LIVIVO - Search results -

Search results

Result 1 - 10 of total 2793

Article: p

Venkatesan, Amalan / Roy, Anitha / Kulandaivel, Srinivasan / Natesan, Vijayakumar / Kim, Sung-Jin

2022 Volume 12, Issue 12

Abstract: Diabetic nephropathy (DN) has become a leading cause of end-stage renal failure worldwide. The goal of the current study was to examine the protective effects of chitosan- ... ...

Abstract	Diabetic nephropathy (DN) has become a leading cause of end-stage renal failure worldwide. The goal of the current study was to examine the protective effects of chitosan-loaded
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12121166
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: ERMA (TMEM94) is a P-type ATPase transporter for Mg

Molecular cell

2024 Volume 84, Issue 7, Page(s) 1321–1337.e11

Abstract: Intracellular ... ...

Abstract	Intracellular Mg
MeSH term(s)	Animals ; Mice ; Humans ; Adenosine Triphosphatases/metabolism ; Membrane Transport Proteins/metabolism ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Biological Transport ; P-type ATPases/metabolism ; Calcium/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases
Chemical Substances	Adenosine Triphosphatases (EC 3.6.1.-) ; Membrane Transport Proteins ; P-type ATPases (EC 3.6.3.-) ; Calcium (SY7Q814VUP) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8)
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.02.033
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Sparsity and $\ell_p$-Restricted Isometry

Guruswami, Venkatesan / Manohar, Peter / Mosheiff, Jonathan

2022

Abstract: A matrix $A$ is said to have the $\ell_p$-Restricted Isometry Property ($\ell_p$-RIP ... if for all vectors $x$ of up to some sparsity $k$, $\|{Ax}\|_p$ is roughly proportional to $\|{x}\|_p$. We study ... regime, $\ell_p$-RIP matrices are closely connected to Euclidean sections, and are "real analogs ...

Abstract	A matrix $A$ is said to have the $\ell_p$-Restricted Isometry Property ($\ell_p$-RIP) if for all vectors $x$ of up to some sparsity $k$, $\\|{Ax}\\|_p$ is roughly proportional to $\\|{x}\\|_p$. We study this property for $m \times n$ matrices of rank proportional to $n$ and $k = \Theta(n)$. In this parameter regime, $\ell_p$-RIP matrices are closely connected to Euclidean sections, and are "real analogs" of testing matrices for locally testable codes. It is known that with high probability, random dense $m\times n$ matrices (e.g., with i.i.d. $\pm 1$ entries) are $\ell_2$-RIP with $k \approx m/\log n$, and sparse random matrices are $\ell_p$-RIP for $p \in [1,2)$ when $k, m = \Theta(n)$. However, when $m = \Theta(n)$, sparse random matrices are known to not be $\ell_2$-RIP with high probability. Against this backdrop, we show that sparse matrices cannot be $\ell_2$-RIP in our parameter regime. On the other hand, for $p \neq 2$, we show that every $\ell_p$-RIP matrix must be sparse. Thus, sparsity is incompatible with $\ell_2$-RIP, but necessary for $\ell_p$-RIP for $p \neq 2$. Under a suitable interpretation, our negative result about $\ell_2$-RIP gives an impossibility result for a certain continuous analog of "$c^3$-LTCs": locally testable codes of constant rate, constant distance and constant locality that were constructed in recent breakthroughs.
Keywords	Computer Science - Computational Complexity ; Computer Science - Information Theory
Subject code	519
Publishing date	2022-05-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A novel mutation in the KCNJ11 gene (p.Val36Glu), predisposes to congenital hyperinsulinemia.

Shah, Idrees A / Rashid, Rabiya / Bhat, Abid / Rashid, Haroon / Bashir, Rohina / Asrar, Mir M / Wani, Imtiyaz A / Charoo, Bashir Ahmad / Radha, Venkatesan / Mohan, V / Ganie, Mohd Ashraf

Gene

2023 Volume 878, Page(s) 147576

Abstract: The hypoglycemia induced by insulin hypersecretion in congenital hyperinsulinemia (CHI), a rare life-threatening condition can lead to irreversible brain damage in neonates. Inactivating mutations in the genes encoding ... ...

Abstract	The hypoglycemia induced by insulin hypersecretion in congenital hyperinsulinemia (CHI), a rare life-threatening condition can lead to irreversible brain damage in neonates. Inactivating mutations in the genes encoding K
MeSH term(s)	Humans ; Infant ; Male ; Congenital Hyperinsulinism/genetics ; Congenital Hyperinsulinism/drug therapy ; Diazoxide/therapeutic use ; Heterozygote ; Insulin/genetics ; Mutation ; Sulfonylurea Receptors/genetics
Chemical Substances	Diazoxide (O5CB12L4FN) ; Insulin ; Sulfonylurea Receptors
Language	English
Publishing date	2023-06-17
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147576
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1357: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In Vitro Detoxification Studies of p-Cresol by Intestinal Bacteria Isolated from Human Feces.

Vijayasarathy, Muthu / Kiran, Gopikrishnan Kalarikkal / Balaji, Sivaraman / Jabastin, Jayamanohar / Bruntha Devi, Palanisamy / Brindha Priyadarisini, Venkatesan

Current microbiology

2020 Volume 77, Issue 10, Page(s) 3000–3012

Abstract: p-Cresol is a neurotoxic and nephrotoxic carcinogenic aromatic substance produced as a result ... of microbial fermentation in the intestine. The derivatives of p-cresol (p-cresyl sulphate or p-cresyl ... However, the knowledge on the role of gut microbes in metabolizing p-cresol is limited. Hence, the present study aims ...

Abstract	p-Cresol is a neurotoxic and nephrotoxic carcinogenic aromatic substance produced as a result of microbial fermentation in the intestine. The derivatives of p-cresol (p-cresyl sulphate or p-cresyl glucuronide) have a deleterious effect on renal failure patients undergoing hemodialysis. Human gut seems to be inhabited with a diverse microbial population capable of detoxifying many aromatic compounds. However, the knowledge on the role of gut microbes in metabolizing p-cresol is limited. Hence, the present study aims to investigate p-cresol detoxification by intestinal bacteria isolated from human feces. Three potential p-cresol tolerant isolates were selected and identified as Enterococcus faecalis strains (UTD-1, UTD-2 and UTD-3) by 16SrRNA gene sequencing. All three E. faecalis isolates decreased the p-cresol concentration (30 µg/ml) at a higher rate with extracellular extracts (2.58-9.53 µg/ml) as compared to intracellular (0.55-5.28 µg/ml) extract. These three potential isolates also exhibited tolerance to gastrointestinal conditions for up to 60 min. Added to its potential, the expression of virulent genes (esp, gelE, and cyl) was found to be suppressed when subjected to bile stress under in vitro conditions. HPLC analysis displayed transformed products from extracellular extract treated samples were comparable to the metabolite standard of the p-cresol degradation pathway. Infrared spectral analysis too showed the spectrum similarity with metabolite standard. Thus, conclusively, intestinal isolates E. faecalis (UTD-1, UTD-2 and UTD-3) might be a promising candidate for mitigating p-cresol detoxification in uremic patients.
MeSH term(s)	Cresols ; Enterococcus faecalis ; Feces ; Fermentation ; Humans
Chemical Substances	Cresols ; 4-cresol (1MXY2UM8NV)
Language	English
Publishing date	2020-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02124-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1446: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: $\ell_p$-Spread and Restricted Isometry Properties of Sparse Random Matrices

Guruswami, Venkatesan / Manohar, Peter / Mosheiff, Jonathan

2021

Abstract: ... constructions of $\ell_p$-RIP matrices for $1 \leq p < p_0$, where $1 < p_0 < 2$ is an absolute constant. ... in particular are not $\ell_2$-spread. On the other hand, for $p < 2$ we prove that such subspaces are $\ell_p$ ... isometry property (RIP) with respect to the $\ell_p$ norm, and this follows solely from the unique ...

Abstract	Random subspaces $X$ of $\mathbb{R}^n$ of dimension proportional to $n$ are, with high probability, well-spread with respect to the $\ell_2$-norm. Namely, every nonzero $x \in X$ is "robustly non-sparse" in the following sense: $x$ is $\varepsilon \\|x\\|_2$-far in $\ell_2$-distance from all $\delta n$-sparse vectors, for positive constants $\varepsilon, \delta$ bounded away from $0$. This "$\ell_2$-spread" property is the natural counterpart, for subspaces over the reals, of the minimum distance of linear codes over finite fields, and corresponds to $X$ being a Euclidean section of the $\ell_1$ unit ball. Explicit $\ell_2$-spread subspaces of dimension $\Omega(n)$, however, are unknown, and the best known constructions (which achieve weaker spread properties), are analogs of low density parity check (LDPC) codes over the reals, i.e., they are kernels of sparse matrices. We study the spread properties of the kernels of sparse random matrices. Rather surprisingly, we prove that with high probability such subspaces contain vectors $x$ that are $o(1)\cdot \\|x\\|_2$-close to $o(n)$-sparse with respect to the $\ell_2$-norm, and in particular are not $\ell_2$-spread. On the other hand, for $p < 2$ we prove that such subspaces are $\ell_p$-spread with high probability. Moreover, we show that a random sparse matrix has the stronger restricted isometry property (RIP) with respect to the $\ell_p$ norm, and this follows solely from the unique expansion of a random biregular graph, yielding a somewhat unexpected generalization of a similar result for the $\ell_1$ norm [BGI+08]. Instantiating this with explicit expanders, we obtain the first explicit constructions of $\ell_p$-RIP matrices for $1 \leq p < p_0$, where $1 < p_0 < 2$ is an absolute constant.
Keywords	Computer Science - Computational Complexity ; Mathematics - Functional Analysis ; Mathematics - Probability
Subject code	519
Publishing date	2021-08-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A novel mutation in the KCNJ11 gene (p.Val36Glu), predisposes to congenital hyperinsulinemia

Shah, Idrees A. / Rashid, Rabiya / Bhat, Abid / Rashid, Haroon / Bashir, Rohina / Asrar, Mir M. / Wani, Imtiyaz A. / Charoo, Bashir Ahmad / Radha, Venkatesan / Mohan, V. / Ganie, Mohd Ashraf

Gene. 2023 Aug., v. 878 p.147576-

2023

Abstract: ... missense mutation in the KCNJ11 gene, (c.107T>A, p.Val36Glu.). The bioinformatic analysis revealed that valine is ... highly conserved and predicted that the variant allele (p.Val36Glu) is likely pathogenic and causal ...

Abstract	The hypoglycemia induced by insulin hypersecretion in congenital hyperinsulinemia (CHI), a rare life-threatening condition can lead to irreversible brain damage in neonates. Inactivating mutations in the genes encoding KATP channel (ABCC8 and KCNJ11) as well as HNF4A, HNF1A, HADH, UCP2, and activating mutations in GLUD1, GCK, and SLC16A1 have been identified as causal. A 3-month-old male infant presenting tonic-clonic seizures and hyperinsulinemia was clinically assessed and subjected to genetic analysis. Besides the index patient, his parents were clinically investigated, and a detailed family history was also recorded. The laboratory investigations and the genetic test results of the parents were compared with the index patient. The biochemical and hormonal profile of the patient confirmed his suffering from CHI and did not respond to diazoxide treatment. The genetic testing revealed that the subject harbored a novel homozygous missense mutation in the KCNJ11 gene, (c.107T>A, p.Val36Glu.). The bioinformatic analysis revealed that valine is highly conserved and predicted that the variant allele (p.Val36Glu) is likely pathogenic and causal for CHI. Parents were heterozygous carriers and did not report any abnormal metabolic profile. Identification of such mutations is critical and likely to change the therapeutic interventions for such patients in the future.
Keywords	alleles ; bioinformatics ; brain damage ; diazoxide ; genetic analysis ; heterozygosity ; homozygosity ; hyperinsulinemia ; hypersecretion ; hypoglycemia ; insulin ; males ; missense mutation ; patients ; therapeutics ; valine ; Diazoxide unresponsiveness ; Glucose ; KCNJ11 ; Mutation ; Neonate ; CHI ; BCC8 ; HNF4A ; HNF1A ; HADH ; UCP2 ; GLUD1 ; GCK ; SLC16A1
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147576
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 79/715: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Photoactivated Mixed In-Plane and Edge-Enriched p-Type MoS

Agrawal, Abhay V / Kumar, Rahul / Venkatesan, Swaminathan / Zakhidov, Alex / Yang, Guang / Bao, Jiming / Kumar, Mahesh / Kumar, Mukesh

ACS sensors

2018 Volume 3, Issue 5, Page(s) 998–1004

Abstract: Toxic gases are produced during the burning of fossil fuels. Room temperature (RT) fast detection of toxic gases is still challenging. Recently, ... ...

Abstract	Toxic gases are produced during the burning of fossil fuels. Room temperature (RT) fast detection of toxic gases is still challenging. Recently, MoS
MeSH term(s)	Adsorption ; Density Functional Theory ; Disulfides/chemistry ; Kinetics ; Limit of Detection ; Microscopy, Electron, Scanning ; Molybdenum/chemistry ; Nitrogen Dioxide/analysis ; Photochemical Processes ; Spectrometry, X-Ray Emission ; Spectrum Analysis, Raman ; Temperature ; Ultraviolet Rays
Chemical Substances	Disulfides ; Molybdenum (81AH48963U) ; Nitrogen Dioxide (S7G510RUBH) ; molybdenum disulfide (ZC8B4P503V)
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.8b00146
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Parameterized Inapproximability of the Minimum Distance Problem over all Fields and the Shortest Vector Problem in all $\ell_p$ Norms

Bennett, Huck / Cheraghchi, Mahdi / Guruswami, Venkatesan / Ribeiro, João

2022

Abstract: ... we prove that SVP in the $\ell_p$ norm is W[1]-hard to approximate within any constant factor for any fixed ... $p >1$ and W[1]-hard to approximate within a factor approaching $2$ for $p=1$. (We show hardness ... for binary linear codes and left the case of general fields open. For SVP in $\ell_p$ norms with $p > 1$ ...

Abstract	We prove that the Minimum Distance Problem (MDP) on linear codes over any fixed finite field and parameterized by the input distance bound is W[1]-hard to approximate within any constant factor. We also prove analogous results for the parameterized Shortest Vector Problem (SVP) on integer lattices. Specifically, we prove that SVP in the $\ell_p$ norm is W[1]-hard to approximate within any constant factor for any fixed $p >1$ and W[1]-hard to approximate within a factor approaching $2$ for $p=1$. (We show hardness under randomized reductions in each case.) These results answer the main questions left open (and explicitly posed) by Bhattacharyya, Bonnet, Egri, Ghoshal, Karthik C. S., Lin, Manurangsi, and Marx (Journal of the ACM, 2021) on the complexity of parameterized MDP and SVP. For MDP, they established similar hardness for binary linear codes and left the case of general fields open. For SVP in $\ell_p$ norms with $p > 1$, they showed inapproximability within some constant factor (depending on $p$) and left open showing such hardness for arbitrary constant factors. They also left open showing W[1]-hardness even of exact SVP in the $\ell_1$ norm. Comment: 38 pages. Implemented reviewers' comments. To appear at STOC 2023
Keywords	Computer Science - Computational Complexity
Subject code	511
Publishing date	2022-11-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: 9-p-Tolyl-9H-carbazole-3-carbonitrile.

Ramathilagam, C / Venkatesan, N / Rajakumar, P / Umarani, P R / Manivannan, V

Acta crystallographica. Section E, Structure reports online

2011 Volume 67, Issue Pt 10, Page(s) o2796

Abstract: In the title compound, C(20)H(14)N(2), the carbazole ring system is essentially planar (r.m.s. deviation = 0.187 Å) and is inclined at an angle of 54.33 (4) ° with respect to the benzene ring. The crystal packing is stabilized by weak C-H⋯N and C-H⋯π ... ...

Abstract	In the title compound, C(20)H(14)N(2), the carbazole ring system is essentially planar (r.m.s. deviation = 0.187 Å) and is inclined at an angle of 54.33 (4) ° with respect to the benzene ring. The crystal packing is stabilized by weak C-H⋯N and C-H⋯π inter-actions.
Language	English
Publishing date	2011-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	1600-5368 ; 1600-5368
ISSN (online)	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536811039286
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito