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Article ; Online: In Regard to Ying Li et al.

Wang, Tao / Tian, Guangyu / Chen, Xiaojun

International journal of radiation oncology, biology, physics

2021 Volume 111, Issue 2, Page(s) 581

Language	English
Publishing date	2021-08-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2021.06.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effects of Ying Yang Bao on Nutritional Status of Children Aged 6-60 Months in Underdeveloped Rural Areas of China.

Feng, Jing / Wang, Yongjun / Liu, Tingting / Huo, Junsheng / Zhuo, Qin / Gong, Zhaolong

Nutrients

2024 Volume 16, Issue 2

Abstract: The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two ...

Abstract	The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two decades. Most previous studies have focused only on the short-term effects of YYB, while the long-term effects remain unexplored. This study was designed to evaluate the long-term effects of YYB in children aged 6-60 months. A sample of 4666 children was divided into intervention and control groups. Information on basic characteristics, physical examination, YYB consumption, etc., was obtained annually from 2018 to 2021. T-tests or chi-square tests were used to compare differences between the groups for continuous or categorical variables. Children in the intervention group showed greater incremental improvements in hemoglobin levels and physical development (
MeSH term(s)	Humans ; Anemia/epidemiology ; Cachexia ; China/epidemiology ; Growth Disorders ; Nutritional Status ; Infant ; Child, Preschool
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis.

Gao, Shuang / Tang, Liyun / Ma, Jiayi / Wang, Kaiming / Yao, Hua / Tong, Jinjin / Zhang, Hua

PloS one

2024 Volume 19, Issue 4, Page(s) e0299234

Abstract: ... the pharmacological mechanism of the traditional Chinese medicine formulation, Gong Ying San (GYS), by infrared ...

Abstract	Objectives: The goal of this investigation was to identify the main compounds and the pharmacological mechanism of the traditional Chinese medicine formulation, Gong Ying San (GYS), by infrared spectral absorption characteristics, metabolomics, network pharmacology, and molecular-docking analysis for mastitis. The antibacterial and antioxidant activities were determined in vitro. Methods: The chemical constituents of GYS were detected by ultra-high-performance liquid chromatography Q-extractive mass spectrometry (UHPLC-QE-MS). Related compounds were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP, http://tcmspw.com/tcmsp.php) and the Encyclopedia of Traditional Chinese Medicine (ETCM, http://www.tcmip.cn/ETCM/index.php/Home/) databases; genes associated with mastitis were identified in DisGENT. A protein-protein interaction (PPI) network was generated using STRING. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment screening was conducted using the R module. Molecular-docking analyses were performed with the AutoDockTools V1.5.6. Results: Fifty-four possible compounds in GYS with forty likely targets were found. The compound-target-network analysis showed that five of the ingredients, quercetin, luteolin, kaempferol, beta-sitosterol, and stigmasterol, had degree values >41.6, and the genes TNF, IL-6, IL-1β, ICAM1, CXCL8, CRP, IFNG, TP53, IL-2, and TGFB1 were core targets in the network. Enrichment analysis revealed that pathways associated with cancer, lipids, atherosclerosis, and PI3K-Akt signaling pathways may be critical in the pharmacology network. Molecular-docking data supported the hypothesis that quercetin and luteolin interacted well with TNF-α and IL-6. Conclusions: An integrative investigation based on a bioinformatics-network topology provided new insights into the synergistic, multicomponent mechanisms of GYS's anti-inflammatory, antibacterial, and antioxidant activities. It revealed novel possibilities for developing new combination medications for reducing mastitis and its complications.
MeSH term(s)	Animals ; Female ; Humans ; Cattle ; Network Pharmacology ; Antioxidants ; Interleukin-6 ; Luteolin ; Phosphatidylinositol 3-Kinases ; Quercetin ; Mastitis ; Anti-Bacterial Agents ; Molecular Docking Simulation ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional
Chemical Substances	Antioxidants ; Interleukin-6 ; Luteolin (KUX1ZNC9J2) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Quercetin (9IKM0I5T1E) ; Anti-Bacterial Agents ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299234
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Article: Enhanced Effect of Qing-Ying Decoction Concurrent with Secukinumab in the Treatment of Plaque Psoriasis.

Tian, Zan / Cang, Rong / Lei, Mingjun / Fan, Lifang / Wang, Hua / Shang, Mengyu / Li, Xiang / Bai, Fan

Alternative therapies in health and medicine

2022 Volume 28, Issue 6, Page(s) 96–102

Abstract: Both Qing-Ying decoction (QYD), a Traditional Chinese Medicine (TCM), and secukinumab, a fully ...

Abstract	Both Qing-Ying decoction (QYD), a Traditional Chinese Medicine (TCM), and secukinumab, a fully humanized anti-interleukin-17A monoclonal antibody, have been used to treat patients with plaque psoriasis. The combined application of TCM and biologics in the treatment of psoriasis, however, has not been investigated. We enrolled a total of 68 patients with plaque psoriasis in our prospective study, and randomly assigned them to either the study group (treated with secukinumab plus QYD), or the control group (treated with secukinumab alone). After 12- and 16-week treatment, the Psoriasis Area and Severity Index (PASI) score and the TCM score were significantly reduced in both the study and the control groups. However, the reduction in PASI and TCM scores was more significant in the study group than in the control group (12-week: PASI: 5.29 ± 0.27 vs 8.87 ± 0.38, respectively; P < .01; TCM: 5.83 ± 0.21 vs 12.39 ± 1.23, respectively; P < .01; 16-week: PASI score: 4.76 ± 0.18 vs 8.36 ± 0.31, respectively; TCM score: 4.98 ± 0.19 vs 11.27 ± 1.13, respectively; P < .01). The total treatment efficacy rate was significantly higher in the study group (97.1%) than the control group (76.5%; P = .012). The number of CD3+ and CD4+ T cells was increased, while the number of CD8+ T cells was decreased after treatment in both groups, with more significant changes in the study group (P < .01). QYD may enhance the therapeutic outcome of secukinumab in the treatment of plaque psoriasis by further suppressing chronic skin inflammation, as well as reducing adverse events and patients' psychological stress.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Prospective Studies ; Psoriasis/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; secukinumab (DLG4EML025)
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article: SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment.

Zhang, Shuyan / Wu, Jiajun / Wang, Leilei / Mu, Lin / Xu, Xiaoyu / Li, Jiahui / Tang, Guoyi / Chen, Guang / Zhang, Cheng / Zhang, Yinjian / Feng, Yibin

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1366020

Abstract: ... visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been ...

Abstract	Objective: Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been identified as an efficient therapy for DR with retinal vascular dysfunction for decades and has been experimentally reported to ameliorate retinal conditions in diabetic mice. This study endeavors to explore the therapeutic potential of HF with key ingredients in DR and its underlying novel mechanisms. Methods: Co-expression gene modules and hub genes were calculated by weighted gene co-expression network analysis (WGCNA) based on transcriptome sequencing data from high-glucose-treated adult retinal pigment epithelial cell line-19 (ARPE-19). The chromatographic fingerprint of HF was established by ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-Q-TOF-MS). The molecular affinity of the herbal compound was measured by molecular docking. Reactive oxygen species (ROS) was measured by a DCFDA/H2DCFDA assay. Apoptosis was detected using the TUNEL Assay Kit, while ELISA, Western blot, and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used for detecting the cytokine, protein, and mRNA expressions, respectively. Results: Key compounds in HF were identified as luteolin, paeoniflorin, and nobiletin. For WGCNA, ME-salmon ("protein deacetylation") was negatively correlated with ME-purple ("oxidative impairment") in high-glucose-treated ARPE-19. Luteolin has a high affinity for SIRT1 and P53, as indicated by molecular docking. Luteolin has a hypoglycemic effect on type I diabetic mice. Moreover, HF and luteolin suppress oxidative stress production (ROS and MDA), inflammatory factor expression (IL-6, TNF-α, IL1-β, and MCP-1), and apoptosis, as shown in the Conclusion: Using HF and its active compound luteolin as therapeutic agents offers a promising approach to diabetic retinopathy treatment. It primarily suppressed protein acetylation and oxidative stress via the SIRT1/P53 pathway in retinal pigment epithelial cells.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1366020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

YingRui, Wang / Zheng, Liu / GuoYan, Liu / Hongjie, Wang / YuLian, Liu / BoWen, Wang

Pharmacological research. 2022,

2022

Abstract: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification ... the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain ... enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component ...

Abstract	Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway" network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
Keywords	Oriental traditional medicine ; choline ; computer software ; databases ; diabetic foot ; drugs ; pharmacology ; quercetin ; research
Language	English
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ISSN	2667-1425
DOI	10.1016/j.prmcm.2022.100084
Database	NAL-Catalogue (AGRICOLA)

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Book: Han-ying-zhen-jiu-cidian

Wang, Hua

= Chinese English dictionary of acupuncture and moxibustion

1999

Title variant	Chinese English dictionary of acupuncture and moxibustion ; Han ying zhen jiu cidian ; Chinese-English dictionary of acupuncture and moxibustion
Author's details	comp. Wang Hua
Language	Chinese ; English
Size	127, 750 S. : Ill.
Edition	[2. ed.]
Publisher	Hubei Science and Technology Press u.a.
Publishing place	Wuhan shi
Publishing country	China
Document type	Book
HBZ-ID	HT012768313
ISBN	7-5352-0914-9 ; 978-7-5352-0914-6
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2001 A 891	order for loan	Magazin

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Article ; Online: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

Wang YingRui / Liu Zheng / Liu GuoYan / Wang Hongjie / Liu YuLian / Wang BoWen

Pharmacological Research - Modern Chinese Medicine, Vol 3, Iss , Pp 100084- (2022)

2022

Abstract	Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway'' network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
Keywords	Public antidote wasolytic wash ; Network pharmacology ; Diabetic foot ulcers ; Molecular mechanism ; External treatment of traditional chinese medicine ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	004
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic Quality Evaluation of Epimedium wushanense T. S. Ying Based on Two Quality Control Standards: Total Flavonoid Glycosides and Epimedin C.

Wang, Congying / Tian, Shuyun / Tang, Qin / Zhou, Ziwei / Peng, Xinheng / Cai, Xiaoxue / Xu, Yanqin

Chemistry & biodiversity

2023 Volume 20, Issue 3, Page(s) e202200579

Abstract: ... Ying, so as to provide reference for its germplasm screening and resource utilization. Seven ...

Abstract	Two quality control standards, total flavonoid glycosides of Epimedii Folium and epimedin C of Epimedii Wushanensis Folium, were used to systematically evaluate the quality of Epimedium wushanense T. S. Ying, so as to provide reference for its germplasm screening and resource utilization. Seven representative populations of E. wushanense covering its main distribution areas were uniformly sampled during the flowering period. There were significant quality differences among the populations of E. wushanense. According to the quality standard of total flavonoid glycosides, all populations were superior to the quality standard of the Chinese Pharmacopoeia for Epimedii Folium, with more than 1.5 % total flavonoid glycosides. The variation ranges of epimedin A, epimedin B, epimedin C, icariin and total flavonoid glycosides were 0.40-0.76 %, 0.51-0.83 %, 1.70-9.31 %, 0.40-1.23 % and 3.05-10.61 %, respectively. According to the quality standard of epimedin C, all populations were better than the quality standard of the Chinese Pharmacopoeia for Epimedii Wushanensis Folium, with more than 1.0 % epimedin C. The variation range of epimedin C was 2.22-10.06 %. When comparing the results of the two methods, a trend of slightly lower mean values was found for total flavonoid glycosides, except for the HBXW population. The quality of E. wushanense was superior to both the quality standard of Epimedii Folium and Epimedii Wushanense Folium in the Chinese Pharmacopoeia. Epimedin C was the most abundant component. Among the investigated populations, HBXW and HBGK exhibited the highest quality, and may provide excellent genetic resources for standardized cultivation. In addition, the habitat of these populations can also serve a reference for cultivation conditions.
MeSH term(s)	Glycosides ; Epimedium ; Flavonoids ; Drugs, Chinese Herbal ; Quality Control
Chemical Substances	epimedin C (110642-44-9) ; Glycosides ; Flavonoids ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200579
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of the Duration of Ying Yang Bao Consumption on Hemoglobin Concentration in Infants and Young Children in Less Developed Areas of China.

Feng, Jing / Wang, Yongjun / Liu, Tingting / Huo, Junsheng / Zhuo, Qin / Gong, Zhaolong

Nutrients

2022 Volume 14, Issue 21

Abstract: Ying Yang Bao (YYB) is conventionally prescribed as a nutritional supplement to infants and ...

Abstract	Ying Yang Bao (YYB) is conventionally prescribed as a nutritional supplement to infants and young children (IYC) in less developed areas of China. However, whether 18-month YYB consumption is reasonable needs assessment. This study examined the influence of the duration of YYB consumption on hemoglobin (Hb) levels and anemia prevalence. Data from the Nutrition Improvement Project on Children in Poor Areas of China in 2018-2019 were used. Questionnaires were used to collect information on basic characteristics, dietary status, and YYB consumption. Propensity score matching (PSM) was used to balance confounders. Hb levels and anemia prevalence in IYC with different durations of YYB consumption were compared. After PSM, all covariates were well-balanced, and 1151 pairs of IYC were included in subsequent analyses. During the 1st-9th months of intervention, YYB effectively increased Hb levels and reduced anemia prevalence in the intervention group. During the 10th-18th months of intervention, Hb levels in the control group increased and anemia prevalence decreased, while Hb levels and anemia prevalence fluctuated in the intervention group. In conclusion, YYB was effective in improving nutritional status of infants, but had a limited effect in young children. Nutritional supplements with different quantities or nutrients should be considered for young children.
MeSH term(s)	Infant ; Child ; Humans ; Child, Preschool ; Rural Population ; China/epidemiology ; Anemia/epidemiology ; Anemia/prevention & control ; Dietary Supplements ; Prevalence ; Hemoglobins/analysis
Chemical Substances	Hemoglobins
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14214539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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