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Article ; Online: Changes in Breast Cancer Risk and Risk Factor Profiles among U.S.-Born and Immigrant Asian American Women Residing in the San Francisco Bay Area.

John, Esther M / Koo, Jocelyn / Ingles, Sue A / Kurian, Allison W / Hines, Lisa M

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2023 Volume 32, Issue 5, Page(s) 666–677

Abstract: Background: Breast cancer incidence rates in women of Asian descent have been increasing in the United States and Asia.: Methods: In a case-control study of Asian American women from the San Francisco Bay Area, we assessed associations with ... ...

Abstract	Background: Breast cancer incidence rates in women of Asian descent have been increasing in the United States and Asia. Methods: In a case-control study of Asian American women from the San Francisco Bay Area, we assessed associations with birthplace and migration-related characteristics and compared risk factors between Asian American and non-Hispanic White women by birthplace and birth cohort. Results: Birthplace and migration-related characteristics were associated with breast cancer risk only among women in the younger birth cohort (1951-1984) that comprised 355 cases diagnosed at age ≤55 years and 276 sister and population controls. Breast cancer risk was marginally increased among foreign-born women [OR = 1.40; 95% confidence interval (CI), 0.97-2.03] and two-fold among foreign-born Chinese women (OR = 2.16; 95% CI, 1.21-3.88). Two-fold increased risks were associated with migration at age ≥40 years and longer U.S. residence (≥30 years or ≥75% of life). The education level was high among both cases and controls. Differences in the prevalence of risk factors by birthplace and birth cohort suggest temporal changes in reproductive and lifestyle-related factors. The prevalence in risk factors was similar between foreign-born and U.S.-born women in the younger birth cohort, and did not fully explain the observed associations with birthplace and other migration characteristics. Conclusions: In contrast to studies from earlier decades, younger foreign-born Asian American women had a higher risk of breast cancer than U.S.-born Asian American women. Impact: It is important and urgent to understand what factors drive the increasing burden of breast cancer in women of Asian descent and implement effective prevention programs.
MeSH term(s)	United States/epidemiology ; Female ; Humans ; Middle Aged ; Adult ; Asian ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Case-Control Studies ; San Francisco/epidemiology ; Risk Factors ; Emigrants and Immigrants
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-22-1128
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Zs.A 3693: Show issues

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Article ; Online: Reporting Adverse Events for Cannabis to the FDA.

Hines, Michelle C / Harinstein, Lisa M / Kortepeter, Cindy M

The New England journal of medicine

2020 Volume 382, Issue 1, Page(s) 98

MeSH term(s)	Adverse Drug Reaction Reporting Systems ; Analgesics ; Cannabis ; Medical Marijuana
Chemical Substances	Analgesics ; Medical Marijuana
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1913460
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Article ; Online: Impact and Continued Relevance of Medication Adherence Measurement.

Shirley, Ben / Castora-Binkley, Melissa / Hines, Lisa

Population health management

2022 Volume 25, Issue 4, Page(s) 575–578

MeSH term(s)	Humans ; Medicare Part D ; Medication Adherence ; Medication Therapy Management ; United States
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2454546-6
ISSN	1942-7905 ; 1942-7891
ISSN (online)	1942-7905
ISSN	1942-7891
DOI	10.1089/pop.2022.0022
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Zs.A 5170: Show issues

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Article ; Online: A Novel ENU-Induced Mfn2 Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy

Hines, Timothy J. / Bailey, Janice / Liu, Hedi / Guntur, Anyonya R. / Seburn, Kevin L. / Pratt, Samia L. / Funke, Jonathan R. / Tarantino, Lisa M. / Burgess, Robert W.

Biology (Basel). 2023 July 03, v. 12, no. 7

2023

Abstract: Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating mitochondrial fusion. Recently, MFN2 has been implicated in other important cellular functions, ... ...

Abstract	Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating mitochondrial fusion. Recently, MFN2 has been implicated in other important cellular functions, such as mitophagy, mitochondrial motility, and coordinating endoplasmic reticulum-mitochondria communication. In humans, over 100 MFN2 mutations are associated with a form of inherited peripheral neuropathy, Charcot–Marie–Tooth disease type 2A (CMT2A). Here we describe an ENU-induced mutant mouse line with a recessive neuromuscular phenotype. Behavioral screening showed progressive weight loss and rapid deterioration of motor function beginning at 8 weeks. Mapping and sequencing revealed a missense mutation in exon 18 of Mfn2 (T1928C; Leu643Pro), within the transmembrane domain. Compared to wild-type and heterozygous littermates, Mfn2ᴸ⁶⁴³ᴾ/ᴸ⁶⁴³ᴾ mice exhibited diminished rotarod performance and decreases in activity in the open field test, muscular endurance, mean mitochondrial diameter, sensory tests, mitochondrial DNA content, and MFN2 protein levels. However, tests of peripheral nerve physiology and histology were largely normal. Mutant leg bones had reduced cortical bone thickness and bone area fraction. Together, our data indicate that Mfn2ᴸ⁶⁴³ᴾ causes a recessive motor phenotype with mild bone and mitochondrial defects in mice. Lack of apparent nerve pathology notwithstanding, this is the first reported mouse model with a mutation in the transmembrane domain of the protein, which may be valuable for researchers studying MFN2 biology.
Keywords	bones ; exons ; heterozygosity ; histology ; mice ; missense mutation ; mitochondria ; mitochondrial DNA ; mitophagy ; models ; mutants ; nerve tissue ; peripheral nervous system diseases ; phenotype ; physiology ; weight loss
Language	English
Dates of publication	2023-0703
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070953
Database	NAL-Catalogue (AGRICOLA)

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Article: A Novel ENU-Induced

Hines, Timothy J / Bailey, Janice / Liu, Hedi / Guntur, Anyonya R / Seburn, Kevin L / Pratt, Samia L / Funke, Jonathan R / Tarantino, Lisa M / Burgess, Robert W

Biology

2023 Volume 12, Issue 7

Abstract	Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating mitochondrial fusion. Recently, MFN2 has been implicated in other important cellular functions, such as mitophagy, mitochondrial motility, and coordinating endoplasmic reticulum-mitochondria communication. In humans, over 100
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070953
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Article ; Online: A combined RAD-Seq and WGS approach reveals the genomic basis of yellow color variation in bumble bee Bombus terrestris.

Rahman, Sarthok Rasique / Cnaani, Jonathan / Kinch, Lisa N / Grishin, Nick V / Hines, Heather M

Scientific reports

2021 Volume 11, Issue 1, Page(s) 7996

Abstract: Bumble bees exhibit exceptional diversity in their segmental body coloration largely as a result of mimicry. In this study we sought to discover genes involved in this variation through studying a lab-generated mutant in bumble bee Bombus terrestris, in ... ...

Abstract	Bumble bees exhibit exceptional diversity in their segmental body coloration largely as a result of mimicry. In this study we sought to discover genes involved in this variation through studying a lab-generated mutant in bumble bee Bombus terrestris, in which the typical black coloration of the pleuron, scutellum, and first metasomal tergite is replaced by yellow, a color variant also found in sister lineages to B. terrestris. Utilizing a combination of RAD-Seq and whole-genome re-sequencing, we localized the color-generating variant to a single SNP in the protein-coding sequence of transcription factor cut. This mutation generates an amino acid change that modifies the conformation of a coiled-coil structure outside DNA-binding domains. We found that all sequenced Hymenoptera, including sister lineages, possess the non-mutant allele, indicating different mechanisms are involved in the same color transition in nature. Cut is important for multiple facets of development, yet this mutation generated no noticeable external phenotypic effects outside of setal characteristics. Reproductive capacity was reduced, however, as queens were less likely to mate and produce female offspring, exhibiting behavior similar to that of workers. Our research implicates a novel developmental player in pigmentation, and potentially caste, thus contributing to a better understanding of the evolution of diversity in both of these processes.
MeSH term(s)	Amino Acid Sequence ; Animals ; Bees/genetics ; Conserved Sequence/genetics ; Genes, Insect ; Genome, Insect ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing ; Insect Proteins/chemistry ; Insect Proteins/genetics ; Male ; Mutation/genetics ; Phenotype ; Pigmentation/genetics ; Polymorphism, Single Nucleotide/genetics ; Protein Domains ; Whole Genome Sequencing
Chemical Substances	Insect Proteins
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-87194-y
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Article ; Online: Risk of stroke/systemic embolism, major bleeding, and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran, or rivaroxaban compared with warfarin in the United States medicare population: updated analysis.

Amin, Alpesh / Keshishian, Allison / Hines, Dionne M / Dina, Oluwaseyi / Le, Hannah / Rosenblatt, Lisa / Liu, Xianchen / Zhang, Qisu / Vo, Lien

Current medical research and opinion

2022 Volume 38, Issue 12, Page(s) 2131–2140

Abstract: Objective: To provide an updated comparison of the risk and cost of stroke/systemic embolism (SE) and major bleeding between direct oral anticoagulants (DOAC: apixaban, rivaroxaban, dabigatran) and warfarin among non-valvular atrial fibrillation (NVAF) ... ...

Abstract	Objective: To provide an updated comparison of the risk and cost of stroke/systemic embolism (SE) and major bleeding between direct oral anticoagulants (DOAC: apixaban, rivaroxaban, dabigatran) and warfarin among non-valvular atrial fibrillation (NVAF) patients. Methods: Adults (≥65 years) initiating warfarin or DOACs between 1 January 2013 and 31 December 2014 were selected from the Medicare database and propensity scores matched 1:1 to balance baseline characteristics. Cox proportional hazards models were used to estimate the risks of stroke/SE and major bleeding of each DOAC Results: Of the 264,479 eligible patients, 38,740 apixaban-warfarin pairs, 76,677 rivaroxaban-warfarin pairs, and 20,955 dabigatran-warfarin pairs were matched. Apixaban (Hazard Ratio [HR] = 0.46; 95% Confidence Interval [CI] 0.38-0.56) and rivaroxaban (HR = 0.71; 95% CI 0.63-0.80) were associated with a significantly lower risk of stroke/SE compared to warfarin. Apixaban (HR = 0.57; 95% CI 0.51-0.63) and dabigatran (HR = 0.80; 95% CI 0.70-0.90) were associated with a significantly lower risk of major bleeding; rivaroxaban (HR = 1.14; 95% CI 1.07-1.21) was associated with a significantly higher risk of major bleeding compared to warfarin. Compared to warfarin, apixaban and rivaroxaban had significantly lower stroke/SE-related medical costs; and apixaban and dabigatran had significantly lower major bleeding-related medical costs. Conclusions: This real-world analysis showed DOACs to be associated with a lower risk of stroke/SE and major bleeding, and lower medical costs compared to warfarin. Among them, only apixaban appears to be associated with a significantly lower risk of all three outcomes collectively: stroke/SE, major bleeding, and lower related medical costs compared to warfarin.
MeSH term(s)	Aged ; Humans ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Dabigatran/adverse effects ; Embolism/epidemiology ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Hemorrhage/complications ; Medicare ; Pyridones/adverse effects ; Rivaroxaban/adverse effects ; Stroke/epidemiology ; Stroke/prevention & control ; Stroke/complications ; United States/epidemiology ; Warfarin/adverse effects
Chemical Substances	Anticoagulants ; apixaban (3Z9Y7UWC1J) ; Dabigatran (I0VM4M70GC) ; Pyridones ; Rivaroxaban (9NDF7JZ4M3) ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2022.2115772
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Article: Persistence to Basal Insulin: Association With Health Outcomes in a Population With Type 2 Diabetes.

Nsiah, Irene / Campbell, Patrick J / Parikh, Megha A / Hines, Lisa E / Pickering, Matthew / Nau, David P

Clinical diabetes : a publication of the American Diabetes Association

2023 Volume 42, Issue 2, Page(s) 257–265

Abstract: This study examined the association between persistence to basal insulin and clinical and economic health outcomes. The question of whether a persistence measure for basal insulin could be leveraged in quality measurement was also explored. Using the IBM- ...

Abstract	This study examined the association between persistence to basal insulin and clinical and economic health outcomes. The question of whether a persistence measure for basal insulin could be leveraged in quality measurement was also explored. Using the IBM-Truven MarketScan Commercial and Medicare Supplemental Databases from 1 January 2011 to 31 December 2015, a total of 14,126 subjects were included in the analyses, wherein 9,898 (70.1%) were categorized as persistent with basal insulin therapy. Basal insulin persistence was associated with lower A1C, fewer hospitalizations and emergency department visits, and lower health care expenditures. Quality measures based on prescription drug claims for basal insulin are feasible and should be considered for guiding quality improvement efforts.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025953-3
ISSN	0891-8929
ISSN	0891-8929
DOI	10.2337/cd23-0016
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Article: One Early Course-Based Undergraduate Research Experience Produces Sustainable Knowledge Gains, but only Transient Perception Gains.

Wolkow, Tom D / Jenkins, Jill / Durrenberger, Lisa / Swanson-Hoyle, Kylie / Hines, Lisa M

Journal of microbiology & biology education

2019 Volume 20, Issue 2

Abstract: Universities have been called upon to integrate research experiences into early, introductory courses to better prepare our STEM workforce. This call is primarily based on short-term studies that link research experiences with knowledge and perception ... ...

Abstract	Universities have been called upon to integrate research experiences into early, introductory courses to better prepare our STEM workforce. This call is primarily based on short-term studies that link research experiences with knowledge and perception gains. However, the influence of pre-existing student characteristics has not been fully disentangled from the research experience, and the long-term stability of these gains is uncertain. To address these issues, we integrated a course-based undergraduate research experience (CURE) into randomly assigned sections of a required freshman-level biology laboratory course. We previously reported that this CURE resulted in immediate targeted knowledge and perception gains. Here, we evaluate the stability of these gains as students progressed through a biology degree program. At sophomore year, the impact of the CURE on student perception was still apparent. When compared to controls, students who participated in the CURE perceived a greater understanding of what researchers do and an increased interest in pursuing a research career. However, by senior year, these positive perceptions had fallen to levels shared by control groups. Targeted knowledge gains persisted throughout this study. Our results support CURE logic models predicting that multiple CUREs will be required to sustain perception gains.
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.v20i2.1679
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Article ; Online: Effectiveness and Safety of Apixaban vs Warfarin in Patients with Venous Thromboembolism with Risk Factors for Bleeding or for Recurrences.

Cohen, Alexander T / Sah, Janvi / Dhamane, Amol D / Hines, Dionne M / Lee, Theodore / Rosenblatt, Lisa / Emir, Birol / Keshishian, Allison / Yuce, Huseyin / Luo, Xuemei

Advances in therapy

2023 Volume 40, Issue 4, Page(s) 1705–1735

Abstract: Introduction: Patients at increased risk of bleeding and recurrent VTE who develop venous thromboembolism (VTE) present challenges for clinical management. This study evaluated the effectiveness and safety of apixaban vs warfarin in patients with VTE ... ...

Abstract	Introduction: Patients at increased risk of bleeding and recurrent VTE who develop venous thromboembolism (VTE) present challenges for clinical management. This study evaluated the effectiveness and safety of apixaban vs warfarin in patients with VTE who have risk factors for bleeding or recurrences. Methods: Adult patients with VTE initiating apixaban or warfarin were identified from five claims databases. Stabilized inverse probability treatment weighting (IPTW) was used to balance characteristics between cohorts for the main analysis. Subgroup interaction analyses were conducted to evaluate treatment effects among patients with and without each of the conditions that increased the risk of bleeding (thrombocytopenia and history of bleed) or recurrent VTE (thrombophilia, chronic liver disease, and immune-mediated disorders). Results: A total of 94,333 warfarin and 60,786 apixaban patients with VTE met selection criteria. After IPTW, all patient characteristics were balanced between cohorts. Apixaban (vs warfarin) patients were at lower risk of recurrent VTE (HR [95% confidence interval (CI) 0.72 [0.67-0.78]), major bleeding (MB) (HR [95% CI] 0.70 [0.64-0.76]), and clinically relevant non-major (CRNM) bleeding (HR [95% CI] 0.83 [0.80-0.86]). Subgroup analyses showed generally consistent findings with the overall analysis. For most subgroup analyses, there were no significant interactions between treatment and subgroup strata on VTE, MB and CRNM bleeding. Conclusion: Patients with prescription fills for apixaban had lower risk of recurrent VTE, MB, and CRNM bleeding compared with warfarin patients. Treatment effects of apixaban vs warfarin were generally consistent across subgroups of patients at increased risk of bleeding/recurrences.
MeSH term(s)	Adult ; Humans ; Warfarin/adverse effects ; Anticoagulants/adverse effects ; Venous Thromboembolism/drug therapy ; Hemorrhage/chemically induced ; Hemorrhage/drug therapy ; Pyridones/adverse effects ; Risk Factors
Chemical Substances	Warfarin (5Q7ZVV76EI) ; Anticoagulants ; apixaban (3Z9Y7UWC1J) ; Pyridones
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-023-02440-1
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