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  1. Article ; Online: Does Serum Creatinine Reflect Muscle Mass in Patients with Kidney Failure?

    Navaneethan, Sankar D / Mitch, William E

    Journal of the American Society of Nephrology : JASN

    2023  Volume 35, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Creatinine ; Kidney ; Renal Insufficiency/complications ; Muscles ; Glomerular Filtration Rate
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000270
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    Zs.A 3344: Show issues Location:
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  2. Article ; Online: Emerging strategies to reduce kidney function decline and improve cardiovascular outcomes.

    Ella, Krishiv / Navaneethan, Sankar D

    Current opinion in nephrology and hypertension

    2023  Volume 32, Issue 5, Page(s) 401–403

    MeSH term(s) Humans ; Kidney ; Cardiovascular Diseases/prevention & control ; Cardiovascular System ; Glomerular Filtration Rate ; Risk Factors ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  3. Article ; Online: Echocardiographic parameters and cardiovascular disease in Japanese- and US-based CKD cohorts.

    Walther, Carl P / Navaneethan, Sankar D

    Kidney international

    2023  Volume 103, Issue 5, Page(s) 837–839

    Abstract: Japanese and US populations have similar chronic kidney disease prevalence but differing clinical outcomes. A secondary analysis compared cardiovascular outcomes in a Japanese- and a US-based chronic kidney disease cohort and found that the US cohort had ...

    Abstract Japanese and US populations have similar chronic kidney disease prevalence but differing clinical outcomes. A secondary analysis compared cardiovascular outcomes in a Japanese- and a US-based chronic kidney disease cohort and found that the US cohort had markedly worse cardiovascular outcomes. Mediation analysis demonstrated that differences in left ventricular structure and function could explain most of the cardiovascular outcome difference. We examine and contextualize this finding and describe implications for precision nephrology and for population health.
    MeSH term(s) Humans ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/pathology ; East Asian People/statistics & numerical data ; Echocardiography/statistics & numerical data ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/ethnology ; Japan/epidemiology ; United States/epidemiology ; Cohort Studies
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  4. Article ; Online: Emerging evidence for glucagon-like peptide-1 agonists in slowing chronic kidney disease progression.

    Holliday, Michael W / Frost, Livia / Navaneethan, Sankar D

    Current opinion in nephrology and hypertension

    2024  Volume 33, Issue 3, Page(s) 331–336

    Abstract: Purpose of review: Diabetic kidney disease continues to increase, and several novel therapeutic agents have been shown to slow the progression of chronic kidney disease in those with diabetes. This review summarizes more recent data on the role of ... ...

    Abstract Purpose of review: Diabetic kidney disease continues to increase, and several novel therapeutic agents have been shown to slow the progression of chronic kidney disease in those with diabetes. This review summarizes more recent data on the role of glucagon-like peptide-1 (GLP-1) receptor agonists and kidney outcomes.
    Recent findings: Posthoc analysis of cardiovascular outcome trials, as well as several retrospective studies, demonstrate benefits of GLP-1 receptor agonist therapy for chronic kidney disease progression in diabetics. Although limited randomized clinical trials evidence assessing the effects of GLP-1 receptor agonists on kidney outcomes in diabetic chronic kidney disease patients have been published, FLOW-CKD trial was halted based on interim data for efficacy, and results are awaited.
    Summary: GLP-1 receptor agonism is a promising therapy for slowing the progression of diabetic chronic kidney disease. Recent studies support kidney benefits GLP-1 receptor agonists over insulin and dipeptidyl peptidase-4-inhibitors, and the FLOW-CKD trial would inform the potential benefits for reducing the need for dialysis and kidney-disease related mortality in those with kidney disease.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/drug therapy ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/agonists ; Hypoglycemic Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Renal Dialysis ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/chemically induced ; Retrospective Studies
    Chemical Substances Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  5. Article ; Online: Editorial: Advancements in the management of kidney disease and electrolyte derangements.

    Holliday, Michael W / Navaneethan, Sankar D

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 5, Page(s) 395–398

    MeSH term(s) Electrolytes ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy
    Chemical Substances Electrolytes
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Editorial
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trials and Tribulations in Studying Kidney Outcomes With Intentional Weight Loss.

    Navaneethan, Sankar D

    Circulation

    2019  Volume 139, Issue 3, Page(s) 376–379

    MeSH term(s) Benzazepines ; Camellia ; Humans ; Obesity ; Overweight ; Weight Loss
    Chemical Substances Benzazepines ; lorcaserin (637E494O0Z)
    Language English
    Publishing date 2019-01-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.038677
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    Ui IV Zs.60: Show issues Location:
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  7. Article ; Online: Steroidal or non-steroidal MRAs: should we still enable RAASi use through K binders?

    Gregg, L Parker / Navaneethan, Sankar D

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 38, Issue 6, Page(s) 1355–1365

    Abstract: Renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs) are important interventions to improve outcomes in patients with chronic kidney disease and heart failure, but their use is limited in some patients ...

    Abstract Renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs) are important interventions to improve outcomes in patients with chronic kidney disease and heart failure, but their use is limited in some patients by the development of hyperkalemia. The risk of hyperkalemia may differ between agents, with one trial showing lower risk of hyperkalemia with the novel non-steroidal MRA finerenone compared with steroidal MRA spironolactone. Novel potassium binders, including patiromer and sodium zirconium cyclosilicate, are available interventions to manage hyperkalemia and enable continuation of RAASi and MRAs in patients who could benefit from these treatments. These agents bind free potassium ions in the lumen of the gastrointestinal tract to prevent the absorption of dietary potassium and increase potassium secretion. Several studies showed that potassium binders are effective compared with placebo for preventing hyperkalemia or steroidal MRA discontinuation, but none has evaluated whether this strategy impacts clinically important endpoints such as cardiovascular events. Due to this and other limitations related to cost, clinical availability, pill burden and patient selection, alternative potential strategies to mitigate hyperkalemia may be more practical. Conservative strategies include increased monitoring and use of loop or thiazide diuretics to increase urinary potassium excretion. Non-steroidal MRAs may have a lower risk of hyperkalemia than steroidal MRAs and have stronger anti-inflammatory and anti-fibrotic effects with resultant reduced risk of kidney disease progression. Sodium-glucose cotransporter-2 inhibitors also decrease hyperkalemia risk in patients on MRAs and decrease cardiovascular events and kidney disease progression. These may be better first-line interventions to obviate the need for potassium binders and offer additional benefits.
    MeSH term(s) Humans ; Disease Progression ; Heart Failure/drug therapy ; Hyperkalemia/chemically induced ; Hyperkalemia/drug therapy ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Potassium ; Renal Insufficiency, Chronic/drug therapy ; Renin-Angiotensin System ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Steroids/pharmacology
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Potassium (RWP5GA015D) ; Sodium-Glucose Transporter 2 Inhibitors ; Steroids
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac284
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  8. Article ; Online: Considerations in the Study of Body Mass Index Variability.

    Gregg, L Parker / Navaneethan, Sankar D

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 10, Page(s) 2395–2397

    MeSH term(s) Body Mass Index ; Humans ; Obesity/epidemiology ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021060844
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  9. Article ; Online: Moving Beyond Tools and Building Bridges: Lessons Learned From a CKD Decision Support in Primary Care.

    Joshi, Priya / Navaneethan, Sankar D / Estrella, Michelle M

    Kidney medicine

    2022  Volume 4, Issue 7, Page(s) 100497

    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Editorial
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2022.100497
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  10. Article ; Online: Are All SGLT2 Inhibitors Created Equal?

    Gregg, L Parker / Navaneethan, Sankar D

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 9, Page(s) 1309–1311

    MeSH term(s) Humans ; Hypoglycemic Agents/adverse effects ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2021-09-04
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.09720721
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    Zs.A 6584: Show issues Location:
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