Article ; Online: Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression.
iScience
2024 Volume 27, Issue 3, Page(s) 109187
Abstract: ... transcription factor IRF8, impairing anti-metastatic activity in models of metastatic breast cancer. G-CSF is a key ...
Abstract | Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic sites, yet their functional contributions to metastasis remain incompletely understood. Here, we show that alveolar macrophages (AMs), the main TRMs of the lung, are susceptible to downregulation of the immune stimulatory transcription factor IRF8, impairing anti-metastatic activity in models of metastatic breast cancer. G-CSF is a key tumor-associated factor (TAF) that acts upon AMs to reduce IRF8 levels and facilitate metastasis. Translational relevance of IRF8 downregulation was observed among macrophage precursors in breast cancer and a |
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Language | English |
Publishing date | 2024-02-10 |
Publishing country | United States |
Document type | Journal Article |
ISSN | 2589-0042 |
ISSN (online) | 2589-0042 |
DOI | 10.1016/j.isci.2024.109187 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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