a basic proficiency in the R or Python programming language. We also constructed a user-facing website to serve as a central repository for information and instructional materials about CoGAPS and its application programming interfaces. The expected timing to setup the packages and conduct a test run is around 15 min, and an additional 30 min to conduct analyses on a precomputed result. The expected runtime on the user's desired dataset can vary from hours to days depending on factors such as dataset size or input parameters.
    MeSH term(s) Bayes Theorem ; Algorithms ; Programming Languages ; Single-Cell Analysis
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-023-00892-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Das Neugeborene im Blick. Hella R. Köster geht auf Blickdiagnostik und Messungen ein

    Köster, Hella R.

    Deutsche Hebammen-Zeitschrift

    2015  Volume -, Issue 1, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 80218-9
    ISSN 0012-026x
    Database Current Contents Medicine

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  4. Book ; Online: Futures Past. Economic Forecasting in the 20th and 21st Century

    Köster, Roman / Lenel, Laetitia / Fritsche, Ulrich

    2020  

    Abstract: Few areas in economics are as controversial as economic forecasting. While the field has sparked great hopes for the prediction of economic trends and events throughout the 20th and 21st centuries, economic forecasts have often proved inaccurate or ... ...

    Abstract Few areas in economics are as controversial as economic forecasting. While the field has sparked great hopes for the prediction of economic trends and events throughout the 20th and 21st centuries, economic forecasts have often proved inaccurate or unreliable, thus provoking severe criticism in times of unpredicted crisis. Despite these failures, economic forecasting has not lost its importance. Futures Past considers the history and present state of economic forecasting, giving a fascinating account of the changing practices involved, their origins, records, and their implications. By bringing together economists, historians, and sociologists, this volume offers fresh perspectives on the place of forecasting in modern industrial societies, thereby making a broader claim for greater interdisciplinary cooperation in the history of economics
    Keywords History (General) ; Economic theory. Demography ; Economic history and conditions
    Size 1 electronic resource (220 pages)
    Publisher Peter Lang International Academic Publishing Group
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020678474
    ISBN 9783631818695 ; 3631818696
    DOI 10.3726/b16817
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Revision Materialwirtschaft und Lieferantenstammdatenpflege unter SAP R/3

    Köster, Christoph / Ribbert, Michael / Vallée, Franz

    Zeitschrift Interne Revision Vol. 44, No. 4 , p. 157-167

    2009  Volume 44, Issue 4, Page(s) 157–167

    Author's details Christoph Köster; Michael Ribbert; Franz Vallée
    Keywords Materialwirtschaft ; Betriebliches Informationssystem ; Risikomanagement ; Compliance-Management
    Language German
    Size graph. Darst.
    Publisher Schmidt
    Publishing place Berlin ; Bielefeld ; München
    Document type Article
    ZDB-ID 209936-6
    ISSN 0044-3816
    Database ECONomics Information System

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  6. Article ; Online: Role of the QuantiFERON(R)-TB Gold In-Tube assay in screening new immigrants for tuberculosis infection.

    Mulder, Christiaan / van Deutekom, Henk / Huisman, Erik M / Toumanian, Sophie / Koster, Ben F P J / Meijer-Veldman, Wieneke / van Loenhout-Rooyackers, Joke H / Appel, Milo / Arend, Sandra M / Borgdorff, Martien W / van Leth, Frank

    The European respiratory journal

    2012  Volume 40, Issue 6, Page(s) 1443–1449

    Abstract: This study aimed to estimate the risk of progression to active tuberculosis (TB) within 2 yrs after entry in newly arriving immigrants who were screened with the QuantiFERON®-TB Gold In-Tube assay (QFT-GIT; Cellestis, Carnegie, Australia). In a case-base ...

    Abstract This study aimed to estimate the risk of progression to active tuberculosis (TB) within 2 yrs after entry in newly arriving immigrants who were screened with the QuantiFERON®-TB Gold In-Tube assay (QFT-GIT; Cellestis, Carnegie, Australia). In a case-base design, we determined the prevalence QFT-GIT-positive subjects among a representative sample of immigrants aged ≥ 18 yrs who arrived between April 2009 and March 2011 (the base cohort). Active TB patients (cases) within 2 yrs post-arrival in 2005, 2006 or 2007 were extracted from the Netherlands Tuberculosis Register. The risk of progression to active TB was estimated using Bayesian analyses to adjust for the sensitivity of QFT-GIT. Among the base cohort, 20% of 1,468 immigrants were QFT-GIT positive. Stratified by TB incidence in the person's country of origin as low (<100 cases per 100,000 population), intermediate (100-199 cases per 100,000) or high (≥ 200 cases per 100,000), the risk of progression to active TB per 100,000 arriving immigrants if QFT-GIT positive (95% credibility interval) was 456 (95% CI 307-589), 590 (397-762) and 386 (259-499), respectively, compared with 18 (0-46), 38 (0-97) and 28 (0-71) if QFT-GIT negative. Screening newly arriving immigrants with QFT-GIT contributes to detecting those at high risk of subsequent TB reactivation within 2 yrs after entry, which offers opportunities for prevention by targeted interventions.
    MeSH term(s) Adolescent ; Adult ; Bayes Theorem ; Cohort Studies ; Communicable Disease Control ; Cost-Benefit Analysis ; Disease Progression ; Emigrants and Immigrants ; Female ; Humans ; Male ; Mass Screening ; Netherlands ; Prevalence ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Tuberculin Test/methods ; Tuberculosis/diagnosis ; Tuberculosis/microbiology
    Chemical Substances Reagent Kits, Diagnostic
    Language English
    Publishing date 2012-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00010612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  7. Article: Density Functional Study of 2-[(R-Phenyl)amine]-1,4-naphthalenediones.

    Gómez-Sandoval, Z / Calaminici, P / Köster, A M / Lotina-Hennsen, B / King-Díaz, B / Macías-Ruvalcaba, N / Aguilar-Martínez, M / Jiménez-Estrada, M

    Journal of chemical theory and computation

    2007  Volume 3, Issue 3, Page(s) 894–904

    Abstract: The molecular and electronic structures of a series of 2-[(R-phenyl)amine]-1,4-naphthalenediones (R ...

    Abstract The molecular and electronic structures of a series of 2-[(R-phenyl)amine]-1,4-naphthalenediones (R = m-Me, p-Me, m-Et, p-CF3, p-Hex, p-Et, m-F, m-Cl, p-OMe, p-COMe, p-Bu, m-COOH, p-Cl, p-COOH, p-Br, m-NO2, m-CN, and p-NO2) and their anions are investigated in the framework of density functional theory. The calculations are of all-electron type using a double zeta valence polarization basis set optimized for density functional theory methods. The theoretical study shows that all compounds are nonplanar. The nonplanarity can be rationalized in terms of occupied π orbitals. A linear correlation between the measured half-wave potentials and the calculated gas-phase electron affinities is found. It holds for local as well as generalized gradient corrected functionals. Structural parameters, harmonic vibrational frequencies, and adiabatic and vertical electron affinities as well as orbital and spin density plots of the studied compounds are presented.
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9618
    ISSN 1549-9618
    DOI 10.1021/ct6003356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Preverbal infants' understanding of social norms.

    Köster, Moritz / Hepach, Robert

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2983

    Abstract: Social norms are foundational to human cooperation and co-existence in social groups. A crucial marker of social norms is that a behavior is not only shared, but that the conformity to the behavior of others is a basis for social evaluation (i.e., ... ...

    Abstract Social norms are foundational to human cooperation and co-existence in social groups. A crucial marker of social norms is that a behavior is not only shared, but that the conformity to the behavior of others is a basis for social evaluation (i.e., reinforcement and sanctioning), taking the is, how individuals usually behave, to an ought, how individuals should behave to be socially approved by others. In this preregistered study, we show that 11-month-old infants grasp this fundamental aspect about social norms already in their first year. They showed a pupillary surprise response for unexpected social responses, namely the disapproval and exclusion of an individual who showed the same behavior like others or the approval and inclusion of an individual who behaved differently. That preverbal infants link the conformity with others' behavior to social evaluations, before they respond to norm violations themselves, indicates that the foundations of social norm understanding lie in early infancy.
    MeSH term(s) Infant ; Humans ; Social Norms ; Social Behavior ; Reinforcement, Psychology
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53110-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effects of unfractionated heparin, low molecular weight heparin and r-hirudin on leukocyte adhesion in ischemia/reperfusion.

    Habazettl, Helmut / Lindert, Jens / Baeter, Simonida / Neumann, Konrad / Kuppe, Hermann / Kuebler, Wolfgang M / Pries, Axel R / Koster, Andreas

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2004  Volume 15, Issue 5, Page(s) 375–381

    Abstract: ... of the anticoagulants unfractionated heparin (UFH), low molecular weight heparin (LMWH) and r-hirudin on leukocyte ... Saline (control), UFH, LMWH or r-hirudin were given 15 min prior to reperfusion and infused for the rest ... IU, 100 IU/h; LMWH, 100 IU, 3 ml/h saline; or r-hirudin, 0.3 mg, 0.15 mg/h. In collecting venules ...

    Abstract Activation of the coagulation cascade during myocardial ischemia and reperfusion may contribute to the post-ischemic inflammatory response, mostly via generation of thrombin. We assessed the effect of the anticoagulants unfractionated heparin (UFH), low molecular weight heparin (LMWH) and r-hirudin on leukocyte adhesion and emigration after ischemia and reperfusion in rats. The rat cremaster muscle was prepared for intravital microscopy. One hundred and twenty minutes of ischemia were followed by 90 min of reperfusion. Saline (control), UFH, LMWH or r-hirudin were given 15 min prior to reperfusion and infused for the rest of the observation period. Dosages per kilogram of body weight were (bolus, infusion): saline, 3 ml, 3 ml/h; UFH, 400 IU, 100 IU/h; LMWH, 100 IU, 3 ml/h saline; or r-hirudin, 0.3 mg, 0.15 mg/h. In collecting venules, rolling, adherent, and extravasated leukocytes were counted from recordings of the intravital microscopy. All three anticoagulants similarly attenuated post-ischemic endothelial leukocyte adhesion. In contrast, emigration of leukocytes was only attenuated by r-hirudin. The emigration efficiency of adherent leukocytes (control, 1.21) was unchanged after UFH (1.74), and LMWH (1.51) but decreased after r-hirudin treatment (0.12). The different efficacy of the three anticoagulants in affecting emigration of adherent leukocytes suggests a specific role for the direct thrombin inhibitor r-hirudin in attenuating the post-ischemic inflammatory response. This effect may contribute to the benefits of direct thrombin inhibitors seen in clinical studies after treatment for acute coronary syndromes.
    MeSH term(s) Animals ; Cell Adhesion/drug effects ; Cell Movement/drug effects ; Endothelium/pathology ; Fibrinolytic Agents/administration & dosage ; Heparin/administration & dosage ; Heparin, Low-Molecular-Weight/administration & dosage ; Hirudins/administration & dosage ; Leukocytes/pathology ; Male ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; Myocardial Ischemia/physiopathology ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Fibrinolytic Agents ; Heparin, Low-Molecular-Weight ; Hirudins ; Heparin (9005-49-6)
    Language English
    Publishing date 2004-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1033551-1
    ISSN 0957-5235
    ISSN 0957-5235
    DOI 10.1097/01.mbc.0000114445.59147.43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2920: Show issues Location:
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  10. Article: IRRT (Imagery Rescripting & Reprocessing Therapy) im psychotherapeutischen Alltag

    Köster, Rolf / Köster, Silvia / Schmucker, Mervyn

    PSYCH up2date

    2024  Volume 18, Issue 02, Page(s) 149–167

    Keywords IRRT ; Imagery Rescripting, Imagination ; Posttraumatische Belastungsstörung ; kPTBS ; Traumatherapie ; Innere-Kind-Arbeit ; Trauertherapie ; anhaltende Trauerstörung ; Rückfallbearbeitung ; Therapie psychosomatischer Störungen
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2683337-2
    ISSN 2194-8909 ; 2194-8895
    ISSN (online) 2194-8909
    ISSN 2194-8895
    DOI 10.1055/a-2122-4413
    Database Thieme publisher's database

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