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Article ; Online: Is exercise becoming a danger for our health? The complex relationship between exercise and atrial fibrillation.

Seccia, Teresa M / Calò, Lorenzo A

European journal of preventive cardiology

2018 Volume 25, Issue 6, Page(s) 621–623

MeSH term(s)	Atrial Fibrillation ; Exercise ; Exercise Tolerance ; Humans
Language	English
Publishing date	2018-02-28
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487318762445
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Article ; Online: Smoking causes atrial fibrillation? Further evidence on a debated issue.

Seccia, Teresa M / Calò, Lorenzo A

European journal of preventive cardiology

2018 Volume 25, Issue 13, Page(s) 1434–1436

MeSH term(s)	Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Global Health ; Heart Conduction System/physiopathology ; Humans ; Incidence ; Middle Aged ; Prevalence ; Risk Factors ; Smoking/adverse effects
Language	English
Publishing date	2018-07-30
Publishing country	England
Document type	Editorial
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487318791272
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Article ; Online: Endothelin-1-induced endothelial mesenchimal transition via endothelin type B receptor stimulation: implication for chronic kidney disease.

Seccia, Teresa M / Calò, Lorenzo A

Journal of hypertension

2017 Volume 35, Issue 6, Page(s) 1329–1330

Language	English
Publishing date	2017-06
Publishing country	England
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000001344
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Challenges in the evaluation of endothelial cell dysfunction: a statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors.

Rossi, Gian Paolo / Barton, Matthias / Dhaun, Neeraj / Rizzoni, Damiano / Seccia, Teresa M

Journal of hypertension

2022 Volume 41, Issue 3, Page(s) 369–379

Abstract: Endothelial cell function is mediated by different mechanisms in different vascular beds. Moreover, in humans, endothelial cell dysfunction triggers and accelerates the progression of cardiovascular and chronic kidney diseases. Progression of such ... ...

Abstract	Endothelial cell function is mediated by different mechanisms in different vascular beds. Moreover, in humans, endothelial cell dysfunction triggers and accelerates the progression of cardiovascular and chronic kidney diseases. Progression of such diseases can be in part mitigated by the control of cardiovascular risk factors and drugs targeting different systems, including endothelin receptor antagonists (ERAs), renin-angiotensin aldosterone antagonists and agents affecting glucose metabolism, all of which were shown to improve endothelial cell function. In recent years, the microRNAs, which are endogenous regulators of gene expression, have been identified as transmitters of information from endothelial cells to vascular smooth muscle cells, suggesting that they can entail tools to assess the endothelial cell dysfunction in arterial hypertension and target for pharmacologic intervention. This article critically reviews current challenges and limitations of available techniques for the invasive and noninvasive assessment of endothelial cell function, and also discusses therapeutic aspects as well as directions for future research in the areas of endothelial cell biology and pathophysiology in humans.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Hypertension ; Endothelins/metabolism ; Endothelins/therapeutic use ; Renal Insufficiency, Chronic ; Endothelium, Vascular ; Endothelin-1/metabolism
Chemical Substances	Endothelins ; Endothelin-1
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003314
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Adrenal Venous Sampling: Where Do We Stand?

Rossi, Gian Paolo / Maiolino, Giuseppe / Seccia, Teresa M

Endocrinology and metabolism clinics of North America

2019 Volume 48, Issue 4, Page(s) 843–858

Abstract: Adrenal venous sampling is the gold standard test to identify surgically curable primary aldosteronism, but it is markedly underused in clinical practice being perceived as a technically challenging and invasive procedure and, moreover, as difficult to ... ...

Abstract	Adrenal venous sampling is the gold standard test to identify surgically curable primary aldosteronism, but it is markedly underused in clinical practice being perceived as a technically challenging and invasive procedure and, moreover, as difficult to interpret. This review provides updated information on current indications to adrenal venous sampling and how to perform and interpret adrenal venous sampling.
MeSH term(s)	Adrenal Glands/blood supply ; Adrenal Glands/metabolism ; Adrenalectomy/methods ; Adrenalectomy/standards ; Aldosterone/blood ; Blood Chemical Analysis/methods ; Blood Chemical Analysis/standards ; Humans ; Hyperaldosteronism/blood ; Hyperaldosteronism/diagnosis ; Procedures and Techniques Utilization/standards ; Veins
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2019-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2019.08.012
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Article: ROCK (RhoA/Rho Kinase) in Cardiovascular-Renal Pathophysiology: A Review of New Advancements.

Seccia, Teresa M / Rigato, Matteo / Ravarotto, Verdiana / Calò, Lorenzo A

Journal of clinical medicine

2020 Volume 9, Issue 5

Abstract: Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC ... ...

Abstract	Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of proteins such as MYPT-1, thereby regulating many key cellular functions including proliferation, motility and viability and the RhoA/ROCK signaling has been shown to be deeply involved in arterial hypertension, cardiovascular-renal remodeling, hypertensive nephropathy and posttransplant hypertension. Given the deep involvement of ROCK in cardiovascular-renal pathophysiology and the interaction of ROCK signaling with other signaling pathways, the reports of trials on the clinical beneficial effects of ROCK's pharmacologic targeting are growing. In this current review, we provide a brief survey of the current understanding of ROCK-signaling pathways, also integrating with the more novel data that overall support a relevant role of ROCK for the cardiovascular-renal physiology and pathophysiology.
Language	English
Publishing date	2020-05-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9051328
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Article ; Online: Role of estrogen receptors in modulating aldosterone biosynthesis and blood pressure.

Rossi, Gian Paolo / Caroccia, Brasilina / Seccia, Teresa M

Steroids

2019 Volume 152, Page(s) 108486

Abstract: Blood pressure is lower in premenopausal women than in age-matched men; after menopause blood pressure values and the prevalence of hypertension show opposite trends indicating that estrogens contribute to maintaining normal blood pressure values in ... ...

Abstract	Blood pressure is lower in premenopausal women than in age-matched men; after menopause blood pressure values and the prevalence of hypertension show opposite trends indicating that estrogens contribute to maintaining normal blood pressure values in women. In experimental studies menopause increases aldosterone levels, an effect alleviated by estrogen treatment. We have recently discovered a role of estrogen receptors (ER) in controlling aldosterone biosynthesis in the human adrenocortical zona glomerulosa, which expresses both the classical ERα and β receptors and G protein-coupled estrogen receptor (GPER). We have also identified that GPER mediates an aldosterone-induced aldosterone response. We found that 17 β-estradiol exerts a dual effect: it blunts aldosterone production via ERβ, but displays a potent aldosterone secretagogue effect via GPER activation after ERβ blockade. Thus, in premenopausal women high estrogen levels might tonically blunt aldosterone synthesis via ERβ, thereby maintaining normal blood pressure; after menopause loss of this estrogen-mediated inhibition can contribute to increasing blood pressure via GPER-mediated aldosterone release. The additional findings that GPER mediates an aldosterone-induced stimulation of aldosterone biosynthesis and that GPER predominates in aldosterone-producing adenomas strongly involves this receptor in the pathophysiology of primary aldosteronism. Our purpose here was to provide an update on estrogen receptor function in the normal adrenal cortex and its relevance for the sex differences in blood pressure in light of the newly discovered role of GPER in regulating aldosterone synthesis. The implications of the novel knowledge for the treatment of estrogen-dependent malignancies with ER modulators are also discussed.
MeSH term(s)	Aldosterone/biosynthesis ; Aldosterone/chemistry ; Aldosterone/pharmacology ; Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Humans ; Receptors, Estrogen/metabolism
Chemical Substances	Receptors, Estrogen ; Aldosterone (4964P6T9RB)
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2019.108486
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Zs.A 87: Show issues

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Article ; Online: Disease monitoring of Primary Aldosteronism.

Rossi, Gian Paolo / Cesari, Maurizio / Lenzini, Livia / Seccia, Teresa M

Best practice & research. Clinical endocrinology & metabolism

2020 Volume 34, Issue 2, Page(s) 101417

Abstract: Primary aldosteronism (PA) is a highly prevalent cause of arterial hypertension featuring excess cardiovascular events. A timely diagnosis and treatment of PA cures hyperaldosteronism and can provide resolution or improvement of arterial hypertension, ... ...

Abstract	Primary aldosteronism (PA) is a highly prevalent cause of arterial hypertension featuring excess cardiovascular events. A timely diagnosis and treatment of PA cures hyperaldosteronism and can provide resolution or improvement of arterial hypertension, even when the latter is resistant to drug treatment. Accordingly, strategies to screen early and widely the hypertensive patients for PA by means of simplified diagnostic algorithms are justified. Such strategies are particularly beneficial in subgroups of hypertensive patients, who are at the highest cardiovascular risk. Broadening of screening strategies means facing with an increased number of patients where monitoring the disease becomes necessary. Hence, after identification of the surgically and non surgically curable cases of PA and implementation of targeted treatment physicians are faced with the challenges of follow-up, which are scantly discussed in the literature. Hence, the purpose of this paper is to provide some recommendations on how to optimize the monitoring of patients in whom the PA subtype has been diagnosed and treatment, either with unilateral laparoscopic adrenalectomy or medically, has been instituted.
MeSH term(s)	Adrenalectomy/adverse effects ; Diagnostic Techniques, Endocrine/trends ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology ; Hyperaldosteronism/therapy ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/etiology ; Mass Screening/methods ; Mass Screening/trends ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/trends ; Prevalence
Language	English
Publishing date	2020-03-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2020.101417
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Article ; Online: The Key Role of Epithelial to Mesenchymal Transition (EMT) in Hypertensive Kidney Disease.

Seccia, Teresa M / Caroccia, Brasilina / Piazza, Maria / Rossi, Gian Paolo

International journal of molecular sciences

2019 Volume 20, Issue 14

Abstract: Accumulating evidence indicates that epithelial-to-mesenchymal transition (EMT), originally described as a key process for organ development and metastasis budding in cancer, plays a key role in the development of renal fibrosis in several diseases, ... ...

Abstract	Accumulating evidence indicates that epithelial-to-mesenchymal transition (EMT), originally described as a key process for organ development and metastasis budding in cancer, plays a key role in the development of renal fibrosis in several diseases, including hypertensive nephroangiosclerosis. We herein reviewed the concept of EMT and its role in renal diseases, with particular focus on hypertensive kidney disease, the second leading cause of end-stage renal disease after diabetes mellitus. After discussing the pathophysiology of hypertensive nephropathy, the 'classic' view of hypertensive nephrosclerosis entailing hyalinization, and sclerosis of interlobular and afferent arterioles, we examined the changes occurring in the glomerulus and tubulo-interstitium and the studies that investigated the role of EMT and its molecular mechanisms in hypertensive kidney disease. Finally, we examined the reasons why some studies failed to provide solid evidence for renal EMT in hypertension.
MeSH term(s)	Angiotensin II/metabolism ; Animals ; Biomarkers ; Disease Susceptibility ; Endothelins/metabolism ; Epithelial-Mesenchymal Transition ; Fibrosis ; Humans ; Hypertension/complications ; Hypertension, Renal/etiology ; Hypertension, Renal/metabolism ; Hypertension, Renal/pathology ; Nephritis/etiology ; Nephritis/metabolism ; Nephritis/pathology
Chemical Substances	Biomarkers ; Endothelins ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2019-07-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20143567
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Article ; Online: ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology

Teresa M. Seccia / Matteo Rigato / Verdiana Ravarotto / Lorenzo A. Calò

Journal of Clinical Medicine, Vol 9, Iss 1328, p

A Review of New Advancements

2020 Volume 1328

Abstract	Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of proteins such as MYPT-1, thereby regulating many key cellular functions including proliferation, motility and viability and the RhoA/ROCK signaling has been shown to be deeply involved in arterial hypertension, cardiovascular–renal remodeling, hypertensive nephropathy and posttransplant hypertension. Given the deep involvement of ROCK in cardiovascular–renal pathophysiology and the interaction of ROCK signaling with other signaling pathways, the reports of trials on the clinical beneficial effects of ROCK’s pharmacologic targeting are growing. In this current review, we provide a brief survey of the current understanding of ROCK-signaling pathways, also integrating with the more novel data that overall support a relevant role of ROCK for the cardiovascular–renal physiology and pathophysiology.
Keywords	cardiovascular remodeling ; kidney remodeling ; ROCK ; Rho ; Rho kinase ; hypertension ; Medicine ; R
Subject code	571
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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