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  1. Article ; Online: Capacity building for infectious disease control in Sub-Saharan Africa.

    Lieber, William C / Rahim, Faraan O / Lartey, Henry S Q / Shah, Devesh / Mmbaga, Blandina T / Thielman, Nathan M / Hertz, Julian T

    Pathogens and global health

    2023  , Page(s) 1–3

    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1080/20477724.2023.2272363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology.

    Stamm, Bessie / Barbhaiya, Medha / Siegel, Caroline / Lieber, Sarah / Lockshin, Michael / Sammaritano, Lisa

    Lupus science & medicine

    2023  Volume 9, Issue 1

    Abstract: Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, ... ...

    Abstract Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, direct disease-related factors are believed to influence fertility. These include diminished ovarian reserve, menstrual irregularities (a function of disease activity) and the presence of antiphospholipid antibodies. The question of whether SLE intrinsically affects fertility, however, remains unanswered. In this review, we address known factors affecting fertility, assess current data regarding a direct impact of SLE on fertility and evaluate potential disease-related risk factors. We focus primarily on studies measuring anti-Müllerian hormone and antral follicle count, the most widely measured markers of ovarian reserve. Our goal is to provide information to rheumatologists faced with counselling patients with SLE regarding their fertility, family planning and options for assisted reproductive technologies, which now include fertility preservation through oocyte cryopreservation.
    MeSH term(s) Pregnancy ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Rheumatologists ; Infertility/etiology ; Ovarian Reserve ; Reproductive Techniques, Assisted
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2779620-6
    ISSN 2053-8790
    ISSN 2053-8790
    DOI 10.1136/lupus-2022-000840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 Infection and Associated Rates of Diabetic Ketoacidosis in a New York City Emergency Department.

    Ditkowsky, Jared / Lieber, Adam C / Leibner, Evan S / Genes, Nicholas

    The western journal of emergency medicine

    2021  Volume 22, Issue 3, Page(s) 599–602

    Abstract: Introduction: In early March 2020, coronavirus 2019 (COVID-19) spread rapidly in New York City. Shortly thereafter, in response to the shelter-in-place orders and concern for infection, emergency department (ED) volumes decreased. While a connection ... ...

    Abstract Introduction: In early March 2020, coronavirus 2019 (COVID-19) spread rapidly in New York City. Shortly thereafter, in response to the shelter-in-place orders and concern for infection, emergency department (ED) volumes decreased. While a connection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia/insulin deficiency is well described, its direct relation to diabetic ketoacidosis (DKA) is not. In this study we describe trends in ED volume and admitted patient diagnoses of DKA among five of our health system's EDs, as they relate to peak SARS-CoV-2 activity in New York City.
    Methods: For the five EDs in our hospital system, deidentified visit data extracted for routine quality review was made available for analysis. We looked at total visits and select visit diagnoses related to DKA, across the months of March, April and May 2019, and compared those counts to the same period in 2020.
    Results: A total of 93,218 visits were recorded across our five EDs from March 1-May 31, 2019. During that period there were 106 diagnoses of DKA made in the EDs (0.114% of visits). Across the same period in 2020 there were 59,009 visits, and 214 diagnoses of DKA (0.363% of visits) CONCLUSION: Despite a decrease in ED volume of 26.9% across our system during this time period, net cases of DKA diagnoses rose drastically by 70.1% compared to the prior year.
    MeSH term(s) COVID-19/epidemiology ; Diabetic Ketoacidosis/diagnosis ; Diabetic Ketoacidosis/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Humans ; New York City/epidemiology ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-9018
    ISSN (online) 1936-9018
    ISSN 1936-9018
    DOI 10.5811/westjem.2021.2.49634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Links between the three-dimensional movements of whale sharks (Rhincodon typus) and the bio-physical environment off a coral reef.

    D'Antonio, Ben / Ferreira, Luciana C / Meekan, Mark / Thomson, Paul G / Lieber, Lilian / Virtue, Patti / Power, Chloe / Pattiaratchi, Charitha B / Brierley, Andrew S / Sequeira, Ana M M / Thums, Michele

    Movement ecology

    2024  Volume 12, Issue 1, Page(s) 10

    Abstract: Background: Measuring coastal-pelagic prey fields at scales relevant to the movements of marine predators is challenging due to the dynamic and ephemeral nature of these environments. Whale sharks (Rhincodon typus) are thought to aggregate in nearshore ... ...

    Abstract Background: Measuring coastal-pelagic prey fields at scales relevant to the movements of marine predators is challenging due to the dynamic and ephemeral nature of these environments. Whale sharks (Rhincodon typus) are thought to aggregate in nearshore tropical waters due to seasonally enhanced foraging opportunities. This implies that the three-dimensional movements of these animals may be associated with bio-physical properties that enhance prey availability. To date, few studies have tested this hypothesis.
    Methods: Here, we conducted ship-based acoustic surveys, net tows and water column profiling (salinity, temperature, chlorophyll fluorescence) to determine the volumetric density, distribution and community composition of mesozooplankton (predominantly euphausiids and copepods) and oceanographic properties of the water column in the vicinity of whale sharks that were tracked simultaneously using satellite-linked tags at Ningaloo Reef, Western Australia. Generalised linear mixed effect models were used to explore relationships between the 3-dimensional movement behaviours of tracked sharks and surrounding prey fields at a spatial scale of ~ 1 km.
    Results: We identified prey density as a significant driver of horizontal space use, with sharks occupying areas along the reef edge where densities were highest. These areas were characterised by complex bathymetry such as reef gutters and pinnacles. Temperature and salinity profiles revealed a well-mixed water column above the height of the bathymetry (top 40 m of the water column). Regions of stronger stratification were associated with reef gutters and pinnacles that concentrated prey near the seabed, and entrained productivity at local scales (~ 1 km). We found no quantitative relationship between the depth use of sharks and vertical distributions of horizontally averaged prey density. Whale sharks repeatedly dove to depths where spatially averaged prey concentration was highest but did not extend the time spent at these depth layers.
    Conclusions: Our work reveals previously unrecognized complexity in interactions between whale sharks and their zooplankton prey.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2724975-X
    ISSN 2051-3933
    ISSN 2051-3933
    DOI 10.1186/s40462-024-00452-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association of Baseline Frailty with Patient-Reported Outcomes in Systemic Lupus Erythematosus at 1 Year.

    Lieber, S B / Nahid, M / Rajan, M / Barbhaiya, M / Sammaritano, L / Lipschultz, R A / Lin, M / Reid, M C / Mandl, L A

    The Journal of frailty & aging

    2023  Volume 12, Issue 3, Page(s) 247–251

    Abstract: The relationship of baseline frailty with subsequent patient-reported outcomes in systemic lupus erythematosus (SLE) remains unclear. We assessed these associations in a pilot prospective cohort study. Frailty based on the FRAIL scale and the Fried ... ...

    Abstract The relationship of baseline frailty with subsequent patient-reported outcomes in systemic lupus erythematosus (SLE) remains unclear. We assessed these associations in a pilot prospective cohort study. Frailty based on the FRAIL scale and the Fried phenotype and patient-reported outcomes, namely Patient Reported Outcomes Measurement Information System computerized adaptive tests and Valued Life Activities disability, were measured at baseline and 1 year among women aged 18-70 years with SLE enrolled at a single center. Differences in Patient Reported Outcomes Measurement Information System computerized adaptive tests between frail and non-frail participants were evaluated using Wilcoxon rank sum tests, and the association of baseline frailty with self-report disability at 1 year was estimated using linear regression. Of 51 participants, 24% (FRAIL scale) and 16% (Fried phenotype) met criteria for frailty at baseline despite median age of 55.0 and 56.0 years, respectively. Women with (versus without) baseline frailty using either measure had worse 1-year Patient Reported Outcomes Measurement Information System computerized adaptive test scores across multiple domains and greater self-report disability. Baseline frailty was significantly associated with self-report disability at 1 year (FRAIL scale: parameter estimate 0.55, 95% confidence interval (CI) 0.21-0.89, p<0.01; Fried phenotype: parameter estimate 0.61, 95% CI 0.22-1.00, p<0.01), including only slight attenuation after adjustment for SLE cumulative organ damage (FRAIL scale: parameter estimate 0.45, 95% CI 0.09-0.81, p=0.02; Fried phenotype: parameter estimate 0.49, 95% CI 0.09-0.90, p=0.02). These preliminary findings support frailty as an independent risk factor for clinically relevant patient-reported outcomes, including disability onset, among women with SLE.
    MeSH term(s) Humans ; Female ; Aged ; Frailty/diagnosis ; Frailty/epidemiology ; Frailty/complications ; Frail Elderly ; Prospective Studies ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/complications ; Patient Reported Outcome Measures
    Language English
    Publishing date 2023-07-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2023.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Medical and nutritional complications of alcoholism

    Lieber, Charles S.

    mechanisms and management

    1992  

    Author's details Charles S. Lieber
    Keywords Ethanol / adverse effects ; Alcoholism / complications ; Nutrition / drug effects ; Nutrition Disorders / etiology ; Nutrition Disorders / therapy ; Alkohol ; Toxizität ; Alkoholismus ; Sekundärkrankheit
    Subject Giftigkeit ; Toxische Wirkung ; Folgekrankheit ; Erworbener Defekt ; Sekundärerkrankung ; Folgeerkrankung ; Zweiterkrankung ; Begleitkrankheit ; Komorbidität ; Begleiterkrankung ; Conduct disorder ; Comorbid disorder ; Alkoholabhängigkeit ; Trunksucht ; Alkoholbedingte Krankheit ; Alkoholkrankheit ; Alkoholsucht ; Alkohol
    Size XVI, 579 S. : Ill., graph. Darst.
    Publisher Plenum Medical Book Co
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004488943
    ISBN 0-306-43558-6 ; 978-0-306-43558-4
    Database Catalogue ZB MED Medicine, Health

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  7. Article: Anatomy of the Orbit.

    Lieber, Stefan / Fernandez-Miranda, Juan C

    Journal of neurological surgery. Part B, Skull base

    2020  Volume 81, Issue 4, Page(s) 319–332

    Abstract: The orbit is a paired, transversely oval, and cone-shaped osseous cavity bounded and formed by the anterior and middle cranial base as well as the viscerocranium. Its main contents are the anterior part of the visual system, globe and optic nerve, and ... ...

    Abstract The orbit is a paired, transversely oval, and cone-shaped osseous cavity bounded and formed by the anterior and middle cranial base as well as the viscerocranium. Its main contents are the anterior part of the visual system, globe and optic nerve, and the associated neural, vascular, muscular, glandular, and ligamentous structures required for oculomotion, lacrimation, accommodation, and sensation. A complex stream of afferent and efferent information passes through the orbit, which necessitates a direct communication with the anterior and middle cranial fossae, the pterygopalatine and infratemporal fossae, as well as the aerated adjacent frontal, sphenoidal, and maxillary sinuses and the nasal cavity. This article provides a detailed illustration and description of the microsurgical anatomy of the orbit, with a focus on the intrinsically complex spatial relationships around the annular tendon and the superior orbital fissure, the transition from cavernous sinus to the orbital apex. Sparse reference will be made to surgical approaches, their indications or limitations, since they are addressed elsewhere in this special issue. Instead, an attempt has been made to highlight anatomical structures and elucidate concepts most relevant to safe and effective transcranial, transfacial, transorbital, or transnasal surgery of orbital, periorbital, and skull base pathologies.
    Language English
    Publishing date 2020-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0040-1715096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Recent advances in the treatment of liver diseases

    Lieber, Charles S.

    a seminar-in-print

    (Drugs ; 40, Suppl. 3)

    1990  

    Author's details guest ed. Charles S. Lieber
    Series title Drugs ; 40, Suppl. 3
    Collection
    Keywords Liver Diseases / drug therapy
    Language English
    Size 138 S. : graph. Darst.
    Publisher Adis
    Publishing place Auckland
    Publishing country New Zealand
    Document type Book
    HBZ-ID HT003706190
    Database Catalogue ZB MED Medicine, Health

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  9. Article: Insights into the evaporation characteristics of saliva droplets and aerosols: Levitation experiments and numerical modeling.

    Lieber, Christian / Melekidis, Stefanos / Koch, Rainer / Bauer, Hans-Jörg

    Journal of aerosol science

    2021  Volume 154, Page(s) 105760

    Abstract: ... for a temperature range from 20  °C to 29  °C and a relative humidity from 6 % to up to 65 %. The experimentally ...

    Abstract Understanding the transmission phenomena of SARS-CoV-2 by virus-laden droplets and aerosols is of paramount importance for controlling the current COVID-19 pandemic. Detailed information about the lifetime and kinematics of airborne droplets of different size is relevant in order to evaluate hygiene measures like wearing masks but also social distancing and ventilation concepts for indoor environments. However, the evaporation process of expiratory droplets and aerosols is not fully understood. Consequently, the main objective of this study is to present evaporation characteristics of saliva droplets. An acoustic levitator is utilized in conjunction with microscopic imaging for recording the temporal evolution of the evaporation of saliva droplets under well-defined ambient conditions. Following the evaporation of the water content, a saliva droplet reaches a final size, which remains stable in the timescale of hours. By investigating numerous droplets of different size, it was found that the final droplet diameter correlates well to 20 % of the initial diameter. This correlation is independent of the ambient conditions for a temperature range from 20  °C to 29  °C and a relative humidity from 6 % to up to 65 %. The experimentally obtained evaporation characteristics are implemented into a numerical model, which is based on one-dimensional droplet kinematics and a rapid mixing evaporation model. By taking into account the evaporation-falling curve as presented by Wells, the significance of the experimental results for predicting the lifetime of saliva droplets and aerosols is demonstrated. The numerical predictions may be used to determine the impact of the droplet size and the ambient conditions on the transmission risks of infectious diseases like COVID-19.
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1499134-2
    ISSN 1879-1964 ; 0021-8502
    ISSN (online) 1879-1964
    ISSN 0021-8502
    DOI 10.1016/j.jaerosci.2021.105760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 Infection and Associated Rates of Diabetic Ketoacidosis in a New York City Emergency Department

    Jared Ditkowsky / Adam C. Lieber / Evan S. Leibner / Nicholas Genes

    Western Journal of Emergency Medicine, Vol 22, Iss

    2021  Volume 3

    Abstract: ... among five of our health system’s EDs, as they relate to peak SARS-CoV-2 activity in New York City. Methods ...

    Abstract Introduction: In early March 2020, coronavirus 2019 (COVID-19) spread rapidly in New York City. Shortly thereafter, in response to the shelter-in-place orders and concern for infection, emergency department (ED) volumes decreased. While a connection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia/insulin deficiency is well described, its direct relation to diabetic ketoacidosis (DKA) is not. In this study we describe trends in ED volume and admitted patient diagnoses of DKA among five of our health system’s EDs, as they relate to peak SARS-CoV-2 activity in New York City. Methods: For the five EDs in our hospital system, deidentified visit data extracted for routine quality review was made available for analysis. We looked at total visits and select visit diagnoses related to DKA, across the months of March, April and May 2019, and compared those counts to the same period in 2020. Results: A total of 93,218 visits were recorded across our five EDs from March 1–May 31, 2019. During that period there were 106 diagnoses of DKA made in the EDs (0.114% of visits). Across the same period in 2020 there were 59,009 visits, and 214 diagnoses of DKA (0.363% of visits) Conclusion: Despite a decrease in ED volume of 26.9% across our system during this time period, net cases of DKA diagnoses rose drastically by 70.1% compared to the prior year.
    Keywords Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Subject code 360
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher eScholarship Publishing, University of California
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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