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Book ; Online: Stable isotope record and aklenonen index of MIS 11 sediments, supplementary data to: Dickson, Alexander J; Beer, Christopher J; Dempsey, Ciara; Maslin, Mark A; Bendle, James A; McClymont, Erin L; Pancost, Richard D (2009): Oceanic forcing of the Marine Isotope Stage 11 interglacial. Nature Geoscience, 2, 428-433

Dickson, Alexander J / Beer, Christopher J / Bendle, James A / Dempsey, Ciara / Maslin, Mark A / McClymont, Erin L / Pancost, Richard D

2009

Abstract: The interglacial known as Marine Isotope Stage 11 has been proposed to be analogous to the Holocene, owing to similarities in the amplitudes of orbital forcing. It has been difficult to compare the periods, however, because of the long duration of Stage ... ...

Abstract	The interglacial known as Marine Isotope Stage 11 has been proposed to be analogous to the Holocene, owing to similarities in the amplitudes of orbital forcing. It has been difficult to compare the periods, however, because of the long duration of Stage 11 and a lack of detailed knowledge of any extreme climate events that may have occurred. Here we use the distinctive phasing between seasurface temperatures and the oxygen-isotope records of benthic foraminifera in the southeast Atlantic Ocean to stratigraphically align the Holocene interglacial with the first half of the Marine Isotope Stage 11 interglacial optimum. This alignment suggests that the second half of Marine Isotope Stage 11 should not be used as a reference for 'pre-anthropogenic' greenhouse-gas emissions. By compiling benthic carbon-isotope records from sites in the Atlantic Ocean on a single timescale, we also find that meridional overturning circulation strengthened about 415,000 years ago, at a time of high orbital obliquity. We propose that this mechanism transported heat to the high northern latitudes, inhibiting significant ice-sheet build-up and prolonging interglacial conditions. We suggest that this mechanism may have also prolonged other interglacial periods throughout the past 800,000 years.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/ngeo527
DOI	10.1594/PANGAEA.768375
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Gut microbiome in the first 1000 days and risk for childhood food allergy.

Davis, Erin C / Monaco, Cynthia L / Insel, Richard / Järvinen, Kirsi M

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2024

Abstract: Objective: To summarize recent data on the association between gut microbiome composition and food allergy (FA) in early childhood and highlight potential host-microbiome interactions that reinforce or abrogate oral tolerance.: Data sources: PubMed ... ...

Abstract	Objective: To summarize recent data on the association between gut microbiome composition and food allergy (FA) in early childhood and highlight potential host-microbiome interactions that reinforce or abrogate oral tolerance. Data sources: PubMed search of English-language articles related to FA, other atopic disease, and the gut microbiome in pregnancy and early childhood. Study selections: Human studies published after 2015 assessing the relationship between the gut bacteriome and virome in the first 2 years of life and FA or food sensitization development in early childhood were prioritized. Additional human studies conducted on the prenatal gut microbiome or other atopic diseases and preclinical studies are also discussed. Results: Children who developed FA harbored lower abundances of Bifidobacterium and Clostridia species and had a less mature microbiome during infancy. The early bacterial microbiome protects against FA through production of anti-inflammatory metabolites and induction of T regulatory cells and may also affect FA risk through a role in trained immunity. Infant enteric phage communities are related to childhood asthma development, though no data are available for FA. Maternal gut microbiome during pregnancy is associated with childhood FA risk, potentially through transplacental delivery of maternal bacterial metabolites, though human studies are lacking. Conclusion: The maternal and infant microbiomes throughout the first 1000 days of life influence FA risk through a number of proposed mechanisms. Further large, longitudinal cohort studies using taxonomic, functional, and metabolomic analysis of the bacterial and viral microbiomes are needed to provide further insight on the host-microbe interactions underlying FA pathogenesis in childhood.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2024.03.010
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Article: Epigenetic Mechanisms in Obesity: Broadening Our Understanding of the Disease.

Smith, Erin N L / Chandanathil, Merin / Millis, Richard M

Cureus

2023 Volume 15, Issue 10, Page(s) e47875

Abstract: Now recognized as more than just the result of overeating or the consumption of poor-quality foods, obesity is understood to be a multifactorial disease, strongly correlated with a variety of environment-gene interactions. In addressing the complex ... ...

Abstract	Now recognized as more than just the result of overeating or the consumption of poor-quality foods, obesity is understood to be a multifactorial disease, strongly correlated with a variety of environment-gene interactions. In addressing the complex public health issue of obesity, medical practitioners, along with their allied healthcare counterparts, face the challenge of reducing its prevalence by utilizing and sharing with patients the current, yet incomplete, scientific knowledge concerning the disease. While continued research is required to strengthen direct cause-effect relationships, substantial evidence links post-translational modifications such as DNA methylation and histone modifications of several candidate "obesity" genes to the predilection for obesity. Additional evidence supports the influence of maternal diet during the gestational period, individual diet, and other lifestyle and genetic factors in obesity. The purpose of this review is to synthesize the current information concerning epigenetic modifications that appear to support, or result from, the development of obesity. Such mechanisms may serve as therapeutic targets for developing novel prevention and/or treatment strategies for obesity or as epigenetic biomarkers for monitoring recovery.
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47875
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Copper Selenophosphate, Cu

Neisius, Nathan A / MacHale, Luke T / Snyder, Erin R / Finke, Richard G / Prieto, Amy L

Nano letters

2023 Volume 23, Issue 24, Page(s) 11430–11437

Abstract: Nanoparticle syntheses are designed to produce the desired product in high yield but traditionally neglect atom-economy. Here we report that the simple, but significant, change of the solvent from 1-octadecene (1-ODE) to the operationally inert ... ...

Abstract	Nanoparticle syntheses are designed to produce the desired product in high yield but traditionally neglect atom-economy. Here we report that the simple, but significant, change of the solvent from 1-octadecene (1-ODE) to the operationally inert octadecane (ODA) permits an atom-economical synthesis of copper selenophosphate (Cu
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c02620
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Article ; Online: Correlations of response rate and progression-free survival with overall survival in immunotherapy trials for metastatic non-small-cell lung cancer: an FDA pooled analysis.

Goulart, Bernardo Haddock Lobo / Mushti, Sirisha L / Chatterjee, Somak / Larkins, Erin / Mishra-Kalyani, Pallavi S / Pazdur, Richard / Kluetz, Paul G / Singh, Harpreet

The Lancet. Oncology

2024 Volume 25, Issue 4, Page(s) 455–462

Abstract: Background: Radiographic changes might not fully capture the treatment effects of immune checkpoint inhibitors (ICIs). We aimed to assess correlations of overall response rate and progression-free survival with overall survival in trials of ICIs for ... ...

Abstract	Background: Radiographic changes might not fully capture the treatment effects of immune checkpoint inhibitors (ICIs). We aimed to assess correlations of overall response rate and progression-free survival with overall survival in trials of ICIs for metastatic non-small-cell lung cancer (NSCLC). Methods: To assess trial-level and patient-level correlations of overall response rate and progression-free survival with overall survival, we conducted a pooled analysis of first-line randomised trials (including patients aged ≥18 years with metastatic squamous and non-squamous NSCLC and an Eastern Cooperative Oncology Group performance status of 0-1) submitted to the US Food and Drug Administration from June 24, 2016, to March 16, 2021. Eligible trials evaluated at least one ICI in the experimental group versus chemotherapy in the control group. At the trial level, we used weighted linear regression to derive coefficients of determination (R Findings: A total of 13 trials including 9285 patients evaluated ICIs alone or in combination with chemotherapy versus chemotherapy alone. At the trial level, the R Interpretation: Correlations of overall response rate and progression-free survival with overall survival were generally moderate in this pooled analysis. The findings support routine analysis of mature overall survival data, where feasible, in first-line randomised trials of ICIs for metastatic NSCLC. Funding: US Food and Drug Administration.
MeSH term(s)	Humans ; Adolescent ; Adult ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Progression-Free Survival ; Lung Neoplasms/drug therapy ; Immunotherapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(24)00040-8
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

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Article ; Online: Accounting for sex-specific differences in gene flow and functional connectivity for cougars and implications for management

Zeller, Katherine A. / Wultsch, Claudia / Welfelt, Lindsay S. / Beausoleil, Richard A. / Landguth, Erin L.

Landsc Ecol. 2023 Jan., v. 38, no. 1 p.223-237

2023

Abstract: CONTEXT: Maintenance of connectivity is a commonly recommended strategy for species management and conservation as habitat loss and fragmentation continues. Therefore, functional connectivity modeling is needed for species over large geographic areas. ... ...

Abstract	CONTEXT: Maintenance of connectivity is a commonly recommended strategy for species management and conservation as habitat loss and fragmentation continues. Therefore, functional connectivity modeling is needed for species over large geographic areas. However, sex-specific functional connectivity is rarely considered, even though the results of such an analysis have the potential to influence applied management practices. OBJECTIVES: We use a large (n = 1902) genetic dataset to identify population level and sex-specific functional connectivity for cougars in Washington, USA. METHODS: We conducted a landscape genetics analysis that pseudo-optimized resistance surfaces for the full sample of cougars as well as for male and female groups. We then modeled connectivity across the top performing resistance surfaces with resistant kernels. RESULTS: The top resistance surface for females had higher resistance and lower connectivity than the males and had more spatial variability. However, we also observed greater resistance to movement and a lack of connectivity for males in and around the Olympic Peninsula. The resistance surface and connectivity models for all cougars contained both the broad features of the male models and the more heterogeneous features of the female models, indicating the importance of both local and regional dispersal and breeding. CONCLUSIONS: In species with sex-specific differences in movement and dispersal, accounting for these differences can be important for understanding functional connectivity. For cougars in Washington, this revealed depressed connectivity for males on the Olympic Peninsula which may indicate a more immediate management concern for the future of this population than previously thought.
Keywords	data collection ; females ; gene flow ; habitat destruction ; landscape genetics ; males
Language	English
Dates of publication	2023-01
Size	p. 223-237.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	1027798-5
ISSN	1572-9761 ; 0921-2973
ISSN (online)	1572-9761
ISSN	0921-2973
DOI	10.1007/s10980-022-01556-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Wearable technology assessing running biomechanics and prospective running-related injuries in Active Duty Soldiers.

Weart, Amy N / Miller, Erin M / Brindle, Richard A / Ford, Kevin R / Goss, Donald L

Sports biomechanics

2023 , Page(s) 1–17

Abstract: The purpose of this study was to determine if running biomechanical variables measured by wearable technology were prospectively associated with running injuries in Active Duty Soldiers. A total of 171 Soldiers wore a shoe pod that collected data on ... ...

Abstract	The purpose of this study was to determine if running biomechanical variables measured by wearable technology were prospectively associated with running injuries in Active Duty Soldiers. A total of 171 Soldiers wore a shoe pod that collected data on running foot strike pattern, step rate, step length and contact time for 6 weeks. Running-related injuries were determined by medical record review 12 months post-study enrollment. Differences in running biomechanics between injured and non-injured runners were compared using independent t-tests or ANCOVA for continuous variables and chi-square analyses for the association of categorical variables. Kaplan-Meier survival curves were used to estimate the time to a running-related injury. Risk factors were carried forward to estimate hazard ratios using Cox proportional hazard regression models. Forty-one participants (24%) sustained a running-related injury. Injured participants had a lower step rate than non-injured participants, but step rate did not have a significant effect on time to injury. Participants with the longest contact time were at a 2.25 times greater risk for a running-related injury; they were also relatively slower, heavier, and older. Concomitant with known demographic risk factors for injury, contact time may be an additional indicator of a running-related injury risk in Active Duty Soldiers.
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ISSN	1752-6116
ISSN (online)	1752-6116
DOI	10.1080/14763141.2023.2208568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anatomic Location of Tissue Expander Placement Is Not Associated With Delay in Adjuvant Therapy in Women With Breast Cancer.

Elder, Erin / Fasola, Carolina / Clavin, Nicholas / Hecksher, Anna / Trufan, Sally / Schepel, Courtney / Donahue, Erin / Warren, Yancey / White, Richard L / Hadzikadic-Gusic, Lejla

Annals of plastic surgery

2023 Volume 91, Issue 6, Page(s) 679–685

Abstract: Background: Tissue expanders in breast reconstruction are traditionally placed retropectoral. Increasingly, patients are undergoing prepectoral placement. The impact of this placement on the initiation of adjuvant treatment is unknown.: Methods: A ... ...

Abstract	Background: Tissue expanders in breast reconstruction are traditionally placed retropectoral. Increasingly, patients are undergoing prepectoral placement. The impact of this placement on the initiation of adjuvant treatment is unknown. Methods: A retrospective review was conducted to identify women diagnosed with breast cancer who underwent mastectomy followed by radiation and/or chemotherapy. Women were divided into 3 groups: prepectoral tissue expander placement, retropectoral tissue expander placement, and no immediate reconstruction. A treatment delay was defined as greater than 8 weeks between tissue expander placement and adjuvant therapy. Results: Of 634 women, 205 (32%) underwent tissue expander placement, and 429 (68%) did not have immediate reconstruction. Of those with tissue expanders placed, 84 (41%) had prepectoral placement, and 121 (59%) had retropectoral placement. The median time to adjuvant therapy was 49 days for the entire cohort: no reconstruction, 47 days; prepectoral, 57 days; and retropectoral, 55 days. Treatment delays were observed in 34% of women: no reconstruction, 28%; prepectoral, 51%; and retropectoral, 46% ( P < 0.001). Tissue expander placement was associated with a delay to adjuvant therapy when compared with no reconstruction ( P < 0.001). The location of the tissue expander did not impact the odds of having a delay. On multivariable analysis, having reconstruction, having postoperative infection, not undergoing chemotherapy treatment, and being a current smoker were associated with a delay to adjuvant therapy. A delay to treatment was not associated with worse survival. Conclusions: Placement of a tissue expander delayed adjuvant therapy. The location of tissue expander placement, retropectoral versus prepectoral, did not impact the time to adjuvant treatment.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Mastectomy ; Tissue Expansion Devices ; Mammaplasty ; Combined Modality Therapy ; Retrospective Studies ; Postoperative Complications/surgery ; Breast Implants
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003694
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Article ; Online: Alcohol-involved sexual assault in the US military: a scoping review.

Miggantz, Erin L / Orchowski, Lindsay M / Beltran, Jessica L / Walter, Kristen H / Hollingsworth, Julia C / Cue Davis, Kelly / Zong, Zoe Y / Meza-Lopez, Richard / Hutchins, Anna / Gilmore, Amanda K

European journal of psychotraumatology

2023 Volume 14, Issue 2, Page(s) 2282020

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; United States/epidemiology ; Sex Offenses ; Military Personnel ; Veterans ; Risk Factors ; Substance-Related Disorders
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008066.2023.2282020
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Article ; Online: Influence of compost application rate on nutrient and heavy metal mobility: Implications for stormwater management.

Kranz, Christina N / Rivers, Erin N / McLaughlin, Richard A / Heitman, Joshua L

Journal of environmental quality

2022 Volume 51, Issue 6, Page(s) 1222–1234

Abstract: Amending soils with compost has become increasingly common in stormwater management practices. Compost can be a source and sink for nutrients and heavy metals, and it is important to understand the effect of compost on pollutant leaching under different ... ...

Abstract	Amending soils with compost has become increasingly common in stormwater management practices. Compost can be a source and sink for nutrients and heavy metals, and it is important to understand the effect of compost on pollutant leaching under different hydrologic conditions. The objectives of this study were (a) to quantify the distribution coefficient (K
MeSH term(s)	Composting ; Cadmium ; Metals, Heavy ; Nutrients ; Soil ; Environmental Pollutants ; Water ; Rain
Chemical Substances	Cadmium (00BH33GNGH) ; Metals, Heavy ; Soil ; Environmental Pollutants ; Water (059QF0KO0R)
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.1002/jeq2.20403
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