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Article ; Online: Perioperative and Anesthetic Considerations in Tetralogy of Fallot With Pulmonary Atresia.

Quinlan, Casey A / Latham, Gregory J / Joffe, Denise / Ross, Faith J

Seminars in cardiothoracic and vascular anesthesia

2021 Volume 25, Issue 3, Page(s) 218–228

Abstract: Tetralogy of Fallot with pulmonary atresia (ToF-PA) is a rare diagnosis that includes an extraordinarily heterogeneous group of complex anatomical findings with significant implications for physiology and prognosis. In addition to the classic findings of ...

Abstract	Tetralogy of Fallot with pulmonary atresia (ToF-PA) is a rare diagnosis that includes an extraordinarily heterogeneous group of complex anatomical findings with significant implications for physiology and prognosis. In addition to the classic findings of ToF, this particular diagnosis is characterized by complete failure of forward flow from the right ventricle to the pulmonary arterial system. As such, pulmonary blood flow is entirely dependent on shunting from the systemic circulation, most frequently via a patent ductus arteriosus, major aortopulmonary collaterals, or a combination of the two. The pathophysiology of ToF-PA is largely attributable to the abnormalities of the pulmonary vasculature. Ultimately, these patients require operative intervention to create a reliable, controlled source of pulmonary blood flow and ideally complete intracardiac repair. Even after operative correction, these patients remain at risk for pulmonary arterial stenoses and pulmonary hypertension. Although there have been significant advances in surgical and interventional management of ToF-PA leading to dramatic improvements in survival and long-term functional status, there is ongoing debate about the optimal management strategy given the risk of development of irreversible abnormalities of the pulmonary vasculature and the morbidity and mortality associated with sometimes multiple, complex operative interventions often occurring early in infancy. This review will discuss the findings in patients with ToF-PA with a focus on the perioperative and anesthetic management and will highlight challenges faced by the anesthesiologist in caring for these patients.
MeSH term(s)	Anesthetics ; Collateral Circulation ; Heart Septal Defects ; Humans ; Infant ; Pulmonary Atresia/surgery ; Retrospective Studies ; Tetralogy of Fallot/surgery
Chemical Substances	Anesthetics
Language	English
Publishing date	2021-08-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2012371-1
ISSN	1940-5596 ; 1089-2532
ISSN (online)	1940-5596
ISSN	1089-2532
DOI	10.1177/10892532211027395
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Article: Clotting Dysfunction in Sepsis: A Role for ROS and Potential for Therapeutic Intervention.

Lopes-Pires, Maria Elisa / Frade-Guanaes, Jéssica Oliveira / Quinlan, Gregory J

Antioxidants (Basel, Switzerland)

2021 Volume 11, Issue 1

Abstract: Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and ... ...

Abstract	Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and nitrogen species (RNS) production occurs, instigated by a variety of sources, including activated inflammatory cells, such as neutrophils, platelets, and cells from the vascular endothelium. Inflammation can become an inappropriate self-sustaining and expansive process, resulting in sepsis. Patients with sepsis often exhibit loss of aspects of normal vascular homeostatic control, resulting in abnormal coagulation events and the development of disseminated intravascular coagulation. Diagnosis and treatment of sepsis remain a significant challenge for healthcare providers globally. Targeting the drivers of excessive oxidative/nitrosative stress using antioxidant treatments might be a therapeutic option. This review focuses on the association between excessive oxidative/nitrosative stress, a common feature in sepsis, and loss of homeostatic control at the level of the vasculature. The literature relating to potential antioxidants is also described.
Language	English
Publishing date	2021-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010088
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Article ; Online: Intrinsic motoneuron properties in typical human development.

Mohammadalinejad, Ghazaleh / Afsharipour, Babak / Yacyshyn, Alex / Duchcherer, Jennifer / Bashuk, Jack / Bennett, Erin / Pearcey, Gregory E P / Negro, Francesco / Quinlan, Katharina A / Bennett, David J / Gorassini, Monica A

The Journal of physiology

2024

Abstract: Motoneuron properties and their firing patterns undergo significant changes throughout development and in response to neuromodulators such as serotonin. Here, we examined the age-related development of self-sustained firing and general excitability of ... ...

Abstract	Motoneuron properties and their firing patterns undergo significant changes throughout development and in response to neuromodulators such as serotonin. Here, we examined the age-related development of self-sustained firing and general excitability of tibialis anterior motoneurons in a young development (7-17 years), young adult (18-28 years) and adult (32-53 years) group, as well as in a separate group of participants taking selective serotonin reuptake inhibitors (SSRIs, aged 11-28 years). Self-sustained firing, as measured by ΔF, was larger in the young development (∼5.8 Hz, n = 20) compared to the young adult (∼4.9 Hz, n = 13) and adult (∼4.8 Hz, n = 8) groups, consistent with a developmental decrease in self-sustained firing mediated by persistent inward currents (PIC). ΔF was also larger in participants taking SSRIs (∼6.5 Hz, n = 9) compared to their age-matched controls (∼5.3 Hz, n = 26), consistent with increased levels of spinal serotonin facilitating the motoneuron PIC. Participants in the young development and SSRI groups also had higher firing rates and a steeper acceleration in initial firing rates (secondary ranges), consistent with the PIC producing a steeper acceleration in membrane depolarization at the onset of motoneuron firing. In summary, both the young development and SSRI groups exhibited increased intrinsic motoneuron excitability compared to the adults, which, in the young development group, was also associated with a larger unsteadiness in the dorsiflexion torque profiles. We propose several intrinsic and extrinsic factors that affect both motoneuron PICs and cell discharge which vary during development, with a time course similar to the changes in motoneuron firing behaviour observed in the present study. KEY POINTS: Neurons in the spinal cord that activate muscles in the limbs (motoneurons) undergo increases in excitability shortly after birth to help animals stand and walk. We examined whether the excitability of human ankle flexor motoneurons also continues to change from child to adulthood by recording the activity of the muscle fibres they innervate. Motoneurons in children and adolescents aged 7-17 years (young development group) had higher signatures of excitability that included faster firing rates and more self-sustained activity compared to adults aged ≥18 years. Participants aged 11-28 years of age taking serotonin reuptake inhibitors had the highest measures of motoneuron excitability compared to their age-matched controls. The young development group also had more unstable contractions, which might partly be related to the high excitability of the motoneurons.
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP285756
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Article ; Online: Phagomimetic action of antibiotics: Revisited. How do antibiotics know where to go?

Gutteridge, John M C / Quinlan, Gregory J / Kovacic, Peter

Biochemical and biophysical research communications

2019 Volume 521, Issue 3, Page(s) 721–724

Abstract: Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen ... ...

Abstract	Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event. Antibiotics in their normal bacterial environment, and ROS, are both increasingly implicated in purposeful signalling functions, rather than their more widely known roles in bacterial killing and molecular damage. Here, we extend our comparison between antibiotics and phagocytic cells to propose that antibiotics actively accumulate at a site of pathogen infection or tumour growth. A common link being virulent cellular growth. When this occurs, new proteins are secreted, aberrant iron acquisition takes place, and lipocalins are released. Each provide a mechanism by which antibiotics can bind, and be retained, at an active site of pathogen infection or tumour growth.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/pharmacology ; Bacteria/drug effects ; Bacteria/metabolism ; Bacterial Infections/drug therapy ; Bacterial Infections/metabolism ; Humans ; Iron/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Phagocytes/drug effects ; Phagocytes/metabolism ; Phagocytosis/drug effects ; Reactive Oxygen Species/metabolism
Chemical Substances	Anti-Bacterial Agents ; Antibiotics, Antineoplastic ; Reactive Oxygen Species ; Iron (E1UOL152H7)
Language	English
Publishing date	2019-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.10.152
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Article: The Use of Social Media by Plastic Surgery Journals.

Quinlan, Christine S / Collins, Anne M / Nason, Gregory J / Dempsey, M

Plastic and reconstructive surgery. Global open

2016 Volume 4, Issue 1, Page(s) e605

Language	English
Publishing date	2016-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000000587
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Article: Clotting Dysfunction in Sepsis: A Role for ROS and Potential for Therapeutic Intervention

Lopes-Pires, Maria Elisa / Frade-Guanaes, Jéssica Oliveira / Quinlan, Gregory J.

Antioxidants. 2021 Dec. 30, v. 11, no. 1

2021

Abstract	Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and nitrogen species (RNS) production occurs, instigated by a variety of sources, including activated inflammatory cells, such as neutrophils, platelets, and cells from the vascular endothelium. Inflammation can become an inappropriate self-sustaining and expansive process, resulting in sepsis. Patients with sepsis often exhibit loss of aspects of normal vascular homeostatic control, resulting in abnormal coagulation events and the development of disseminated intravascular coagulation. Diagnosis and treatment of sepsis remain a significant challenge for healthcare providers globally. Targeting the drivers of excessive oxidative/nitrosative stress using antioxidant treatments might be a therapeutic option. This review focuses on the association between excessive oxidative/nitrosative stress, a common feature in sepsis, and loss of homeostatic control at the level of the vasculature. The literature relating to potential antioxidants is also described.
Keywords	antioxidants ; coagulation ; death ; disseminated intravascular coagulation ; endothelium ; health services ; inflammation ; neutrophils ; nitrogen ; oxygen ; pathogens ; therapeutics
Language	English
Dates of publication	2021-1230
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010088
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The use of social media by plastic surgery journals.

Quinlan, Christine S / Collins, Anne M / Nason, Gregory J / Dempsey, Marlese

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2016 Volume 69, Issue 7, Page(s) 1009–1011

MeSH term(s)	Humans ; Periodicals as Topic ; Social Media/statistics & numerical data ; Surgery, Plastic/methods ; Surgery, Plastic/organization & administration
Language	English
Publishing date	2016-07
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2016.04.004
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Article: Phagomimetic action of antibiotics: Revisited. How do antibiotics know where to go?

Gutteridge, John M.C / Quinlan, Gregory J / Kovacic, Peter

Biochemical and biophysical research communications. 2020 Jan. 15, v. 521, no. 3

2020

Abstract: Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a ‘respiratory burst’ in which superoxide radicals are released. We have previously compared the release of reactive oxygen ... ...

Abstract	Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a ‘respiratory burst’ in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event. Antibiotics in their normal bacterial environment, and ROS, are both increasingly implicated in purposeful signalling functions, rather than their more widely known roles in bacterial killing and molecular damage. Here, we extend our comparison between antibiotics and phagocytic cells to propose that antibiotics actively accumulate at a site of pathogen infection or tumour growth. A common link being virulent cellular growth. When this occurs, new proteins are secreted, aberrant iron acquisition takes place, and lipocalins are released. Each provide a mechanism by which antibiotics can bind, and be retained, at an active site of pathogen infection or tumour growth.
Keywords	active sites ; cell growth ; chemotaxis ; electron transfer ; neoplasms ; pathogens ; phagocytosis ; research ; virulence
Language	English
Dates of publication	2020-0115
Size	p. 721-724.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.10.152
Database	NAL-Catalogue (AGRICOLA)

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Article: Pulmonary Arterial Hypertension: Iron Matters.

Ramakrishnan, Latha / Pedersen, Sofia L / Toe, Quezia K / Quinlan, Gregory J / Wort, Stephen J

Frontiers in physiology

2018 Volume 9, Page(s) 641

Abstract: The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost ... ...

Abstract	The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease. This review provides a background for iron regulation in humans, describes PAH classifications, and discusses emerging literature, which suggests a role for disrupted iron homeostatic control in various sub-types of PAH, including a role for decompartmentalization of hemoglobin. Finally, the potential for therapeutic options to restore iron homeostatic balance in PAH are discussed.
Language	English
Publishing date	2018-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.00641
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Article ; Online: Using FDA-approved drugs as off-label fluorescent dyes for optical biopsies: from in silico design to

Larson, Michael C / Gmitro, Arthur F / Utzinger, Urs / Rouse, Andrew R / Woodhead, Gregory J / Carlson, Quinlan / Hennemeyer, Charles T / Barton, Jennifer K

Methods and applications in fluorescence

2021 Volume 9, Issue 3

Abstract: Optical biopsies bring the microscope to the patient rather than the tissue to the microscope, and may complement or replace the tissue-harvesting component of the traditional biopsy process with its associated risks. In general, optical biopsies are ... ...

Abstract	Optical biopsies bring the microscope to the patient rather than the tissue to the microscope, and may complement or replace the tissue-harvesting component of the traditional biopsy process with its associated risks. In general, optical biopsies are limited by the lack of endogenous tissue contrast and the small number of clinically approved
MeSH term(s)	Animals ; Biopsy/methods ; Cattle ; Computer Simulation ; Fluorescent Dyes/chemistry ; Humans ; Lung/diagnostic imaging ; Off-Label Use ; Optical Imaging/methods ; Pharmaceutical Preparations/chemistry ; Proof of Concept Study ; Sheep
Chemical Substances	Fluorescent Dyes ; Pharmaceutical Preparations
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article
ISSN	2050-6120
ISSN (online)	2050-6120
DOI	10.1088/2050-6120/ac0619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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